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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acetylcholine
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Accession:CHEBI:15355 term browser browse the term
Definition:Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
Synonyms:related_synonym: 2-(acetyloxy)-N,N,N-trimethylethanaminium;   ACh;   Azetylcholin;   Formula=C7H16NO2;   InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1;   InChIKey=OIPILFWXSMYKGL-UHFFFAOYSA-N;   O-Acetylcholine;   SMILES=CC(=O)OCC[N+](C)(C)C;   choline acetate
 alt_id: CHEBI:12686;   CHEBI:13715;   CHEBI:22197;   CHEBI:2416;   CHEBI:40559
 xref: Beilstein:1764436;   CAS:51-84-3;   DrugBank:DB03128;   Drug_Central:65;   Gmelin:326108;   KEGG:C01996;   LINCS:LSM-5888
 xref_mesh: MESH:D000109
 xref: PDBeChem:ACH;   PMID:14764638;   PMID:15014918;   PMID:15231705;   PMID:15361288;   PMID:18050502;   PMID:18407448;   PMID:19255787;   PMID:20963497;   PMID:21130809;   PMID:21246223;   PMID:21545631;   PMID:21601579;   Wikipedia:Acetylcholine


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acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 multiple interactions EXP ABCC8 protein inhibits the reaction [Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]] CTD PMID:15894309 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982 		JBrowse link
G Ache acetylcholinesterase increases hydrolysis
affects abundance
multiple interactions
increases abundance
increases activity 		ISO
EXP 		ACHE protein results in increased hydrolysis of Acetylcholine
ACHE protein affects the abundance of Acetylcholine
[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine; Acetylcholine inhibits the reaction [ACHE protein results in increased hydrolysis of Acetylthiocholine]; Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]
ACHE gene mutant form results in increased abundance of Acetylcholine
Acetylcholine results in increased activity of ACHE protein
[Botulinum Toxins, Type A results in increased expression of and results in increased activity of ACHE protein] which results in decreased abundance of Acetylcholine; [Soman results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine; Rivastigmine inhibits the reaction [[Botulinum Toxins, Type A results in increased expression of and results in increased activity of ACHE protein] which results in decreased abundance of Acetylcholine] 		CTD PMID:18602908 PMID:19100287 PMID:19818744 PMID:20105433 PMID:20396698 More... NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Acetylcholine CTD PMID:12869393 NCBI chr11:78,976,861...79,123,343
Ensembl chr11:78,976,861...79,123,343 		JBrowse link
G Adora2a adenosine A2a receptor increases response to substance
multiple interactions 		EXP ADORA2A protein results in increased susceptibility to Acetylcholine
ZM 241385 inhibits the reaction [ADORA2A protein results in increased susceptibility to Acetylcholine] 		CTD PMID:16616212 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802 		JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine] CTD PMID:16815979 NCBI chr 3:135,038,481...135,042,527
Ensembl chr 3:135,038,474...135,042,525 		JBrowse link
G Agt angiotensinogen multiple interactions
decreases response to substance 		ISO ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]; ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]; SB 203580 inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]; tempol inhibits the reaction [ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]]; tempol promotes the reaction [ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]]
AGT protein modified form results in decreased susceptibility to Acetylcholine; AGT protein results in decreased susceptibility to Acetylcholine 		CTD PMID:18174886 PMID:18768397 PMID:21289285 PMID:22753205 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Alb albumin multiple interactions ISO [ALB protein co-treated with Particulate Matter] results in increased susceptibility to Acetylcholine; ALB protein promotes the reaction [Particulate Matter results in increased susceptibility to Acetylcholine] CTD PMID:30953400 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO [ALOX15 protein affects the metabolism of Arachidonic Acid] which affects the susceptibility to Acetylcholine CTD PMID:21193584 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723 		JBrowse link
G Apoe apolipoprotein E affects response to substance
decreases response to substance 		ISO APOE protein affects the susceptibility to Acetylcholine
APOE gene mutant form results in decreased susceptibility to Acetylcholine 		CTD PMID:11397713 PMID:17899169 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855 		JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases secretion 		ISO
EXP 		[IL1B protein co-treated with APP protein] results in increased secretion of Acetylcholine; IL1B protein inhibits the reaction [APP protein results in decreased secretion of Acetylcholine]
APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]; spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one inhibits the reaction [APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]]
GW 501516 inhibits the reaction [APP gene mutant form results in decreased susceptibility to Acetylcholine] 		CTD PMID:16122837 PMID:16474004 PMID:22886847 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Ass1 argininosuccinate synthase 1 increases response to substance ISO ASS1 protein results in increased susceptibility to Acetylcholine CTD PMID:25033204 NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627 		JBrowse link
G Atox1 antioxidant 1 copper chaperone increases response to substance
multiple interactions 		ISO ATOX1 protein results in increased susceptibility to Acetylcholine
ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]; tempol promotes the reaction [ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]] 		CTD PMID:22753205 NCBI chr10:40,065,525...40,080,627
Ensembl chr10:40,065,527...40,080,585 		JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]; tempol inhibits the reaction [ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]] CTD PMID:18768397 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:75,159,782...75,267,093 		JBrowse link
G Bche butyrylcholinesterase increases degradation
multiple interactions 		ISO BCHE protein results in increased degradation of Acetylcholine
Acetylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of benzoylthiocholine]; Acetylcholine inhibits the reaction [Tripelennamine results in decreased activity of BCHE protein] 		CTD PMID:236606 PMID:16020944 PMID:31247192 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases response to substance 		EXP calcitonin gene-related peptide (8-37) inhibits the reaction [CALCA protein results in increased susceptibility to Acetylcholine] CTD PMID:16616212 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO Sodium, Dietary affects the reaction [CAV1 protein affects the susceptibility to Acetylcholine] CTD PMID:18178722 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases activity
multiple interactions
affects binding 		ISO
EXP 		Acetylcholine results in increased activity of CHRM1 protein
[Acetylcholine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; Acetylcholine binds to and results in increased activity of CHRM1 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]; Endocannabinoids promotes the reaction [Acetylcholine binds to and results in increased activity of CHRM1 protein]; KT 5720 promotes the reaction [Acetylcholine binds to CHRM1 protein]; Quinuclidinyl Benzilate inhibits the reaction [brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]]
Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM1 protein]; Progesterone inhibits the reaction [Acetylcholine binds to CHRM1 protein]; Propofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein]
Acetylcholine binds to CHRM1 protein; CHRM1 protein binds to Acetylcholine 		CTD PMID:9224827 PMID:9495826 PMID:10069518 PMID:10101037 PMID:10860942 More... NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions
affects binding 		ISO Acetylcholine binds to and results in increased activity of CHRM2 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM2 protein]; eburnamonine promotes the reaction [Acetylcholine binds to CHRM2 protein]; N-chloromethylbrucine inhibits the reaction [Acetylcholine results in increased activity of CHRM2 protein]
Acetylcholine binds to CHRM2 protein; CHRM2 protein binds to Acetylcholine 		CTD PMID:9224827 PMID:10069518 PMID:10101037 NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases activity
multiple interactions
affects binding
increases response to substance 		EXP
ISO 		Acetylcholine results in increased activity of CHRM3 protein
Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM3 protein]; Progesterone inhibits the reaction [Acetylcholine binds to CHRM3 protein]; WIN 62577 analog inhibits the reaction [Acetylcholine binds to CHRM3 protein]; WIN 62577 promotes the reaction [Acetylcholine binds to CHRM3 protein]
Acetylcholine binds to and results in increased activity of CHRM3 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM3 protein]; brucine N-oxide promotes the reaction [Acetylcholine binds to CHRM3 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM3 protein]; N-chloromethylbrucine promotes the reaction [Acetylcholine binds to CHRM3 protein]; N-chloromethylbrucine promotes the reaction [Acetylcholine results in increased activity of CHRM3 protein]
Acetylcholine binds to CHRM3 protein; CHRM3 protein binds to Acetylcholine
CHRM3 protein results in increased susceptibility to Acetylcholine 		CTD PMID:9224827 PMID:9495826 PMID:10069518 PMID:10101037 PMID:11755166 More... NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding 		ISO [WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Acetylcholine binds to CHRM4 protein]; Acetylcholine binds to and results in increased activity of CHRM4 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM4 protein]; brucine N-oxide promotes the reaction [Acetylcholine binds to CHRM4 protein]; brucine N-oxide promotes the reaction [Acetylcholine results in increased activity of CHRM4 protein]; eburnamonine promotes the reaction [Acetylcholine binds to CHRM4 protein]
Acetylcholine binds to CHRM4 protein; CHRM4 protein binds to Acetylcholine 		CTD PMID:9224827 PMID:9495826 PMID:10069518 PMID:10101037 PMID:16709648 NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:98,348,650...98,358,771 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 affects response to substance
decreases response to substance
multiple interactions
increases activity 		ISO CHRM5 protein affects the susceptibility to Acetylcholine
CHRM5 protein mutant form results in decreased susceptibility to Acetylcholine
Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein] 		CTD PMID:14607263 PMID:31323226 NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:119,735,975...119,792,166 		JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions ISO
EXP 		Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein]
Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]; LYNX1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; LYPD1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]] 		CTD PMID:16931985 PMID:19619141 PMID:22461452 NCBI chr 3:78,862,286...78,877,353
Ensembl chr 3:78,862,286...78,877,353 		JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit multiple interactions ISO 2-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; 3-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; 4-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]; ethylbenzene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]] CTD PMID:18602458 NCBI chr 1:165,898,932...165,905,348
Ensembl chr 1:165,899,261...165,903,458 		JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions
affects response to substance 		ISO
EXP 		1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]
CHRNA2 gene mutant form affects the susceptibility to Acetylcholine
Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]
acetylcholine affects binding competes with [Epibatidine binds to Chrna2 protein] 		CTD
RGD		 PMID:7808438 PMID:9454827 PMID:11821649 PMID:19383498 PMID:15016836 RGD:2303194 NCBI chr15:44,517,862...44,534,144
Ensembl chr15:44,517,862...44,534,144 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP 		4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; celastrol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; celastrol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; triptolide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; triptolide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA3 protein binds to CHRNB4 protein]; Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]
Acetylcholine affects binding [Epibatidine binds to Chrna3 protein] 		CTD
RGD		 PMID:7808438 PMID:9454827 PMID:11711029 PMID:12130716 PMID:15885267 More... RGD:2303194 NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:64,297,755...64,311,412 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
increases response to substance
affects binding 		ISO
EXP 		1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 3,5-dibromo-2-(2,4-dibromophenoxy)phenol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; [Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB4 protein]; Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Aluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; antimony trioxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Bentonite inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; decabromobiphenyl ether inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; desformylflustrabromine promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Fire Trol 934 inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Flame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Flame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; triphenyl phosphate inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
CHRNA4 protein mutant form results in increased susceptibility to Acetylcholine
Acetylcholine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine binds to [CHRNA4 protein binds to CHRNB2 protein]
[CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Calcium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the susceptibility to Acetylcholine; [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]; [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB4 protein]; [pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine; Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Excitatory Amino Acid Antagonists inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; FG 9041 inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Mecamylamine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Urethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
acetylcholine affects binding to Chrna4 protein; acetylcholine competes with [Epibatidine binds to Chrna4 protein] 		CTD
RGD		 PMID:9454827 PMID:11517245 PMID:11711029 PMID:11812690 PMID:12130716 More... RGD:2303194 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
increases activity
increases response to substance 		EXP
ISO 		1,2-linoleoylphosphatidylcholine promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Acetylcholine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Toluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]
1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; [Acetylcholine results in increased activity of CHRNA7 protein] which results in increased uptake of Calcium; Acetylcholine binds to and results in increased activity of CHRNA7 protein; Atracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; beta-thujone inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; desformylflustrabromine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Toluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]
CHRNA7 protein mutant form results in increased susceptibility to Acetylcholine 		CTD PMID:10082212 PMID:12626641 PMID:15885267 PMID:16931985 PMID:19100751 More... NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858 		JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions ISO 2-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; 3-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; 4-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]; ethylbenzene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]] CTD PMID:18602458 NCBI chr14:42,588,948...42,595,669
Ensembl chr14:42,588,948...42,595,669 		JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit multiple interactions ISO
EXP 		Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein] CTD PMID:16931985 PMID:22461452 NCBI chr10:54,999,943...55,015,137
Ensembl chr10:55,002,788...55,015,107 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
affects binding 		ISO
EXP 		1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 3,5-dibromo-2-(2,4-dibromophenoxy)phenol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; [Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]; Aluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; antimony trioxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Bentonite inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; celastrol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; decabromobiphenyl ether inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; desformylflustrabromine promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Fire Trol 934 inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Flame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Flame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; triphenyl phosphate inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; triptolide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
Acetylcholine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine binds to [CHRNA4 protein binds to CHRNB2 protein]
[CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Calcium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the susceptibility to Acetylcholine; [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]; [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; [pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine; Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; Acetylcholine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]; Acetylcholine results in increased activity of [NACHRALPHA1 protein co-treated with NACHRALPHA2 protein co-treated with CHRNB2 protein]; Acetylcholine results in increased activity of [NACHRALPHA2 protein co-treated with CHRNB2 protein]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRALPHA1 protein co-treated with NACHRALPHA2 protein co-treated with CHRNB2 protein]]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRALPHA2 protein co-treated with CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Excitatory Amino Acid Antagonists inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; FG 9041 inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; LYNX1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; LYPD1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; Mecamylamine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Urethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
acetylcholine affects binding to Chrnb2 protein; acetylcholine competes with [Epibatidine binds to Chrnb2 protein] 		CTD
RGD		 PMID:7808438 PMID:11517245 PMID:11711029 PMID:11812690 PMID:12130716 More... RGD:2303194 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO
EXP 		1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB4 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; celastrol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; triptolide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA3 protein binds to CHRNB4 protein]; [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB4 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]] 		CTD PMID:7808438 PMID:9454827 PMID:11711029 PMID:11821649 PMID:12130716 More... NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:64,313,669...64,333,248 		JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit multiple interactions ISO
EXP 		Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein] CTD PMID:16931985 PMID:22461452 NCBI chr 9:95,310,316...95,318,734
Ensembl chr 9:95,310,298...95,318,745 		JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit multiple interactions ISO
EXP 		Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein] CTD PMID:16931985 PMID:22461452 NCBI chr10:55,829,835...55,838,853
Ensembl chr10:55,829,836...55,834,154 		JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit multiple interactions EXP
ISO 		Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 9:95,325,984...95,332,092
Ensembl chr 9:95,325,984...95,332,092 		JBrowse link
G Crh corticotropin releasing hormone increases expression EXP Acetylcholine results in increased expression of CRH mRNA CTD PMID:7588217 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Csf2 colony stimulating factor 2 increases secretion ISO Acetylcholine results in increased secretion of CSF2 protein CTD PMID:9606035 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO CYBB gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine] CTD PMID:18522491 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Edn1 endothelin 1 multiple interactions
decreases response to substance 		EXP acetovanillone inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]; Catechin inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]; Polyphenols inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine] CTD PMID:20977430 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Epo erythropoietin multiple interactions
increases response to substance 		ISO EPO protein inhibits the reaction [GCH1 gene mutant form results in decreased susceptibility to Acetylcholine]
EPO protein results in increased susceptibility to Acetylcholine 		CTD PMID:25490417 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Acetylcholine]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine] CTD PMID:17158209 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Fbn1 fibrillin 1 multiple interactions ISO FBN1 protein affects the susceptibility to [Acetylcholine co-treated with Indomethacin] CTD PMID:17641673 NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:133,008,361...133,204,283 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions ISO FKBP1B gene mutant form inhibits the reaction [Acetylcholine affects the localization of and affects the abundance of Calcium]; Ryanodine inhibits the reaction [FKBP1B gene mutant form inhibits the reaction [Acetylcholine affects the localization of and affects the abundance of Calcium]] CTD PMID:17261647 NCBI chr 6:33,551,583...33,570,055
Ensembl chr 6:33,558,517...33,568,129 		JBrowse link
G Gch1 GTP cyclohydrolase 1 multiple interactions
decreases response to substance 		EXP
ISO 		[2,4-diaminohypoxanthine results in decreased activity of GCH1 protein] which affects the susceptibility to Acetylcholine
EPO protein inhibits the reaction [GCH1 gene mutant form results in decreased susceptibility to Acetylcholine] 		CTD PMID:12855421 PMID:25490417 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:22,884,006...22,917,412 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases response to substance ISO GCLC promoter SNP results in decreased susceptibility to Acetylcholine CTD PMID:12598062 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit affects response to substance ISO GCLM gene SNP affects the susceptibility to Acetylcholine CTD PMID:12975258 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases response to substance ISO GPX1 gene mutant form results in decreased susceptibility to Acetylcholine CTD PMID:24296279 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Hmox1 heme oxygenase 1 affects response to substance
multiple interactions 		EXP HMOX1 protein affects the susceptibility to Acetylcholine
[chromium mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Desoxycorticosterone Acetate results in decreased susceptibility to Acetylcholine] 		CTD PMID:14693679 PMID:16309587 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion 		ISO [IL1B protein co-treated with APP protein] results in increased secretion of Acetylcholine; IL1B protein inhibits the reaction [APP protein results in decreased secretion of Acetylcholine]
IL1B protein results in increased secretion of Acetylcholine 		CTD PMID:16122837 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist affects response to substance ISO IL1RN protein affects the susceptibility to Acetylcholine CTD PMID:10487780 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il5 interleukin 5 increases response to substance ISO IL5 protein results in increased susceptibility to Acetylcholine CTD PMID:11897983 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il5ra interleukin 5 receptor subunit alpha increases response to substance
affects response to substance 		ISO IL5RA protein results in increased susceptibility to Acetylcholine
IL5RA protein affects the susceptibility to Acetylcholine 		CTD PMID:10487780 PMID:10848907 PMID:11897983 NCBI chr 4:141,186,749...141,221,348
Ensembl chr 4:141,171,158...141,220,943 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 affects response to substance ISO KCNJ5 protein affects the susceptibility to Acetylcholine CTD PMID:26831068 NCBI chr 8:38,981,598...39,011,197
Ensembl chr 8:38,983,034...39,011,101 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 multiple interactions EXP ABCC8 protein inhibits the reaction [Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]]; Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium] CTD PMID:15894309 NCBI chr 4:177,240,692...177,246,548
Ensembl chr 4:177,239,908...177,246,531 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 affects response to substance EXP KCNMA1 protein affects the susceptibility to Acetylcholine CTD PMID:22226998 NCBI chr15:351,065...1,057,117
Ensembl chr15:351,659...1,057,117 		JBrowse link
G Lepr leptin receptor multiple interactions
decreases response to substance 		ISO acetovanillone inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; resveratrol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; tempol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; TNF gene mutant form affects the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine] CTD PMID:19478208 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Lpl lipoprotein lipase affects response to substance ISO LPL protein affects the susceptibility to Acetylcholine CTD PMID:11786490 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Lynx1 Ly6/neurotoxin 1 multiple interactions EXP LYNX1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]] CTD PMID:19619141 NCBI chr 7:108,521,783...108,527,012
Ensembl chr 7:108,521,780...108,527,130 		JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 multiple interactions EXP LYPD1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]] CTD PMID:19619141 NCBI chr13:39,874,937...39,922,385
Ensembl chr13:39,879,096...39,922,338 		JBrowse link
G Mmp9 matrix metallopeptidase 9 affects response to substance ISO MMP9 protein affects the susceptibility to Acetylcholine CTD PMID:16979597 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO NCF1 gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine] CTD PMID:18522491 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine] CTD PMID:11498454 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 affects response to substance
increases response to substance
multiple interactions
increases phosphorylation 		ISO
EXP 		NOS3 protein affects the susceptibility to Acetylcholine
NOS3 protein results in increased susceptibility to Acetylcholine
AICA ribonucleotide inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; Metformin inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; NOS3 protein results in increased susceptibility to [Acetylcholine co-treated with Phenylephrine]; Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]; resveratrol inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; Salicylic Acid inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]] 		CTD PMID:10954898 PMID:15381055 PMID:17403420 PMID:25108154 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 protein] CTD PMID:34547296 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950 		JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting affects response to substance ISO PKD1 protein affects the susceptibility to Acetylcholine CTD PMID:18679710 NCBI chr10:14,077,733...14,125,682
Ensembl chr10:14,078,679...14,125,681 		JBrowse link
G Pomc proopiomelanocortin increases expression
multiple interactions 		EXP Acetylcholine results in increased expression of POMC mRNA; Acetylcholine results in increased expression of POMC protein
Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein]; Pentobarbital inhibits the reaction [Acetylcholine results in increased expression of POMC protein] 		CTD PMID:7588217 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A increases phosphorylation
multiple interactions 		EXP Acetylcholine results in increased phosphorylation of PPP1R14A protein
Beclomethasone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein]; Prednisolone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein] 		CTD PMID:18577381 NCBI chr 1:93,708,269...93,718,218
Ensembl chr 1:93,708,218...93,719,147 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN protein] CTD PMID:34547296 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304 		JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine; Beclomethasone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]; Prednisolone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine] CTD PMID:18391481 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Senp2 SUMO specific peptidase 2 affects localization ISO SENP2 protein affects the localization of Acetylcholine CTD PMID:34509475 NCBI chr11:92,487,259...92,522,795
Ensembl chr11:92,485,931...92,522,735 		JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions EXP [1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4-dihydro-5-methoxy-2(1H)-quinolinone binds to and results in increased activity of SIGMAR1 protein] which results in increased secretion of Acetylcholine; [N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride binds to and results in decreased activity of SIGMAR1 protein] inhibits the reaction [1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4-dihydro-5-methoxy-2(1H)-quinolinone results in increased secretion of Acetylcholine] CTD PMID:11907181 NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:61,700,021...61,702,855 		JBrowse link
G Sirt1 sirtuin 1 affects response to substance EXP SIRT1 protein affects the susceptibility to Acetylcholine CTD PMID:23422569 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 affects secretion ISO SLC17A8 protein affects the secretion of Acetylcholine CTD PMID:18278042 NCBI chr 7:25,881,557...25,936,837
Ensembl chr 7:25,881,557...25,935,410 		JBrowse link
G Slurp1 secreted Ly6/Plaur domain containing 1 multiple interactions
increases abundance 		ISO methyllycaconitine inhibits the reaction [SLURP1 protein results in increased abundance of Acetylcholine] CTD PMID:24365495 NCBI chr 7:108,500,933...108,502,349
Ensembl chr 7:108,500,933...108,502,349 		JBrowse link
G Sod1 superoxide dismutase 1 affects activity EXP Acetylcholine affects the activity of SOD1 protein CTD PMID:9024144 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 affects response to substance
multiple interactions 		ISO SOD2 protein affects the susceptibility to Acetylcholine
catalase-polyethylene glycol affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]; Indomethacin affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]; tempol affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]; valerylsalicylate affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine] 		CTD PMID:20304815 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 protein] CTD PMID:34547296 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
affects abundance 		EXP Urethane affects the reaction [TAC1 protein affects the abundance of Acetylcholine] CTD PMID:11020227 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression 		EXP conotoxin AuIB inhibits the reaction [Acetylcholine results in increased expression of TH mRNA]; conotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]]; imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Acetylcholine results in increased expression of TH mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]] CTD PMID:29246838 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227 		JBrowse link
G Thrb thyroid hormone receptor beta affects response to substance ISO THRB protein affects the susceptibility to Acetylcholine CTD PMID:17461985 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF gene mutant form affects the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine] CTD PMID:19478208 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions EXP 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; 1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; 2-aminoethyl diphenylborinate inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]; Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Manganese] CTD PMID:11535132 NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:14,043,877...14,149,304 		JBrowse link
G Vim vimentin multiple interactions ISO VIM protein affects the susceptibility to [Acetylcholine co-treated with Cyclic GMP co-treated with Indomethacin]; VIM protein affects the susceptibility to [Acetylcholine co-treated with Indomethacin] CTD PMID:11588525 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        molecular messenger 19442
          hormone 19261
            acetylcholine 82
              acetylcholine bromide 0
              acetylcholine chloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      monocarboxylic acid 18309
                                        acetic acid 11175
                                          acetate ester 4092
                                            acetylcholine 82
                                              acetylcholine bromide 0
                                              acetylcholine chloride 0
paths to the root