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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glycine
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Accession:CHEBI:15428 term browser browse the term
Definition:The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.
Synonyms:related_synonym: Aminoacetic acid;   Aminoessigsaeure;   Formula=C2H5NO2;   G;   Gly;   Glycin;   Glycocoll;   Glykokoll;   Glyzin;   H2N-CH2-COOH;   Hgly;   InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5);   InChIKey=DHMQDGOQFOQNFH-UHFFFAOYSA-N;   Leimzucker;   SMILES=NCC(O)=O;   aminoethanoic acid
 alt_id: CHEBI:10792;   CHEBI:14344;   CHEBI:24368;   CHEBI:42964;   CHEBI:5460
 xref: Beilstein:635782;   CAS:56-40-6;   DrugBank:DB00145;   Drug_Central:1319;   ECMDB:ECMDB00123;   Gmelin:1808;   HMDB:HMDB0000123;   KEGG:C00037;   KEGG:D00011;   KNApSAcK:C00001361
 xref_mesh: MESH:D005998
 xref: MetaCyc:GLY;   PDBeChem:GLY;   PMID:10930630;   PMID:11019925;   PMID:11174716;   PMID:11542461;   PMID:11806864;   PMID:12631515;   PMID:12754315;   PMID:12770151;   PMID:12921899;   PMID:15331688;   PMID:15388434;   PMID:15710237;   PMID:16105183;   PMID:16151895;   PMID:16214212;   PMID:16417482;   PMID:16444815;   PMID:16664855;   PMID:16901953;   PMID:16918424;   PMID:16986325;   PMID:16998855;   PMID:17154252;   PMID:17383967;   PMID:17582620;   PMID:17970719;   PMID:18079355;   PMID:18396796;   PMID:18440992;   PMID:18593588;   PMID:18816054;   PMID:18840508;   PMID:19028609;   PMID:19120667;   PMID:19449910;   PMID:19526731;   PMID:19544666;   PMID:19738917;   PMID:19916621;   PMID:19924257;   PMID:21751272;   PMID:22044190;   PMID:22079563;   PMID:22234938;   PMID:22264337;   PMID:22293292;   PMID:22401276;   PMID:22434786;   Reaxys:635782;   Wikipedia:Glycine;   YMDB:YMDB00016
 cyclic_relationship: is_conjugate_acid_of CHEBI:32508;   is_conjugate_base_of CHEBI:32507;   is_tautomer_of CHEBI:57305


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glycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSF2 colony stimulating factor 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of CSF2 mRNA CTD PMID:14662146 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of PTGS1 CTD PMID:14662146 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in increased expression of PTGS2 CTD PMID:14662146 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
glycine betaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein CTD PMID:29129240 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA CTD PMID:28445388 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA CTD PMID:28445388 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA CTD PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G GYS1 glycogen synthase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter CTD PMID:29065941 NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP [bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter CTD PMID:29065941 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,812,453...40,826,715
JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA CTD PMID:28445388 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,636...71,881,820
JBrowse link
G SI sucrase-isomaltase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,566,343...48,705,841
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA CTD PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
glyphosate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase increases activity EXP glyphosate results in increased activity of CAT protein CTD PMID:31677563 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CLDN1 claudin 1 decreases expression EXP glyphosate results in decreased expression of CLDN1 mRNA CTD PMID:31677563 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,767...127,730,657
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit decreases expression EXP glyphosate results in decreased expression of GCLM mRNA CTD PMID:31677563 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,135
JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression EXP glyphosate results in decreased expression of GPX1 mRNA CTD PMID:31677563 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G HMOX1 heme oxygenase 1 decreases expression EXP glyphosate results in decreased expression of HMOX1 mRNA CTD PMID:31677563
G IL6 interleukin 6 increases expression EXP glyphosate results in increased expression of IL6 mRNA CTD PMID:31677563 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression EXP glyphosate results in increased expression of NFE2L2 mRNA; glyphosate results in increased expression of NFE2L2 protein CTD PMID:31677563 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 increases expression EXP glyphosate results in increased expression of NFKB1 mRNA CTD PMID:31677563 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,637...118,506,691
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP glyphosate results in increased expression of NQO1 mRNA CTD PMID:31677563 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G TJP1 tight junction protein 1 decreases expression EXP glyphosate results in decreased expression of TJP1 mRNA CTD PMID:31677563 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,368...145,195,836
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 903
    role 862
      biological role 862
        molecular messenger 223
          neurotransmitter 51
            glycine 22
              2,2-dialkylglycine + 0
              3-methylcrotonyl glycine 0
              4-hydroxyphenylglycine + 0
              4-nitrophenyl phthalimidoacetate 0
              Ala-Ala-Gly 0
              Ala-Asp-Gly 0
              Ala-Cys-Gly 0
              Ala-Gly-Ala-Gly 0
              Ala-Gly-His 0
              Ala-Gly-Pro 0
              Ala-Gly-Ser 0
              Ala-Gly-Tyr 0
              Ala-Leu-Asp-Gly 0
              Arg-Asn-Gly-Ser 0
              Arg-Lys-Cys-Gly 0
              Asn-Gly 0
              Asp-Gly 0
              Asp-Gly-Pro 0
              Asp-Val-Gly-Pro 0
              Cys-Asp-Gly 0
              Cys-Phe-Phe-Gly 0
              Glu-Glu-Gly 0
              Glu-Gly 0
              Glu-Gly-Arg-chloromethylketone 0
              Glu-Gly-Trp 0
              Gly-Ala-Ala 0
              Gly-Arg-Pro 0
              Gly-His 0
              Gly-Hyp 0
              Gly-Leu 0
              Gly-Pro 0
              Gly-Pro-Hyp 0
              Gly-Ser + 0
              Gly-Tyr 0
              Leu-Ala-Gly 0
              Leu-Asp-Gly 0
              Leu-Gly-Pro 0
              Leu-Gly-Ser 0
              Leu-Leu-Gly 0
              Leu-Val-Gly 0
              Leu-enkephalin 0
              Lys-Gly 0
              Met-Gly 0
              N-(2-anilino-2-oxoethyl)-2-methoxybenzamide 0
              N-carbamoylglycine + 0
              N-hydroxyglycine 0
              N-nonanoylglycine 0
              N-octanoylglycine 0
              N-purin-6-oylglycine 0
              N-tridecanoylglycine 0
              N-tris(hydroxymethyl)methylglycine 0
              N-undecanoylglycine 0
              N-vinylacetylglycine 0
              Phe-Ala-Gly 0
              Phe-Gly 0
              Pro-Trp-Val-Gly 0
              Pro-Val-Gly-Pro 0
              Thr-Asp-Gly 0
              Trp-Ala-Gly 0
              Val-Gly 0
              glycine derivative + 19
              glycine residue + 0
              glycine-d5 0
              glycino group + 0
              glycyl group 0
              glycyl radical + 0
              glycylglycine 0
              norophthalmic acid 0
              poly(glycyl-L-arginine) 0
              pyroglutamylglycine 0
              salicyluric acid + 0
              tiglylglycine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 903
    subatomic particle 888
      composite particle 888
        hadron 888
          baryon 888
            nucleon 888
              atomic nucleus 888
                atom 888
                  main group element atom 857
                    p-block element atom 854
                      carbon group element atom 830
                        carbon atom 829
                          organic molecular entity 829
                            organic group 392
                              organic divalent group 390
                                organodiyl group 390
                                  carbonyl group 389
                                    carbonyl compound 389
                                      carboxylic acid 267
                                        amino acid 137
                                          alpha-amino acid 105
                                            L-alpha-amino acid 104
                                              serine family amino acid 48
                                                glycine 22
                                                  2,2-dialkylglycine + 0
                                                  3-methylcrotonyl glycine 0
                                                  4-hydroxyphenylglycine + 0
                                                  4-nitrophenyl phthalimidoacetate 0
                                                  Ala-Ala-Gly 0
                                                  Ala-Asp-Gly 0
                                                  Ala-Cys-Gly 0
                                                  Ala-Gly-Ala-Gly 0
                                                  Ala-Gly-His 0
                                                  Ala-Gly-Pro 0
                                                  Ala-Gly-Ser 0
                                                  Ala-Gly-Tyr 0
                                                  Ala-Leu-Asp-Gly 0
                                                  Arg-Asn-Gly-Ser 0
                                                  Arg-Lys-Cys-Gly 0
                                                  Asn-Gly 0
                                                  Asp-Gly 0
                                                  Asp-Gly-Pro 0
                                                  Asp-Val-Gly-Pro 0
                                                  Cys-Asp-Gly 0
                                                  Cys-Phe-Phe-Gly 0
                                                  Glu-Glu-Gly 0
                                                  Glu-Gly 0
                                                  Glu-Gly-Arg-chloromethylketone 0
                                                  Glu-Gly-Trp 0
                                                  Gly-Ala-Ala 0
                                                  Gly-Arg-Pro 0
                                                  Gly-His 0
                                                  Gly-Hyp 0
                                                  Gly-Leu 0
                                                  Gly-Pro 0
                                                  Gly-Pro-Hyp 0
                                                  Gly-Ser + 0
                                                  Gly-Tyr 0
                                                  Leu-Ala-Gly 0
                                                  Leu-Asp-Gly 0
                                                  Leu-Gly-Pro 0
                                                  Leu-Gly-Ser 0
                                                  Leu-Leu-Gly 0
                                                  Leu-Val-Gly 0
                                                  Leu-enkephalin 0
                                                  Lys-Gly 0
                                                  Met-Gly 0
                                                  N-(2-anilino-2-oxoethyl)-2-methoxybenzamide 0
                                                  N-carbamoylglycine + 0
                                                  N-hydroxyglycine 0
                                                  N-nonanoylglycine 0
                                                  N-octanoylglycine 0
                                                  N-purin-6-oylglycine 0
                                                  N-tridecanoylglycine 0
                                                  N-tris(hydroxymethyl)methylglycine 0
                                                  N-undecanoylglycine 0
                                                  N-vinylacetylglycine 0
                                                  Phe-Ala-Gly 0
                                                  Phe-Gly 0
                                                  Pro-Trp-Val-Gly 0
                                                  Pro-Val-Gly-Pro 0
                                                  Thr-Asp-Gly 0
                                                  Trp-Ala-Gly 0
                                                  Val-Gly 0
                                                  glycine derivative + 19
                                                  glycine residue + 0
                                                  glycine-d5 0
                                                  glycino group + 0
                                                  glycyl group 0
                                                  glycyl radical + 0
                                                  glycylglycine 0
                                                  norophthalmic acid 0
                                                  poly(glycyl-L-arginine) 0
                                                  pyroglutamylglycine 0
                                                  salicyluric acid + 0
                                                  tiglylglycine 0
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