CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: limonene
Accession: CHEBI:15384
browse the term
Definition: A monoterpene that is cyclohex-1-ene substituted by a methyl group at position 1 and a prop-1-en-2-yl group at position 4 respectively.
Synonyms: exact_synonym: 1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; p-mentha-1,8-diene
related_synonym: (+-)-(RS)-limonene; 1,8-p-menthadiene; 1-methyl-4-(1-methylethenyl)cyclohexene; 4-isopropenyl-1-methylcyclohexene; Cajeputene; Dipentene; Formula=C10H16; InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3; InChIKey=XMGQYMWWDOXHJM-UHFFFAOYSA-N; Kautschin; SMILES=CC(=C)C1CCC(C)=CC1; dl-Limonene
alt_id: CHEBI:14506; CHEBI:18466; CHEBI:6463
xref: CAS:138-86-3; CAS:7705-14-8; KEGG:C06078; KNApSAcK:C00000823; KNApSAcK:C00003043
xref_mesh: MESH:C008281
xref: Reaxys:774123; UM-BBD_compID:c0626
G
Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD
PMID:29251412
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
[carvone co-treated with limonene] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD
PMID:29191726
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
G
Akr1d1
aldo-keto reductase family 1, member D1
decreases expression
EXP
limonene results in decreased expression of AKR1D1 mRNA
CTD
PMID:12815608
NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:67,120,024...67,154,540
G
Alb
albumin
increases expression multiple interactions
EXP
limonene results in increased expression of ALB protein limonene inhibits the reaction [Carbon Tetrachloride results in decreased secretion of ALB protein]
CTD
PMID:23159986 PMID:29251412
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
G
Arg1
arginase 1
increases expression
EXP
limonene results in increased expression of ARG1 mRNA
CTD
PMID:12815608
NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713
G
Atf3
activating transcription factor 3
increases expression
ISO
limonene results in increased expression of ATF3 mRNA
CTD
PMID:27965148
NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750
G
Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
increases expression
EXP
limonene results in increased expression of ATP1A1 mRNA
CTD
PMID:12815608
NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
limonene results in decreased expression of BCL2 protein
CTD
PMID:12921557
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
G
Calm1
calmodulin 1
increases expression
EXP
limonene results in increased expression of CALM1 mRNA
CTD
PMID:12815608
NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381
G
Cat
catalase
multiple interactions
EXP
limonene inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
CTD
PMID:29251412
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
G
Ccng1
cyclin G1
increases expression
EXP
limonene results in increased expression of CCNG1 mRNA
CTD
PMID:12815608
NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766
G
Cdk1
cyclin-dependent kinase 1
increases expression
EXP
limonene results in increased expression of CDK1 mRNA
CTD
PMID:12815608
NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455
G
Col3a1
collagen type III alpha 1 chain
increases expression
EXP
limonene results in increased expression of COL3A1 mRNA
CTD
PMID:12815608
NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232
G
Cox4i1
cytochrome c oxidase subunit 4i1
increases expression
EXP
limonene results in increased expression of COX4I1 mRNA
CTD
PMID:12815608
NCBI chr19:65,630,383...65,636,623
Ensembl chr19:65,630,432...65,636,624
G
Cox5a
cytochrome c oxidase subunit 5A
increases expression
EXP
limonene results in increased expression of COX5A mRNA
CTD
PMID:12815608
NCBI chr 8:66,818,284...66,829,691
Ensembl chr 8:66,818,196...66,830,279
G
Cox6c
cytochrome c oxidase subunit 6C
decreases expression
EXP
limonene results in decreased expression of COX6C mRNA
CTD
PMID:12815608
NCBI chr 7:69,014,410...69,027,145
Ensembl chr 7:69,014,417...69,027,166
G
Ctsd
cathepsin D
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [Limonene results in increased expression of CTSD mRNA]
CTD
PMID:31393563
NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821
G
Cyb5a
cytochrome b5 type A
increases expression
EXP
limonene results in increased expression of CYB5A mRNA
CTD
PMID:12815608
NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094 Ensembl chr18:14,453,966...14,455,094
G
Cycs
cytochrome c, somatic
increases expression
EXP
limonene results in increased expression of CYCS mRNA
CTD
PMID:12815608
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816 Ensembl chr18:80,982,668...80,984,816
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
limonene results in increased expression of CYP1A1 mRNA
CTD
PMID:20491607
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
decreases activity
EXP
limonene results in decreased activity of CYP2B1 protein
CTD
PMID:9242356
NCBI chr 1:90,646,098...90,669,762
G
Cyp2b12
cytochrome P450, family 2, subfamily b, polypeptide 12
increases expression
EXP
limonene results in increased expression of CYP2B12 mRNA
CTD
PMID:12815608
NCBI chr 1:91,135,294...91,147,094
Ensembl chr 1:91,135,294...91,208,159
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
Limonene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]
CTD
PMID:18385293
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
G
Cyp4f6
cytochrome P450, family 4, subfamily f, polypeptide 6
multiple interactions
ISO
Limonene inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA]
CTD
PMID:31393563
NCBI chr 7:12,680,799...12,708,378
Ensembl chr 7:12,680,806...12,708,402
G
Cyp51
cytochrome P450, family 51
increases expression
EXP
limonene results in increased expression of CYP51 mRNA
CTD
PMID:12815608
NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450
G
Decr1
2,4-dienoyl-CoA reductase 1
increases expression
EXP
limonene results in increased expression of DECR1 mRNA
CTD
PMID:12815608
NCBI chr 5:34,208,195...34,236,074
Ensembl chr 5:34,208,195...34,236,033
G
Dnaja2
DnaJ heat shock protein family (Hsp40) member A2
increases expression
EXP
limonene results in increased expression of DNAJA2 mRNA
CTD
PMID:12815608
NCBI chr19:37,671,019...37,689,163
Ensembl chr19:37,670,945...37,690,120
G
Dut
deoxyuridine triphosphatase
increases expression
EXP
limonene results in increased expression of DUT mRNA
CTD
PMID:12815608
NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:132,952,394...132,964,956
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
EXP
limonene results in increased expression of GADD45A mRNA
CTD
PMID:12815608
NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
limonene results in increased expression of GCLM mRNA
CTD
PMID:27965148
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
G
Gjb2
gap junction protein, beta 2
increases expression
EXP
limonene results in increased expression of GJB2 mRNA
CTD
PMID:12815608
NCBI chr15:35,375,977...35,393,817
Ensembl chr15:35,375,692...35,393,877
G
Glo1
glyoxalase 1
multiple interactions
ISO
limonene inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]
CTD
PMID:28986142
NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,665,061...8,683,191
G
Gna15
G protein subunit alpha 15
increases response to substance multiple interactions
ISO
GNA15 protein results in increased susceptibility to limonene [GNA15 protein results in increased susceptibility to Limonene] which results in increased activity of OR2V1 protein
CTD
PMID:9875846
NCBI chr 7:8,835,396...8,856,269
Ensembl chr 7:8,835,357...8,856,268
G
Gpx1
glutathione peroxidase 1
increases expression
EXP
limonene results in increased expression of GPX1 mRNA
CTD
PMID:12815608
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
G
Gpx4
glutathione peroxidase 4
increases expression
EXP
limonene results in increased expression of GPX4 mRNA
CTD
PMID:12815608
NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629
G
Greb1
growth regulating estrogen receptor binding 1
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [Limonene results in increased expression of GREB1 mRNA]
CTD
PMID:31393563
NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:45,169,289...45,291,126
G
Grpel1
GrpE-like 1, mitochondrial
increases expression
EXP
limonene results in increased expression of GRPEL1 mRNA
CTD
PMID:12815608
NCBI chr14:78,517,049...78,522,868
Ensembl chr14:78,517,052...78,522,861
G
Gstm1
glutathione S-transferase mu 1
increases expression
EXP
limonene results in increased expression of GSTM1 protein
CTD
PMID:23159986
NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569
G
Gstm5l
glutathione S-transferase, mu 5-like
increases expression
EXP
Limonene results in increased expression of GSTM5 mRNA
CTD
PMID:12815608
NCBI chr 2:198,231,285...198,238,122
Ensembl chr 2:198,232,596...198,238,252
G
Hmox1
heme oxygenase 1
increases expression multiple interactions
ISO
limonene results in increased expression of HMOX1 mRNA limonene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]
CTD
PMID:20491607 PMID:28986142
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
G
Hras
HRas proto-oncogene, GTPase
multiple interactions
ISO
limonene inhibits the reaction [HRAS protein results in increased susceptibility to Methylnitrosourea]
CTD
PMID:11802805
NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590
G
Hsp90ab1
heat shock protein 90 alpha family class B member 1
increases expression
EXP
limonene results in increased expression of HSP90AB1 mRNA
CTD
PMID:12815608
NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926
G
Hspd1
heat shock protein family D (Hsp60) member 1
increases expression
EXP
limonene results in increased expression of HSPD1 mRNA
CTD
PMID:12815608
NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037
G
Il1a
interleukin 1 alpha
affects expression
ISO
Limonene affects the expression of IL1A protein
CTD
PMID:19878710
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
G
Il6
interleukin 6
multiple interactions
ISO
limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of IL6 protein]
CTD
PMID:28986142
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
limonene inhibits the reaction [Diethylnitrosamine results in increased expression of JUN protein]
CTD
PMID:10425313
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
G
Lif
LIF, interleukin 6 family cytokine
affects expression
ISO
Limonene affects the expression of LIF protein
CTD
PMID:19878710
NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053
G
Mapk14
mitogen activated protein kinase 14
increases expression
EXP
limonene results in increased expression of MAPK14 mRNA
CTD
PMID:12815608
NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
G
Mapk6
mitogen-activated protein kinase 6
increases expression
EXP
limonene results in increased expression of MAPK6 mRNA
CTD
PMID:12815608
NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:85,027,144...85,050,236
G
Mgat2
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
increases expression
EXP
limonene results in increased expression of MGAT2 mRNA
CTD
PMID:12815608
NCBI chr 6:93,392,416...93,394,905
Ensembl chr 6:93,390,555...93,395,176
G
Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions increases expression
ISO EXP
limonene inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein] limonene results in increased expression of MYC mRNA
CTD
PMID:10425313 PMID:12815608
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
G
Nfkb1
nuclear factor kappa B subunit 1
increases expression
EXP
limonene results in increased expression of NFKB1 mRNA
CTD
PMID:12815608
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
G
Npy
neuropeptide Y
decreases expression
ISO EXP
limonene results in decreased expression of NPY protein limonene results in decreased expression of NPY mRNA
CTD
PMID:22757684
NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310
G
Obp3
alpha-2u globulin PGCL4
affects binding increases expression
EXP
limonene binds to OBP3 protein limonene results in increased expression of OBP3 protein
CTD
PMID:19428932 PMID:20069279
NCBI chr 5:79,637,234...79,640,810
Ensembl chr 5:79,637,234...79,640,675
G
Or2v1
olfactory receptor family 2 subfamily V member 1
multiple interactions increases activity
ISO
[GNA15 protein results in increased susceptibility to Limonene] which results in increased activity of OR2V1 protein Limonene results in increased activity of OR2V1 protein
CTD
PMID:9875846
NCBI chr10:33,901,067...33,905,416
Ensembl chr10:33,900,397...33,905,496
G
Pcna
proliferating cell nuclear antigen
increases expression
EXP
limonene results in increased expression of PCNA mRNA
CTD
PMID:12815608
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
G
Pdia3
protein disulfide isomerase family A, member 3
increases expression
EXP
limonene results in increased expression of PDIA3 mRNA
CTD
PMID:12815608
NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327
G
Pgr
progesterone receptor
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [Limonene results in increased expression of PGR mRNA]
CTD
PMID:31393563
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271
G
Ppargc1a
PPARG coactivator 1 alpha
multiple interactions
ISO
[limonene co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein
CTD
PMID:28986142
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
G
Ppia
peptidylprolyl isomerase A
increases expression
EXP
limonene results in increased expression of PPIA mRNA
CTD
PMID:12815608
NCBI chr14:85,491,223...85,496,884
Ensembl chr14:85,492,484...85,497,115
G
Ppib
peptidylprolyl isomerase B
increases expression
EXP
limonene results in increased expression of PPIB mRNA
CTD
PMID:12815608
NCBI chr 8:75,498,966...75,504,823
Ensembl chr 8:75,498,797...75,504,847
G
Rara
retinoic acid receptor, alpha
decreases expression
EXP
limonene results in decreased expression of RARA mRNA
CTD
PMID:12815608
NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]
CTD
PMID:29251412
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
G
Scd
stearoyl-CoA desaturase
increases expression
EXP
limonene results in increased expression of SCD1 mRNA
CTD
PMID:12815608
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785
G
Scn5a
sodium voltage-gated channel alpha subunit 5
multiple interactions
ISO
limonene inhibits the reaction [2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate results in increased activity of SCN5A protein]
CTD
PMID:29306026
NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470
G
Sec14l2
SEC14-like lipid binding 2
multiple interactions
ISO
Limonene inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA]
CTD
PMID:31393563
NCBI chr14:78,973,805...78,998,480
Ensembl chr14:83,197,387...83,217,317
G
Sod1
superoxide dismutase 1
decreases expression
EXP
limonene results in decreased expression of SOD1 mRNA
CTD
PMID:12815608
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
G
Tgfa
transforming growth factor alpha
increases expression
EXP
limonene results in increased expression of TGFA mRNA
CTD
PMID:12815608
NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
CTD
PMID:29251412
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
G
Tnf
tumor necrosis factor
multiple interactions
ISO EXP
limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of TNF protein] limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
CTD
PMID:28986142 PMID:29251412
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
G
Tp53
tumor protein p53
increases expression
ISO
limonene results in increased expression of TP53 protein
CTD
PMID:12921557
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
G
Vip
vasoactive intestinal peptide
increases expression
EXP
limonene results in increased expression of VIP protein
CTD
PMID:20934418
NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:44,470,462...44,478,558
G
Bak1
BCL2-antagonist/killer 1
increases expression
ISO
perillyl alcohol results in increased expression of BAK1 protein
CTD
PMID:12530055
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of BAX protein]
CTD
PMID:19161993
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]
CTD
PMID:19161993
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
G
Cat
catalase
multiple interactions
ISO EXP
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein] perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein]
CTD
PMID:19161993 PMID:20923693
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
G
Ccna2
cyclin A2
decreases expression
ISO
perillyl alcohol results in decreased expression of CCNA2 protein
CTD
PMID:17138864
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701
G
Ccnb1
cyclin B1
decreases expression
ISO
perillyl alcohol results in decreased expression of CCNB1 protein
CTD
PMID:17138864
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
G
Cdk2
cyclin dependent kinase 2
decreases expression multiple interactions
ISO
perillyl alcohol results in decreased expression of CDK2 protein perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD
PMID:17138864
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases response to substance multiple interactions increases expression
ISO
CDKN1A protein results in increased susceptibility to perillyl alcohol perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein] perillyl alcohol results in increased expression of CDKN1A protein
CTD
PMID:17138864
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression increases response to substance multiple interactions
ISO
perillyl alcohol results in increased expression of CDKN1B protein CDKN1B protein results in increased susceptibility to perillyl alcohol perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD
PMID:17138864
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
G
Fbxo32
F-box protein 32
increases expression
ISO
perillyl alcohol results in increased expression of FBXO32 mRNA; perillyl alcohol results in increased expression of FBXO32 protein
CTD
PMID:19406843
NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491
G
Fnta
farnesyltransferase, CAAX box, subunit alpha
multiple interactions
EXP
[Vitamin A co-treated with perillyl alcohol] results in decreased expression of FNTA protein
CTD
PMID:15959631
NCBI chr16:72,767,864...72,786,193
Ensembl chr16:72,767,627...72,788,229
G
Fntb
farnesyltransferase, CAAX box, subunit beta
multiple interactions increases expression decreases expression
EXP
[perillyl alcohol co-treated with Vitamin A] results in decreased expression of FNTB mRNA perillyl alcohol results in increased expression of FNTB protein perillyl alcohol results in decreased expression of FNTB mRNA
CTD
PMID:15959631
NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:101,269,671...101,352,716
G
Gsr
glutathione-disulfide reductase
multiple interactions
ISO EXP
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GSR protein] perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of GSR protein]
CTD
PMID:19161993 PMID:20923693
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
G
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
multiple interactions
EXP
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of H6PD protein]
CTD
PMID:20923693
NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:165,721,654...165,753,125
G
Ivl
involucrin
decreases expression
ISO
perillyl alcohol results in decreased expression of IVL protein
CTD
PMID:10769631
NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:180,842,307...180,846,578
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
CTD
PMID:19161993
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
CTD
PMID:19161993
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
G
Odc1
ornithine decarboxylase 1
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]
CTD
PMID:19161993
NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RAF1 protein]
CTD
PMID:19161993
NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813
G
Rap1a
RAP1A, member of RAS oncogene family
multiple interactions increases expression
ISO
Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein]
CTD
PMID:12671036
NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
perillyl alcohol inhibits the reaction [Ethanol results in increased activity of RELA protein]
CTD
PMID:20923693
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
G
Rhoa
ras homolog family member A
multiple interactions increases expression
ISO EXP
Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein] [perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA
CTD
PMID:12671036 PMID:15959631
NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302
G
Rhob
ras homolog family member B
multiple interactions increases expression
ISO EXP
Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein] perillyl alcohol results in increased expression of RHOB mRNA; perillyl alcohol results in increased expression of RHOB protein [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB mRNA; [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB protein
CTD
PMID:12671036 PMID:15959631
NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772
G
Tnf
tumor necrosis factor
multiple interactions
EXP
perillyl alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein]
CTD
PMID:20923693
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
G
Clec10a
C-type lectin domain containing 10A
multiple interactions
ISO
carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CLEC10A mRNA]
CTD
PMID:37967808
NCBI chr10:55,374,914...55,379,110
Ensembl chr10:55,374,887...55,379,108
G
Il13
interleukin 13
multiple interactions
ISO
carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CLEC10A mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of MRC1 mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein]
CTD
PMID:37967808
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
G
Il1b
interleukin 1 beta
multiple interactions
ISO
carveol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD
PMID:37967808
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
G
Il4
interleukin 4
multiple interactions
ISO
carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CLEC10A mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of MRC1 mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein]
CTD
PMID:37967808
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
G
Il6
interleukin 6
multiple interactions
ISO
carveol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:37967808
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
G
Mrc1
mannose receptor, C type 1
multiple interactions
ISO
carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of MRC1 mRNA]
CTD
PMID:37967808
NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
carveol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD
PMID:37967808
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
G
Rhob
ras homolog family member B
increases expression multiple interactions
ISO
carveol results in increased expression of RHOB protein Mevalonic Acid affects the reaction [carveol results in increased expression of RHOB protein]
CTD
PMID:12671036
NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772
G
Stat6
signal transducer and activator of transcription 6
multiple interactions
ISO
carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein]
CTD
PMID:37967808
NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795
G
Tnf
tumor necrosis factor
multiple interactions
ISO
carveol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD
PMID:37967808
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
G
Ugt2b15
UDP glucuronosyltransferase family 2 member B15
increases metabolic processing
EXP
UGT2B15 protein results in increased metabolism of carveol
CTD
PMID:7574722
NCBI chr14:21,122,866...21,138,450
Ensembl chr14:21,122,861...21,138,467
G
Akt1
AKT serine/threonine kinase 1
increases phosphorylation
ISO
Perillyl alcohol increases phosphorylation of AKT1 protein in DU145 prostate gland cancer cells
RGD
PMID:17601486
RGD:408364950
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
G
Bak1
BCL2-antagonist/killer 1
increases expression
ISO
perillyl alcohol results in increased expression of BAK1 protein
CTD
PMID:12530055
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of BAX protein]
CTD
PMID:19161993
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]
CTD
PMID:19161993
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
G
Cat
catalase
multiple interactions
ISO EXP
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein] perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein]
CTD
PMID:19161993 PMID:20923693
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
G
Ccna2
cyclin A2
decreases expression
ISO
perillyl alcohol results in decreased expression of CCNA2 protein
CTD
PMID:17138864
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701
G
Ccnb1
cyclin B1
decreases expression
ISO
perillyl alcohol results in decreased expression of CCNB1 protein
CTD
PMID:17138864
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
G
Cdk2
cyclin dependent kinase 2
decreases expression multiple interactions
ISO
perillyl alcohol results in decreased expression of CDK2 protein perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD
PMID:17138864
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases response to substance multiple interactions increases expression
ISO
CDKN1A protein results in increased susceptibility to perillyl alcohol perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein] perillyl alcohol results in increased expression of CDKN1A protein
CTD
PMID:17138864
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases response to substance increases expression multiple interactions
ISO
CDKN1B protein results in increased susceptibility to perillyl alcohol perillyl alcohol results in increased expression of CDKN1B protein perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD
PMID:17138864
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
G
Fbxo32
F-box protein 32
increases expression
ISO
perillyl alcohol results in increased expression of FBXO32 mRNA; perillyl alcohol results in increased expression of FBXO32 protein
CTD
PMID:19406843
NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491
G
Fnta
farnesyltransferase, CAAX box, subunit alpha
multiple interactions
EXP
[Vitamin A co-treated with perillyl alcohol] results in decreased expression of FNTA protein
CTD
PMID:15959631
NCBI chr16:72,767,864...72,786,193
Ensembl chr16:72,767,627...72,788,229
G
Fntb
farnesyltransferase, CAAX box, subunit beta
multiple interactions increases expression decreases expression
EXP
[perillyl alcohol co-treated with Vitamin A] results in decreased expression of FNTB mRNA perillyl alcohol results in increased expression of FNTB protein perillyl alcohol results in decreased expression of FNTB mRNA
CTD
PMID:15959631
NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:101,269,671...101,352,716
G
Gsr
glutathione-disulfide reductase
multiple interactions
ISO EXP
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GSR protein] perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of GSR protein]
CTD
PMID:19161993 PMID:20923693
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
G
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
multiple interactions
EXP
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of H6PD protein]
CTD
PMID:20923693
NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:165,721,654...165,753,125
G
Ivl
involucrin
decreases expression
ISO
perillyl alcohol results in decreased expression of IVL protein
CTD
PMID:10769631
NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:180,842,307...180,846,578
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
CTD
PMID:19161993
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
CTD
PMID:19161993
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
G
Odc1
ornithine decarboxylase 1
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]
CTD
PMID:19161993
NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RAF1 protein]
CTD
PMID:19161993
NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813
G
Rap1a
RAP1A, member of RAS oncogene family
multiple interactions increases expression
ISO
Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein]
CTD
PMID:12671036
NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
perillyl alcohol inhibits the reaction [Ethanol results in increased activity of RELA protein]
CTD
PMID:20923693
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
G
Rhoa
ras homolog family member A
multiple interactions increases expression
ISO EXP
Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein] [perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA
CTD
PMID:12671036 PMID:15959631
NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302
G
Rhob
ras homolog family member B
multiple interactions increases expression
ISO EXP
Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein] perillyl alcohol results in increased expression of RHOB mRNA; perillyl alcohol results in increased expression of RHOB protein [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB mRNA; [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB protein
CTD
PMID:12671036 PMID:15959631
NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772
G
Tnf
tumor necrosis factor
multiple interactions
EXP
perillyl alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein]
CTD
PMID:20923693
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all