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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prostaglandin F2alpha
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Accession:CHEBI:15553 term browser browse the term
Definition:A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.
Synonyms:exact_synonym: (5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid
 related_synonym: (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate;   7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoic acid;   9,11,15-Trihydroxy-(5Z,9a,11a,13E,15S)-prosta-5,13-dien-1-oic acid;   9a,11a-PGF2;   Amoglandin;   Cyclosin;   Dinoprost;   Enzaprost;   Enzaprost F;   Formula=C20H34O5;   InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1;   InChIKey=PXGPLTODNUVGFL-YNNPMVKQSA-N;   PGF2a;   PGF2alpha;   Panacelan;   Prostaglandin F2a;   Prostin F 2 alpha;   Protamodin;   SMILES=CCCCC[C@H](O)\\C=C\\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\\C=C/CCCC(O)=O;   U 14583;   dinoprosta;   dinoprostum;   l-PGF2-alpha;   l-Prostaglandin F2-alpha
 alt_id: CHEBI:10913;   CHEBI:26327;   CHEBI:8516
 xref: Beilstein:2225571;   CAS:551-11-1;   Drug_Central:912;   HMDB:HMDB0001139;   KEGG:C00639;   KEGG:D00081;   LIPID_MAPS_instance:LMFA03010002
 xref_mesh: MESH:D015237
 xref: MetaCyc:5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY;   PMID:11438482;   PMID:23807981;   Reaxys:2225571;   VSDB:1803;   Wikipedia:Dinoprost
 cyclic_relationship: is_conjugate_acid_of CHEBI:57404


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prostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases metabolic processing ISO AKR1C2 protein results in increased metabolism of Dinoprost CTD PMID:8573067 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO [AKR1C3 protein results in increased reduction of Prostaglandin D2] which results in increased chemical synthesis of Dinoprost; [Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2; Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost] CTD PMID:19997560, PMID:20036328 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Anxa4 annexin A4 increases expression EXP Dinoprost results in increased expression of ANXA4 mRNA CTD PMID:11517196 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP Dinoprost results in increased expression of ATP1A1 mRNA CTD PMID:11517196 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 increases response to substance ISO ATP2B4 protein results in increased susceptibility to Dinoprost CTD PMID:12933703 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Cat catalase multiple interactions EXP CAT protein inhibits the reaction [Dinoprost results in increased expression of PTGS2 mRNA]; CAT protein inhibits the reaction [Dinoprost results in increased localization of RELA protein] CTD PMID:20826536 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd2 cyclin D2 decreases expression EXP Dinoprost results in decreased expression of CCND2 mRNA CTD PMID:11517196 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis ISO CES1 protein results in increased hydrolysis of Dinoprost CTD PMID:21049984 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Dinoprost CTD PMID:21049984 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression ISO Dinoprost results in increased expression of COL10A1 mRNA; Dinoprost results in increased expression of COL10A1 protein CTD PMID:27050768 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633
JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression ISO Dinoprost results in increased expression of COL2A1 mRNA; Dinoprost results in increased expression of COL2A1 protein CTD PMID:27050768 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression
multiple interactions
ISO
EXP
Dinoprost results in decreased expression of CYP19A1 mRNA
Dinoprost results in decreased expression of CYP19A1 mRNA; Dinoprost results in decreased expression of CYP19A1 protein
Dinoprost promotes the reaction [GATA4 protein binds to CYP19A1 promoter]
CTD PMID:11517196, PMID:15271885 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Dll4 delta like canonical Notch ligand 4 decreases expression EXP Dinoprost results in decreased expression of DLL4 mRNA CTD PMID:21209419 NCBI chr 3:111,135,011...111,146,746
Ensembl chr 3:111,135,021...111,145,986
JBrowse link
G Ereg epiregulin multiple interactions
increases expression
ISO [AL 8810 results in decreased activity of PTGFR protein] inhibits the reaction [[trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG]; [trans-10,cis-12-conjugated linoleic acid promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprost]] which results in increased expression of EREG; [trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG
Dinoprost results in increased expression of EREG
CTD PMID:22583689 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Esr1 estrogen receptor 1 increases expression EXP Dinoprost results in increased expression of ESR1 mRNA CTD PMID:21654155 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [Niacin results in decreased abundance of Dinoprost] which results in increased expression of FABP4 mRNA; [Niacin results in decreased abundance of Dinoprost] which results in increased expression of FABP4 protein CTD PMID:21236357 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
affects localization
EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGF2 protein]; Cycloheximide inhibits the reaction [Dinoprost affects the localization of FGF2 protein]; Dinoprost affects the localization of [FGF2 protein binds to FGFR2 protein]; Dinoprost promotes the reaction [FGF2 protein binds to FGFR2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of FGF2 protein] CTD PMID:15654655, PMID:16365892 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions
affects localization
decreases expression
EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGFR2 protein]; Dinoprost affects the localization of [FGF2 protein binds to FGFR2 protein]; Dinoprost promotes the reaction [FGF2 protein binds to FGFR2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of FGFR2 protein]
Dinoprost results in decreased expression of FGFR2 mRNA
CTD PMID:15654655, PMID:16365892 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression EXP Dinoprost results in increased expression of FOSL2 mRNA CTD PMID:11517196 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions
increases activity
EXP Dinoprost promotes the reaction [GATA4 protein binds to CYP19A1 promoter]
Dinoprost results in increased activity of GATA4 protein
CTD PMID:15271885 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gpx1 glutathione peroxidase 1 increases response to substance ISO GPX1 gene mutant form results in increased susceptibility to Dinoprost CTD PMID:24296279 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP Dinoprost results in decreased expression of HMGCS2 mRNA CTD PMID:11517196 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity
decreases expression
ISO
EXP
Dinoprost results in decreased activity of HSD11B2 protein
Dinoprost results in decreased expression of HSD11B2 mRNA
CTD PMID:10377029, PMID:11517196 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression EXP Dinoprost results in decreased expression of ID1 mRNA CTD PMID:11517196 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression EXP Dinoprost results in decreased expression of ID2 mRNA CTD PMID:11517196 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression EXP Dinoprost results in decreased expression of ID3 mRNA CTD PMID:11517196 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Il10 interleukin 10 multiple interactions
increases abundance
ISO IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]
IL10 protein results in increased abundance of Dinoprost
CTD PMID:12548226 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha increases abundance ISO IL1A protein results in increased abundance of Dinoprost CTD PMID:21513769 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases abundance
multiple interactions
ISO IL1B protein results in increased abundance of Dinoprost
Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; licochalcone A inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]
CTD PMID:12548226, PMID:16354411 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression EXP Dinoprost results in increased expression of IL2RA mRNA CTD PMID:11517196 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il4 interleukin 4 increases secretion
multiple interactions
ISO IL4 protein results in increased secretion of Dinoprost
[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprost
CTD PMID:23688403 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Kpnb1 karyopherin subunit beta 1 increases expression EXP Dinoprost results in increased expression of KPNB1 protein CTD PMID:16365892 NCBI chr10:85,096,517...85,124,641
Ensembl chr10:85,093,841...85,124,644
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP Dinoprost results in decreased expression of LHCGR mRNA CTD PMID:11517196 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Lypla2 lysophospholipase 2 increases hydrolysis ISO LYPLA2 protein results in increased hydrolysis of Dinoprost analog CTD PMID:25301951 NCBI chr 5:154,315,033...154,319,629
Ensembl chr 5:154,315,033...154,319,629
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases phosphorylation
multiple interactions
ISO Dinoprost results in increased phosphorylation of MAP2K1 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein]
CTD PMID:24333336 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases phosphorylation
multiple interactions
ISO Dinoprost results in increased phosphorylation of MAP2K2 protein
Resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K2 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K2 protein]
CTD PMID:24333336 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects localization
multiple interactions
increases phosphorylation
EXP
ISO
Dinoprost affects the localization of MAPK1 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]
Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of MAPK1 protein]
CTD PMID:15654655, PMID:24333336 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects localization
increases phosphorylation
multiple interactions
EXP
ISO
Dinoprost affects the localization of MAPK3 protein
Dinoprost results in increased phosphorylation of MAPK3 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]
Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of MAPK3 protein]
CTD PMID:15654655, PMID:24333336 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression EXP Dinoprost results in increased expression of MAPK6 mRNA CTD PMID:11517196 NCBI chr 8:82,328,013...82,351,108
Ensembl chr 8:82,328,020...82,351,108
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Dinoprost results in increased phosphorylation of MAPK8 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK8 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK8 protein]
CTD PMID:24333336 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO Dinoprost results in increased phosphorylation of MAPK9 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK9 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK9 protein]
CTD PMID:24333336 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Dinoprost results in increased expression of and results in increased activity of MMP2 protein CTD PMID:11719597 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Dinoprost results in increased expression of and results in increased activity of MMP9 protein CTD PMID:11719597 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Notch1 notch receptor 1 decreases cleavage
decreases expression
EXP Dinoprost results in decreased cleavage of NOTCH1 protein
Dinoprost results in decreased expression of NOTCH1 mRNA
CTD PMID:21209419 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Notch4 notch receptor 4 decreases expression
decreases cleavage
EXP Dinoprost results in decreased expression of NOTCH4 mRNA
Dinoprost results in decreased cleavage of NOTCH4 protein
CTD PMID:21209419 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 decreases expression EXP Dinoprost results in decreased expression of PDIA4 mRNA CTD PMID:11517196 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
JBrowse link
G Plcd1 phospholipase C, delta 1 increases expression EXP Dinoprost results in increased expression of PLCD1 mRNA CTD PMID:11517196 NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression EXP Dinoprost results in increased expression of POR mRNA CTD PMID:11517196 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Niacin results in decreased abundance of Dinoprost] which results in increased expression of PPARG mRNA; [Niacin results in decreased abundance of Dinoprost] which results in increased expression of PPARG protein CTD PMID:21236357 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prl prolactin multiple interactions EXP [Dinoprost results in decreased abundance of Progesterone] which results in increased expression of PRL protein CTD PMID:21654155 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prlr prolactin receptor increases expression EXP Dinoprost results in increased expression of PRLR mRNA CTD PMID:21654155 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Ptgdr prostaglandin D2 receptor multiple interactions ISO Dinoprost binds to and results in increased activity of PTGDR protein; Dinoprost inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725, PMID:27636113 NCBI chr15:19,195,606...19,196,508 JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions ISO Dinoprost binds to and results in increased activity of PTGER2 protein CTD PMID:27636113 NCBI chr15:19,336,029...19,349,759
Ensembl chr15:19,338,175...19,350,210
JBrowse link
G Ptgfr prostaglandin F receptor increases expression
multiple interactions
EXP
ISO
Dinoprost results in increased expression of PTGFR mRNA
[AL 8810 results in decreased activity of PTGFR protein] inhibits the reaction [[trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG]
CTD PMID:11517196, PMID:22583689 NCBI chr 2:257,005,813...257,039,036
Ensembl chr 2:257,005,829...257,038,105
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases abundance
increases expression
ISO
EXP
[Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased chemical synthesis of Dinoprost]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased chemical synthesis of Dinoprost]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [Niacin results in decreased expression of PTGS2 mRNA] which results in decreased abundance of Dinoprost; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprost; [trans-10,cis-12-conjugated linoleic acid promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprost]] which results in increased expression of EREG
PTGS2 protein results in increased abundance of Dinoprost
Dinoprost results in increased expression of PTGS2 mRNA
[Linoleic Acids, Conjugated results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprost; [Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [CGB3 protein results in increased chemical synthesis of Dinoprost]; resveratrol inhibits the reaction [[Linoleic Acids, Conjugated results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprost]; resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]; SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]]
[Dinoprost results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprost; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased secretion of Dinoprost; CAT protein inhibits the reaction [Dinoprost results in increased expression of PTGS2 mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [PTGS2 protein results in increased abundance of Dinoprost]
CTD PMID:18555068, PMID:18776171, PMID:18834901, PMID:20826536, PMID:20844277, PMID:21236357, PMID:22306367, PMID:22583689, PMID:27050768 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta increases expression EXP Dinoprost results in increased expression of PTK2B mRNA CTD PMID:11517196 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression
multiple interactions
ISO Dinoprost results in increased expression of RAF1 protein modified form
resveratrol inhibits the reaction [Dinoprost results in increased expression of RAF1 protein modified form]; SRT1720 inhibits the reaction [Dinoprost results in increased expression of RAF1 protein modified form]
CTD PMID:24333336 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases expression EXP Dinoprost results in decreased expression of RBL2 mRNA CTD PMID:11517196 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP CAT protein inhibits the reaction [Dinoprost results in increased localization of RELA protein]; Dinoprost results in increased localization of and results in increased activity of RELA protein CTD PMID:20826536 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Dinoprost results in increased expression of RUNX2 mRNA; Dinoprost results in increased expression of RUNX2 protein CTD PMID:27050768 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 increases expression EXP Dinoprost results in increased expression of SCN1B mRNA CTD PMID:11517196 NCBI chr 1:89,550,738...89,560,469
Ensembl chr 1:89,550,738...89,560,719
JBrowse link
G Shc1 SHC adaptor protein 1 increases phosphorylation EXP Dinoprost results in increased phosphorylation of SHC1 protein alternative form CTD PMID:19168439 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]] CTD PMID:20844277 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases uptake ISO SLC22A7 protein results in increased uptake of Dinoprost CTD PMID:15901346 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases transport ISO SLC22A8 protein results in increased transport of Dinoprost CTD PMID:15100168 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression EXP Dinoprost results in increased expression of SOCS1 mRNA CTD PMID:21654155 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Dinoprost results in increased expression of SOCS3 mRNA CTD PMID:21654155 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression ISO Dinoprost results in increased expression of SOX9 mRNA; Dinoprost results in increased expression of SOX9 protein CTD PMID:27050768 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Stat5a signal transducer and activator of transcription 5A increases expression EXP Dinoprost results in increased expression of STAT5A mRNA CTD PMID:21654155 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Syn2 synapsin II decreases expression EXP Dinoprost results in decreased expression of SYN2 mRNA CTD PMID:11517196 NCBI chr 4:147,037,179...147,195,096
Ensembl chr 4:147,037,179...147,195,096
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Dinoprost results in increased expression of TGFB1 mRNA CTD PMID:11517196 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thrsp thyroid hormone responsive decreases expression ISO Dinoprost results in decreased expression of THRSP mRNA CTD PMID:10357836 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression ISO Dinoprost results in decreased expression of TIMP1 protein CTD PMID:11719597 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression EXP Dinoprost results in decreased expression of TIMP3 mRNA CTD PMID:11517196 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tnf tumor necrosis factor increases abundance ISO TNF protein results in increased abundance of Dinoprost CTD PMID:1993070 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein; pyrazolanthrone inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; resveratrol inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; resveratrol inhibits the reaction [Dinoprost results in increased expression of TNFRSF11B mRNA]; SB 203580 inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; SRT1720 inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein] CTD PMID:24333336 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases chemical synthesis EXP UGT1A1 protein mutant form results in increased chemical synthesis of Dinoprost CTD PMID:3864191 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP Dinoprost results in decreased expression of VEGFA mRNA CTD PMID:11517196 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression EXP Dinoprost results in increased expression of YWHAE mRNA CTD PMID:11517196 NCBI chr10:63,884,338...63,921,709
Ensembl chr10:63,884,338...63,921,709
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma increases expression EXP Dinoprost results in increased expression of YWHAG mRNA CTD PMID:11517196 NCBI chr12:23,789,547...23,817,884
Ensembl chr12:23,789,638...23,817,883
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta increases expression EXP Dinoprost results in increased expression of YWHAZ mRNA CTD PMID:11517196 NCBI chr 7:75,573,553...75,598,295
Ensembl chr 7:75,574,967...75,597,276
JBrowse link
13,14-dihydro-15-keto-PGF2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases abundance
multiple interactions
ISO PTGR1 protein results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
CTD PMID:25619643 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
15-oxoprostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases metabolic processing
multiple interactions
ISO PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
CTD PMID:25619643 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
8-epi-prostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E multiple interactions ISO [APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased abundance of 8-epi-prostaglandin F2alpha CTD PMID:17118406 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases abundance
ISO [Lead co-treated with APP protein modified form] results in increased abundance of 8-epi-prostaglandin F2alpha
APP protein modified form results in increased abundance of 8-epi-prostaglandin F2alpha
CTD PMID:22610977 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
increases chemical synthesis
ISO
EXP
1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Dehydroascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; resveratrol inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]
pyrrolidine dithiocarbamic acid inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]; Rotenone inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]
CTD PMID:11530235, PMID:16529823, PMID:19751497 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Pafah2 platelet-activating factor acetylhydrolase 2 affects metabolic processing
multiple interactions
ISO PAFAH2 protein affects the metabolism of 8-epi-prostaglandin F2alpha
PAFAH2 protein affects the reaction [Carbon Tetrachloride results in increased abundance of 8-epi-prostaglandin F2alpha]
CTD PMID:18024956 NCBI chr 5:152,606,850...152,635,956
Ensembl chr 5:152,606,847...152,634,803
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [L 745337 results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of 8-epi-prostaglandin F2alpha; [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha CTD PMID:8621535 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions
affects response to substance
ISO 8-epi-prostaglandin F2alpha binds to and results in increased activity of TBXA2R protein
TBXA2R protein affects the susceptibility to 8-epi-prostaglandin F2alpha
CTD PMID:18158556, PMID:22565502 NCBI chr 7:11,253,153...11,259,233
Ensembl chr 7:11,253,180...11,257,977
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      chemical role 19250
        donor 18378
          Bronsted acid 18241
            oxoacid 18193
              carbon oxoacid 18073
                carboxylic acid 18061
                  monocarboxylic acid 17407
                    prostaglandin F2alpha 86
                      11-epi-prostaglandin F2alpha + 0
                      13,14-dihydro-15-keto-PGF2alpha + 1
                      13,14-dihydroprostaglandin F2alpha 0
                      15-oxoprostaglandin F2alpha + 1
                      2,3-dinor-8-epi-prostaglandin F2alpha 0
                      8-epi-prostaglandin F2alpha + 6
                      carboprost 0
                      prostaglandin F2alpha 1-ethanolamide 0
                      prostaglandin F2alpha 1-glyceryl ester 0
                      prostaglandin F2alpha 2-glyceryl ester 0
                      prostaglandin F2alpha dimethylamine 0
                      tafluprost 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            fatty acid derivative 1021
                                              icosanoid 453
                                                prostanoid 395
                                                  prostaglandin 390
                                                    prostaglandins F 97
                                                      prostaglandins Falpha 96
                                                        prostaglandin F2alpha 86
                                                          11-epi-prostaglandin F2alpha + 0
                                                          13,14-dihydro-15-keto-PGF2alpha + 1
                                                          13,14-dihydroprostaglandin F2alpha 0
                                                          15-oxoprostaglandin F2alpha + 1
                                                          2,3-dinor-8-epi-prostaglandin F2alpha 0
                                                          8-epi-prostaglandin F2alpha + 6
                                                          carboprost 0
                                                          prostaglandin F2alpha 1-ethanolamide 0
                                                          prostaglandin F2alpha 1-glyceryl ester 0
                                                          prostaglandin F2alpha 2-glyceryl ester 0
                                                          prostaglandin F2alpha dimethylamine 0
                                                          tafluprost 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.