CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: all-trans-retinoic acid
Accession: CHEBI:15367
browse the term
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Synonyms: exact_synonym: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
related_synonym: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid; (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid; 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-all-trans-tetraenoic acid; 3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2E,4E,6E,8E-tetraenoic acid; AGN 100335; Acide retinoique (French); Altreno; Atralin; Avita; Betarretin; Biacna; Cordes vas; Dermairol; Formula=C20H28O2; InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+; InChIKey=SHGAZHPCJJPHSC-YCNIQYBTSA-N; RETINOIC ACID; Refissa; Renova; Retin-A; Retisol-A; Ro 1-5488; SMILES=CC(\\C=C\\C1=C(C)CCCC1(C)C)=C/C=C/C(C)=C/C(O)=O; Stieva-A; Tretin M; Tri-luma; Veltin; Vesanoid; Vitamin A acid; all-(E)-Retinoic acid; all-trans-Tretinoin; all-trans-Vitamin A acid; all-trans-Vitamin A1 acid; all-trans-beta-Retinoic acid; beta-Retinoic acid; trans-Retinoic acid; tretinoin; tretinoina; tretinoine; tretinoinum
alt_id: CHEBI:45376; CHEBI:8815
xref: Beilstein:2057223; CAS:302-79-4; DrugBank:DB00755; Drug_Central:2722; FooDB:FDB022710; HMDB:HMDB0001852; KEGG:C00777; KEGG:D00094; LIPID_MAPS_instance:LMPR01090019
xref_mesh: MESH:D014212
xref: PDBeChem:REA; PMID:10022884; PMID:10970886; PMID:11073974; PMID:11214352; PMID:11332619; PMID:11343416; PMID:11437362; PMID:11556813; PMID:11722649; PMID:11896294; PMID:11904404; PMID:12958591; PMID:14581379; PMID:14605492; PMID:14627725; PMID:14704332; PMID:14705145; PMID:14978018; PMID:15194426; PMID:15318809; PMID:15327395; PMID:15359008; PMID:15376324; PMID:15476854; PMID:15537748; PMID:15539337; PMID:15675886; PMID:15839997; PMID:16569247; PMID:16685080; PMID:16688769; PMID:16720557; PMID:16819260; PMID:16847436; PMID:16920920; PMID:17073551; PMID:17166212; PMID:17204142; PMID:17447762; PMID:18052213; PMID:18085670; PMID:18162363; PMID:18183617; PMID:18318655; PMID:18322276; PMID:18400206; PMID:18404486; PMID:18440196; PMID:18678272; PMID:18800767; PMID:18819820; PMID:18977311; PMID:19018099; PMID:19112091; PMID:19144697; PMID:19427305; PMID:19587328; PMID:19597529; PMID:19814868; PMID:19841174; PMID:21898109; PMID:21924320; PMID:21993673; PMID:22134377; PMID:22177959; PMID:22180426; PMID:22244299; PMID:22261335; PMID:22428994; PMID:22514600; PMID:22532966; PMID:22534100; PMID:22538278; PMID:22741806; PMID:27759097; PMID:29492455; PMID:33662750; PMID:33820492; PMID:34050114; PMID:34050360; PMID:34091189; PMID:7501014; PMID:7704533; PMID:7961949; Reaxys:2057223; Wikipedia:Retinoic_acid; Wikipedia:Tretinoin
cyclic_relationship: is_conjugate_acid_of CHEBI:35291
G
CASP3
caspase 3
increases activity
EXP
Tretinoin results in increased activity of CASP3 protein
CTD
PMID:16953078
NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
G
CLDN1
claudin 1
multiple interactions increases expression
EXP
CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA] Tretinoin results in increased expression of CLDN1 mRNA; Tretinoin results in increased expression of CLDN1 protein
CTD
PMID:17035595
NCBI chr34:22,303,058...22,319,101
Ensembl chr34:22,303,850...22,319,033
G
CLDN4
claudin 4
increases expression multiple interactions
EXP
Tretinoin results in increased expression of CLDN4 mRNA; Tretinoin results in increased expression of CLDN4 protein CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]
CTD
PMID:17035595
NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
G
CYP26A1
cytochrome P450 family 26 subfamily A member 1
increases degradation multiple interactions
EXP
CYP26A1 protein results in increased degradation of Tretinoin CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]
CTD
PMID:17035595
NCBI chr28:7,423,955...7,432,359
Ensembl chr28:7,428,772...7,432,370
G
NOS3
nitric oxide synthase 3
increases expression
EXP
Tretinoin results in increased expression of NOS3 mRNA; Tretinoin results in increased expression of NOS3 protein
CTD
PMID:17267746
NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
G
OCLN
occludin
multiple interactions increases expression
EXP
CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA] Tretinoin results in increased expression of OCLN mRNA; Tretinoin results in increased expression of OCLN protein
CTD
PMID:17035595
NCBI chr 2:54,500,299...54,545,430
Ensembl chr 2:54,500,299...54,545,430
G
TJP1
tight junction protein 1
increases expression multiple interactions
EXP
Tretinoin results in increased expression of TJP1 mRNA; Tretinoin results in increased expression of TJP1 protein CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]
CTD
PMID:17035595
NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
494
role
501
chemical role
420
antioxidant
43
all-trans-retinoic acid
7
1-O-all-trans-retinoyl-beta-glucuronic acid
0
4-hydroxyphenyl retinamide
0
5,6-epoxyretinoic acid +
0
SR11302
0
all-trans-13,14-dihydroretinoic acid +
0
all-trans-16-hydroxyretinoic acid
0
all-trans-18-hydroxyretinoic acid
0
all-trans-3,4-didehydroretinoic acid
0
all-trans-4,16-dihydroxyretinoic acid
0
all-trans-4,18-dihydroxyretinoic acid
0
all-trans-4-hydroxyretinoic acid +
0
all-trans-4-oxo-16-hydroxyretinoic acid
0
all-trans-4-oxo-18-hydroxyretinoic acid
0
all-trans-4-oxoretinoic acid +
0
Path 2
CHEBI ontology
494
subatomic particle
494
composite particle
494
hadron
501
baryon
494
nucleon
494
atomic nucleus
494
atom
494
main group element atom
487
main group molecular entity
487
s-block molecular entity
438
hydrogen molecular entity
437
hydrides
362
organic hydride
71
organic fundamental parent
71
hydrocarbon
49
terpene
20
terpenoid
20
diterpenoid
15
retinoid
8
vitamin A
7
all-trans-retinoic acid
7
1-O-all-trans-retinoyl-beta-glucuronic acid
0
4-hydroxyphenyl retinamide
0
5,6-epoxyretinoic acid +
0
SR11302
0
all-trans-13,14-dihydroretinoic acid +
0
all-trans-16-hydroxyretinoic acid
0
all-trans-18-hydroxyretinoic acid
0
all-trans-3,4-didehydroretinoic acid
0
all-trans-4,16-dihydroxyretinoic acid
0
all-trans-4,18-dihydroxyretinoic acid
0
all-trans-4-hydroxyretinoic acid +
0
all-trans-4-oxo-16-hydroxyretinoic acid
0
all-trans-4-oxo-18-hydroxyretinoic acid
0
all-trans-4-oxoretinoic acid +
0