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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dihydrofolic acid
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Accession:CHEBI:15633 term browser browse the term
Definition:A folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis.
Synonyms:related_synonym: 7,8-Dihydrofolate;   7,8-Dihydrofolic acid;   7,8-Dihydropteroylglutamate;   Dihydrofolate;   Formula=C19H21N7O6;   InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1;   InChIKey=OZRNSSUDZOLUSN-LBPRGKRZSA-N;   N-(4-{[(2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid;   N-(7,8-dihydropteroyl)-L-glutamic acid;   SMILES=Nc1nc2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=Nc2c(=O)[nH]1
 alt_id: CHEBI:12245;   CHEBI:14150;   CHEBI:20768;   CHEBI:42000;   CHEBI:4564
 xref: CAS:4033-27-6;   DrugBank:DB02015;   KEGG:C00415;   KNApSAcK:C00007248
 xref_mesh: MESH:C010920
 cyclic_relationship: is_conjugate_acid_of CHEBI:57451

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dihydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase increases activity EXP Dihydrofolic acid increases activity of purified Hmbs protein RGD PMID:593266 RGD:26884337 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO dihydrofolate results in decreased expression of IGF1R mRNA CTD PMID:16728583 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO dihydrofolate results in decreased activity of NAT1 protein CTD PMID:16003948 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO dihydrofolate results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity
EXP dihydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
dihydrofolate results in decreased activity of SLC19A1 protein
CTD PMID:14612385 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            prokaryotic metabolite 18356
              bacterial metabolite 18356
                Escherichia coli metabolite 18260
                  dihydrofolic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        amino acid 14072
                                          alpha-amino acid 11539
                                            L-alpha-amino acid 11374
                                              glutamine family amino acid 10243
                                                L-glutamic acid 10190
                                                  L-glutamic acid derivative 9354
                                                    folic acids 9354
                                                      dihydrofolic acids 5
                                                        dihydrofolic acid 5
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