Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:15-oxo-ETE
go back to main search page
Accession:CHEBI:15559 term browser browse the term
Definition:An oxoicosatetraenoic acid having (5Z,8Z,11Z,13E) double bond stereochemistry, and an oxo group in position 15.
Synonyms:related_synonym: (5Z,8Z,11Z,13E)-15-Oxoicosa-5,8,11,13-tetraenoic acid;   (5Z,8Z,11Z,13E)-15-ketoeicosa-5,8,11,13-tetraenoic acid;   (5Z,8Z,11Z,13E)-15-oxo-5,8,11,13-eicosatetraenoic acid;   (5Z,8Z,11Z,13E)-15-oxoeicosa-5,8,11,13-tetraenoic acid;   15-Kete;   15-Oxo-5,8,11-cis-13-trans-eicosatetraenoate;   15-OxoETE;   Formula=C20H30O3;   InChI=1S/C20H30O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+;   InChIKey=YGJTUEISKATQSM-USWFWKISSA-N;   SMILES=CCCCCC(=O)\\C=C\\C=C/C\\C=C/C\\C=C/CCCC(O)=O
 alt_id: CHEBI:11326;   CHEBI:19155;   CHEBI:761
 xref: CAS:81416-72-0;   HMDB:HMDB0010210;   KEGG:C04577;   LIPID_MAPS_instance:LMFA03060051
 xref_mesh: MESH:C054992
 xref: PMID:17459323;   PMID:17910482;   PMID:19535459;   PMID:23945567;   Reaxys:6217055
 cyclic_relationship: is_conjugate_acid_of CHEBI:57410


show annotations for term's descendants           Sort by:
 
15-oxo-ETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression ISO 15-keto-5,8,11,13-eicosatetraenoic acid results in increased expression of HMOX1 protein CTD PMID:25450232 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
decreases activity
ISO [15-keto-5,8,11,13-eicosatetraenoic acid results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein CTD PMID:25450232 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 15-keto-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:25450232 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 15-keto-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:25450232 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [15-keto-5,8,11,13-eicosatetraenoic acid results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein CTD PMID:25450232 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 15-keto-5,8,11,13-eicosatetraenoic acid results in increased expression of NQO1 protein CTD PMID:25450232 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO 15-keto-5,8,11,13-eicosatetraenoic acid results in decreased expression of TNF mRNA
15-keto-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:25450232 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          carbon atom 19597
            organic molecular entity 19597
              olefinic compound 14474
                olefinic fatty acid 612
                  oxoicosatetraenoic acid 8
                    15-oxo-ETE 7
                      15-oxo-ETE-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        monocarboxylic acid 17476
                                          fatty acid 15990
                                            unsaturated fatty acid 923
                                              polyunsaturated fatty acid 664
                                                fatty acid 20:4 313
                                                  icosatetraenoic acid 313
                                                    icosa-5,8,11,13-tetraenoic acid 30
                                                      15-oxo-ETE 7
                                                        15-oxo-ETE-CoA 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.