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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:15-oxo-ETE
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Accession:CHEBI:15559 term browser browse the term
Definition:An oxoicosatetraenoic acid having (5Z,8Z,11Z,13E) double bond stereochemistry, and an oxo group in position 15.
Synonyms:related_synonym: (5Z,8Z,11Z,13E)-15-Oxoicosa-5,8,11,13-tetraenoic acid;   (5Z,8Z,11Z,13E)-15-ketoeicosa-5,8,11,13-tetraenoic acid;   (5Z,8Z,11Z,13E)-15-oxo-5,8,11,13-eicosatetraenoic acid;   (5Z,8Z,11Z,13E)-15-oxoeicosa-5,8,11,13-tetraenoic acid;   15-Kete;   15-Oxo-5,8,11-cis-13-trans-eicosatetraenoate;   15-OxoETE;   Formula=C20H30O3;   InChI=1S/C20H30O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+;   InChIKey=YGJTUEISKATQSM-USWFWKISSA-N;   SMILES=CCCCCC(=O)\\C=C\\C=C/C\\C=C/C\\C=C/CCCC(O)=O
 alt_id: CHEBI:11326;   CHEBI:19155;   CHEBI:761
 xref: CAS:81416-72-0;   HMDB:HMDB0010210;   KEGG:C04577;   LIPID_MAPS_instance:LMFA03060051
 xref_mesh: MESH:C054992
 xref: PMID:17459323;   PMID:17910482;   PMID:19535459;   PMID:23945567;   Reaxys:6217055
 cyclic_relationship: is_conjugate_acid_of CHEBI:57410


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15-oxo-ETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMOX1 heme oxygenase 1 increases expression EXP 15-keto-5,8,11,13-eicosatetraenoic acid results in increased expression of HMOX1 protein CTD PMID:25450232 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
decreases activity		 EXP [15-keto-5,8,11,13-eicosatetraenoic acid results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein CTD PMID:25450232 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP 15-keto-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:25450232 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP 15-keto-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:25450232 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP [15-keto-5,8,11,13-eicosatetraenoic acid results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein CTD PMID:25450232 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP 15-keto-5,8,11,13-eicosatetraenoic acid results in increased expression of NQO1 protein CTD PMID:25450232 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G TNF tumor necrosis factor decreases expression
multiple interactions		 EXP 15-keto-5,8,11,13-eicosatetraenoic acid results in decreased expression of TNF mRNA
15-keto-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]		 CTD PMID:25450232 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    chemical entity 26020
      atom 26016
        nonmetal atom 25505
          carbon atom 25399
            organic molecular entity 25399
              olefinic compound 18231
                olefinic fatty acid 802
                  oxoicosatetraenoic acid 8
                    15-oxo-ETE 7
                      15-oxo-ETE-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            heteroorganic entity 24773
                              organochalcogen compound 24384
                                organooxygen compound 24061
                                  carbon oxoacid 22757
                                    carboxylic acid 22737
                                      monocarboxylic acid 21735
                                        fatty acid 19000
                                          unsaturated fatty acid 1114
                                            polyunsaturated fatty acid 848
                                              fatty acid 20:4 368
                                                icosatetraenoic acid 368
                                                  icosa-5,8,11,13-tetraenoic acid 32
                                                    15-oxo-ETE 7
                                                      15-oxo-ETE-CoA 0
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