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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:limonene
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Accession:CHEBI:15384 term browser browse the term
Definition:A monoterpene that is cyclohex-1-ene substituted by a methyl group at position 1 and a prop-1-en-2-yl group at position 4 respectively.
Synonyms:exact_synonym: 1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene;   p-mentha-1,8-diene
 related_synonym: (+-)-(RS)-limonene;   1,8-p-menthadiene;   1-methyl-4-(1-methylethenyl)cyclohexene;   4-isopropenyl-1-methylcyclohexene;   Cajeputene;   Dipentene;   Formula=C10H16;   InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3;   InChIKey=XMGQYMWWDOXHJM-UHFFFAOYSA-N;   Kautschin;   SMILES=CC(=C)C1CCC(C)=CC1;   dl-Limonene
 alt_id: CHEBI:14506;   CHEBI:18466;   CHEBI:6463
 xref: CAS:138-86-3;   CAS:7705-14-8;   KEGG:C06078;   KNApSAcK:C00000823;   KNApSAcK:C00003043
 xref_mesh: MESH:C008281
 xref: Reaxys:774123;   UM-BBD_compID:c0626

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limonene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:29251412 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO [carvone co-treated with limonene] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 decreases expression EXP limonene results in decreased expression of AKR1D1 mRNA CTD PMID:12815608 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941 		JBrowse link
G Alb albumin increases expression
multiple interactions		 EXP limonene results in increased expression of ALB protein
limonene inhibits the reaction [Carbon Tetrachloride results in decreased secretion of ALB protein]		 CTD PMID:23159986 PMID:29251412 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Arg1 arginase 1 increases expression EXP limonene results in increased expression of ARG1 mRNA CTD PMID:12815608 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO limonene results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP limonene results in increased expression of ATP1A1 mRNA CTD PMID:12815608 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO limonene results in decreased expression of BCL2 protein CTD PMID:12921557 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Calm1 calmodulin 1 increases expression EXP limonene results in increased expression of CALM1 mRNA CTD PMID:12815608 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292 		JBrowse link
G Cat catalase multiple interactions EXP limonene inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:29251412 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP limonene results in increased expression of CCNG1 mRNA CTD PMID:12815608 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP limonene results in increased expression of CDK1 mRNA CTD PMID:12815608 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression EXP limonene results in increased expression of COL3A1 mRNA CTD PMID:12815608 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 increases expression EXP limonene results in increased expression of COX4I1 mRNA CTD PMID:12815608 NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression EXP limonene results in increased expression of COX5A mRNA CTD PMID:12815608 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765 		JBrowse link
G Cox6c cytochrome c oxidase subunit 6C decreases expression EXP limonene results in decreased expression of COX6C mRNA CTD PMID:12815608 NCBI chr 7:74,723,177...74,735,650
Ensembl chr 7:74,723,179...74,735,650 		JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [Limonene results in increased expression of CTSD mRNA] CTD PMID:31393563 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Cyb5a cytochrome b5 type A increases expression EXP limonene results in increased expression of CYB5A mRNA CTD PMID:12815608 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821 		JBrowse link
G Cycs cytochrome c, somatic increases expression EXP limonene results in increased expression of CYCS mRNA CTD PMID:12815608 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO limonene results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP limonene results in decreased activity of CYP2B1 protein CTD PMID:9242356 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 increases expression EXP limonene results in increased expression of CYP2B12 mRNA CTD PMID:12815608 NCBI chr 1:83,511,167...83,522,965
Ensembl chr 1:83,511,167...83,584,589 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO Limonene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 multiple interactions ISO Limonene inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA] CTD PMID:31393563 NCBI chr 7:15,198,950...15,225,547
Ensembl chr 7:15,198,940...15,225,410 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP limonene results in increased expression of CYP51 mRNA CTD PMID:12815608 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018 		JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 increases expression EXP limonene results in increased expression of DECR1 mRNA CTD PMID:12815608 NCBI chr 5:29,573,893...29,601,731
Ensembl chr 5:29,573,898...29,601,748 		JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 increases expression EXP limonene results in increased expression of DNAJA2 mRNA CTD PMID:12815608 NCBI chr19:22,569,999...22,588,143
Ensembl chr19:22,569,999...22,588,137 		JBrowse link
G Dut deoxyuridine triphosphatase increases expression EXP limonene results in increased expression of DUT mRNA CTD PMID:12815608 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP limonene results in increased expression of GADD45A mRNA CTD PMID:12815608 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO limonene results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP limonene results in increased expression of GJB2 mRNA CTD PMID:12815608 NCBI chr15:37,377,313...37,394,494
Ensembl chr15:37,377,316...37,383,277 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO limonene inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:28986142 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610 		JBrowse link
G Gna15 G protein subunit alpha 15 increases response to substance
multiple interactions		 ISO GNA15 protein results in increased susceptibility to limonene
[GNA15 protein results in increased susceptibility to limonene] which results in increased activity of OLFR56 protein		 CTD PMID:9875846 NCBI chr 7:11,054,249...11,075,152
Ensembl chr 7:11,054,333...11,077,251 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression EXP limonene results in increased expression of GPX1 mRNA CTD PMID:12815608 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression EXP limonene results in increased expression of GPX4 mRNA CTD PMID:12815608 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [Limonene results in increased expression of GREB1 mRNA] CTD PMID:31393563 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819 		JBrowse link
G Grpel1 GrpE-like 1, mitochondrial increases expression EXP limonene results in increased expression of GRPEL1 mRNA CTD PMID:12815608 NCBI chr14:79,458,951...79,464,782
Ensembl chr14:79,458,963...79,464,770 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP limonene results in increased expression of GSTM1 protein CTD PMID:23159986 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstm3l glutathione S-transferase mu 3-like increases expression EXP limonene results in increased expression of GSTM5 mRNA CTD PMID:12815608 NCBI chr 2:210,761,729...210,766,501
Ensembl chr 2:210,761,729...210,766,501 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO limonene results in increased expression of HMOX1 mRNA
limonene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]		 CTD PMID:20491607 PMID:28986142 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO limonene inhibits the reaction [HRAS protein results in increased susceptibility to Methylnitrosourea] CTD PMID:11802805 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression EXP limonene results in increased expression of HSP90AB1 mRNA CTD PMID:12815608 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP limonene results in increased expression of HSPD1 mRNA CTD PMID:12815608 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Il1a interleukin 1 alpha affects expression ISO Limonene affects the expression of IL1A protein CTD PMID:19878710 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of IL6 protein] CTD PMID:28986142 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO limonene inhibits the reaction [Diethylnitrosamine results in increased expression of JUN protein] CTD PMID:10425313 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Lif LIF, interleukin 6 family cytokine affects expression ISO Limonene affects the expression of LIF protein CTD PMID:19878710 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression EXP limonene results in increased expression of MAPK14 mRNA CTD PMID:12815608 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression EXP limonene results in increased expression of MAPK6 mRNA CTD PMID:12815608 NCBI chr 8:82,328,013...82,351,108
Ensembl chr 8:82,328,020...82,351,108 		JBrowse link
G Mgat2 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase increases expression EXP limonene results in increased expression of MGAT2 mRNA CTD PMID:12815608 NCBI chr 6:91,476,698...91,479,187
Ensembl chr 6:91,476,698...91,479,183 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression		 ISO
EXP		 limonene inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein]
limonene results in increased expression of MYC mRNA		 CTD PMID:10425313 PMID:12815608 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression EXP limonene results in increased expression of NFKB1 mRNA CTD PMID:12815608 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Npy neuropeptide Y decreases expression ISO
EXP		 limonene results in decreased expression of NPY protein
limonene results in decreased expression of NPY mRNA		 CTD PMID:22757684 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097 		JBrowse link
G Obp3 alpha-2u globulin PGCL4 affects binding
increases expression		 EXP limonene binds to OBP3 protein
limonene results in increased expression of OBP3 protein		 CTD PMID:19428932 PMID:20069279 NCBI chr 5:77,313,357...77,316,875 JBrowse link
G Olr1386 olfactory receptor 1386 multiple interactions
increases activity		 ISO [GNA15 protein results in increased susceptibility to limonene] which results in increased activity of OLFR56 protein
limonene results in increased activity of OLFR56 protein		 CTD PMID:9875846 NCBI chr10:34,380,438...34,384,343
Ensembl chr10:34,383,396...34,384,343 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP limonene results in increased expression of PCNA mRNA CTD PMID:12815608 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression EXP limonene results in increased expression of PDIA3 mRNA CTD PMID:12815608 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707 		JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [Limonene results in increased expression of PGR mRNA] CTD PMID:31393563 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [limonene co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein CTD PMID:28986142 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ppia peptidylprolyl isomerase A increases expression EXP limonene results in increased expression of PPIA mRNA CTD PMID:12815608 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443 		JBrowse link
G Ppib peptidylprolyl isomerase B increases expression EXP limonene results in increased expression of PPIB mRNA CTD PMID:12815608 NCBI chr 8:71,719,681...71,725,538
Ensembl chr 8:71,719,563...71,725,562 		JBrowse link
G Rara retinoic acid receptor, alpha decreases expression EXP limonene results in decreased expression of RARA mRNA CTD PMID:12815608 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein] CTD PMID:29251412 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP limonene results in increased expression of SCD1 mRNA CTD PMID:12815608 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 multiple interactions ISO limonene inhibits the reaction [2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate results in increased activity of SCN5A protein] CTD PMID:29306026 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639 		JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO Limonene inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:84,335,594...84,360,354
Ensembl chr14:84,335,597...84,355,528 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP limonene results in decreased expression of SOD1 mRNA CTD PMID:12815608 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Tgfa transforming growth factor alpha increases expression EXP limonene results in increased expression of TGFA mRNA CTD PMID:12815608 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:29251412 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of TNF protein]
limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]		 CTD PMID:28986142 PMID:29251412 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO limonene results in increased expression of TP53 protein CTD PMID:12921557 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vip vasoactive intestinal peptide increases expression EXP limonene results in increased expression of VIP protein CTD PMID:20934418 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582 		JBrowse link
(S)-(-)-perillyl alcohol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 increases expression ISO perillyl alcohol results in increased expression of BAK1 protein CTD PMID:12530055 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of BAX protein] CTD PMID:19161993 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein] CTD PMID:19161993 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein]		 CTD PMID:19161993 PMID:20923693 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO perillyl alcohol results in decreased expression of CCNA2 protein CTD PMID:17138864 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO perillyl alcohol results in decreased expression of CCNB1 protein CTD PMID:17138864 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions		 ISO perillyl alcohol results in decreased expression of CDK2 protein
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]		 CTD PMID:17138864 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases response to substance
multiple interactions
increases expression		 ISO CDKN1A protein results in increased susceptibility to perillyl alcohol
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
perillyl alcohol results in increased expression of CDKN1A protein		 CTD PMID:17138864 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
increases response to substance
multiple interactions		 ISO perillyl alcohol results in increased expression of CDKN1B protein
CDKN1B protein results in increased susceptibility to perillyl alcohol
perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]		 CTD PMID:17138864 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Fbxo32 F-box protein 32 increases expression ISO perillyl alcohol results in increased expression of FBXO32 mRNA; perillyl alcohol results in increased expression of FBXO32 protein CTD PMID:19406843 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268 		JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha multiple interactions EXP [Vitamin A co-treated with perillyl alcohol] results in decreased expression of FNTA protein CTD PMID:15959631 NCBI chr16:70,834,957...70,854,724
Ensembl chr16:70,834,957...70,854,724 		JBrowse link
G Fntb farnesyltransferase, CAAX box, beta multiple interactions
increases expression
decreases expression		 EXP [perillyl alcohol co-treated with Vitamin A] results in decreased expression of FNTB mRNA
perillyl alcohol results in increased expression of FNTB protein
perillyl alcohol results in decreased expression of FNTB mRNA		 CTD PMID:15959631 NCBI chr 6:99,883,959...99,966,988
Ensembl chr 6:99,883,959...99,966,988 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP		 perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GSR protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of GSR protein]		 CTD PMID:19161993 PMID:20923693 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of H6PD protein] CTD PMID:20923693 NCBI chr 5:166,994,683...167,030,441
Ensembl chr 5:166,998,881...167,030,441 		JBrowse link
G Ivl involucrin decreases expression ISO perillyl alcohol results in decreased expression of IVL protein CTD PMID:10769631 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:19161993 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:19161993 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] CTD PMID:19161993 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RAF1 protein] CTD PMID:19161993 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions
increases expression		 ISO Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein] CTD PMID:12671036 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in increased activity of RELA protein] CTD PMID:20923693 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases expression		 ISO
EXP		 Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein]
[perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA		 CTD PMID:12671036 PMID:15959631 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167 		JBrowse link
G Rhob ras homolog family member B multiple interactions
increases expression		 ISO
EXP		 Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein]
perillyl alcohol results in increased expression of RHOB mRNA; perillyl alcohol results in increased expression of RHOB protein
[perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB mRNA; [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB protein		 CTD PMID:12671036 PMID:15959631 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:20923693 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
carveol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhob ras homolog family member B increases expression
multiple interactions		 ISO carveol results in increased expression of RHOB protein
Mevalonic Acid affects the reaction [carveol results in increased expression of RHOB protein]		 CTD PMID:12671036 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of carveol CTD PMID:7574722 NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720 		JBrowse link
perillyl alcohol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 increases expression ISO perillyl alcohol results in increased expression of BAK1 protein CTD PMID:12530055 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of BAX protein] CTD PMID:19161993 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein] CTD PMID:19161993 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein]		 CTD PMID:19161993 PMID:20923693 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO perillyl alcohol results in decreased expression of CCNA2 protein CTD PMID:17138864 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO perillyl alcohol results in decreased expression of CCNB1 protein CTD PMID:17138864 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions		 ISO perillyl alcohol results in decreased expression of CDK2 protein
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]		 CTD PMID:17138864 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases response to substance
multiple interactions
increases expression		 ISO CDKN1A protein results in increased susceptibility to perillyl alcohol
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
perillyl alcohol results in increased expression of CDKN1A protein		 CTD PMID:17138864 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases response to substance
increases expression
multiple interactions		 ISO CDKN1B protein results in increased susceptibility to perillyl alcohol
perillyl alcohol results in increased expression of CDKN1B protein
perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]		 CTD PMID:17138864 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Fbxo32 F-box protein 32 increases expression ISO perillyl alcohol results in increased expression of FBXO32 mRNA; perillyl alcohol results in increased expression of FBXO32 protein CTD PMID:19406843 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268 		JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha multiple interactions EXP [Vitamin A co-treated with perillyl alcohol] results in decreased expression of FNTA protein CTD PMID:15959631 NCBI chr16:70,834,957...70,854,724
Ensembl chr16:70,834,957...70,854,724 		JBrowse link
G Fntb farnesyltransferase, CAAX box, beta multiple interactions
increases expression
decreases expression		 EXP [perillyl alcohol co-treated with Vitamin A] results in decreased expression of FNTB mRNA
perillyl alcohol results in increased expression of FNTB protein
perillyl alcohol results in decreased expression of FNTB mRNA		 CTD PMID:15959631 NCBI chr 6:99,883,959...99,966,988
Ensembl chr 6:99,883,959...99,966,988 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP		 perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GSR protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of GSR protein]		 CTD PMID:19161993 PMID:20923693 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of H6PD protein] CTD PMID:20923693 NCBI chr 5:166,994,683...167,030,441
Ensembl chr 5:166,998,881...167,030,441 		JBrowse link
G Ivl involucrin decreases expression ISO perillyl alcohol results in decreased expression of IVL protein CTD PMID:10769631 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:19161993 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:19161993 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] CTD PMID:19161993 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RAF1 protein] CTD PMID:19161993 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions
increases expression		 ISO Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein] CTD PMID:12671036 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in increased activity of RELA protein] CTD PMID:20923693 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases expression		 ISO
EXP		 Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein]
[perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA		 CTD PMID:12671036 PMID:15959631 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167 		JBrowse link
G Rhob ras homolog family member B multiple interactions
increases expression		 ISO
EXP		 Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein]
perillyl alcohol results in increased expression of RHOB mRNA; perillyl alcohol results in increased expression of RHOB protein
[perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB mRNA; [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB protein		 CTD PMID:12671036 PMID:15959631 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:20923693 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          carbon atom 19625
            organic molecular entity 19625
              isoprenoid 9623
                terpene 9623
                  monoterpene 1222
                    limonene 93
                      (4R)-limonene + 0
                      (4S)-limonene + 0
                      limonene monoterpenoid + 25
                      limonene-1,2-diol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    main group molecular entity 19732
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18745
                            organic hydride 18291
                              organic fundamental parent 18291
                                hydrocarbon 18015
                                  olefin 7206
                                    cyclic olefin 108
                                      monocyclic olefin 105
                                        cycloalkene 96
                                          limonene 93
                                            (4R)-limonene + 0
                                            (4S)-limonene + 0
                                            limonene monoterpenoid + 25
                                            limonene-1,2-diol + 0
paths to the root