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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prostaglandin I2
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Accession:CHEBI:15552 term browser browse the term
Definition:A prostaglandins I that has formula C20H32O5.
Synonyms:exact_synonym: (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoic acid
 related_synonym: (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate;   (5Z,9alpha,11alpha,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid;   Epoprostenol;   Flolan;   Formula=C20H32O5;   InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1;   InChIKey=KAQKFAOMNZTLHT-OZUDYXHBSA-N;   PGI2;   PGX;   Prostacyclin;   SMILES=[H][C@]12C[C@@H](O)[C@H](\\C=C\\[C@@H](O)CCCCC)[C@@]1([H])C\\C(O2)=C\\CCCC(O)=O;   Vasocyclin;   prostaglandin X
 alt_id: CHEBI:10912;   CHEBI:245;   CHEBI:26331
 xref: Beilstein:1690090;   CAS:35121-78-9;   DrugBank:DB01240;   Drug_Central:1034;   KEGG:C01312;   KEGG:D00106;   LIPID_MAPS_instance:LMFA03010087
 xref_mesh: MESH:D011464
 cyclic_relationship: is_conjugate_acid_of CHEBI:57403

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prostaglandin I2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions ISO ACE inhibits the reaction [Cocaine affects the abundance of Epoprostenol] CTD PMID:14738173 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Agt angiotensinogen multiple interactions
increases abundance		 EXP 1-Butanol inhibits the reaction [AGT protein results in increased abundance of Epoprostenol]; arachidonyltrifluoromethane inhibits the reaction [AGT protein results in increased abundance of Epoprostenol]; midostaurin inhibits the reaction [AGT protein results in increased abundance of Epoprostenol]; PTGS2 protein affects the reaction [AGT protein results in increased abundance of Epoprostenol]
AGT protein results in increased abundance of Epoprostenol; AGT results in increased abundance of Epoprostenol		 CTD PMID:3888613 PMID:14613874 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Epoprostenol results in increased expression of CCL2 protein CTD PMID:15302794 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Fbn1 fibrillin 1 multiple interactions ISO FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Epoprostenol metabolite] CTD PMID:17641673 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Epoprostenol] CTD PMID:12632514 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1a interleukin 1 alpha increases abundance ISO IL1A protein results in increased abundance of Epoprostenol CTD PMID:21513769 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta increases secretion EXP IL1B protein results in increased secretion of Epoprostenol CTD PMID:11882577 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Kng2 kininogen 2 increases abundance EXP KNG1 results in increased abundance of Epoprostenol CTD PMID:3888613 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO Epoprostenol results in increased activity of MAPK1 protein CTD PMID:19201774 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO Epoprostenol results in increased activity of MAPK3 protein CTD PMID:19201774 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions
increases abundance		 ISO 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]; celecoxib inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]; Ibuprofen inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [PDGFA results in increased abundance of Epoprostenol] CTD PMID:19201774 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Epoprostenol results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP PTGS2 protein affects the reaction [AGT protein results in increased abundance of Epoprostenol] CTD PMID:14613874 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        biochemical role 19310
          metabolite 19292
            eukaryotic metabolite 18963
              animal metabolite 18790
                mammalian metabolite 18789
                  mouse metabolite 18491
                    prostaglandin I2 13
                      15-dehydro-prostaglandin I2 0
                      19-hydroxyprostaglandin I2 0
                      prostaglandin I2 2-glyceryl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        monocarboxylic acid 17526
                                          fatty acid 16004
                                            fatty acid derivative 1039
                                              icosanoid 455
                                                prostanoid 395
                                                  prostaglandin 390
                                                    prostaglandins I 13
                                                      prostaglandin I2 13
                                                        15-dehydro-prostaglandin I2 0
                                                        19-hydroxyprostaglandin I2 0
                                                        prostaglandin I2 2-glyceryl ester 0
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