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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:limonene
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Accession:CHEBI:15384 term browser browse the term
Definition:A monoterpene that is cyclohex-1-ene substituted by a methyl group at position 1 and a prop-1-en-2-yl group at position 4 respectively.
Synonyms:exact_synonym: 1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene;   p-mentha-1,8-diene
 related_synonym: (+-)-(RS)-limonene;   1,8-p-menthadiene;   1-methyl-4-(1-methylethenyl)cyclohexene;   4-isopropenyl-1-methylcyclohexene;   Cajeputene;   Dipentene;   Formula=C10H16;   InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3;   InChIKey=XMGQYMWWDOXHJM-UHFFFAOYSA-N;   Kautschin;   SMILES=CC(=C)C1CCC(C)=CC1;   dl-Limonene
 alt_id: CHEBI:14506;   CHEBI:18466;   CHEBI:6463
 xref: CAS:138-86-3;   CAS:7705-14-8;   KEGG:C06078;   KNApSAcK:C00000823;   KNApSAcK:C00003043
 xref_mesh: MESH:C008281
 xref: Reaxys:774123;   UM-BBD_compID:c0626


show annotations for term's descendants           Sort by:
limonene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:29251412 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO [carvone co-treated with limonene] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 decreases expression EXP limonene results in decreased expression of AKR1D1 mRNA CTD PMID:12815608 NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:67,120,024...67,154,540 		JBrowse link
G Alb albumin increases expression
multiple interactions 		EXP limonene results in increased expression of ALB protein
limonene inhibits the reaction [Carbon Tetrachloride results in decreased secretion of ALB protein] 		CTD PMID:23159986 PMID:29251412 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Arg1 arginase 1 increases expression EXP limonene results in increased expression of ARG1 mRNA CTD PMID:12815608 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO limonene results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP limonene results in increased expression of ATP1A1 mRNA CTD PMID:12815608 NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO limonene results in decreased expression of BCL2 protein CTD PMID:12921557 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Calm1 calmodulin 1 increases expression EXP limonene results in increased expression of CALM1 mRNA CTD PMID:12815608 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381 		JBrowse link
G Cat catalase multiple interactions EXP limonene inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:29251412 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP limonene results in increased expression of CCNG1 mRNA CTD PMID:12815608 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP limonene results in increased expression of CDK1 mRNA CTD PMID:12815608 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression EXP limonene results in increased expression of COL3A1 mRNA CTD PMID:12815608 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 increases expression EXP limonene results in increased expression of COX4I1 mRNA CTD PMID:12815608 NCBI chr19:65,630,383...65,636,623
Ensembl chr19:65,630,432...65,636,624 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression EXP limonene results in increased expression of COX5A mRNA CTD PMID:12815608 NCBI chr 8:66,818,284...66,829,691
Ensembl chr 8:66,818,196...66,830,279 		JBrowse link
G Cox6c cytochrome c oxidase subunit 6C decreases expression EXP limonene results in decreased expression of COX6C mRNA CTD PMID:12815608 NCBI chr 7:69,014,410...69,027,145
Ensembl chr 7:69,014,417...69,027,166 		JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression 		ISO Fulvestrant inhibits the reaction [Limonene results in increased expression of CTSD mRNA] CTD PMID:31393563 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821 		JBrowse link
G Cyb5a cytochrome b5 type A increases expression EXP limonene results in increased expression of CYB5A mRNA CTD PMID:12815608 NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094 		JBrowse link
G Cycs cytochrome c, somatic increases expression EXP limonene results in increased expression of CYCS mRNA CTD PMID:12815608 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO limonene results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP limonene results in decreased activity of CYP2B1 protein CTD PMID:9242356 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 increases expression EXP limonene results in increased expression of CYP2B12 mRNA CTD PMID:12815608 NCBI chr 1:91,135,294...91,147,094
Ensembl chr 1:91,135,294...91,208,159 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Limonene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 multiple interactions ISO Limonene inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA] CTD PMID:31393563 NCBI chr 7:12,680,799...12,708,378
Ensembl chr 7:12,680,806...12,708,402 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP limonene results in increased expression of CYP51 mRNA CTD PMID:12815608 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 increases expression EXP limonene results in increased expression of DECR1 mRNA CTD PMID:12815608 NCBI chr 5:34,208,195...34,236,074
Ensembl chr 5:34,208,195...34,236,033 		JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 increases expression EXP limonene results in increased expression of DNAJA2 mRNA CTD PMID:12815608 NCBI chr19:37,671,019...37,689,163
Ensembl chr19:37,670,945...37,690,120 		JBrowse link
G Dut deoxyuridine triphosphatase increases expression EXP limonene results in increased expression of DUT mRNA CTD PMID:12815608 NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:132,952,394...132,964,956 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP limonene results in increased expression of GADD45A mRNA CTD PMID:12815608 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO limonene results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP limonene results in increased expression of GJB2 mRNA CTD PMID:12815608 NCBI chr15:35,375,977...35,393,817
Ensembl chr15:35,375,692...35,393,877 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO limonene inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:28986142 NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,665,061...8,683,191 		JBrowse link
G Gna15 G protein subunit alpha 15 increases response to substance
multiple interactions 		ISO GNA15 protein results in increased susceptibility to limonene
[GNA15 protein results in increased susceptibility to Limonene] which results in increased activity of OR2V1 protein 		CTD PMID:9875846 NCBI chr 7:8,835,396...8,856,269
Ensembl chr 7:8,835,357...8,856,268 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression EXP limonene results in increased expression of GPX1 mRNA CTD PMID:12815608 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression EXP limonene results in increased expression of GPX4 mRNA CTD PMID:12815608 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression 		ISO Fulvestrant inhibits the reaction [Limonene results in increased expression of GREB1 mRNA] CTD PMID:31393563 NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:45,169,289...45,291,126 		JBrowse link
G Grpel1 GrpE-like 1, mitochondrial increases expression EXP limonene results in increased expression of GRPEL1 mRNA CTD PMID:12815608 NCBI chr14:78,517,049...78,522,868
Ensembl chr14:78,517,052...78,522,861 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP limonene results in increased expression of GSTM1 protein CTD PMID:23159986 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Gstm5l glutathione S-transferase, mu 5-like increases expression EXP Limonene results in increased expression of GSTM5 mRNA CTD PMID:12815608 NCBI chr 2:198,231,285...198,238,122
Ensembl chr 2:198,232,596...198,238,252 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions 		ISO limonene results in increased expression of HMOX1 mRNA
limonene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein] 		CTD PMID:20491607 PMID:28986142 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO limonene inhibits the reaction [HRAS protein results in increased susceptibility to Methylnitrosourea] CTD PMID:11802805 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression EXP limonene results in increased expression of HSP90AB1 mRNA CTD PMID:12815608 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP limonene results in increased expression of HSPD1 mRNA CTD PMID:12815608 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037 		JBrowse link
G Il1a interleukin 1 alpha affects expression ISO Limonene affects the expression of IL1A protein CTD PMID:19878710 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of IL6 protein] CTD PMID:28986142 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO limonene inhibits the reaction [Diethylnitrosamine results in increased expression of JUN protein] CTD PMID:10425313 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Lif LIF, interleukin 6 family cytokine affects expression ISO Limonene affects the expression of LIF protein CTD PMID:19878710 NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression EXP limonene results in increased expression of MAPK14 mRNA CTD PMID:12815608 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression EXP limonene results in increased expression of MAPK6 mRNA CTD PMID:12815608 NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:85,027,144...85,050,236 		JBrowse link
G Mgat2 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase increases expression EXP limonene results in increased expression of MGAT2 mRNA CTD PMID:12815608 NCBI chr 6:93,392,416...93,394,905
Ensembl chr 6:93,390,555...93,395,176 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression 		ISO
EXP 		limonene inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein]
limonene results in increased expression of MYC mRNA 		CTD PMID:10425313 PMID:12815608 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression EXP limonene results in increased expression of NFKB1 mRNA CTD PMID:12815608 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Npy neuropeptide Y decreases expression ISO
EXP 		limonene results in decreased expression of NPY protein
limonene results in decreased expression of NPY mRNA 		CTD PMID:22757684 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310 		JBrowse link
G Obp3 alpha-2u globulin PGCL4 affects binding
increases expression 		EXP limonene binds to OBP3 protein
limonene results in increased expression of OBP3 protein 		CTD PMID:19428932 PMID:20069279 NCBI chr 5:79,637,234...79,640,810
Ensembl chr 5:79,637,234...79,640,675 		JBrowse link
G Or2v1 olfactory receptor family 2 subfamily V member 1 multiple interactions
increases activity 		ISO [GNA15 protein results in increased susceptibility to Limonene] which results in increased activity of OR2V1 protein
Limonene results in increased activity of OR2V1 protein 		CTD PMID:9875846 NCBI chr10:33,901,067...33,905,416
Ensembl chr10:33,900,397...33,905,496 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP limonene results in increased expression of PCNA mRNA CTD PMID:12815608 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression EXP limonene results in increased expression of PDIA3 mRNA CTD PMID:12815608 NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327 		JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression 		ISO Fulvestrant inhibits the reaction [Limonene results in increased expression of PGR mRNA] CTD PMID:31393563 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [limonene co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein CTD PMID:28986142 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ppia peptidylprolyl isomerase A increases expression EXP limonene results in increased expression of PPIA mRNA CTD PMID:12815608 NCBI chr14:85,491,223...85,496,884
Ensembl chr14:85,492,484...85,497,115 		JBrowse link
G Ppib peptidylprolyl isomerase B increases expression EXP limonene results in increased expression of PPIB mRNA CTD PMID:12815608 NCBI chr 8:75,498,966...75,504,823
Ensembl chr 8:75,498,797...75,504,847 		JBrowse link
G Rara retinoic acid receptor, alpha decreases expression EXP limonene results in decreased expression of RARA mRNA CTD PMID:12815608 NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein] CTD PMID:29251412 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP limonene results in increased expression of SCD1 mRNA CTD PMID:12815608 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 multiple interactions ISO limonene inhibits the reaction [2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate results in increased activity of SCN5A protein] CTD PMID:29306026 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470 		JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO Limonene inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:78,973,805...78,998,480
Ensembl chr14:83,197,387...83,217,317 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP limonene results in decreased expression of SOD1 mRNA CTD PMID:12815608 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Tgfa transforming growth factor alpha increases expression EXP limonene results in increased expression of TGFA mRNA CTD PMID:12815608 NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:29251412 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of TNF protein]
limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] 		CTD PMID:28986142 PMID:29251412 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO limonene results in increased expression of TP53 protein CTD PMID:12921557 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Vip vasoactive intestinal peptide increases expression EXP limonene results in increased expression of VIP protein CTD PMID:20934418 NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:44,470,462...44,478,558 		JBrowse link
(S)-(-)-perillyl alcohol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 increases expression ISO perillyl alcohol results in increased expression of BAK1 protein CTD PMID:12530055 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of BAX protein] CTD PMID:19161993 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein] CTD PMID:19161993 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Cat catalase multiple interactions ISO
EXP 		perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein] 		CTD PMID:19161993 PMID:20923693 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO perillyl alcohol results in decreased expression of CCNA2 protein CTD PMID:17138864 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO perillyl alcohol results in decreased expression of CCNB1 protein CTD PMID:17138864 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions 		ISO perillyl alcohol results in decreased expression of CDK2 protein
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein] 		CTD PMID:17138864 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases response to substance
multiple interactions
increases expression 		ISO CDKN1A protein results in increased susceptibility to perillyl alcohol
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
perillyl alcohol results in increased expression of CDKN1A protein 		CTD PMID:17138864 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
increases response to substance
multiple interactions 		ISO perillyl alcohol results in increased expression of CDKN1B protein
CDKN1B protein results in increased susceptibility to perillyl alcohol
perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein] 		CTD PMID:17138864 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Fbxo32 F-box protein 32 increases expression ISO perillyl alcohol results in increased expression of FBXO32 mRNA; perillyl alcohol results in increased expression of FBXO32 protein CTD PMID:19406843 NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491 		JBrowse link
G Fnta farnesyltransferase, CAAX box, subunit alpha multiple interactions EXP [Vitamin A co-treated with perillyl alcohol] results in decreased expression of FNTA protein CTD PMID:15959631 NCBI chr16:72,767,864...72,786,193
Ensembl chr16:72,767,627...72,788,229 		JBrowse link
G Fntb farnesyltransferase, CAAX box, subunit beta multiple interactions
increases expression
decreases expression 		EXP [perillyl alcohol co-treated with Vitamin A] results in decreased expression of FNTB mRNA
perillyl alcohol results in increased expression of FNTB protein
perillyl alcohol results in decreased expression of FNTB mRNA 		CTD PMID:15959631 NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:101,269,671...101,352,716 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP 		perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GSR protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of GSR protein] 		CTD PMID:19161993 PMID:20923693 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of H6PD protein] CTD PMID:20923693 NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:165,721,654...165,753,125 		JBrowse link
G Ivl involucrin decreases expression ISO perillyl alcohol results in decreased expression of IVL protein CTD PMID:10769631 NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:180,842,307...180,846,578 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:19161993 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:19161993 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] CTD PMID:19161993 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RAF1 protein] CTD PMID:19161993 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions
increases expression 		ISO Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein] CTD PMID:12671036 NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in increased activity of RELA protein] CTD PMID:20923693 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases expression 		ISO
EXP 		Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein]
[perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA 		CTD PMID:12671036 PMID:15959631 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Rhob ras homolog family member B multiple interactions
increases expression 		ISO
EXP 		Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein]
perillyl alcohol results in increased expression of RHOB mRNA; perillyl alcohol results in increased expression of RHOB protein
[perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB mRNA; [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB protein 		CTD PMID:12671036 PMID:15959631 NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:20923693 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
carveol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec10a C-type lectin domain containing 10A multiple interactions ISO carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CLEC10A mRNA] CTD PMID:37967808 NCBI chr10:55,374,914...55,379,110
Ensembl chr10:55,374,887...55,379,108 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CLEC10A mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of MRC1 mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein] CTD PMID:37967808 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO carveol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:37967808 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CLEC10A mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of MRC1 mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein] CTD PMID:37967808 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO carveol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:37967808 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of MRC1 mRNA] CTD PMID:37967808 NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO carveol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:37967808 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Rhob ras homolog family member B increases expression
multiple interactions 		ISO carveol results in increased expression of RHOB protein
Mevalonic Acid affects the reaction [carveol results in increased expression of RHOB protein] 		CTD PMID:12671036 NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein] CTD PMID:37967808 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO carveol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:37967808 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of carveol CTD PMID:7574722 NCBI chr14:21,122,866...21,138,450
Ensembl chr14:21,122,861...21,138,467 		JBrowse link
perillyl alcohol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Perillyl alcohol increases phosphorylation of AKT1 protein in DU145 prostate gland cancer cells RGD PMID:17601486 RGD:408364950 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO perillyl alcohol results in increased expression of BAK1 protein CTD PMID:12530055 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of BAX protein] CTD PMID:19161993 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein] CTD PMID:19161993 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Cat catalase multiple interactions ISO
EXP 		perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein] 		CTD PMID:19161993 PMID:20923693 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO perillyl alcohol results in decreased expression of CCNA2 protein CTD PMID:17138864 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO perillyl alcohol results in decreased expression of CCNB1 protein CTD PMID:17138864 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions 		ISO perillyl alcohol results in decreased expression of CDK2 protein
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein] 		CTD PMID:17138864 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases response to substance
multiple interactions
increases expression 		ISO CDKN1A protein results in increased susceptibility to perillyl alcohol
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
perillyl alcohol results in increased expression of CDKN1A protein 		CTD PMID:17138864 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases response to substance
increases expression
multiple interactions 		ISO CDKN1B protein results in increased susceptibility to perillyl alcohol
perillyl alcohol results in increased expression of CDKN1B protein
perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein] 		CTD PMID:17138864 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Fbxo32 F-box protein 32 increases expression ISO perillyl alcohol results in increased expression of FBXO32 mRNA; perillyl alcohol results in increased expression of FBXO32 protein CTD PMID:19406843 NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491 		JBrowse link
G Fnta farnesyltransferase, CAAX box, subunit alpha multiple interactions EXP [Vitamin A co-treated with perillyl alcohol] results in decreased expression of FNTA protein CTD PMID:15959631 NCBI chr16:72,767,864...72,786,193
Ensembl chr16:72,767,627...72,788,229 		JBrowse link
G Fntb farnesyltransferase, CAAX box, subunit beta multiple interactions
increases expression
decreases expression 		EXP [perillyl alcohol co-treated with Vitamin A] results in decreased expression of FNTB mRNA
perillyl alcohol results in increased expression of FNTB protein
perillyl alcohol results in decreased expression of FNTB mRNA 		CTD PMID:15959631 NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:101,269,671...101,352,716 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP 		perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GSR protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of GSR protein] 		CTD PMID:19161993 PMID:20923693 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of H6PD protein] CTD PMID:20923693 NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:165,721,654...165,753,125 		JBrowse link
G Ivl involucrin decreases expression ISO perillyl alcohol results in decreased expression of IVL protein CTD PMID:10769631 NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:180,842,307...180,846,578 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:19161993 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:19161993 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] CTD PMID:19161993 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RAF1 protein] CTD PMID:19161993 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions
increases expression 		ISO Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein] CTD PMID:12671036 NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in increased activity of RELA protein] CTD PMID:20923693 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases expression 		ISO
EXP 		Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein]
[perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA 		CTD PMID:12671036 PMID:15959631 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Rhob ras homolog family member B multiple interactions
increases expression 		ISO
EXP 		Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein]
perillyl alcohol results in increased expression of RHOB mRNA; perillyl alcohol results in increased expression of RHOB protein
[perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB mRNA; [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB protein 		CTD PMID:12671036 PMID:15959631 NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:20923693 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          metabolite 20245
            eukaryotic metabolite 19958
              animal metabolite 19803
                mammalian metabolite 19802
                  human metabolite 19220
                    limonene 101
                      (4R)-limonene + 0
                      (4S)-limonene + 0
                      limonene monoterpenoid + 34
                      limonene-1,2-diol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            organic hydride 19079
                              organic fundamental parent 19079
                                hydrocarbon 18731
                                  olefin 9077
                                    cyclic olefin 421
                                      monocyclic olefin 419
                                        cycloalkene 406
                                          limonene 101
                                            (4R)-limonene + 0
                                            (4S)-limonene + 0
                                            limonene monoterpenoid + 34
                                            limonene-1,2-diol + 0
paths to the root