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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prostaglandin E1
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Accession:CHEBI:15544 term browser browse the term
Definition:A prostaglandins E that has formula C20H34O5.
Synonyms:exact_synonym: (13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-oic acid
 related_synonym: (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid;   (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate;   11alpha,15alpha-dihydroxy-9-oxo-13-trans-prostenoic acid;   Alprostadil;   Befar;   Caverject;   Edex;   Formula=C20H34O5;   InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1;   InChIKey=GMVPRGQOIOIIMI-DWKJAMRDSA-N;   Muse;   PGE-1;   PGE1;   Prostin VR;   SMILES=CCCCC[C@H](O)\\C=C\\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O;   alprostadilum
 alt_id: CHEBI:10820;   CHEBI:142;   CHEBI:26322
 xref: Beilstein:2061617;   CAS:745-65-3;   DrugBank:DB00770;   Drug_Central:138;   HMDB:HMDB0001442;   KEGG:C04741;   KEGG:D00180;   LIPID_MAPS_instance:LMFA03010134
 xref_mesh: MESH:D000527
 xref: PMID:15295081;   PMID:18176061;   PMID:7732902;   Reaxys:2061617;   Wikipedia:Prostaglandin_E1
 cyclic_relationship: is_conjugate_acid_of CHEBI:57397



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prostaglandin E1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Quercetin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]; Silymarin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:16156793 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Adrb2 adrenoceptor beta 2 increases phosphorylation ISO Alprostadil results in increased phosphorylation of ADRB2 protein CTD PMID:14722251 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Agt angiotensinogen increases expression ISO Alprostadil results in increased expression of AGT protein CTD PMID:9195357 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Alprostadil inhibits the reaction [Galactosamine results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:15565661 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Alprostadil inhibits the reaction [[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA]; Alprostadil inhibits the reaction [Carbamazepine results in increased expression of CXCL2 mRNA] CTD PMID:22790970 PMID:23986454 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO Alprostadil inhibits the reaction [Carbamazepine results in increased expression of IL23A mRNA] CTD PMID:22790970 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP
ISO
Alprostadil results in increased expression of IL6 protein
Dexamethasone inhibits the reaction [Alprostadil results in increased expression of IL6 protein]
Alprostadil inhibits the reaction [Carbamazepine results in increased expression of IL6 mRNA]
CTD PMID:7536779 PMID:22790970 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Alprostadil inhibits the reaction [Galactosamine results in decreased expression of NFKBIA protein]; Enzyme Inhibitors inhibits the reaction [Alprostadil inhibits the reaction [Galactosamine results in decreased expression of NFKBIA protein]] CTD PMID:15565661 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP Alprostadil results in increased expression of NOS2 mRNA; Alprostadil results in increased expression of NOS2 promoter; Alprostadil results in increased expression of NOS2 protein
Alprostadil inhibits the reaction [Galactosamine results in increased expression of NOS2 mRNA]; Alprostadil inhibits the reaction [Galactosamine results in increased expression of NOS2 promoter]; Alprostadil inhibits the reaction [Galactosamine results in increased expression of NOS2 protein]; Enzyme Inhibitors inhibits the reaction [Alprostadil inhibits the reaction [Galactosamine results in increased expression of NOS2 protein]]; Galactosamine promotes the reaction [Alprostadil results in increased expression of NOS2 protein]
CTD PMID:15189274 PMID:15565661 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Alprostadil results in decreased expression of NPPA protein CTD PMID:10506854 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B decreases expression ISO Alprostadil results in decreased expression of NPPB protein CTD PMID:16084762 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Ptgdr prostaglandin D2 receptor affects binding
multiple interactions
ISO Alprostadil binds to PTGDR protein
Alprostadil inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]
CTD PMID:9579725 NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Alprostadil results in increased localization of and results in increased activity of RELA protein CTD PMID:15189274 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin increases expression ISO Alprostadil results in increased expression of REN protein CTD PMID:9195357 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression EXP Alprostadil results in decreased expression of TIMP1 CTD PMID:16859129 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
decreases expression
ISO
EXP
Alprostadil inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]
Alprostadil results in decreased secretion of TNF protein
Alprostadil promotes the reaction [Galactosamine results in increased expression of TNF protein]
Alprostadil results in decreased expression of TNF protein
CTD PMID:7536779 PMID:7956562 PMID:9298541 PMID:10221824 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases secretion
increases expression
multiple interactions
ISO Alprostadil results in increased secretion of TNFRSF11B protein
Alprostadil results in increased expression of TNFRSF11B mRNA
pyrazolanthrone inhibits the reaction [Alprostadil results in increased secretion of TNFRSF11B protein]; resveratrol inhibits the reaction [Alprostadil results in increased expression of TNFRSF11B mRNA]; resveratrol inhibits the reaction [Alprostadil results in increased secretion of TNFRSF11B protein]; SB 203580 inhibits the reaction [Alprostadil results in increased secretion of TNFRSF11B protein]; SRT1720 inhibits the reaction [Alprostadil results in increased secretion of TNFRSF11B protein]
CTD PMID:25677506 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO Alprostadil results in increased phosphorylation of VASP protein CTD PMID:20129490 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
13,14-dihydro-15-oxoprostaglandin E1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases abundance
multiple interactions
ISO PTGR1 protein results in increased abundance of 13,14-dihydro-15-ketoprostaglandin E1
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E] which results in increased abundance of 13,14-dihydro-15-ketoprostaglandin E1
CTD PMID:25619643 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19840
    role 19816
      application 19658
        pharmaceutical 19499
          drug 19499
            cardiovascular drug 8637
              vasodilator agent 6031
                prostaglandin E1 19
                  13,14-dihydro-15-oxoprostaglandin E1 1
                  15-dehydro-prostaglandin E1 0
                  20-hydroxyprostaglandin E1 0
                  6-oxoprostaglandin E1 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19788
                    p-block element atom 19788
                      carbon group element atom 19734
                        carbon atom 19730
                          organic molecular entity 19730
                            heteroorganic entity 19485
                              organochalcogen compound 19247
                                organooxygen compound 19165
                                  carbon oxoacid 18633
                                    carboxylic acid 18630
                                      monocarboxylic acid 18004
                                        fatty acid 16811
                                          fatty acid derivative 8967
                                            icosanoid 471
                                              prostanoid 407
                                                prostaglandin 399
                                                  prostaglandins E 236
                                                    prostaglandin E1 19
                                                      13,14-dihydro-15-oxoprostaglandin E1 1
                                                      15-dehydro-prostaglandin E1 0
                                                      20-hydroxyprostaglandin E1 0
                                                      6-oxoprostaglandin E1 0
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