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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(2S)-flavanone
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Accession:CHEBI:15606 term browser browse the term
Definition:The (S)-enantiomer of flavanone.
Synonyms:exact_synonym: (2S)-2-phenyl-2,3-dihydro-4H-chromen-4-one
 related_synonym: Formula=C15H12O2;   InChI=1S/C15H12O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-9,15H,10H2/t15-/m0/s1;   InChIKey=ZONYXWQDUYMKFB-HNNXBMFYSA-N;   SMILES=O=C1C[C@H](Oc2ccccc12)c1ccccc1
 alt_id: CHEBI:10868;   CHEBI:18547;   CHEBI:18549;   CHEBI:188
 xref: Beilstein:5379356;   Beilstein:85288;   KEGG:C02099;   Reaxys:85288
 cyclic_relationship: is_enantiomer_of CHEBI:36105


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kurarinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO kurarinol results in decreased expression of BCL2L1 mRNA; kurarinol results in decreased expression of BCL2L1 protein
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]
CTD PMID:24997323 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO kurarinol results in increased activity of CASP3 protein
STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
CTD PMID:24997323 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO kurarinol results in decreased expression of CCND1 protein CTD PMID:24997323 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO kurarinol results in decreased expression of MCL1 mRNA; kurarinol results in decreased expression of MCL1 protein CTD PMID:24997323 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]; STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
kurarinol results in decreased phosphorylation of STAT3 protein
CTD PMID:24997323 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
sophoranone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO sophoranone results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO sophoranone results in decreased activity of CYP2D6 protein CTD PMID:29753067 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO sophoranone results in decreased activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          oxygen atom 19445
            oxygen molecular entity 19445
              flavonoids 11135
                flavonoid 6513
                  flavans 3017
                    flavanones 320
                      flavanone 54
                        (2S)-flavanone 8
                          (2S)-(-)-kurarinone + 0
                          (2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanone 0
                          (2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone 0
                          (2S)-5,7-dihydroxy-6,8-dimethylflavanone 0
                          (2S)-5-Hydroxy-7-methoxy-8-[(E)-3-oxo-1-butenyl]flavanone 0
                          (2S)-5-hydroxy-7-methoxy-6,8-dimethylflavanone 0
                          (2S)-6-formyl-8-methyl-7-O-methylpinocembrin 0
                          (2S)-7,4'-dihydroxy-8-geranylflavanone 0
                          (2S)-7-hydroxy-5-methoxy-8-methylflavanone 0
                          (2S)-7-hydroxyflavanone 0
                          (S)-2-(3,5-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(3-methylbut-2-enyl)chroman-4-one 0
                          (S)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one 0
                          5,7,3'-trihydroxy-4',5'-(2'''',2''''-dimethylpyran)-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                          5,7,3'-trihydroxy-4'-methoxy-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                          erylatissin C 0
                          exiguaflavanone A 0
                          exiguaflavanone B 0
                          glepidotin B 0
                          isonymphaeol B 0
                          kurarinol 5
                          leachianone A 0
                          lespeflorin B2 0
                          lespeflorin B3 0
                          lespeflorin B4 0
                          matteucinol + 0
                          monotesone A 0
                          pinostrobin 0
                          pisonivanol 0
                          pisonivanone 0
                          plantagoside 0
                          sigmoidin A 0
                          sigmoidin B 0
                          sophoranone 3
                          strobopinin 0
                          tephrocandidin A 0
                          tephrocandidin B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  oxacycle 17587
                                    benzopyran 10402
                                      1-benzopyran 10129
                                        flavonoid 6513
                                          flavans 3017
                                            flavanones 320
                                              flavanone 54
                                                (2S)-flavanone 8
                                                  (2S)-(-)-kurarinone + 0
                                                  (2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanone 0
                                                  (2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone 0
                                                  (2S)-5,7-dihydroxy-6,8-dimethylflavanone 0
                                                  (2S)-5-Hydroxy-7-methoxy-8-[(E)-3-oxo-1-butenyl]flavanone 0
                                                  (2S)-5-hydroxy-7-methoxy-6,8-dimethylflavanone 0
                                                  (2S)-6-formyl-8-methyl-7-O-methylpinocembrin 0
                                                  (2S)-7,4'-dihydroxy-8-geranylflavanone 0
                                                  (2S)-7-hydroxy-5-methoxy-8-methylflavanone 0
                                                  (2S)-7-hydroxyflavanone 0
                                                  (S)-2-(3,5-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(3-methylbut-2-enyl)chroman-4-one 0
                                                  (S)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one 0
                                                  5,7,3'-trihydroxy-4',5'-(2'''',2''''-dimethylpyran)-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                                                  5,7,3'-trihydroxy-4'-methoxy-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                                                  erylatissin C 0
                                                  exiguaflavanone A 0
                                                  exiguaflavanone B 0
                                                  glepidotin B 0
                                                  isonymphaeol B 0
                                                  kurarinol 5
                                                  leachianone A 0
                                                  lespeflorin B2 0
                                                  lespeflorin B3 0
                                                  lespeflorin B4 0
                                                  matteucinol + 0
                                                  monotesone A 0
                                                  pinostrobin 0
                                                  pisonivanol 0
                                                  pisonivanone 0
                                                  plantagoside 0
                                                  sigmoidin A 0
                                                  sigmoidin B 0
                                                  sophoranone 3
                                                  strobopinin 0
                                                  tephrocandidin A 0
                                                  tephrocandidin B 0
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