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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(2S)-flavanone
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Accession:CHEBI:15606 term browser browse the term
Definition:The (S)-enantiomer of flavanone.
Synonyms:exact_synonym: (2S)-2-phenyl-2,3-dihydro-4H-chromen-4-one
 related_synonym: Formula=C15H12O2;   InChI=1S/C15H12O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-9,15H,10H2/t15-/m0/s1;   InChIKey=ZONYXWQDUYMKFB-HNNXBMFYSA-N;   SMILES=O=C1C[C@H](Oc2ccccc12)c1ccccc1
 alt_id: CHEBI:10868;   CHEBI:18547;   CHEBI:18549;   CHEBI:188
 xref: Beilstein:5379356;   Beilstein:85288;   KEGG:C02099;   Reaxys:85288
 cyclic_relationship: is_enantiomer_of CHEBI:36105


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kurarinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO kurarinol results in decreased expression of BCL2L1 mRNA; kurarinol results in decreased expression of BCL2L1 protein
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]
CTD PMID:24997323 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO kurarinol results in increased activity of CASP3 protein
STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
CTD PMID:24997323 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO kurarinol results in decreased expression of CCND1 protein CTD PMID:24997323 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO kurarinol results in decreased expression of MCL1 mRNA; kurarinol results in decreased expression of MCL1 protein CTD PMID:24997323 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]; STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
kurarinol results in decreased phosphorylation of STAT3 protein
CTD PMID:24997323 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
sophoranone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO sophoranone results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO sophoranone results in decreased activity of CYP2D6 protein CTD PMID:29753067 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19769
      atom 19768
        nonmetal atom 19642
          oxygen atom 19320
            oxygen molecular entity 19320
              flavonoids 10478
                flavonoid 6351
                  flavans 2970
                    flavanones 299
                      flavanone 53
                        (2S)-flavanone 7
                          (2S)-(-)-kurarinone + 0
                          (2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanone 0
                          (2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone 0
                          (2S)-5,7-dihydroxy-6,8-dimethylflavanone 0
                          (2S)-5-Hydroxy-7-methoxy-8-[(E)-3-oxo-1-butenyl]flavanone 0
                          (2S)-5-hydroxy-7-methoxy-6,8-dimethylflavanone 0
                          (2S)-6-formyl-8-methyl-7-O-methylpinocembrin 0
                          (2S)-7,4'-dihydroxy-8-geranylflavanone 0
                          (2S)-7-hydroxy-5-methoxy-8-methylflavanone 0
                          (2S)-7-hydroxyflavanone 0
                          (S)-2-(3,5-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(3-methylbut-2-enyl)chroman-4-one 0
                          (S)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one 0
                          5,7,3'-trihydroxy-4',5'-(2'''',2''''-dimethylpyran)-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                          5,7,3'-trihydroxy-4'-methoxy-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                          erylatissin C 0
                          exiguaflavanone A 0
                          exiguaflavanone B 0
                          glepidotin B 0
                          isonymphaeol B 0
                          kurarinol 5
                          leachianone A 0
                          lespeflorin B2 0
                          lespeflorin B3 0
                          lespeflorin B4 0
                          matteucinol + 0
                          monotesone A 0
                          pinostrobin 0
                          pisonivanol 0
                          pisonivanone 0
                          plantagoside 0
                          sigmoidin A 0
                          sigmoidin B 0
                          sophoranone 2
                          strobopinin 0
                          tephrocandidin A 0
                          tephrocandidin B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic molecule 19461
                              organic cyclic compound 19232
                                organic heterocyclic compound 18404
                                  oxacycle 17170
                                    benzopyran 10121
                                      1-benzopyran 9836
                                        flavonoid 6351
                                          flavans 2970
                                            flavanones 299
                                              flavanone 53
                                                (2S)-flavanone 7
                                                  (2S)-(-)-kurarinone + 0
                                                  (2S)-2,7-dihydroxy-5-methoxy-6,8-dimethylflavanone 0
                                                  (2S)-5,7,3',5'-tetrahydroxy-8-[3'',8''-dimethylocta-2''(E),7''-dienyl]flavonone 0
                                                  (2S)-5,7-dihydroxy-6,8-dimethylflavanone 0
                                                  (2S)-5-Hydroxy-7-methoxy-8-[(E)-3-oxo-1-butenyl]flavanone 0
                                                  (2S)-5-hydroxy-7-methoxy-6,8-dimethylflavanone 0
                                                  (2S)-6-formyl-8-methyl-7-O-methylpinocembrin 0
                                                  (2S)-7,4'-dihydroxy-8-geranylflavanone 0
                                                  (2S)-7-hydroxy-5-methoxy-8-methylflavanone 0
                                                  (2S)-7-hydroxyflavanone 0
                                                  (S)-2-(3,5-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(3-methylbut-2-enyl)chroman-4-one 0
                                                  (S)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one 0
                                                  5,7,3'-trihydroxy-4',5'-(2'''',2''''-dimethylpyran)-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                                                  5,7,3'-trihydroxy-4'-methoxy-8,2'-di(3-methyl-2-butenyl)-(2S)-flavanone 0
                                                  erylatissin C 0
                                                  exiguaflavanone A 0
                                                  exiguaflavanone B 0
                                                  glepidotin B 0
                                                  isonymphaeol B 0
                                                  kurarinol 5
                                                  leachianone A 0
                                                  lespeflorin B2 0
                                                  lespeflorin B3 0
                                                  lespeflorin B4 0
                                                  matteucinol + 0
                                                  monotesone A 0
                                                  pinostrobin 0
                                                  pisonivanol 0
                                                  pisonivanone 0
                                                  plantagoside 0
                                                  sigmoidin A 0
                                                  sigmoidin B 0
                                                  sophoranone 2
                                                  strobopinin 0
                                                  tephrocandidin A 0
                                                  tephrocandidin B 0
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