CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: (-)-ephedrine
Accession: CHEBI:15407
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Definition: A phenethylamine alkaloid that is 2-phenylethanamine substituted by a methyl group at the amino nitrogen and a methyl and a hydroxy group at position 2 and 1 respectively.
Synonyms: exact_synonym: (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol
related_synonym: (1R,2S)-1-phenyl-1-hydroxy-2-methylaminopropane; Formula=C10H15NO; InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1; InChIKey=KWGRBVOPPLSCSI-WPRPVWTQSA-N; L-Ephedrine; L-erythro-2-(methylamino)-1-phenylpropan-1-ol; SMILES=CN[C@@H](C)[C@H](O)c1ccccc1
alt_id: CHEBI:10776; CHEBI:132176; CHEBI:18483; CHEBI:4801
xref: CAS:299-42-3; Chemspider:4856; DrugBank:DB01364; Drug_Central:1024; Gmelin:261389; KEGG:C01575; KEGG:D00124; KNApSAcK:C00001409
xref_mesh: MESH:D004809
xref: PMID:13359219; PMID:13809594; PMID:21465337; PMID:25660335; PMID:27662264; PMID:27846433; Reaxys:2208730; VSDB:2959; Wikipedia:Ephedrine
cyclic_relationship: is_conjugate_base_of CHEBI:57295
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Apoa1
apolipoprotein A1
multiple interactions
ISO
[Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein
CTD
PMID:16324916
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Apoa2
apolipoprotein A2
multiple interactions
ISO
[Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein
CTD
PMID:16324916
NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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Apob
apolipoprotein B
multiple interactions
ISO
[Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein
CTD
PMID:16324916
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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Apoc1
apolipoprotein C1
multiple interactions
ISO
[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein
CTD
PMID:16324916
NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375
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Apoc2
apolipoprotein C2
multiple interactions
ISO
[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein
CTD
PMID:16324916
NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476
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Apoc3
apolipoprotein C3
multiple interactions
ISO
[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein
CTD
PMID:16324916
NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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Casp3
caspase 3
multiple interactions
EXP
[Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 protein
CTD
PMID:15537744
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cfd
complement factor D
multiple interactions
ISO
[Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD mRNA]; [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD protein]
CTD
PMID:2307116
NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Ephedrine results in increased expression of FOS mRNA
CTD
PMID:12730611
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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H2ax
H2A.X variant histone
multiple interactions
EXP
[Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein
CTD
PMID:15537744
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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