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G
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Abcc8
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ATP binding cassette subfamily C member 8
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multiple interactions
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EXP
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ABCC8 protein inhibits the reaction [Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]]
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CTD |
PMID:15894309 |
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NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982
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G
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Ache
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acetylcholinesterase
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increases hydrolysis affects abundance multiple interactions increases abundance increases activity
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ISO EXP
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ACHE protein results in increased hydrolysis of Acetylcholine ACHE protein affects the abundance of Acetylcholine [Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine; Acetylcholine inhibits the reaction [ACHE protein results in increased hydrolysis of Acetylthiocholine]; Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine] ACHE gene mutant form results in increased abundance of Acetylcholine Acetylcholine results in increased activity of ACHE protein [Botulinum Toxins, Type A results in increased expression of and results in increased activity of ACHE protein] which results in decreased abundance of Acetylcholine; [Soman results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine; Rivastigmine inhibits the reaction [[Botulinum Toxins, Type A results in increased expression of and results in increased activity of ACHE protein] which results in decreased abundance of Acetylcholine]
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CTD |
PMID:18602908 PMID:19100287 PMID:19818744 PMID:20105433 PMID:20396698 PMID:22542756 PMID:23047027 PMID:31247192 PMID:37507053 More...
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NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
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G
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Adcy5
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adenylate cyclase 5
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increases response to substance
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ISO
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ADCY5 protein results in increased susceptibility to Acetylcholine
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CTD |
PMID:12869393 |
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NCBI chr11:78,976,861...79,123,343
Ensembl chr11:78,976,861...79,123,343
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G
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Adora2a
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adenosine A2a receptor
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increases response to substance multiple interactions
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EXP
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ADORA2A protein results in increased susceptibility to Acetylcholine ZM 241385 inhibits the reaction [ADORA2A protein results in increased susceptibility to Acetylcholine]
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CTD |
PMID:16616212 |
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NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802
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G
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Adra2b
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adrenoceptor alpha 2B
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multiple interactions
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ISO
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ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]
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CTD |
PMID:16815979 |
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NCBI chr 3:135,038,481...135,042,527
Ensembl chr 3:135,038,474...135,042,525
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G
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Agt
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angiotensinogen
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multiple interactions decreases response to substance
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ISO
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ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]; ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]; SB 203580 inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]; tempol inhibits the reaction [ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]]; tempol promotes the reaction [ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]] AGT protein modified form results in decreased susceptibility to Acetylcholine; AGT protein results in decreased susceptibility to Acetylcholine
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CTD |
PMID:18174886 PMID:18768397 PMID:21289285 PMID:22753205 |
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NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
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G
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Alb
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albumin
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multiple interactions
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ISO
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[ALB protein co-treated with Particulate Matter] results in increased susceptibility to Acetylcholine; ALB protein promotes the reaction [Particulate Matter results in increased susceptibility to Acetylcholine]
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CTD |
PMID:30953400 |
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NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
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G
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Alox15
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arachidonate 15-lipoxygenase
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multiple interactions
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ISO
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[ALOX15 protein affects the metabolism of Arachidonic Acid] which affects the susceptibility to Acetylcholine
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CTD |
PMID:21193584 |
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NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723
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G
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Apoe
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apolipoprotein E
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affects response to substance decreases response to substance
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ISO
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APOE protein affects the susceptibility to Acetylcholine APOE gene mutant form results in decreased susceptibility to Acetylcholine
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CTD |
PMID:11397713 PMID:17899169 |
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NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855
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G
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App
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amyloid beta precursor protein
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multiple interactions decreases secretion
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ISO EXP
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[IL1B protein co-treated with APP protein] results in increased secretion of Acetylcholine; IL1B protein inhibits the reaction [APP protein results in decreased secretion of Acetylcholine] APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]; spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one inhibits the reaction [APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]] GW 501516 inhibits the reaction [APP gene mutant form results in decreased susceptibility to Acetylcholine]
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CTD |
PMID:16122837 PMID:16474004 PMID:22886847 |
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NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
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G
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Ass1
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argininosuccinate synthase 1
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increases response to substance
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ISO
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ASS1 protein results in increased susceptibility to Acetylcholine
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CTD |
PMID:25033204 |
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NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627
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G
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Atox1
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antioxidant 1 copper chaperone
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increases response to substance multiple interactions
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ISO
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ATOX1 protein results in increased susceptibility to Acetylcholine ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]; tempol promotes the reaction [ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]]
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CTD |
PMID:22753205 |
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NCBI chr10:40,065,525...40,080,627
Ensembl chr10:40,065,527...40,080,585
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G
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Atp7a
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ATPase copper transporting alpha
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multiple interactions
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ISO
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ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]; tempol inhibits the reaction [ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]]
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CTD |
PMID:18768397 |
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NCBI chr X:75,159,635...75,267,094
Ensembl chr X:75,159,782...75,267,093
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G
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Bche
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butyrylcholinesterase
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increases degradation multiple interactions
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ISO
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BCHE protein results in increased degradation of Acetylcholine Acetylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of benzoylthiocholine]; Acetylcholine inhibits the reaction [Tripelennamine results in decreased activity of BCHE protein]
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CTD |
PMID:236606 PMID:16020944 PMID:31247192 |
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NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
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G
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Calca
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calcitonin-related polypeptide alpha
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multiple interactions increases response to substance
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EXP
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calcitonin gene-related peptide (8-37) inhibits the reaction [CALCA protein results in increased susceptibility to Acetylcholine]
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CTD |
PMID:16616212 |
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NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529
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G
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Cav1
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caveolin 1
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multiple interactions
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ISO
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Sodium, Dietary affects the reaction [CAV1 protein affects the susceptibility to Acetylcholine]
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CTD |
PMID:18178722 |
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NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740
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G
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Chrm1
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cholinergic receptor, muscarinic 1
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increases activity multiple interactions affects binding
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ISO EXP
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Acetylcholine results in increased activity of CHRM1 protein [Acetylcholine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; Acetylcholine binds to and results in increased activity of CHRM1 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]; Endocannabinoids promotes the reaction [Acetylcholine binds to and results in increased activity of CHRM1 protein]; KT 5720 promotes the reaction [Acetylcholine binds to CHRM1 protein]; Quinuclidinyl Benzilate inhibits the reaction [brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]] Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM1 protein]; Progesterone inhibits the reaction [Acetylcholine binds to CHRM1 protein]; Propofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein] Acetylcholine binds to CHRM1 protein; CHRM1 protein binds to Acetylcholine
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CTD |
PMID:9224827 PMID:9495826 PMID:10069518 PMID:10101037 PMID:10860942 PMID:11527950 PMID:14534362 PMID:15900516 PMID:30102254 PMID:31830555 More...
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NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602
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G
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Chrm2
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cholinergic receptor, muscarinic 2
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multiple interactions affects binding
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ISO
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Acetylcholine binds to and results in increased activity of CHRM2 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM2 protein]; eburnamonine promotes the reaction [Acetylcholine binds to CHRM2 protein]; N-chloromethylbrucine inhibits the reaction [Acetylcholine results in increased activity of CHRM2 protein] Acetylcholine binds to CHRM2 protein; CHRM2 protein binds to Acetylcholine
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CTD |
PMID:9224827 PMID:10069518 PMID:10101037 |
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NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464
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G
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Chrm3
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cholinergic receptor, muscarinic 3
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increases activity multiple interactions affects binding increases response to substance
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EXP ISO
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Acetylcholine results in increased activity of CHRM3 protein Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM3 protein]; Progesterone inhibits the reaction [Acetylcholine binds to CHRM3 protein]; WIN 62577 analog inhibits the reaction [Acetylcholine binds to CHRM3 protein]; WIN 62577 promotes the reaction [Acetylcholine binds to CHRM3 protein] Acetylcholine binds to and results in increased activity of CHRM3 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM3 protein]; brucine N-oxide promotes the reaction [Acetylcholine binds to CHRM3 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM3 protein]; N-chloromethylbrucine promotes the reaction [Acetylcholine binds to CHRM3 protein]; N-chloromethylbrucine promotes the reaction [Acetylcholine results in increased activity of CHRM3 protein] Acetylcholine binds to CHRM3 protein; CHRM3 protein binds to Acetylcholine CHRM3 protein results in increased susceptibility to Acetylcholine
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CTD |
PMID:9224827 PMID:9495826 PMID:10069518 PMID:10101037 PMID:11755166 PMID:12435818 PMID:15900516 PMID:15964566 PMID:19407017 PMID:31830555 More...
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NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304
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G
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Chrm4
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cholinergic receptor, muscarinic 4
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multiple interactions affects binding
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ISO
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[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Acetylcholine binds to CHRM4 protein]; Acetylcholine binds to and results in increased activity of CHRM4 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM4 protein]; brucine N-oxide promotes the reaction [Acetylcholine binds to CHRM4 protein]; brucine N-oxide promotes the reaction [Acetylcholine results in increased activity of CHRM4 protein]; eburnamonine promotes the reaction [Acetylcholine binds to CHRM4 protein] Acetylcholine binds to CHRM4 protein; CHRM4 protein binds to Acetylcholine
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CTD |
PMID:9224827 PMID:9495826 PMID:10069518 PMID:10101037 PMID:16709648 |
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NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:98,348,650...98,358,771
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G
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Chrm5
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cholinergic receptor, muscarinic 5
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affects response to substance decreases response to substance multiple interactions increases activity
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ISO
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CHRM5 protein affects the susceptibility to Acetylcholine CHRM5 protein mutant form results in decreased susceptibility to Acetylcholine Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein]
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CTD |
PMID:14607263 PMID:31323226 |
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NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:119,735,975...119,792,166
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G
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Chrna1
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cholinergic receptor nicotinic alpha 1 subunit
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multiple interactions
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ISO EXP
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Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein] Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]; LYNX1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; LYPD1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]
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CTD |
PMID:16931985 PMID:19619141 PMID:22461452 |
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NCBI chr 3:78,862,286...78,877,353
Ensembl chr 3:78,862,286...78,877,353
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G
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Chrna10
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cholinergic receptor nicotinic alpha 10 subunit
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multiple interactions
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ISO
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2-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; 3-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; 4-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]; ethylbenzene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]
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CTD |
PMID:18602458 |
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NCBI chr 1:165,898,932...165,905,348
Ensembl chr 1:165,899,261...165,903,458
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G
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Chrna2
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cholinergic receptor nicotinic alpha 2 subunit
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multiple interactions affects response to substance
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ISO EXP
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1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] CHRNA2 gene mutant form affects the susceptibility to Acetylcholine Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]] acetylcholine affects binding competes with [Epibatidine binds to Chrna2 protein]
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CTD RGD |
PMID:7808438 PMID:9454827 PMID:11821649 PMID:19383498 PMID:15016836 |
RGD:2303194 |
NCBI chr15:44,517,862...44,534,144
Ensembl chr15:44,517,862...44,534,144
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G
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Chrna3
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cholinergic receptor nicotinic alpha 3 subunit
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multiple interactions
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ISO EXP
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4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; celastrol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; celastrol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; triptolide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; triptolide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA3 protein binds to CHRNB4 protein]; Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]] Acetylcholine affects binding [Epibatidine binds to Chrna3 protein]
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CTD RGD |
PMID:7808438 PMID:9454827 PMID:11711029 PMID:12130716 PMID:15885267 PMID:16931985 PMID:34628512 PMID:39914504 PMID:15016836 More...
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RGD:2303194 |
NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:64,297,755...64,311,412
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G
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Chrna4
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cholinergic receptor nicotinic alpha 4 subunit
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multiple interactions increases response to substance affects binding
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ISO EXP
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1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 3,5-dibromo-2-(2,4-dibromophenoxy)phenol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; [Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB4 protein]; Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Aluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; antimony trioxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Bentonite inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; decabromobiphenyl ether inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; desformylflustrabromine promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Fire Trol 934 inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Flame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Flame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; triphenyl phosphate inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CHRNA4 protein mutant form results in increased susceptibility to Acetylcholine Acetylcholine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine binds to [CHRNA4 protein binds to CHRNB2 protein] [CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Calcium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the susceptibility to Acetylcholine; [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]; [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB4 protein]; [pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine; Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Excitatory Amino Acid Antagonists inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; FG 9041 inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Mecamylamine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Urethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] acetylcholine affects binding to Chrna4 protein; acetylcholine competes with [Epibatidine binds to Chrna4 protein]
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CTD RGD |
PMID:9454827 PMID:11517245 PMID:11711029 PMID:11812690 PMID:12130716 PMID:12604691 PMID:12754307 PMID:14645658 PMID:15733544 PMID:15885267 PMID:16339034 PMID:16931985 PMID:18385335 PMID:19252481 PMID:20132834 PMID:20861069 PMID:21538459 PMID:21905680 PMID:22547355 PMID:22750351 PMID:34628512 PMID:39914504 PMID:15016836 More...
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RGD:2303194 |
NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105
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G
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Chrna7
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cholinergic receptor nicotinic alpha 7 subunit
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multiple interactions increases activity increases response to substance
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EXP ISO
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1,2-linoleoylphosphatidylcholine promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Acetylcholine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Toluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; [Acetylcholine results in increased activity of CHRNA7 protein] which results in increased uptake of Calcium; Acetylcholine binds to and results in increased activity of CHRNA7 protein; Atracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; beta-thujone inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; desformylflustrabromine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Toluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CHRNA7 protein mutant form results in increased susceptibility to Acetylcholine
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CTD |
PMID:10082212 PMID:12626641 PMID:15885267 PMID:16931985 PMID:19100751 PMID:19448648 PMID:20132834 PMID:21051662 PMID:21905680 PMID:28395994 PMID:29191791 PMID:39393466 PMID:39914504 More...
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NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858
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G
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Chrna9
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cholinergic receptor nicotinic alpha 9 subunit
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multiple interactions
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ISO
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2-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; 3-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; 4-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]; ethylbenzene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]
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CTD |
PMID:18602458 |
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NCBI chr14:42,588,948...42,595,669
Ensembl chr14:42,588,948...42,595,669
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G
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Chrnb1
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cholinergic receptor nicotinic beta 1 subunit
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multiple interactions
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ISO EXP
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Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein]
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CTD |
PMID:16931985 PMID:22461452 |
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NCBI chr10:54,999,943...55,015,137
Ensembl chr10:55,002,788...55,015,107
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G
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Chrnb2
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cholinergic receptor nicotinic beta 2 subunit
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multiple interactions affects binding
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ISO EXP
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1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 3,5-dibromo-2-(2,4-dibromophenoxy)phenol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; [Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]; Aluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; antimony trioxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Bentonite inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; celastrol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; decabromobiphenyl ether inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; desformylflustrabromine promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Fire Trol 934 inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Flame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Flame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; triphenyl phosphate inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; triptolide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] Acetylcholine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine binds to [CHRNA4 protein binds to CHRNB2 protein] [CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Calcium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the susceptibility to Acetylcholine; [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]; [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; [pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine; Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; Acetylcholine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]; Acetylcholine results in increased activity of [NACHRALPHA1 protein co-treated with NACHRALPHA2 protein co-treated with CHRNB2 protein]; Acetylcholine results in increased activity of [NACHRALPHA2 protein co-treated with CHRNB2 protein]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRALPHA1 protein co-treated with NACHRALPHA2 protein co-treated with CHRNB2 protein]]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRALPHA2 protein co-treated with CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Excitatory Amino Acid Antagonists inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; FG 9041 inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; LYNX1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; LYPD1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; Mecamylamine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Urethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] acetylcholine affects binding to Chrnb2 protein; acetylcholine competes with [Epibatidine binds to Chrnb2 protein]
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CTD RGD |
PMID:7808438 PMID:11517245 PMID:11711029 PMID:11812690 PMID:12130716 PMID:12604691 PMID:12754307 PMID:14645658 PMID:15733544 PMID:15885267 PMID:16931985 PMID:16981889 PMID:18385335 PMID:19046356 PMID:19252481 PMID:19619141 PMID:20132834 PMID:20861069 PMID:21538459 PMID:21905680 PMID:22547355 PMID:22750351 PMID:25459289 PMID:34628512 PMID:39914504 PMID:15016836 More...
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RGD:2303194 |
NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326
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G
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Chrnb4
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cholinergic receptor nicotinic beta 4 subunit
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multiple interactions
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ISO EXP
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1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB4 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; celastrol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; triptolide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA3 protein binds to CHRNB4 protein]; [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB4 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]
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CTD |
PMID:7808438 PMID:9454827 PMID:11711029 PMID:11821649 PMID:12130716 PMID:16931985 PMID:34628512 PMID:39914504 More...
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NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:64,313,669...64,333,248
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G
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Chrnd
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cholinergic receptor nicotinic delta subunit
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multiple interactions
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ISO EXP
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Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein]
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CTD |
PMID:16931985 PMID:22461452 |
|
NCBI chr 9:95,310,316...95,318,734
Ensembl chr 9:95,310,298...95,318,745
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G
|
Chrne
|
cholinergic receptor nicotinic epsilon subunit
|
multiple interactions
|
ISO EXP
|
Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein]
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CTD |
PMID:16931985 PMID:22461452 |
|
NCBI chr10:55,829,835...55,838,853
Ensembl chr10:55,829,836...55,834,154
|
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G
|
Chrng
|
cholinergic receptor nicotinic gamma subunit
|
multiple interactions
|
EXP ISO
|
Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]
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CTD |
PMID:22461452 |
|
NCBI chr 9:95,325,984...95,332,092
Ensembl chr 9:95,325,984...95,332,092
|
|
G
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Crh
|
corticotropin releasing hormone
|
increases expression
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EXP
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Acetylcholine results in increased expression of CRH mRNA
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CTD |
PMID:7588217 |
|
NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
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|
G
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Csf2
|
colony stimulating factor 2
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increases secretion
|
ISO
|
Acetylcholine results in increased secretion of CSF2 protein
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CTD |
PMID:9606035 |
|
NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031
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|
G
|
Cybb
|
cytochrome b-245 beta chain
|
multiple interactions
|
ISO
|
CYBB gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]
|
CTD |
PMID:18522491 |
|
NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065
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|
G
|
Edn1
|
endothelin 1
|
multiple interactions decreases response to substance
|
EXP
|
acetovanillone inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]; Catechin inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]; Polyphenols inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]
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CTD |
PMID:20977430 |
|
NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687
|
|
G
|
Epo
|
erythropoietin
|
multiple interactions increases response to substance
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ISO
|
EPO protein inhibits the reaction [GCH1 gene mutant form results in decreased susceptibility to Acetylcholine] EPO protein results in increased susceptibility to Acetylcholine
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CTD |
PMID:25490417 |
|
NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725
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G
|
Esr1
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estrogen receptor 1
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multiple interactions
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ISO
|
ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Acetylcholine]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine]
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CTD |
PMID:17158209 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
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G
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Fbn1
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fibrillin 1
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multiple interactions
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ISO
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FBN1 protein affects the susceptibility to [Acetylcholine co-treated with Indomethacin]
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CTD |
PMID:17641673 |
|
NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:133,008,361...133,204,283
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G
|
Fkbp1b
|
FKBP prolyl isomerase 1B
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multiple interactions
|
ISO
|
FKBP1B gene mutant form inhibits the reaction [Acetylcholine affects the localization of and affects the abundance of Calcium]; Ryanodine inhibits the reaction [FKBP1B gene mutant form inhibits the reaction [Acetylcholine affects the localization of and affects the abundance of Calcium]]
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CTD |
PMID:17261647 |
|
NCBI chr 6:33,551,583...33,570,055
Ensembl chr 6:33,558,517...33,568,129
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G
|
Gch1
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GTP cyclohydrolase 1
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multiple interactions decreases response to substance
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EXP ISO
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[2,4-diaminohypoxanthine results in decreased activity of GCH1 protein] which affects the susceptibility to Acetylcholine EPO protein inhibits the reaction [GCH1 gene mutant form results in decreased susceptibility to Acetylcholine]
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CTD |
PMID:12855421 PMID:25490417 |
|
NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412
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G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
decreases response to substance
|
ISO
|
GCLC promoter SNP results in decreased susceptibility to Acetylcholine
|
CTD |
PMID:12598062 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
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G
|
Gclm
|
glutamate cysteine ligase, modifier subunit
|
affects response to substance
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ISO
|
GCLM gene SNP affects the susceptibility to Acetylcholine
|
CTD |
PMID:12975258 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
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G
|
Gpx1
|
glutathione peroxidase 1
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decreases response to substance
|
ISO
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GPX1 gene mutant form results in decreased susceptibility to Acetylcholine
|
CTD |
PMID:24296279 |
|
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
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G
|
Hmox1
|
heme oxygenase 1
|
affects response to substance multiple interactions
|
EXP
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HMOX1 protein affects the susceptibility to Acetylcholine [chromium mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Desoxycorticosterone Acetate results in decreased susceptibility to Acetylcholine]
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CTD |
PMID:14693679 PMID:16309587 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
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|
G
|
Il1b
|
interleukin 1 beta
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multiple interactions increases secretion
|
ISO
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[IL1B protein co-treated with APP protein] results in increased secretion of Acetylcholine; IL1B protein inhibits the reaction [APP protein results in decreased secretion of Acetylcholine] IL1B protein results in increased secretion of Acetylcholine
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CTD |
PMID:16122837 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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G
|
Il1rn
|
interleukin 1 receptor antagonist
|
affects response to substance
|
ISO
|
IL1RN protein affects the susceptibility to Acetylcholine
|
CTD |
PMID:10487780 |
|
NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732
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|
G
|
Il5
|
interleukin 5
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increases response to substance
|
ISO
|
IL5 protein results in increased susceptibility to Acetylcholine
|
CTD |
PMID:11897983 |
|
NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003
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|
G
|
Il5ra
|
interleukin 5 receptor subunit alpha
|
increases response to substance affects response to substance
|
ISO
|
IL5RA protein results in increased susceptibility to Acetylcholine IL5RA protein affects the susceptibility to Acetylcholine
|
CTD |
PMID:10487780 PMID:10848907 PMID:11897983 |
|
NCBI chr 4:141,186,749...141,221,348
Ensembl chr 4:141,171,158...141,220,943
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G
|
Kcnj5
|
potassium inwardly-rectifying channel, subfamily J, member 5
|
affects response to substance
|
ISO
|
KCNJ5 protein affects the susceptibility to Acetylcholine
|
CTD |
PMID:26831068 |
|
NCBI chr 8:38,981,598...39,011,197
Ensembl chr 8:38,983,034...39,011,101
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G
|
Kcnj8
|
potassium inwardly-rectifying channel, subfamily J, member 8
|
multiple interactions
|
EXP
|
ABCC8 protein inhibits the reaction [Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]]; Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]
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CTD |
PMID:15894309 |
|
NCBI chr 4:177,240,692...177,246,548
Ensembl chr 4:177,239,908...177,246,531
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G
|
Kcnma1
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potassium calcium-activated channel subfamily M alpha 1
|
affects response to substance
|
EXP
|
KCNMA1 protein affects the susceptibility to Acetylcholine
|
CTD |
PMID:22226998 |
|
NCBI chr15:351,065...1,057,117
Ensembl chr15:351,659...1,057,117
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|
G
|
Lepr
|
leptin receptor
|
multiple interactions decreases response to substance
|
ISO
|
acetovanillone inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; resveratrol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; tempol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; TNF gene mutant form affects the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]
|
CTD |
PMID:19478208 |
|
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215
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|
G
|
Lpl
|
lipoprotein lipase
|
affects response to substance
|
ISO
|
LPL protein affects the susceptibility to Acetylcholine
|
CTD |
PMID:11786490 |
|
NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107
|
|
G
|
Lynx1
|
Ly6/neurotoxin 1
|
multiple interactions
|
EXP
|
LYNX1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]
|
CTD |
PMID:19619141 |
|
NCBI chr 7:108,521,783...108,527,012
Ensembl chr 7:108,521,780...108,527,130
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G
|
Lypd1
|
Ly6/Plaur domain containing 1
|
multiple interactions
|
EXP
|
LYPD1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]
|
CTD |
PMID:19619141 |
|
NCBI chr13:39,874,937...39,922,385
Ensembl chr13:39,879,096...39,922,338
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G
|
Mmp9
|
matrix metallopeptidase 9
|
affects response to substance
|
ISO
|
MMP9 protein affects the susceptibility to Acetylcholine
|
CTD |
PMID:16979597 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
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|
G
|
Ncf1
|
neutrophil cytosolic factor 1
|
multiple interactions
|
ISO
|
NCF1 gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]
|
CTD |
PMID:18522491 |
|
NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079
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|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO
|
NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]
|
CTD |
PMID:11498454 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
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|
G
|
Nos3
|
nitric oxide synthase 3
|
affects response to substance increases response to substance multiple interactions increases phosphorylation
|
ISO EXP
|
NOS3 protein affects the susceptibility to Acetylcholine NOS3 protein results in increased susceptibility to Acetylcholine AICA ribonucleotide inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; Metformin inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; NOS3 protein results in increased susceptibility to [Acetylcholine co-treated with Phenylephrine]; Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]; resveratrol inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; Salicylic Acid inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]
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CTD |
PMID:10954898 PMID:15381055 PMID:17403420 PMID:25108154 |
|
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
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|
G
|
Pink1
|
PTEN induced kinase 1
|
multiple interactions
|
ISO
|
Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 protein]
|
CTD |
PMID:34547296 |
|
NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950
|
|
G
|
Pkd1
|
polycystin 1, transient receptor potential channel interacting
|
affects response to substance
|
ISO
|
PKD1 protein affects the susceptibility to Acetylcholine
|
CTD |
PMID:18679710 |
|
NCBI chr10:14,077,733...14,125,682
Ensembl chr10:14,078,679...14,125,681
|
|
G
|
Pomc
|
proopiomelanocortin
|
increases expression multiple interactions
|
EXP
|
Acetylcholine results in increased expression of POMC mRNA; Acetylcholine results in increased expression of POMC protein Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein]; Pentobarbital inhibits the reaction [Acetylcholine results in increased expression of POMC protein]
|
CTD |
PMID:7588217 |
|
NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
|
|
G
|
Ppp1r14a
|
protein phosphatase 1, regulatory (inhibitor) subunit 14A
|
increases phosphorylation multiple interactions
|
EXP
|
Acetylcholine results in increased phosphorylation of PPP1R14A protein Beclomethasone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein]; Prednisolone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein]
|
CTD |
PMID:18577381 |
|
NCBI chr 1:93,708,269...93,718,218
Ensembl chr 1:93,708,218...93,719,147
|
|
G
|
Prkn
|
parkin RBR E3 ubiquitin protein ligase
|
multiple interactions
|
ISO
|
Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN protein]
|
CTD |
PMID:34547296 |
|
NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304
|
|
G
|
Rhoa
|
ras homolog family member A
|
multiple interactions
|
EXP
|
[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine; Beclomethasone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]; Prednisolone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]
|
CTD |
PMID:18391481 |
|
NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302
|
|
G
|
Senp2
|
SUMO specific peptidase 2
|
affects localization
|
ISO
|
SENP2 protein affects the localization of Acetylcholine
|
CTD |
PMID:34509475 |
|
NCBI chr11:92,487,259...92,522,795
Ensembl chr11:92,485,931...92,522,735
|
|
G
|
Sigmar1
|
sigma non-opioid intracellular receptor 1
|
multiple interactions
|
EXP
|
[1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4-dihydro-5-methoxy-2(1H)-quinolinone binds to and results in increased activity of SIGMAR1 protein] which results in increased secretion of Acetylcholine; [N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride binds to and results in decreased activity of SIGMAR1 protein] inhibits the reaction [1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4-dihydro-5-methoxy-2(1H)-quinolinone results in increased secretion of Acetylcholine]
|
CTD |
PMID:11907181 |
|
NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:61,700,021...61,702,855
|
|
G
|
Sirt1
|
sirtuin 1
|
affects response to substance
|
EXP
|
SIRT1 protein affects the susceptibility to Acetylcholine
|
CTD |
PMID:23422569 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
|
|
G
|
Slc17a8
|
solute carrier family 17 member 8
|
affects secretion
|
ISO
|
SLC17A8 protein affects the secretion of Acetylcholine
|
CTD |
PMID:18278042 |
|
NCBI chr 7:25,881,557...25,936,837
Ensembl chr 7:25,881,557...25,935,410
|
|
G
|
Slurp1
|
secreted Ly6/Plaur domain containing 1
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multiple interactions increases abundance
|
ISO
|
methyllycaconitine inhibits the reaction [SLURP1 protein results in increased abundance of Acetylcholine]
|
CTD |
PMID:24365495 |
|
NCBI chr 7:108,500,933...108,502,349
Ensembl chr 7:108,500,933...108,502,349
|
|
G
|
Sod1
|
superoxide dismutase 1
|
affects activity
|
EXP
|
Acetylcholine affects the activity of SOD1 protein
|
CTD |
PMID:9024144 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
|
|
G
|
Sod2
|
superoxide dismutase 2
|
affects response to substance multiple interactions
|
ISO
|
SOD2 protein affects the susceptibility to Acetylcholine catalase-polyethylene glycol affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]; Indomethacin affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]; tempol affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]; valerylsalicylate affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]
|
CTD |
PMID:20304815 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
|
|
G
|
Sqstm1
|
sequestosome 1
|
multiple interactions
|
ISO
|
Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 protein]
|
CTD |
PMID:34547296 |
|
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
|
|
G
|
Tac1
|
tachykinin, precursor 1
|
multiple interactions affects abundance
|
EXP
|
Urethane affects the reaction [TAC1 protein affects the abundance of Acetylcholine]
|
CTD |
PMID:11020227 |
|
NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546
|
|
G
|
Th
|
tyrosine hydroxylase
|
multiple interactions increases expression
|
EXP
|
conotoxin AuIB inhibits the reaction [Acetylcholine results in increased expression of TH mRNA]; conotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]]; imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Acetylcholine results in increased expression of TH mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]]
|
CTD |
PMID:29246838 |
|
NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
|
|
G
|
Thrb
|
thyroid hormone receptor beta
|
affects response to substance
|
ISO
|
THRB protein affects the susceptibility to Acetylcholine
|
CTD |
PMID:17461985 |
|
NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
ISO
|
TNF gene mutant form affects the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]
|
CTD |
PMID:19478208 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
G
|
Trpc6
|
transient receptor potential cation channel, subfamily C, member 6
|
multiple interactions
|
EXP
|
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; 1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; 2-aminoethyl diphenylborinate inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]; Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Manganese]
|
CTD |
PMID:11535132 |
|
NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:14,043,877...14,149,304
|
|
G
|
Vim
|
vimentin
|
multiple interactions
|
ISO
|
VIM protein affects the susceptibility to [Acetylcholine co-treated with Cyclic GMP co-treated with Indomethacin]; VIM protein affects the susceptibility to [Acetylcholine co-treated with Indomethacin]
|
CTD |
PMID:11588525 |
|
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
|
|