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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:GSK2181236A
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Accession:CHEBI:155824 term browser browse the term
Definition:A biphenyl that is 1,1'-biphenyl substituted by a methyl group at position 3, a (2-{6-[4-carboxy-5-(trifluoromethyl)-1H-pyrazol-1-yl]pyridin-2-yl}phenoxy)methyl group at position 4 and by a trifluoromethoxy at position 4'. It is a potent guanylate cyclase activator.
Synonyms:exact_synonym: 1-[6-(2-{[3-methyl-4'-(trifluoromethoxy)[biphenyl]-4-yl]methoxy}phenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
 related_synonym: 1-(6-{2-[({3-methyl-4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)oxy]phenyl}-2-pyridinyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid;   Formula=C31H21F6N3O4;   GSK 2181236A;   InChI=1S/C31H21F6N3O4/c1-18-15-20(19-11-13-22(14-12-19)44-31(35,36)37)9-10-21(18)17-43-26-7-3-2-5-23(26)25-6-4-8-27(39-25)40-28(30(32,33)34)24(16-38-40)29(41)42/h2-16H,17H2,1H3,(H,41,42);   InChIKey=YNDMDCJWXXDPFE-UHFFFAOYSA-N;   SMILES=C=1C=C(C=CC1C=2C=CC(=C(C2)C)COC=3C=CC=CC3C=4N=C(C=CC4)N5C(=C(C=N5)C(O)=O)C(F)(F)F)OC(F)(F)F
 xref: CAS:1160426-89-0;   PMID:22783192;   PMID:25302549;   PMID:25645316;   PMID:27853261



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GSK2181236A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle decreases expression EXP GSK2181236A decreases expression of Acta1 mRNA in rat myocardium RGD PMID:22783192 RGD:25824851 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
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G Nppa natriuretic peptide A decreases expression EXP GSK2181236A decreases expression of Nppa mRNA in rat myocardium RGD PMID:22783192 RGD:25824851 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link

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  CHEBI ontology 19659
    role 19634
      biological role 19633
        biochemical role 19388
          effector 124
            soluble guanylate cyclase activator 11
              GSK2181236A 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic molecule 19506
                              organic cyclic compound 19324
                                organic heterocyclic compound 18682
                                  heteroarene 16681
                                    monocyclic heteroarene 14210
                                      azole 13579
                                        diazole 8624
                                          pyrazoles 2303
                                            GSK2181236A 2
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