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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prostaglandin E1
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Accession:CHEBI:15544 term browser browse the term
Definition:A prostaglandins E that has formula C20H34O5.
Synonyms:exact_synonym: (13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-oic acid
 related_synonym: (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid;   (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate;   11alpha,15alpha-dihydroxy-9-oxo-13-trans-prostenoic acid;   Alprostadil;   Befar;   Caverject;   Edex;   Formula=C20H34O5;   InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1;   InChIKey=GMVPRGQOIOIIMI-DWKJAMRDSA-N;   Muse;   PGE-1;   PGE1;   Prostin VR;   SMILES=CCCCC[C@H](O)\\C=C\\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O;   alprostadilum
 alt_id: CHEBI:10820;   CHEBI:142;   CHEBI:26322
 xref: Beilstein:2061617;   CAS:745-65-3;   DrugBank:DB00770;   Drug_Central:138;   HMDB:HMDB0001442;   KEGG:C04741;   KEGG:D00180;   LIPID_MAPS_instance:LMFA03010134
 xref_mesh: MESH:D000527
 xref: PMID:15295081;   PMID:18176061;   PMID:7732902;   Reaxys:2061617;   Wikipedia:Prostaglandin_E1
 cyclic_relationship: is_conjugate_acid_of CHEBI:57397


show annotations for term's descendants           Sort by:
prostaglandin E1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Quercetin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]; Silymarin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]] CTD PMID:16156793 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Adrb2 adrenoceptor beta 2 increases phosphorylation ISO Alprostadil results in increased phosphorylation of ADRB2 protein CTD PMID:14722251 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Agt angiotensinogen increases expression ISO Alprostadil results in increased expression of AGT protein CTD PMID:9195357 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Alprostadil inhibits the reaction [Galactosamine results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:15565661 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Alprostadil inhibits the reaction [[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA]; Alprostadil inhibits the reaction [Carbamazepine results in increased expression of CXCL2 mRNA] CTD PMID:22790970 PMID:23986454 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO Alprostadil inhibits the reaction [Carbamazepine results in increased expression of IL23A mRNA] CTD PMID:22790970 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 EXP
ISO		 Alprostadil results in increased expression of IL6 protein
Alprostadil inhibits the reaction [Carbamazepine results in increased expression of IL6 mRNA]
Dexamethasone inhibits the reaction [Alprostadil results in increased expression of IL6 protein]		 CTD PMID:7536779 PMID:22790970 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Alprostadil inhibits the reaction [Galactosamine results in decreased expression of NFKBIA protein]; Enzyme Inhibitors inhibits the reaction [Alprostadil inhibits the reaction [Galactosamine results in decreased expression of NFKBIA protein]] CTD PMID:15565661 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 EXP Alprostadil results in increased expression of NOS2 mRNA; Alprostadil results in increased expression of NOS2 promoter; Alprostadil results in increased expression of NOS2 protein
Alprostadil inhibits the reaction [Galactosamine results in increased expression of NOS2 mRNA]; Alprostadil inhibits the reaction [Galactosamine results in increased expression of NOS2 promoter]; Alprostadil inhibits the reaction [Galactosamine results in increased expression of NOS2 protein]; Enzyme Inhibitors inhibits the reaction [Alprostadil inhibits the reaction [Galactosamine results in increased expression of NOS2 protein]]; Galactosamine promotes the reaction [Alprostadil results in increased expression of NOS2 protein]		 CTD PMID:15189274 PMID:15565661 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Alprostadil results in decreased expression of NPPA protein CTD PMID:10506854 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B decreases expression ISO Alprostadil results in decreased expression of NPPB protein CTD PMID:16084762 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Ptgdr prostaglandin D2 receptor affects binding
multiple interactions		 ISO Alprostadil binds to PTGDR protein
Alprostadil inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]		 CTD PMID:9579725 NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Alprostadil results in increased localization of and results in increased activity of RELA protein CTD PMID:15189274 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin increases expression ISO Alprostadil results in increased expression of REN protein CTD PMID:9195357 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression EXP Alprostadil results in decreased expression of TIMP1 CTD PMID:16859129 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases secretion		 ISO
EXP		 Alprostadil inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]
Alprostadil results in decreased expression of TNF protein
Alprostadil promotes the reaction [Galactosamine results in increased expression of TNF protein]
Alprostadil results in decreased secretion of TNF protein		 CTD PMID:7536779 PMID:7956562 PMID:9298541 PMID:10221824 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases secretion
multiple interactions
increases expression		 ISO Alprostadil results in increased secretion of TNFRSF11B protein
pyrazolanthrone inhibits the reaction [Alprostadil results in increased secretion of TNFRSF11B protein]; resveratrol inhibits the reaction [Alprostadil results in increased expression of TNFRSF11B mRNA]; resveratrol inhibits the reaction [Alprostadil results in increased secretion of TNFRSF11B protein]; SB 203580 inhibits the reaction [Alprostadil results in increased secretion of TNFRSF11B protein]; SRT1720 inhibits the reaction [Alprostadil results in increased secretion of TNFRSF11B protein]		 CTD PMID:25677506 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO Alprostadil results in increased phosphorylation of VASP protein CTD PMID:20129490 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
13,14-dihydro-15-oxoprostaglandin E1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases abundance
multiple interactions		 ISO PTGR1 protein results in increased abundance of 13,14-dihydro-15-ketoprostaglandin E1
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E] which results in increased abundance of 13,14-dihydro-15-ketoprostaglandin E1		 CTD PMID:25619643 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        pharmaceutical 19499
          drug 19499
            cardiovascular drug 8502
              vasodilator agent 5853
                prostaglandin E1 19
                  13,14-dihydro-15-oxoprostaglandin E1 1
                  15-dehydro-prostaglandin E1 0
                  20-hydroxyprostaglandin E1 0
                  6-oxoprostaglandin E1 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        monocarboxylic acid 17903
                                          fatty acid 16560
                                            fatty acid derivative 8913
                                              icosanoid 469
                                                prostanoid 404
                                                  prostaglandin 397
                                                    prostaglandins E 233
                                                      prostaglandin E1 19
                                                        13,14-dihydro-15-oxoprostaglandin E1 1
                                                        15-dehydro-prostaglandin E1 0
                                                        20-hydroxyprostaglandin E1 0
                                                        6-oxoprostaglandin E1 0
paths to the root