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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dihydrofolic acid
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Accession:CHEBI:15633 term browser browse the term
Definition:A folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis.
Synonyms:related_synonym: 7,8-Dihydrofolate;   7,8-Dihydrofolic acid;   7,8-Dihydropteroylglutamate;   Dihydrofolate;   Formula=C19H21N7O6;   InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1;   InChIKey=OZRNSSUDZOLUSN-LBPRGKRZSA-N;   N-(4-{[(2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid;   N-(7,8-dihydropteroyl)-L-glutamic acid;   SMILES=Nc1nc2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=Nc2c(=O)[nH]1
 alt_id: CHEBI:12245;   CHEBI:14150;   CHEBI:20768;   CHEBI:42000;   CHEBI:4564
 xref: CAS:4033-27-6;   DrugBank:DB02015;   KEGG:C00415;   KNApSAcK:C00007248
 xref_mesh: MESH:C010920
 cyclic_relationship: is_conjugate_acid_of CHEBI:57451

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dihydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase increases activity EXP Dihydrofolic acid increases activity of purified Hmbs protein RGD PMID:593266 RGD:26884337 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO dihydrofolate results in decreased expression of IGF1R mRNA CTD PMID:16728583 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO dihydrofolate results in decreased activity of NAT1 protein CTD PMID:16003948 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO dihydrofolate results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity
EXP dihydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
dihydrofolate results in decreased activity of SLC19A1 protein
CTD PMID:14612385 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        biochemical role 19377
          metabolite 19352
            prokaryotic metabolite 18418
              bacterial metabolite 18418
                Escherichia coli metabolite 18307
                  dihydrofolic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      carboxylic acid 18361
                                        amino acid 14876
                                          alpha-amino acid 12852
                                            L-alpha-amino acid 11558
                                              glutamine family amino acid 10266
                                                L-glutamic acid 10211
                                                  L-glutamic acid derivative 9372
                                                    folic acids 9372
                                                      dihydrofolic acids 5
                                                        dihydrofolic acid 5
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