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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acrolein
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Accession:CHEBI:15368 term browser browse the term
Definition:An enal that is prop-2-ene with an oxo group at position 1.
Synonyms:related_synonym: Acrylaldehyde;   Acrylic aldehyde;   Formula=C3H4O;   InChI=1S/C3H4O/c1-2-3-4/h2-3H,1H2;   InChIKey=HGINCPLSRVDWNT-UHFFFAOYSA-N;   Propenal;   SMILES=[H]C(=C)C([H])=O
 alt_id: CHEBI:13720;   CHEBI:22214;   CHEBI:2434
 xref: CAS:107-02-8;   HMDB:HMDB0041822;   KEGG:C01471
 xref_mesh: MESH:D000171
 xref: MetaCyc:ACROLEIN;   PMID:11888018;   PMID:16725382;   PMID:18023956;   PMID:18234483;   PMID:18686065;   PMID:18823586;   PPDB:1016;   Reaxys:741856;   Wikipedia:Acrolein


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acrolein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actc1 actin, alpha, cardiac muscle 1 affects metabolic processing ISO Acrolein affects the metabolism of ACTC1 protein CTD PMID:17921335 NCBI chr 3:105,507,403...105,512,939
Ensembl chr 3:105,507,403...105,512,939
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 decreases expression
increases expression
multiple interactions
ISO
EXP
Acrolein results in decreased expression of ADAM10 protein
Acrolein results in increased expression of ADAM10 protein
ADAM10 protein affects the reaction [Acrolein results in increased cleavage of CASP1 protein]; ADAM10 protein affects the reaction [Acrolein results in increased expression of and results in increased cleavage of IL1B protein]; ADAM10 protein affects the reaction [Acrolein results in increased expression of NLRP3 protein]
CTD PMID:23296102, PMID:29355571, PMID:31639409 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO ADAM17 protein promotes the reaction [Acrolein results in increased expression of MUC5AC mRNA] CTD PMID:15531749 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adgre5 adhesion G protein-coupled receptor E5 increases expression ISO Acrolein results in increased expression of ADGRE5 mRNA CTD PMID:18515264 NCBI chr19:24,854,981...24,875,712
Ensembl chr19:24,855,299...24,875,137
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) affects reduction EXP ADH1 protein affects the reduction of Acrolein CTD PMID:12604195 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO
EXP
Acrolein results in increased expression of AGER protein CTD PMID:23296102, PMID:29355571 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO Acrolein affects the localization of AIFM1 protein CTD PMID:19596284 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction
affects reduction
ISO
EXP
AKR1A1 protein results in increased reduction of Acrolein
AKR1A1 protein affects the reduction of Acrolein
CTD PMID:10510318, PMID:12604195 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B affects reduction
increases expression
increases reduction
ISO AKR1B1 protein affects the reduction of Acrolein
Acrolein results in increased expression of AKR1B3 protein
AKR1B1 protein results in increased reduction of Acrolein; AKR1B1 protein results in increased reduction of Acrolein metabolite
CTD PMID:9890881, PMID:10510318, PMID:11306073, PMID:21329684, PMID:28482051 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 affects metabolic processing
increases reduction
decreases response to substance
ISO Acrolein affects the metabolism of AKR1B10 protein; AKR1B10 protein affects the metabolism of Acrolein
AKR1B10 protein results in increased reduction of Acrolein; AKR1B10 protein results in increased reduction of Acrolein metabolite
AKR1B10 protein results in decreased susceptibility to Acrolein
CTD PMID:17329238, PMID:17597105, PMID:21329684 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of Acrolein CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 affects metabolic processing
decreases response to substance
EXP AKR7A3 protein affects the metabolism of Acrolein
AKR7A3 protein results in decreased susceptibility to Acrolein
CTD PMID:15019089 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein; Acrolein results in increased expression of and results in increased phosphorylation of AKT1 protein; resorcinol inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]
[ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of AKT1 protein
Acrolein inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]
CTD PMID:19596284, PMID:24812010, PMID:24847785, PMID:26262998 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO [Acrolein binds to Acrolein] which binds to ALB protein; dinitrophenylhydrazine binds to [Acrolein binds to ALB protein]; Hydralazine binds to [Acrolein binds to ALB protein]
[Acrolein binds to ALB protein] which results in increased expression of HMOX1 mRNA; Acrolein binds to and results in increased oxidation of ALB protein; ALB protein inhibits the reaction [Acrolein results in increased expression of ATF3 mRNA]; ALB protein inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Hydralazine inhibits the reaction [[Acrolein binds to ALB protein] which results in increased expression of HMOX1 mRNA]
CTD PMID:15207723, PMID:32530271 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression
increases oxidation
multiple interactions
increases metabolic processing
decreases response to substance
ISO Acrolein results in increased expression of ALDH1A1 mRNA
ALDH1A1 protein results in increased oxidation of Acrolein
[NAD co-treated with propionaldehyde] inhibits the reaction [Acrolein results in decreased activity of ALDH1A1 protein]; Acrolein binds to and results in decreased activity of ALDH1A1 protein; NAD inhibits the reaction [Acrolein binds to and results in decreased activity of ALDH1A1 protein]; propionaldehyde inhibits the reaction [Acrolein results in decreased activity of ALDH1A1 protein]
ALDH1A1 protein results in increased metabolism of Acrolein
ALDH1A1 protein results in decreased susceptibility to Acrolein
ALDH1A1 protein inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]
CTD PMID:21256123, PMID:22339434 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
increases oxidation
ISO Acrolein binds to and results in decreased activity of ALDH2 protein; NAD inhibits the reaction [Acrolein binds to and results in decreased activity of ALDH2 protein]
ALDH2 protein results in increased oxidation of Acrolein
CTD PMID:22339434 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases metabolic processing ISO ALDH3A1 protein results in increased metabolism of Acrolein CTD PMID:21256123 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 affects oxidation EXP ALDH3A2 protein affects the oxidation of Acrolein CTD PMID:12604195 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression
multiple interactions
increases activity
ISO Acrolein results in increased expression of ALOX5 mRNA; Acrolein results in increased expression of ALOX5 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of ALOX5 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased expression of ALOX5 protein]
Acrolein results in increased activity of ALOX5 protein
CTD PMID:20153347 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO Acrolein results in increased expression of AMPD3 mRNA CTD PMID:24211530 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G Anapc2 anaphase promoting complex subunit 2 decreases expression ISO Acrolein results in decreased expression of ANAPC2 mRNA CTD PMID:26719373 NCBI chr 3:2,490,496...2,502,247
Ensembl chr 3:2,490,518...2,502,248
JBrowse link
G Apoa1 apolipoprotein A1 affects metabolic processing
multiple interactions
ISO Acrolein affects the metabolism of APOA1 protein
[Acrolein affects the metabolism of APOA1 protein] which results in decreased secretion of Cholesterol; Acrolein inhibits the reaction [APOA1 protein affects the transport of Cholesterol]
CTD PMID:16037261, PMID:16126721 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoe apolipoprotein E affects folding
decreases activity
ISO Acrolein affects the folding of APOE protein
Acrolein results in decreased activity of APOE protein
CTD PMID:17580963 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases expression
affects binding
ISO
EXP
Acrolein promotes the reaction [APP protein binds to APP protein]; APP protein promotes the reaction [Acrolein binds to Acrolein]
Acrolein results in increased expression of APP protein
[Acrolein binds to APP protein] binds to [Acrolein binds to APP protein]; Acrolein binds to APP protein
CTD PMID:16081039, PMID:23296102, PMID:29355571 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation EXP [Acrolein results in increased phosphorylation of MAPK14 protein] which results in increased phosphorylation of ATF2 protein CTD PMID:12487375 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression
ISO
EXP
Acrolein results in increased expression of and affects the localization of ATF3 protein; ALB protein inhibits the reaction [Acrolein results in increased expression of ATF3 mRNA]; Phenylbutyrates inhibits the reaction [Acrolein results in increased expression of ATF3 protein]
Acrolein results in increased expression of ATF3 mRNA; Acrolein results in increased expression of ATF3 protein
CTD PMID:18951912, PMID:28119953, PMID:32530271 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO
EXP
Acrolein results in increased expression of and affects the localization of ATF4 protein
Acrolein results in increased expression of ATF4 mRNA; Acrolein results in increased expression of ATF4 protein
CTD PMID:18951912, PMID:28119953 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atg12 autophagy related 12 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG12 protein] CTD PMID:30205151 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg16l1 autophagy related 16-like 1 increases expression
multiple interactions
ISO Acrolein results in increased expression of ATG16L1 protein
Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG16L1 protein]
CTD PMID:30205151 NCBI chr 9:94,879,876...94,915,231
Ensembl chr 9:94,879,745...94,915,228
JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions
ISO Acrolein results in increased expression of ATG5 protein
Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG5 protein]
CTD PMID:30205151 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG7 protein] CTD PMID:30205151 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 affects binding EXP Acrolein binds to ATP1A3 protein CTD PMID:17023561 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha affects metabolic processing ISO Acrolein affects the metabolism of ATP5A1 protein CTD PMID:17921335 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta affects metabolic processing ISO Acrolein affects the metabolism of ATP5B protein CTD PMID:17921335 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G B2m beta-2 microglobulin decreases expression ISO Acrolein results in decreased expression of B2M mRNA CTD PMID:28482051 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Bace1 beta-secretase 1 increases expression EXP
ISO
Acrolein results in increased expression of BACE1 protein CTD PMID:23296102, PMID:29355571 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased phosphorylation of BAD protein]; Akt-I-1 compound inhibits the reaction [Acrolein results in increased phosphorylation of BAD protein]; wortmannin inhibits the reaction [Acrolein results in increased phosphorylation of BAD protein]
Acrolein results in increased expression of BAD mRNA
CTD PMID:18515264, PMID:19596284 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
multiple interactions
increases expression
ISO
EXP
Acrolein affects the localization of BAX protein
3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in increased expression of BAX mRNA]; 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in increased expression of BAX protein]; [Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of BAX protein; Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX mRNA]; Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX protein]; oleuropein inhibits the reaction [Acrolein results in increased expression of BAX mRNA]; oleuropein inhibits the reaction [Acrolein results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX mRNA]]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX protein]]
Acrolein results in increased expression of BAX mRNA; Acrolein results in increased expression of BAX protein
capsazepine inhibits the reaction [Acrolein results in increased expression of BAX protein]; Glutathione inhibits the reaction [Acrolein results in increased expression of BAX protein]
CTD PMID:19596284, PMID:24376112, PMID:29414845 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Acrolein results in decreased expression of BCL2 protein
3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of BCL2 mRNA]; 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of BCL2 protein]; [Acrolein results in increased susceptibility to Isoproterenol] which results in decreased expression of BCL2 protein; Acrolein promotes the reaction [Isoproterenol results in decreased expression of BCL2 mRNA]; oleuropein inhibits the reaction [Acrolein results in decreased expression of BCL2 mRNA]; oleuropein inhibits the reaction [Acrolein results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in decreased expression of BCL2 mRNA]]
Acrolein results in decreased expression of BCL2 mRNA; Acrolein results in decreased expression of BCL2 protein
capsazepine inhibits the reaction [Acrolein results in decreased expression of BCL2 protein]; Glutathione inhibits the reaction [Acrolein results in decreased expression of BCL2 protein]
CTD PMID:24376112, PMID:29414845 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
EXP CREBBP protein inhibits the reaction [Acrolein results in decreased expression of BDNF mRNA]
Acrolein results in decreased expression of BDNF mRNA; Acrolein results in decreased expression of BDNF protein
CTD PMID:16337876, PMID:29355571 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of BIRC2 protein]; Akt-I-1 compound inhibits the reaction [Acrolein results in increased expression of BIRC2 protein]; wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC2 protein] CTD PMID:19596284 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of BIRC3 protein]; Akt-I-1 compound inhibits the reaction [Acrolein results in increased expression of BIRC3 protein]; wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC3 protein] CTD PMID:19596284 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Bpifc BPI fold containing family C increases expression ISO Acrolein results in increased expression of BPIFC mRNA CTD PMID:18515264 NCBI chr 7:23,854,846...23,911,953
Ensembl chr 7:23,854,846...23,911,953
JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression EXP Acrolein results in increased expression of CALCA protein CTD PMID:1696540 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp1 caspase 1 multiple interactions
increases cleavage
ISO
EXP
1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; [Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein; Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]
ADAM10 protein affects the reaction [Acrolein results in increased cleavage of CASP1 protein]; MCC-950 inhibits the reaction [Acrolein results in increased cleavage of CASP1 protein]; SB 203580 inhibits the reaction [Acrolein results in increased cleavage of CASP1 protein]
CTD PMID:30205151, PMID:31639409 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp2 caspase 2 decreases expression ISO Acrolein results in decreased expression of CASP2 mRNA CTD PMID:18515264 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 affects alkylation
multiple interactions
increases cleavage
decreases expression
increases activity
increases expression
decreases activity
ISO
EXP
Acrolein affects the alkylation of CASP3 protein
3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]
3-methyladenine inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]; [Acrolein co-treated with Zidovudine] results in increased cleavage of CASP3 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]; TP53 protein affects the reaction [Acrolein results in increased cleavage of CASP3 protein]
Acrolein results in decreased expression of CASP3 mRNA
Acrolein results in increased activity of CASP3 protein
Acrolein results in increased expression of CASP3 mRNA
Acrolein results in increased expression of CASP3 protein
ALDH1A1 protein inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]; capsazepine inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]; CD8A protein promotes the reaction [Acrolein results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]
Acrolein results in decreased activity of CASP3 protein
CTD PMID:11504702, PMID:11803030, PMID:16267686, PMID:16337876, PMID:17222828, PMID:17950725, PMID:18515264, PMID:19596284, PMID:19815060, PMID:21256123, PMID:24376112, PMID:26719373, PMID:27238871, PMID:29902662, PMID:29964147, PMID:31639409 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 increases activity ISO Acrolein results in increased activity of CASP6 protein CTD PMID:19596284 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 increases activity ISO Acrolein results in increased activity of CASP7 protein CTD PMID:19596284 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 affects activity
increases cleavage
multiple interactions
increases expression
decreases activity
affects cleavage
affects alkylation
ISO Acrolein affects the activity of CASP8 protein
Acrolein results in increased cleavage of CASP8 protein
capsazepine inhibits the reaction [Acrolein results in increased expression of CASP8 protein]; Glutathione inhibits the reaction [Acrolein results in increased expression of CASP8 protein]
Acrolein results in decreased activity of CASP8 protein
Acrolein inhibits the reaction [FAS protein results in increased activity of CASP8 protein]; Acrolein inhibits the reaction [FAS protein results in increased cleavage of CASP8 protein]; Acrolein promotes the reaction [Zidovudine results in increased cleavage of CASP8 protein]; Zidovudine promotes the reaction [Acrolein results in increased cleavage of CASP8 protein]
Acrolein affects the cleavage of CASP8 protein
Acrolein affects the alkylation of CASP8 protein
CTD PMID:11803030, PMID:17222828, PMID:24376112, PMID:27238871 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
multiple interactions
decreases activity
ISO Acrolein results in increased activity of CASP9 protein
Acrolein results in increased cleavage of CASP9 protein
3-methyladenine inhibits the reaction [Acrolein results in increased cleavage of CASP9 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Acrolein results in increased cleavage of CASP9 protein]; TP53 protein affects the reaction [Acrolein results in increased cleavage of CASP9 protein]
Acrolein results in decreased activity of CASP9 protein
CTD PMID:11803030, PMID:19596284, PMID:29902662, PMID:29964147 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases expression ISO Acrolein results in increased expression of CAT protein CTD PMID:28482051 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO Acrolein results in increased expression of CCL2 mRNA
CD8A protein promotes the reaction [Acrolein results in increased expression of CCL2 mRNA]
CTD PMID:17950725 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression
ISO CD8A protein promotes the reaction [Acrolein results in increased expression of CCL5 mRNA] CTD PMID:17950725 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [TP53 protein affects the susceptibility to Acrolein] which affects the localization of CCNB1 protein CTD PMID:29964147 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cd14 CD14 molecule increases expression ISO Acrolein results in increased expression of CD14 mRNA CTD PMID:18515264 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd28 Cd28 molecule increases expression ISO Acrolein results in increased expression of CD28 mRNA CTD PMID:18515264 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Acrolein results in increased expression of CD44 mRNA CTD PMID:18515264 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd8a CD8a molecule multiple interactions ISO CD8A gene mutant form inhibits the reaction [Acrolein results in increased activity of MMP2 protein]; CD8A gene mutant form inhibits the reaction [Acrolein results in increased activity of MMP9 protein]; CD8A gene mutant form inhibits the reaction [Acrolein results in increased expression of CXCL10 mRNA]; CD8A gene mutant form inhibits the reaction [Acrolein results in increased expression of IFNG mRNA]; CD8A gene mutant form inhibits the reaction [Acrolein results in increased expression of IL12B mRNA]; CD8A protein promotes the reaction [Acrolein results in increased activity of CASP3 protein]; CD8A protein promotes the reaction [Acrolein results in increased expression of CCL2 mRNA]; CD8A protein promotes the reaction [Acrolein results in increased expression of CCL5 mRNA] CTD PMID:17950725 NCBI chr 4:99,217,640...99,243,352
Ensembl chr 4:99,239,115...99,243,351
JBrowse link
G Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme decreases expression ISO Acrolein results in decreased expression of CDC34 protein CTD PMID:24812010 NCBI chr 7:12,899,957...12,905,339
Ensembl chr 7:12,899,958...12,905,339
JBrowse link
G Cdh2 cadherin 2 multiple interactions
increases cleavage
EXP 3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [Acrolein results in increased cleavage of CDH2 protein] CTD PMID:31639409 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in decreased expression of CDKN1B protein CTD PMID:24847785 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Ckmt2 creatine kinase, mitochondrial 2 affects metabolic processing ISO Acrolein affects the metabolism of CKMT2 protein CTD PMID:17921335 NCBI chr 2:21,422,680...21,452,797
Ensembl chr 2:21,422,818...21,437,193
JBrowse link
G Cldn17 claudin 17 increases expression
multiple interactions
ISO Acrolein results in increased expression of CLDN17 protein
[Ovalbumin co-treated with Acrolein] results in increased expression of CLDN17 protein
CTD PMID:30608172 NCBI chr11:28,477,184...28,478,360
Ensembl chr11:28,477,184...28,478,360
JBrowse link
G Cldn4 claudin 4 multiple interactions
increases expression
ISO [Ovalbumin co-treated with Acrolein] results in increased expression of CLDN4 protein
Acrolein results in increased expression of CLDN4 protein
CTD PMID:30608172 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Cldn5 claudin 5 decreases expression
multiple interactions
increases expression
ISO Acrolein results in decreased expression of CLDN5 mRNA
[Ovalbumin co-treated with Acrolein] results in increased expression of CLDN5 protein
Acrolein results in increased expression of CLDN5 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of CLDN5 mRNA]
CTD PMID:20525806, PMID:30608172 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Cp ceruloplasmin multiple interactions ISO CP protein inhibits the reaction [Rotenone results in increased abundance of Acrolein] CTD PMID:18804145 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO
EXP
Acrolein results in increased phosphorylation of CREB1 protein
3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [Acrolein results in increased phosphorylation of CREB1 protein]
CTD PMID:16337876, PMID:31639409 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crebbp CREB binding protein multiple interactions EXP CREBBP protein inhibits the reaction [Acrolein results in decreased expression of BDNF mRNA] CTD PMID:16337876 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Cs citrate synthase affects binding EXP Acrolein binds to CS protein CTD PMID:17023561 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Csf2 colony stimulating factor 2 decreases secretion
increases secretion
ISO Acrolein results in decreased secretion of CSF2 protein
Acrolein results in increased secretion of CSF2 protein
CTD PMID:17491020, PMID:30204913 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO Acrolein results in increased expression of CTNNB1 protein CTD PMID:20525806 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 decreases expression ISO Acrolein results in decreased expression of CTNNBIP1 mRNA CTD PMID:18515264 NCBI chr 5:166,464,170...166,513,030
Ensembl chr 5:166,464,252...166,513,027
JBrowse link
G Ctsb cathepsin B increases expression
multiple interactions
ISO Acrolein results in increased expression of CTSB protein
3-methyladenine inhibits the reaction [Acrolein results in increased expression of CTSB protein]
CTD PMID:29902662 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Acrolein results in increased expression of CXCL1 mRNA CTD PMID:25145656 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
increases expression
ISO CD8A gene mutant form inhibits the reaction [Acrolein results in increased expression of CXCL10 mRNA] CTD PMID:17950725 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 decreases expression ISO Acrolein results in decreased expression of CXCL16 mRNA CTD PMID:18515264 NCBI chr10:57,060,005...57,064,600
Ensembl chr10:57,060,007...57,064,600
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Acrolein results in increased expression of CXCL2 mRNA CTD PMID:18515264 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Acrolein results in increased expression of CXCL1 mRNA CTD PMID:18515264 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Acrolein affects the localization of CYCS protein CTD PMID:19596284 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP2C19 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of Acrolein CTD PMID:30500380 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO
EXP
Acrolein results in increased expression of DDIT3 mRNA
3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in increased expression of DDIT3 mRNA]; 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in increased expression of DDIT3 protein]; [Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of DDIT3 protein; Acrolein promotes the reaction [Isoproterenol results in increased expression of DDIT3 mRNA]; oleuropein inhibits the reaction [Acrolein results in increased expression of DDIT3 protein]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of DDIT3 protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of DDIT3 mRNA]]
Acrolein results in increased expression of DDIT3 mRNA; Acrolein results in increased expression of DDIT3 protein
Acrolein results in increased expression of and affects the localization of DDIT3 protein
CTD PMID:18951912, PMID:21703327, PMID:28119953, PMID:29414845 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Defb4 defensin beta 4 decreases expression ISO Acrolein results in decreased expression of DEFB4 mRNA; Acrolein results in decreased expression of DEFB4 protein CTD PMID:18201443 NCBI chr16:75,634,598...75,637,789
Ensembl chr16:75,634,598...75,637,789
JBrowse link
G Des desmin affects metabolic processing ISO Acrolein affects the metabolism of DES protein CTD PMID:17921335 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
ISO Acrolein results in increased expression of EDN1 protein
cesium chloride inhibits the reaction [Acrolein results in increased expression of EDN1 protein]; Rotenone inhibits the reaction [Acrolein results in increased expression of EDN1 protein]
CTD PMID:22928487 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor increases activity
increases phosphorylation
multiple interactions
ISO
EXP
Acrolein results in increased activity of EGFR protein
Acrolein results in increased phosphorylation of EGFR protein
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]
EGFR protein affects the reaction [Acrolein results in increased expression of MUC5AC mRNA]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]
CTD PMID:11329622, PMID:15531749, PMID:20153347, PMID:20359552 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 increases expression ISO Acrolein results in increased expression of EGR1 mRNA; Acrolein results in increased expression of EGR1 protein CTD PMID:18515264, PMID:20015449 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Acrolein results in increased phosphorylation of EIF2A protein CTD PMID:18206657, PMID:19041636 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO Acrolein results in increased phosphorylation of EIF2AK3 protein CTD PMID:19041636 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Acrolein results in increased phosphorylation of EIF2S1 protein CTD PMID:18951912 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Emd emerin affects expression ISO Acrolein affects the expression of EMD mRNA CTD PMID:19527780 NCBI chr  X:156,452,847...156,455,858
Ensembl chr  X:156,452,818...156,456,035
JBrowse link
G Esr1 estrogen receptor 1 affects expression ISO Acrolein affects the expression of ESR1 mRNA CTD PMID:19527780 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 decreases expression ISO Acrolein results in decreased expression of FAIM2 mRNA CTD PMID:18515264 NCBI chr 7:141,158,769...141,185,781
Ensembl chr 7:141,157,963...141,185,710
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Acrolein inhibits the reaction [FAS protein results in increased activity of CASP8 protein]; Acrolein inhibits the reaction [FAS protein results in increased cleavage of CASP8 protein] CTD PMID:17222828 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression
multiple interactions
ISO
EXP
Acrolein results in increased expression of FASL protein
Acrolein results in increased expression of FASLG mRNA
Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Acrolein results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]]; Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]
[Acrolein co-treated with Zidovudine] results in increased expression of FASLG protein; Acrolein promotes the reaction [RELA protein binds to FASLG promoter]; Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Acrolein results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]]; Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]; Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]
capsazepine inhibits the reaction [Acrolein results in increased expression of FASL protein]; Glutathione inhibits the reaction [Acrolein results in increased expression of FASL protein]
CTD PMID:24376112, PMID:27238871 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf10 fibroblast growth factor 10 decreases expression ISO Acrolein results in decreased expression of FGF10 mRNA CTD PMID:18515264 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369
JBrowse link
G Fgl2 fibrinogen-like 2 increases expression ISO Acrolein results in increased expression of FGL2 mRNA CTD PMID:18515264 NCBI chr 4:10,323,598...10,329,241
Ensembl chr 4:10,323,607...10,329,241
JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand increases expression ISO Acrolein results in increased expression of FLT3L mRNA CTD PMID:18515264 NCBI chr 1:101,126,006...101,131,413
Ensembl chr 1:101,124,479...101,131,413
JBrowse link
G Foxo1 forkhead box O1 increases phosphorylation ISO Acrolein results in increased phosphorylation of FOXO1 protein CTD PMID:20525806 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO Acrolein results in increased expression of FTH1 mRNA CTD PMID:24211530 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Acrolein results in increased expression of FTL mRNA CTD PMID:24211530 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Acrolein results in increased expression of GADD45B mRNA; Acrolein results in increased expression of GADD45B protein CTD PMID:20015449 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 affects expression ISO Acrolein affects the expression of GAL3ST1 mRNA CTD PMID:19527780 NCBI chr14:84,231,473...84,247,371
Ensembl chr14:84,231,639...84,247,369
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects binding
multiple interactions
EXP
ISO
Acrolein binds to GAPDH protein
Acrolein binds to and results in decreased activity of GAPDH protein
CTD PMID:17023561, PMID:22084934 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
Acrolein results in increased expression of GCLC mRNA
[1,2-dithiol-3-thione results in increased activity of GCLC protein] which results in decreased susceptibility to Acrolein
CTD PMID:12084617, PMID:12535742, PMID:25145656, PMID:28109747 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Acrolein results in increased expression of GCLM mRNA CTD PMID:12763045, PMID:24211530 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gfap glial fibrillary acidic protein increases expression
multiple interactions
EXP Acrolein results in increased expression of GFAP protein
3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [Acrolein results in increased expression of GFAP protein]
CTD PMID:31639409 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gnb1 G protein subunit beta 1 affects binding EXP Acrolein binds to GNB1 protein CTD PMID:17023561 NCBI chr 5:172,914,025...172,981,403
Ensembl chr 5:172,934,990...172,979,986
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases secretion
EXP 15-deoxyprostaglandin J2 promotes the reaction [Acrolein results in increased secretion of GPT protein]; chelerythrine inhibits the reaction [Acrolein results in increased secretion of GPT protein]; rottlerin inhibits the reaction [Acrolein results in increased secretion of GPT protein] CTD PMID:12755590, PMID:14657518 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Acrolein results in decreased activity of GSR protein CTD PMID:14673659 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression EXP Acrolein results in increased expression of GSTA1 mRNA CTD PMID:9799558 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression EXP Acrolein results in increased expression of GSTA4 mRNA; Acrolein results in increased expression of GSTA4 protein CTD PMID:9799558 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases response to substance
increases expression
EXP
ISO
GSTA5 protein results in decreased susceptibility to Acrolein
Acrolein results in increased expression of GSTA1 mRNA
CTD PMID:12076520, PMID:12763045 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases metabolic processing
increases expression
ISO
EXP
Acrolein binds to and results in decreased activity of GSTP1 protein
GSTP1 protein results in increased metabolism of Acrolein
Acrolein results in increased expression of GSTP1 mRNA; Acrolein results in increased expression of GSTP1 protein
GSTP1 protein polymorphism results in increased metabolism of Acrolein; GSTP1 protein results in increased metabolism of Acrolein
CTD PMID:9463521, PMID:10799737, PMID:11600134, PMID:16242832, PMID:18515264, PMID:19696094, PMID:28482051 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hdac2 histone deacetylase 2 affects binding ISO Acrolein binds to HDAC2 protein CTD PMID:26481333 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression
decreases expression
ISO Acrolein results in increased expression of HERPUD1 protein
Acrolein results in decreased expression of HERPUD1 mRNA
CTD PMID:18951912, PMID:28482051 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hmgb1 high mobility group box 1 increases expression ISO Acrolein results in increased expression of HMGB1 mRNA CTD PMID:18515264 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
affects expression
increases expression
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; [Acrolein binds to ALB protein] which results in increased expression of HMOX1 mRNA; ALB protein inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Hydralazine inhibits the reaction [[Acrolein binds to ALB protein] which results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Ro 31-8220 inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Staurosporine inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]
Acrolein affects the expression of HMOX1 mRNA
Acrolein results in increased expression of HMOX1 protein
Acrolein results in increased expression of HMOX1 mRNA; Acrolein results in increased expression of HMOX1 protein
CTD PMID:18048804, PMID:20015449, PMID:22954530, PMID:23416264, PMID:24211530, PMID:25145656, PMID:28109747, PMID:28482051, PMID:28947239, PMID:30204913, PMID:32530271 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression
increases expression
ISO
EXP
Acrolein results in decreased expression of HSP90B1 mRNA
Acrolein results in increased expression of HSP90B1 mRNA
CTD PMID:28119953, PMID:28482051 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
decreases expression
ISO
EXP
Acrolein results in increased expression of HSPA5 protein
3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in increased expression of HSPA5 mRNA]; 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in increased expression of HSPA5 protein]; [Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of HSPA5 protein; Acrolein promotes the reaction [Isoproterenol results in increased expression of HSPA5 mRNA]; oleuropein inhibits the reaction [Acrolein results in increased expression of HSPA5 protein]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of HSPA5 protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of HSPA5 mRNA]]
Acrolein results in increased expression of HSPA5 mRNA; Acrolein results in increased expression of HSPA5 protein
Acrolein results in decreased expression of HSPA5 mRNA
CTD PMID:18951912, PMID:28119953, PMID:28482051, PMID:29414845 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icos inducible T-cell co-stimulator increases expression ISO Acrolein results in increased expression of ICOS mRNA CTD PMID:18515264 NCBI chr 9:67,748,157...67,786,808
Ensembl chr 9:67,763,897...67,785,580
JBrowse link
G Ier5 immediate early response 5 increases expression ISO Acrolein results in increased expression of IER5 mRNA CTD PMID:18515264 NCBI chr13:72,742,210...72,744,302
Ensembl chr13:72,742,210...72,744,303
JBrowse link
G Ifng interferon gamma decreases secretion
increases secretion
multiple interactions
increases expression
ISO Acrolein results in decreased secretion of IFNG protein
Acrolein results in increased secretion of IFNG protein
CD8A gene mutant form inhibits the reaction [Acrolein results in increased expression of IFNG mRNA]
CTD PMID:17491020, PMID:17950725, PMID:30204913 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Acrolein results in increased expression of IFNGR1 mRNA CTD PMID:18515264 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Ifngr2 interferon gamma receptor 2 increases expression ISO Acrolein results in increased expression of IFNGR2 mRNA CTD PMID:18515264 NCBI chr11:31,694,339...31,712,611
Ensembl chr11:31,694,339...31,712,611
JBrowse link
G Ifnlr1 interferon, lambda receptor 1 increases expression ISO Acrolein results in increased expression of IFNLR1 mRNA CTD PMID:18515264 NCBI chr 5:154,037,243...154,058,862
Ensembl chr 5:154,037,202...154,058,880
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects metabolic processing ISO Acrolein affects the metabolism of IKBKB protein CTD PMID:15650393 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases expression ISO Acrolein results in decreased expression of IKBKE mRNA CTD PMID:18515264 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Acrolein results in decreased secretion of IL10 protein CTD PMID:17491020 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression
ISO CD8A gene mutant form inhibits the reaction [Acrolein results in increased expression of IL12B mRNA] CTD PMID:17950725 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 increases expression ISO Acrolein results in increased expression of IL12RB1 mRNA CTD PMID:18515264 NCBI chr16:20,370,722...20,383,576
Ensembl chr16:20,371,338...20,383,337
JBrowse link
G Il18 interleukin 18 multiple interactions ISO 1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; [Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein; Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; NLRP3 protein affects the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; Rotenone promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of IL18 protein]; Rotenone promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein] CTD PMID:30205151 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il18r1 interleukin 18 receptor 1 affects expression ISO Acrolein affects the expression of IL18R1 mRNA CTD PMID:18515264 NCBI chr 9:47,184,404...47,217,403
Ensembl chr 9:47,185,443...47,219,175
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
increases secretion
EXP
ISO
Acrolein results in increased expression of IL1B mRNA; Acrolein results in increased expression of IL1B protein
1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; [Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; Rotenone promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]
Acrolein results in increased secretion of IL1B protein
3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [Acrolein results in increased cleavage of IL1B protein]; 3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [Acrolein results in increased expression of and results in increased secretion of IL1B protein]; Acrolein results in increased expression of and results in increased cleavage of IL1B protein; ADAM10 protein affects the reaction [Acrolein results in increased expression of and results in increased cleavage of IL1B protein]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B protein]; MCC-950 inhibits the reaction [Acrolein results in increased cleavage of IL1B protein]; Rosiglitazone inhibits the reaction [Acrolein results in increased secretion of IL1B protein]; SB 203580 inhibits the reaction [Acrolein results in increased cleavage of IL1B protein]; SB 203580 inhibits the reaction [Acrolein results in increased expression of and results in increased secretion of IL1B protein]
CTD PMID:19464576, PMID:21265103, PMID:30204913, PMID:30205151, PMID:31639409 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases secretion
ISO Acrolein inhibits the reaction [NFKB1 protein binds to IL2 promoter]
Acrolein results in decreased secretion of IL2 protein
CTD PMID:17491020 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il3 interleukin 3 increases expression ISO Acrolein results in increased expression of IL3 mRNA CTD PMID:18515264 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il4r interleukin 4 receptor increases expression ISO Acrolein results in increased expression of IL4RA mRNA CTD PMID:18515264 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il5 interleukin 5 increases expression
multiple interactions
ISO Acrolein results in increased expression of IL5 protein
[Ovalbumin co-treated with Acrolein] results in increased expression of IL5 protein
CTD PMID:30608172 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
increases expression
EXP
ISO
Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 protein]
Acrolein results in increased secretion of IL6 protein
Acrolein results in increased expression of IL6 mRNA; Acrolein results in increased expression of IL6 protein
[Acrolein co-treated with Formaldehyde co-treated with Ozone] results in increased expression of IL6 protein; Phenylbutyrates inhibits the reaction [Acrolein results in increased expression of IL6 mRNA]
CTD PMID:16860297, PMID:18951912, PMID:21265103, PMID:22961095, PMID:25145656, PMID:30204913 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Acrolein inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:24812010 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irf1 interferon regulatory factor 1 increases expression ISO Acrolein results in increased expression of IRF1 mRNA CTD PMID:18515264 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Itgb2 integrin subunit beta 2 increases expression ISO Acrolein results in increased expression of ITGB2 mRNA CTD PMID:18515264 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Itgb3 integrin subunit beta 3 increases expression
decreases expression
ISO Acrolein results in increased expression of ITGB3 mRNA
Acrolein results in decreased expression of ITGB3 protein
CTD PMID:18515264, PMID:24812010 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects binding
multiple interactions
increases phosphorylation
decreases activity
affects metabolic processing
ISO
EXP
Acrolein binds to JUN protein
pyrazolanthrone inhibits the reaction [Acrolein results in increased phosphorylation of JUN protein]
RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of JUN protein]
[Acrolein results in increased phosphorylation of MAPK8 protein] which results in increased phosphorylation of JUN protein
Acrolein results in decreased activity of JUN protein
Acrolein affects the metabolism of JUN protein
CTD PMID:11329622, PMID:11849044, PMID:12487375, PMID:16337876 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 increases expression
multiple interactions
ISO Acrolein results in increased expression of KCNA5 mRNA; Acrolein results in increased expression of KCNA5 protein
Rotenone inhibits the reaction [Acrolein results in increased expression of KCNA5 mRNA]; Rotenone inhibits the reaction [Acrolein results in increased expression of KCNA5 protein]
CTD PMID:22928487 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
increases expression
ISO [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein]
[Ovalbumin co-treated with Acrolein] results in increased expression of KEAP1 protein
Acrolein results in increased expression of KEAP1 protein
CTD PMID:19608619, PMID:30608172 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression ISO Acrolein results in increased expression of KIT mRNA CTD PMID:18515264 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Klrc1 killer cell lectin like receptor C1 affects expression ISO Acrolein affects the expression of KLRC1 mRNA CTD PMID:18515264 NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases expression ISO Acrolein results in decreased expression of KRAS protein CTD PMID:24812010 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Krt18 keratin 18 increases metabolic processing ISO Acrolein results in increased metabolism of KRT18 protein CTD PMID:20015449 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt7 keratin 7 increases metabolic processing ISO Acrolein results in increased metabolism of KRT7 protein CTD PMID:20015449 NCBI chr 7:143,059,731...143,075,907
Ensembl chr 7:143,059,764...143,075,907
JBrowse link
G Krt8 keratin 8 increases metabolic processing
increases phosphorylation
ISO Acrolein results in increased metabolism of KRT8 protein
Acrolein results in increased phosphorylation of KRT8 protein
CTD PMID:20015449, PMID:24594012 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in decreased expression of LAMP1 protein CTD PMID:24847785 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419
JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO [Acrolein results in increased abundance of Cholesterol, VLDL] which results in decreased expression of and results in decreased activity of LIPC protein CTD PMID:20034506 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 decreases expression ISO Acrolein results in decreased expression of LPAR1 mRNA CTD PMID:18515264 NCBI chr 5:75,557,038...75,678,067
Ensembl chr 5:75,557,042...75,676,584
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]
[ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of MAPK1 protein; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]
CTD PMID:11329622, PMID:11504702, PMID:12487375, PMID:15531749, PMID:18951912, PMID:20153347, PMID:20359552, PMID:24847785, PMID:29964147 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation
multiple interactions
EXP
ISO
[Acrolein results in increased phosphorylation of MAPK14 protein] which results in increased phosphorylation of ATF2 protein; Acrolein results in increased phosphorylation of MAPK14 protein
SB 203580 inhibits the reaction [Acrolein results in increased phosphorylation of MAPK14 protein]
RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK14 protein]
CTD PMID:11329622, PMID:11504702, PMID:12487375, PMID:18951912, PMID:29964147 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]
[ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of MAPK3 protein; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]
CTD PMID:11329622, PMID:11504702, PMID:12487375, PMID:15531749, PMID:18951912, PMID:20153347, PMID:20359552, PMID:24847785, PMID:29964147 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
EXP
ISO
[Acrolein results in increased phosphorylation of MAPK8 protein] which results in increased phosphorylation of JUN protein; Acrolein results in increased phosphorylation of MAPK8 protein
Phenylbutyrates inhibits the reaction [Acrolein results in increased phosphorylation of MAPK8 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK8 protein]
SB 203580 promotes the reaction [Acrolein results in increased phosphorylation of MAPK8 protein]
CTD PMID:11329622, PMID:12487375, PMID:15531749, PMID:18951912 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapt microtubule-associated protein tau increases phosphorylation
multiple interactions
ISO Acrolein results in increased phosphorylation of MAPT protein
Acrolein promotes the reaction [MAPT protein binds to MAPT protein]
Lithium inhibits the reaction [Acrolein results in increased phosphorylation of MAPT protein]; SB 203580 inhibits the reaction [Acrolein results in increased phosphorylation of MAPT protein]
CTD PMID:12605413, PMID:17082178 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mdh2 malate dehydrogenase 2 affects binding EXP Acrolein binds to MDH2 protein CTD PMID:17023561 NCBI chr12:23,941,451...23,954,406
Ensembl chr12:23,941,448...23,954,431
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases response to substance ISO MGMT protein results in decreased susceptibility to Acrolein CTD PMID:17485251 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 affects activity EXP Acrolein affects the activity of MGST1 protein CTD PMID:28780321 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mir188 microRNA 188 decreases expression ISO Acrolein results in decreased expression of MIR188 CTD PMID:24812010 NCBI chr  X:16,110,270...16,110,349
Ensembl chr  X:16,110,270...16,110,349
JBrowse link
G Mir191 microRNA 191 increases expression ISO Acrolein results in increased expression of MIR191 CTD PMID:24812010 NCBI chr 8:117,354,364...117,354,454 JBrowse link
G Mir223 microRNA 223 increases expression ISO Acrolein results in increased expression of MIR223 CTD PMID:24812010 NCBI chr  X:65,367,812...65,367,921
Ensembl chr  X:65,367,812...65,367,921
JBrowse link
G Mir224 microRNA 224 increases expression ISO Acrolein results in increased expression of MIR224 CTD PMID:24812010 NCBI chr  X:152,223,754...152,223,835
Ensembl chr  X:152,223,754...152,223,835
JBrowse link
G Mir296 microRNA 296 decreases expression ISO Acrolein results in decreased expression of MIR296 CTD PMID:24812010 NCBI chr 3:172,357,490...172,357,567
Ensembl chr 3:172,357,490...172,357,567
JBrowse link
G Mir301a microRNA 301a increases expression ISO Acrolein results in increased expression of MIR301A CTD PMID:24812010 NCBI chr10:74,417,746...74,417,845
Ensembl chr10:74,417,746...74,417,845
JBrowse link
G Mir370 microRNA 370 decreases expression ISO Acrolein results in decreased expression of MIR370 CTD PMID:24812010 NCBI chr 6:133,739,916...133,739,994
Ensembl chr 6:133,739,916...133,739,994
JBrowse link
G Mir671 microRNA 671 decreases expression ISO Acrolein results in decreased expression of MIR671 CTD PMID:24812010 NCBI chr 4:7,108,747...7,108,827
Ensembl chr 4:7,108,738...7,108,835
JBrowse link
G Mir98 microRNA 98 increases expression ISO Acrolein results in increased expression of MIR98 CTD PMID:24812010 NCBI chr  X:21,583,875...21,583,982
Ensembl chr  X:21,583,875...21,583,982
JBrowse link
G Mirlet7d microRNA let-7d increases expression ISO Acrolein results in increased expression of MIRLET7D CTD PMID:24812010 NCBI chr17:16,419,980...16,420,077
Ensembl chr17:16,419,980...16,420,077
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases secretion
decreases expression
increases expression
ISO Acrolein results in increased secretion of MMP1 protein
Acrolein results in decreased expression of MMP1A mRNA
Acrolein results in increased expression of MMP1 mRNA
CTD PMID:18515264, PMID:21742783 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp10 matrix metallopeptidase 10 affects secretion ISO Acrolein affects the secretion of MMP10 protein CTD PMID:30204913 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases secretion ISO Acrolein results in increased secretion of MMP12 protein CTD PMID:30204913 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp13 matrix metallopeptidase 13 affects secretion ISO Acrolein affects the secretion of MMP13 protein CTD PMID:30204913 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp14 matrix metallopeptidase 14 affects binding
increases expression
multiple interactions
increases activity
ISO Acrolein binds to MMP14 protein
Acrolein results in increased expression of MMP14 mRNA
Acrolein results in increased expression of and results in increased activity of MMP14 protein; Erlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]; hexaarginine amide inhibits the reaction [Acrolein results in increased activity of MMP14 protein]; MMP14 protein affects the reaction [Acrolein results in increased expression of MUC5AC mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]; pyrazolanthrone inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]; RTKI cpd inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]
CTD PMID:19661247 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
multiple interactions
increases secretion
ISO Acrolein results in increased activity of MMP2 protein
CD8A gene mutant form inhibits the reaction [Acrolein results in increased activity of MMP2 protein]
Acrolein results in increased secretion of MMP2 protein
CTD PMID:15531749, PMID:17950725 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp7 matrix metallopeptidase 7 increases secretion ISO Acrolein results in increased secretion of MMP7 protein CTD PMID:30204913 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
affects secretion
increases expression
increases activity
increases secretion
increases cleavage
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Acrolein results in increased expression of MMP9 protein]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Acrolein results in increased expression of MMP9 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of MMP9 mRNA]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of MMP9 protein]; Acrolein results in increased expression of and results in increased secretion of MMP9 protein; Allopurinol inhibits the reaction [Acrolein results in increased expression of MMP9 protein]; MMP9 protein promotes the reaction [Acrolein results in increased expression of MUC5AC mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Acrolein results in increased expression of MMP9 mRNA]; Oxypurinol inhibits the reaction [Acrolein results in increased expression of MMP9 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased expression of MMP9 mRNA]
Acrolein affects the secretion of MMP9 protein
Acrolein results in increased expression of MMP9 mRNA; Acrolein results in increased expression of MMP9 protein
Acrolein results in increased activity of MMP9 protein
Acrolein results in increased expression of and results in increased activity of MMP9 protein; CD8A gene mutant form inhibits the reaction [Acrolein results in increased activity of MMP9 protein]; MMP9 gene mutant form inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]
Acrolein results in increased secretion of MMP9 protein
Acrolein results in increased cleavage of MMP9 protein
CTD PMID:15531749, PMID:17950725, PMID:18006877, PMID:19371603, PMID:20153347, PMID:28947239 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpeg1 macrophage expressed 1 increases expression ISO Acrolein results in increased expression of MPEG1 mRNA CTD PMID:18515264 NCBI chr 1:228,724,559...228,729,054
Ensembl chr 1:228,724,900...228,727,160
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein; [MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein; resorcinol inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein] CTD PMID:26262998 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression
affects secretion
multiple interactions
ISO
EXP
Acrolein results in increased expression of MUC5AC mRNA; Acrolein results in increased expression of MUC5AC protein
Acrolein affects the secretion of MUC5AC protein
Erlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]; MMP9 gene mutant form inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]
rosiglitazone inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]; rosiglitazone inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]; Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]; Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]; ADAM17 protein promotes the reaction [Acrolein results in increased expression of MUC5AC mRNA]; EGFR protein affects the reaction [Acrolein results in increased expression of MUC5AC mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]]; MMP14 protein affects the reaction [Acrolein results in increased expression of MUC5AC mRNA]; MMP9 protein promotes the reaction [Acrolein results in increased expression of MUC5AC mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]; Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]; TIMP3 protein inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]
CTD PMID:15531749, PMID:18006877, PMID:19464576, PMID:19661247, PMID:20359552, PMID:30204913 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Acrolein results in increased expression of MYC mRNA CTD PMID:24211530 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myl3 myosin light chain 3 affects metabolic processing ISO Acrolein affects the metabolism of MYL3 protein CTD PMID:17921335 NCBI chr 8:119,030,852...119,036,996
Ensembl chr 8:119,030,875...119,036,996
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
affects metabolic processing
ISO Acrolein inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NCF1 protein]
Acrolein affects the metabolism of NCF1 protein
CTD PMID:11246141 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO Acrolein inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NCF2 protein] CTD PMID:11246141 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Nfe2l1 nuclear factor, erythroid 2-like 1 multiple interactions
decreases expression
ISO 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of NFE2L1 mRNA]; 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of NFE2L1 protein]
Acrolein results in decreased expression of NFE2L1 mRNA; Acrolein results in decreased expression of NFE2L1 protein
CTD PMID:20938484 NCBI chr10:84,686,762...84,699,313
Ensembl chr10:84,682,460...84,698,886
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
increases expression
increases response to substance
affects response to substance
multiple interactions
decreases response to substance
decreases expression
increases activity
ISO
EXP
Acrolein affects the localization of NFE2L2 protein
Acrolein results in increased expression of NFE2L2 protein
NFE2L2 gene mutant form results in increased susceptibility to Acrolein
[NFE2L2 affects the susceptibility to sulforafan] which affects the susceptibility to Acrolein
1,2-dithiol-3-thione promotes the reaction [NFE2L2 results in decreased susceptibility to Acrolein]; [Ovalbumin co-treated with Acrolein] results in increased expression of NFE2L2 protein; Buthionine Sulfoximine affects the reaction [[NFE2L2 affects the susceptibility to sulforafan] which affects the susceptibility to Acrolein]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforafan results in decreased susceptibility to Acrolein]]; NFE2L2 protein affects the reaction [[cafestol co-treated with kahweol] results in decreased susceptibility to Acrolein]; NFE2L2 protein promotes the reaction [sulforafan results in decreased susceptibility to Acrolein]
Acrolein results in decreased expression of NFE2L2 protein
[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein]; lipoamide inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Curcumin analog results in decreased susceptibility to Acrolein]; NFE2L2 protein affects the reaction [Curcumin results in decreased susceptibility to Acrolein]; NFE2L2 protein promotes the reaction [Acrolein results in increased expression of HMOX1 mRNA]; PRKCD protein promotes the reaction [Acrolein affects the localization of NFE2L2 protein]; rottlerin inhibits the reaction [Acrolein affects the localization of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]
Acrolein results in increased activity of NFE2L2 protein
CTD PMID:12084617, PMID:12763045, PMID:17197552, PMID:18028974, PMID:18048804, PMID:18258206, PMID:18367636, PMID:19303893, PMID:19608619, PMID:20932822, PMID:23954767, PMID:25145656, PMID:27633142, PMID:28109747, PMID:28482051, PMID:30608172 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression
decreases activity
ISO
EXP
Acrolein inhibits the reaction [NFKB1 protein binds to IL2 promoter]; Acrolein inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Acrolein results in increased alkylation of and results in decreased activity of NFKB1 protein
Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 protein]
Acrolein results in increased expression of NFKB1 mRNA; Acrolein results in increased expression of NFKB1 protein
Acrolein results in decreased activity of NFKB1 protein
CTD PMID:15650393, PMID:17491020, PMID:21265102 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation
increases expression
ISO
EXP
Acrolein promotes the reaction [TNF protein results in increased expression of NFKBIA protein]
rosiglitazone inhibits the reaction [Acrolein results in increased phosphorylation of NFKBIA protein]
Acrolein results in increased expression of NFKBIA protein
CTD PMID:15650393, PMID:19464576 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
ISO
EXP
3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]; [Acrolein co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein; Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; NLRP3 protein affects the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; Rotenone promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]; Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]
3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [Acrolein results in increased expression of NLRP3 protein]; ADAM10 protein affects the reaction [Acrolein results in increased expression of NLRP3 protein]; SB 203580 inhibits the reaction [Acrolein results in increased expression of NLRP3 protein]
CTD PMID:30205151, PMID:31639409 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
decreases expression
multiple interactions
EXP
ISO
Acrolein results in increased expression of NOS2 protein
Acrolein results in decreased expression of NOS2 protein
pimagedine inhibits the reaction [Acrolein results in increased expression of NOS2 protein]
CTD PMID:20940037, PMID:22961095 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npr3 natriuretic peptide receptor 3 affects expression ISO Acrolein affects the expression of NPR3 mRNA CTD PMID:19527780 NCBI chr 2:61,883,946...61,950,291
Ensembl chr 2:61,888,950...61,949,926
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO
EXP
Acrolein results in increased expression of NQO1 mRNA
Acrolein results in increased expression of NQO1 mRNA; Acrolein results in increased expression of NQO1 protein
CTD PMID:12084617, PMID:12763045, PMID:20015449, PMID:24211530, PMID:25145656 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Acrolein results in increased expression of NR4A1 mRNA; Acrolein results in increased expression of NR4A1 protein CTD PMID:20015449 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases expression EXP Acrolein results in decreased expression of NTRK2 protein CTD PMID:29355571 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ogdh oxoglutarate dehydrogenase decreases activity EXP Acrolein results in decreased activity of OGDH protein CTD PMID:16725382 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase affects response to substance ISO OGG1 protein affects the susceptibility to Acrolein CTD PMID:17003489 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO
EXP
Acrolein results in increased cleavage of PARP1 protein
3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [Acrolein results in increased cleavage of PARP1 protein]
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Acrolein results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [Acrolein results in increased cleavage of PARP1 protein]
CTD PMID:19596284, PMID:29964147, PMID:31639409 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pf4 platelet factor 4 increases expression ISO Acrolein results in increased expression of PF4 protein CTD PMID:20678513 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [PON1 protein results in increased metabolism of [Acrolein binds to Ascorbic Acid]] which results in increased chemical synthesis of 5,6,7,8-tetrahydroxy-4-oxooctanal; PON1 protein results in increased metabolism of [Acrolein binds to Ascorbic Acid] CTD PMID:20353174 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pon2 paraoxonase 2 multiple interactions ISO [PON2 protein results in increased metabolism of [Acrolein binds to Ascorbic Acid]] which results in increased chemical synthesis of 5,6,7,8-tetrahydroxy-4-oxooctanal; PON2 protein results in increased metabolism of [Acrolein binds to Ascorbic Acid] CTD PMID:20353174 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
JBrowse link
G Prdx1 peroxiredoxin 1 increases oxidation ISO Acrolein results in increased oxidation of PRDX1 protein CTD PMID:19135121 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx3 peroxiredoxin 3 increases oxidation ISO Acrolein results in increased oxidation of PRDX3 protein CTD PMID:19135121 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Prkcd protein kinase C, delta affects localization
multiple interactions
EXP
ISO
Acrolein affects the localization of PRKCD protein
PRKCD protein promotes the reaction [Acrolein affects the localization of NFE2L2 protein]
CTD PMID:12755590, PMID:18048804 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression ISO Acrolein results in decreased expression of PTGIS mRNA; Acrolein results in decreased expression of PTGIS protein CTD PMID:17255567 NCBI chr 3:163,950,746...163,986,129 JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of Acrolein CTD PMID:11524419 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Acrolein results in increased expression of PTGS2 mRNA; Acrolein results in increased expression of PTGS2 protein
rottlerin inhibits the reaction [Acrolein results in increased expression of PTGS2 mRNA]; rottlerin inhibits the reaction [Acrolein results in increased expression of PTGS2 protein]
CTD PMID:17363696, PMID:28482051 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity
multiple interactions
ISO Acrolein results in decreased activity of PTPN1 protein
Vanadates inhibits the reaction [Acrolein results in decreased activity of PTPN1 protein]
CTD PMID:17655273 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C increases expression ISO Acrolein results in increased expression of PTPRC mRNA CTD PMID:18515264 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
increases phosphorylation
multiple interactions
EXP
ISO
Acrolein results in increased expression of RELA protein
Acrolein results in increased phosphorylation of RELA protein
Acrolein promotes the reaction [RELA protein binds to FASLG promoter]; Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Acrolein results in increased activity of and affects the localization of RELA protein; Hydralazine inhibits the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]]; Phenylbutyrates inhibits the reaction [Acrolein results in increased activity of and affects the localization of RELA protein]; Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]
3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [Acrolein results in increased phosphorylation of RELA protein]; Rosiglitazone affects the reaction [Acrolein results in increased expression of RELA protein]; SB 203580 inhibits the reaction [Acrolein results in increased phosphorylation of RELA protein]
CTD PMID:18951912, PMID:19464576, PMID:27238871, PMID:31639409 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK1 protein CTD PMID:24847785 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK3 protein CTD PMID:24847785 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO Acrolein results in decreased expression of RPS6KB1 protein modified form CTD PMID:21742783 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression ISO Acrolein results in increased expression of S100A4 mRNA CTD PMID:18515264 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO Acrolein results in increased expression of SEL1L3 mRNA CTD PMID:24211530 NCBI chr14:60,122,968...60,229,565
Ensembl chr14:60,123,169...60,229,734
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Acrolein results in increased expression of SERPINE1 mRNA CTD PMID:18515264 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc1a3 solute carrier family 1 member 3 multiple interactions
decreases expression
EXP 3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [Acrolein results in decreased expression of SLC1A3 protein] CTD PMID:31639409 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363
JBrowse link
G Slc25a4 solute carrier family 25 member 4 affects binding EXP SLC25A4 protein binds to Acrolein CTD PMID:17385840 NCBI chr16:49,266,903...49,270,698
Ensembl chr16:49,266,903...49,270,698
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Acrolein results in increased expression of SLC7A11 mRNA CTD PMID:24211530 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Smox spermine oxidase multiple interactions ISO [SMOX results in increased susceptibility to Acetaldehyde] which results in increased abundance of Acrolein CTD PMID:23707493 NCBI chr 3:124,068,796...124,103,726
Ensembl chr 3:124,068,865...124,102,240
JBrowse link
G Snca synuclein alpha affects binding
affects metabolic processing
ISO Acrolein binds to SNCA protein
Acrolein affects the metabolism of SNCA protein
CTD PMID:17690948 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO coenzyme Q10 inhibits the reaction [Acrolein results in increased expression of SOD2 protein]; resveratrol inhibits the reaction [Acrolein results in increased expression of SOD2 protein] CTD PMID:24008411, PMID:28482051 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 increases expression ISO Acrolein results in increased expression of SOD3 protein CTD PMID:28482051 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
decreases expression
ISO Acrolein results in increased expression of SQSTM1 mRNA
Acetylcysteine inhibits the reaction [Acrolein results in decreased expression of SQSTM1 protein]
CTD PMID:24211530, PMID:29902662, PMID:30205151 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 decreases expression ISO Acrolein results in decreased expression of SYNE2 mRNA CTD PMID:24211530 NCBI chr 6:98,884,269...99,153,551 JBrowse link
G Tac1 tachykinin, precursor 1 increases expression EXP Acrolein results in increased expression of TAC1 protein CTD PMID:1696540 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions
decreases expression
ISO 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of TFAM mRNA] CTD PMID:20938484 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tfdp1 transcription factor Dp-1 decreases expression ISO Acrolein results in decreased expression of TFDP1 mRNA CTD PMID:26719373 NCBI chr16:81,088,642...81,127,244
Ensembl chr16:81,089,292...81,127,257
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression
multiple interactions
ISO Acrolein results in decreased expression of TIMP3 mRNA
TIMP3 protein inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]
CTD PMID:15531749, PMID:18006877, PMID:21742783 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tnf tumor necrosis factor decreases secretion
increases secretion
increases expression
multiple interactions
ISO
EXP
Acrolein results in decreased secretion of TNF protein
Acrolein results in increased secretion of TNF protein
Acrolein results in increased expression of TNF mRNA
Acrolein inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Acrolein inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Acrolein inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Acrolein promotes the reaction [TNF protein results in increased expression of NFKBIA protein]; Phenylbutyrates inhibits the reaction [Acrolein results in increased expression of TNF mRNA]
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased secretion of TNF protein]]; rosiglitazone inhibits the reaction [Acrolein results in increased secretion of TNF protein]; Simvastatin inhibits the reaction [Acrolein results in increased secretion of TNF protein]
CTD PMID:15650393, PMID:17491020, PMID:18951912, PMID:19464576, PMID:20359552, PMID:26481333, PMID:28947239, PMID:30204913 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression ISO Acrolein results in increased expression of TNFSF11 mRNA CTD PMID:18515264 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnnt2 troponin T2, cardiac type decreases expression ISO Acrolein results in decreased expression of TNNT2 mRNA CTD PMID:24211530 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Tp53 tumor protein p53 affects metabolic processing
affects response to substance
multiple interactions
increases mutagenesis
decreases activity
affects binding
ISO
EXP
Acrolein affects the metabolism of TP53 protein
TP53 protein affects the susceptibility to Acrolein
[ferric oxide analog co-treated with Acrolein] results in increased expression of TP53 protein
Acrolein results in increased mutagenesis of TP53 gene
Acrolein results in decreased activity of TP53 protein
Acrolein binds to TP53 gene
[TP53 protein affects the susceptibility to Acrolein] which affects the localization of CCNB1 protein; Acrolein inhibits the reaction [Benzo(a)pyrene results in increased activity of TP53 protein]; TP53 protein affects the reaction [Acrolein results in increased cleavage of CASP3 protein]; TP53 protein affects the reaction [Acrolein results in increased cleavage of CASP9 protein]; TP53 protein affects the reaction [Acrolein results in increased cleavage of PARP1 protein]
CTD PMID:12807757, PMID:16753831, PMID:17030796, PMID:24847785, PMID:29964147 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity
multiple interactions
decreases response to substance
affects response to substance
increases response to substance
EXP
ISO
Acrolein results in increased activity of TRPA1 protein
TRPA1 gene mutant form affects the susceptibility to [Particulate Matter co-treated with Acrolein]
TRPA1 gene mutant form results in decreased susceptibility to Acrolein
TRPA1 gene mutant form affects the susceptibility to Acrolein; TRPA1 protein affects the susceptibility to Acrolein
TRPA1 gene mutant form results in increased susceptibility to Acrolein
TRPA1 mRNA affects the reaction [Acrolein results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [Acrolein results in increased uptake of Calcium]
TRPA1 mRNA affects the susceptibility to Acrolein
CTD PMID:18568077, PMID:19507004, PMID:21591660, PMID:27592100, PMID:27746315, PMID:29627347, PMID:30351402 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases expression ISO Acrolein results in increased expression of TRPV1 protein CTD PMID:24376112 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Tubb4a tubulin, beta 4A class IVa affects binding EXP Acrolein binds to TUBB4A protein CTD PMID:17023561 NCBI chr 9:9,961,020...9,968,420
Ensembl chr 9:9,961,021...9,968,486
JBrowse link
G Txn1 thioredoxin 1 multiple interactions
increases oxidation
decreases activity
affects metabolic processing
ISO Acetylcysteine inhibits the reaction [Acrolein results in increased oxidation of TXN protein]
Acrolein results in decreased activity of TXN protein
Acrolein affects the metabolism of TXN protein
CTD PMID:15388247, PMID:17982132, PMID:18023956, PMID:19135121 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txn2 thioredoxin 2 increases oxidation ISO Acrolein results in increased oxidation of TXN2 protein CTD PMID:18023956, PMID:19135121 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
increases expression
decreases activity
ISO Acetylcysteine inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]; Cycloheximide inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]; Dactinomycin inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]
Acrolein results in decreased activity of TXNRD1 protein
CTD PMID:15388247, PMID:15652504, PMID:19135121, PMID:24211530 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Acrolein results in increased expression of UGT1A6 mRNA CTD PMID:12763045 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO Acrolein results in increased expression of VEGFA protein
[Ovalbumin co-treated with Acrolein] results in increased expression of VEGFA protein
cesium chloride inhibits the reaction [Acrolein results in increased expression of VEGFA protein]; Rotenone inhibits the reaction [Acrolein results in increased expression of VEGFA protein]
CTD PMID:22928487, PMID:30608172 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin increases metabolic processing ISO Acrolein results in increased metabolism of VIM protein CTD PMID:20015449 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vwf von Willebrand factor decreases expression ISO Acrolein results in decreased expression of VWF protein CTD PMID:31634544 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression ISO Acrolein results in increased expression of WEE1 mRNA CTD PMID:26719373 NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361
JBrowse link
G Xbp1 X-box binding protein 1 affects splicing ISO Acrolein affects the splicing of XBP1 mRNA CTD PMID:18951912 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pesticide 16263
          herbicide 11200
            acrolein 248
              2-(2,2,3-trimethylcyclopent-3-enyl)acrylaldehyde 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            formyl group 7845
                                              aldehyde 7845
                                                alpha,beta-unsaturated aldehyde 1297
                                                  enal 1297
                                                    acrolein 248
                                                      2-(2,2,3-trimethylcyclopent-3-enyl)acrylaldehyde 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.