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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:15-dehydro-prostaglandin E2
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Accession:CHEBI:15547 term browser browse the term
Definition:A prostaglandins E that has formula C20H30O5.
Synonyms:exact_synonym: (5Z,13E)-11alpha-hydroxy-9,15-dioxoprosta-5,13-dienoic acid
 related_synonym: (5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprosta-13-enoate;   (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate;   15-Keto-PGE2;   15-Keto-prostaglandin E2;   15-Ketoprostaglandin E2;   15-Oxo-PGE2;   15-deoxy-15-oxo-prostaglandin E2;   Formula=C20H30O5;   InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,16-17,19,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t16-,17-,19-/m1/s1;   InChIKey=YRTJDWROBKPZNV-KMXMBPPJSA-N;   SMILES=CCCCCC(=O)\\C=C\\[C@H]1[C@H](O)CC(=O)[C@@H]1C\\C=C/CCCC(O)=O
 alt_id: CHEBI:10908;   CHEBI:10917;   CHEBI:18588;   CHEBI:243;   CHEBI:247
 xref: CAS:26441-05-4;   KEGG:C04707;   KEGG:C04743;   LIPID_MAPS_instance:LMFA03010030
 xref_mesh: MESH:C026346
 cyclic_relationship: is_conjugate_acid_of CHEBI:57400



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15-dehydro-prostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) increases chemical synthesis EXP HPGD protein results in increased chemical synthesis of 15-ketoprostaglandin E2 CTD PMID:20448048 NCBI chr 8:56,747,587...56,774,081
Ensembl chr 8:56,747,620...56,774,078
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G Ptgr1 prostaglandin reductase 1 multiple interactions
increases reduction
increases metabolic processing
ISO 15-ketoprostaglandin E2 inhibits the reaction [PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog]; Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2]; Indomethacin inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2]
PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E2
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E2] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin E2
CTD PMID:23878198 PMID:25619643 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22188
    role 22173
      application 21755
        pharmaceutical 21163
          drug 21163
            oxytocic 247
              prostaglandin E2 231
                15-dehydro-prostaglandin E2 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    p-block element atom 22114
                      carbon group element atom 21915
                        carbon atom 21840
                          organic molecular entity 21840
                            organic group 20283
                              organic divalent group 20165
                                organodiyl group 20165
                                  carbonyl group 20159
                                    carbonyl compound 20159
                                      carboxylic acid 19557
                                        monocarboxylic acid 18919
                                          fatty acid 17128
                                            fatty acid derivative 8968
                                              icosanoid 469
                                                prostanoid 406
                                                  prostaglandin 399
                                                    prostaglandins E 234
                                                      prostaglandin E2 231
                                                        15-dehydro-prostaglandin E2 2
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