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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acetylcholine
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Accession:CHEBI:15355 term browser browse the term
Definition:Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
Synonyms:related_synonym: 2-(acetyloxy)-N,N,N-trimethylethanaminium;   ACh;   Azetylcholin;   Formula=C7H16NO2;   InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1;   InChIKey=OIPILFWXSMYKGL-UHFFFAOYSA-N;   O-Acetylcholine;   SMILES=CC(=O)OCC[N+](C)(C)C;   choline acetate
 alt_id: CHEBI:12686;   CHEBI:13715;   CHEBI:22197;   CHEBI:2416;   CHEBI:40559
 xref: Beilstein:1764436;   CAS:51-84-3;   DrugBank:DB03128;   Drug_Central:65;   Gmelin:326108;   KEGG:C01996;   LINCS:LSM-5888
 xref_mesh: MESH:D000109
 xref: PDBeChem:ACH;   PMID:14764638;   PMID:15014918;   PMID:15231705;   PMID:15361288;   PMID:18050502;   PMID:18407448;   PMID:19255787;   PMID:20963497;   PMID:21130809;   PMID:21246223;   PMID:21545631;   PMID:21601579;   Wikipedia:Acetylcholine

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acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 multiple interactions EXP ABCC8 protein inhibits the reaction [Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]] CTD PMID:15894309 NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287 		JBrowse link
G Ache acetylcholinesterase increases hydrolysis
multiple interactions
increases activity
increases abundance
affects abundance		 ISO
EXP		 ACHE protein results in increased hydrolysis of Acetylcholine
[Soman results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine
Acetylcholine results in increased activity of ACHE protein
ACHE gene mutant form results in increased abundance of Acetylcholine
[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine; Acetylcholine inhibits the reaction [ACHE protein results in increased hydrolysis of Acetylthiocholine]; Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]
ACHE protein affects the abundance of Acetylcholine		 CTD PMID:18602908, PMID:19100287, PMID:19818744, PMID:20105433, PMID:20396698, PMID:22542756, PMID:23047027, PMID:31247192 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Acetylcholine CTD PMID:12869393 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320 		JBrowse link
G Adora2a adenosine A2a receptor increases response to substance
multiple interactions		 EXP ADORA2A protein results in increased susceptibility to Acetylcholine
ZM 241385 inhibits the reaction [ADORA2A protein results in increased susceptibility to Acetylcholine]		 CTD PMID:16616212 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873 		JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine] CTD PMID:16815979 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987 		JBrowse link
G Agt angiotensinogen multiple interactions
decreases response to substance		 ISO ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]; ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]; SB 203580 inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]; tempol inhibits the reaction [ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]]; tempol promotes the reaction [ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]]
AGT protein modified form results in decreased susceptibility to Acetylcholine; AGT protein results in decreased susceptibility to Acetylcholine		 CTD PMID:18174886, PMID:18768397, PMID:21289285, PMID:22753205 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Alb albumin multiple interactions ISO [ALB protein co-treated with Particulate Matter] results in increased susceptibility to Acetylcholine; ALB protein promotes the reaction [Particulate Matter results in increased susceptibility to Acetylcholine] CTD PMID:30953400 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO [ALOX15 protein affects the metabolism of Arachidonic Acid] which affects the susceptibility to Acetylcholine CTD PMID:21193584 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161 		JBrowse link
G Apoe apolipoprotein E affects response to substance
decreases response to substance		 ISO APOE protein affects the susceptibility to Acetylcholine
APOE gene mutant form results in decreased susceptibility to Acetylcholine		 CTD PMID:11397713, PMID:17899169 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases secretion		 ISO
EXP		 [IL1B protein co-treated with APP protein] results in increased secretion of Acetylcholine; IL1B protein inhibits the reaction [APP protein results in decreased secretion of Acetylcholine]
GW 501516 inhibits the reaction [APP gene mutant form results in decreased susceptibility to Acetylcholine]
APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]; spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one inhibits the reaction [APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]]		 CTD PMID:16122837, PMID:16474004, PMID:22886847 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Ass1 argininosuccinate synthase 1 increases response to substance ISO ASS1 protein results in increased susceptibility to Acetylcholine CTD PMID:25033204 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826 		JBrowse link
G Atox1 antioxidant 1 copper chaperone increases response to substance
multiple interactions		 ISO ATOX1 protein results in increased susceptibility to Acetylcholine
ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]; tempol promotes the reaction [ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]]		 CTD PMID:22753205 NCBI chr10:40,790,850...40,805,886
Ensembl chr10:40,790,845...40,805,941 		JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]; tempol inhibits the reaction [ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]] CTD PMID:18768397 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644 		JBrowse link
G Bche butyrylcholinesterase increases degradation
multiple interactions		 ISO BCHE protein results in increased degradation of Acetylcholine
Acetylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of benzoylthiocholine]; Acetylcholine inhibits the reaction [Tripelennamine results in decreased activity of BCHE protein]		 CTD PMID:236606, PMID:16020944, PMID:31247192 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases response to substance		 EXP calcitonin gene-related peptide (8-37) inhibits the reaction [CALCA protein results in increased susceptibility to Acetylcholine] CTD PMID:16616212 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO Sodium, Dietary affects the reaction [CAV1 protein affects the susceptibility to Acetylcholine] CTD PMID:18178722 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases activity
affects binding
multiple interactions		 ISO
EXP		 Acetylcholine results in increased activity of CHRM1 protein
Acetylcholine binds to CHRM1 protein; CHRM1 protein binds to Acetylcholine
Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM1 protein]; Progesterone inhibits the reaction [Acetylcholine binds to CHRM1 protein]; Propofol inhibits the reaction [Acetylcholine results in increased activity of CHRM1 protein]
[Acetylcholine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; Acetylcholine binds to and results in increased activity of CHRM1 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM1 protein]; brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]; KT 5720 promotes the reaction [Acetylcholine binds to CHRM1 protein]; Quinuclidinyl Benzilate inhibits the reaction [brucine promotes the reaction [Acetylcholine results in increased activity of CHRM1 protein]]		 CTD PMID:9224827, PMID:9495826, PMID:10069518, PMID:10101037, PMID:10860942, PMID:11527950, PMID:14534362, PMID:15900516, PMID:31830555 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions
affects binding		 ISO Acetylcholine binds to and results in increased activity of CHRM2 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM2 protein]; eburnamonine promotes the reaction [Acetylcholine binds to CHRM2 protein]; N-chloromethylbrucine inhibits the reaction [Acetylcholine results in increased activity of CHRM2 protein]
Acetylcholine binds to CHRM2 protein; CHRM2 protein binds to Acetylcholine		 CTD PMID:9224827, PMID:10069518, PMID:10101037 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases activity
increases response to substance
affects binding
multiple interactions		 EXP
ISO		 Acetylcholine results in increased activity of CHRM3 protein
CHRM3 protein results in increased susceptibility to Acetylcholine
Acetylcholine binds to CHRM3 protein
Acetylcholine binds to CHRM3 protein; CHRM3 protein binds to Acetylcholine
Acetylcholine binds to and results in increased activity of CHRM3 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM3 protein]; brucine N-oxide promotes the reaction [Acetylcholine binds to CHRM3 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM3 protein]; N-chloromethylbrucine promotes the reaction [Acetylcholine binds to CHRM3 protein]; N-chloromethylbrucine promotes the reaction [Acetylcholine results in increased activity of CHRM3 protein]
Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM3 protein]; Progesterone inhibits the reaction [Acetylcholine binds to CHRM3 protein]; WIN 62577 analog inhibits the reaction [Acetylcholine binds to CHRM3 protein]; WIN 62577 promotes the reaction [Acetylcholine binds to CHRM3 protein]		 CTD PMID:9224827, PMID:9495826, PMID:10069518, PMID:10101037, PMID:11755166, PMID:12435818, PMID:15900516, PMID:15964566, PMID:19407017, PMID:31830555 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding		 ISO [WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Acetylcholine binds to CHRM4 protein]; Acetylcholine binds to and results in increased activity of CHRM4 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM4 protein]; brucine N-oxide promotes the reaction [Acetylcholine binds to CHRM4 protein]; brucine N-oxide promotes the reaction [Acetylcholine results in increased activity of CHRM4 protein]; eburnamonine promotes the reaction [Acetylcholine binds to CHRM4 protein]
Acetylcholine binds to CHRM4 protein; CHRM4 protein binds to Acetylcholine		 CTD PMID:9224827, PMID:9495826, PMID:10069518, PMID:10101037, PMID:16709648 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 affects response to substance
increases activity
multiple interactions
decreases response to substance		 ISO CHRM5 protein affects the susceptibility to Acetylcholine
Acetylcholine results in increased activity of CHRM5 protein
Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein]
CHRM5 protein mutant form results in decreased susceptibility to Acetylcholine		 CTD PMID:14607263, PMID:31323226 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861 		JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions ISO
EXP		 Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein]
Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]; LYNX1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; LYPD1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]		 CTD PMID:16931985, PMID:19619141, PMID:22461452 NCBI chr 3:60,445,657...60,460,724
Ensembl chr 3:60,445,666...60,460,724 		JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit multiple interactions ISO 2-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; 3-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; 4-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]; ethylbenzene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]] CTD PMID:18602458 NCBI chr 1:167,206,722...167,212,199
Ensembl chr 1:167,206,722...167,210,919 		JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions
affects response to substance		 ISO
EXP		 1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]
Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]
CHRNA2 gene mutant form affects the susceptibility to Acetylcholine		 CTD PMID:7808438, PMID:9454827, PMID:11821649, PMID:19383498 NCBI chr15:42,808,897...42,825,179
Ensembl chr15:42,808,897...42,825,179 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP		 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA3 protein binds to CHRNB4 protein]; Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]		 CTD PMID:7808438, PMID:9454827, PMID:11711029, PMID:12130716, PMID:15885267, PMID:16931985 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding
increases response to substance		 ISO
EXP		 1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 3,5-dibromo-2-(2,4-dibromophenoxy)phenol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; [Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Aluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; antimony trioxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Bentonite inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; decabromobiphenyl ether inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; desformylflustrabromine promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Fire Trol 934 inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Flame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Flame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; triphenyl phosphate inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
[CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Calcium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the susceptibility to Acetylcholine; [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]; [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB4 protein]; [pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine; Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Excitatory Amino Acid Antagonists inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; FG 9041 inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Mecamylamine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Urethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
Acetylcholine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine binds to [CHRNA4 protein binds to CHRNB2 protein]
CHRNA4 protein mutant form results in increased susceptibility to Acetylcholine		 CTD PMID:9454827, PMID:11517245, PMID:11711029, PMID:11812690, PMID:12130716, PMID:12604691, PMID:12754307, PMID:14645658, PMID:15733544, PMID:15885267, PMID:16339034, PMID:16931985, PMID:18385335, PMID:19252481, PMID:20132834, PMID:20861069, PMID:21538459, PMID:21905680, PMID:22547355, PMID:22750351 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
increases activity
increases response to substance		 EXP
ISO		 1,2-linoleoylphosphatidylcholine promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Acetylcholine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Toluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]
CHRNA7 protein mutant form results in increased susceptibility to Acetylcholine
1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; [Acetylcholine results in increased activity of CHRNA7 protein] which results in increased uptake of Calcium; Acetylcholine binds to and results in increased activity of CHRNA7 protein; Atracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; beta-thujone inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; desformylflustrabromine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Toluene inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]		 CTD PMID:10082212, PMID:12626641, PMID:15885267, PMID:16931985, PMID:19100751, PMID:19448648, PMID:20132834, PMID:21051662, PMID:21905680, PMID:28395994, PMID:29191791 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196 		JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions ISO 2-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; 3-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; 4-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]; Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]; ethylbenzene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]] CTD PMID:18602458 NCBI chr14:43,883,450...43,890,171
Ensembl chr14:43,883,458...43,890,171 		JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit multiple interactions ISO
EXP		 Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein] CTD PMID:16931985, PMID:22461452 NCBI chr10:56,390,671...56,403,255
Ensembl chr10:56,390,671...56,403,188 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
affects binding		 ISO
EXP		 1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 3,5-dibromo-2-(2,4-dibromophenoxy)phenol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; [Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]; Aluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; antimony trioxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Bentonite inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; decabromobiphenyl ether inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; desformylflustrabromine promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Fire Trol 934 inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Flame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Flame Retardants inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; triphenyl phosphate inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
[CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Calcium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein co-treated with CHRNB2 protein] affects the susceptibility to Acetylcholine; [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine]; [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine]; [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; [pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine; Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]; Acetylcholine results in increased activity of [NACHRA1 protein co-treated with NACHRA2 protein co-treated with CHRNB2 protein]; Acetylcholine results in increased activity of [NACHRA2 protein co-treated with CHRNB2 protein]; Acetylcholine results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRA1 protein co-treated with NACHRA2 protein co-treated with CHRNB2 protein]]; Bungarotoxins inhibits the reaction [Acetylcholine results in increased activity of [NACHRA2 protein co-treated with CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Excitatory Amino Acid Antagonists inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; FG 9041 inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; LYNX1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; LYPD1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; Mecamylamine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Urethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
Acetylcholine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Acetylcholine binds to [CHRNA4 protein binds to CHRNB2 protein]		 CTD PMID:7808438, PMID:11517245, PMID:11711029, PMID:11812690, PMID:12130716, PMID:12604691, PMID:12754307, PMID:14645658, PMID:15733544, PMID:15885267, PMID:16931985, PMID:16981889, PMID:18385335, PMID:19046356, PMID:19252481, PMID:19619141, PMID:20132834, PMID:20861069, PMID:21538459, PMID:21905680, PMID:22547355, PMID:22750351, PMID:25459289 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO
EXP		 1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]; Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Acetylcholine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Estradiol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]; isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA3 protein binds to CHRNB4 protein]; [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB4 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]		 CTD PMID:7808438, PMID:9454827, PMID:11711029, PMID:11821649, PMID:12130716, PMID:16931985 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133 		JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit multiple interactions ISO
EXP		 Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein] CTD PMID:16931985, PMID:22461452 NCBI chr 9:94,286,550...94,294,968
Ensembl chr 9:94,286,550...94,294,968 		JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit multiple interactions ISO
EXP		 Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRND protein binds to CHRNE protein]; Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB1 protein binds to CHRNE protein binds to CHRND protein] CTD PMID:16931985, PMID:22461452 NCBI chr10:57,238,960...57,246,750
Ensembl chr10:57,238,946...57,243,435 		JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit multiple interactions EXP
ISO		 Acetylcholine binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 9:94,302,218...94,308,591 JBrowse link
G Crh corticotropin releasing hormone increases expression EXP Acetylcholine results in increased expression of CRH mRNA CTD PMID:7588217 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Csf2 colony stimulating factor 2 increases secretion ISO Acetylcholine results in increased secretion of CSF2 protein CTD PMID:9606035 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO CYBB gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine] CTD PMID:18522491 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Edn1 endothelin 1 multiple interactions
decreases response to substance		 EXP acetovanillone inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]; Catechin inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]; Polyphenols inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine] CTD PMID:20977430 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Epo erythropoietin multiple interactions
increases response to substance		 ISO EPO protein inhibits the reaction [GCH1 gene mutant form results in decreased susceptibility to Acetylcholine]
EPO protein results in increased susceptibility to Acetylcholine		 CTD PMID:25490417 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Acetylcholine]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine] CTD PMID:17158209 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Fbn1 fibrillin 1 multiple interactions ISO FBN1 protein affects the susceptibility to [Acetylcholine co-treated with Indomethacin] CTD PMID:17641673 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions ISO FKBP1B gene mutant form inhibits the reaction [Acetylcholine affects the localization of and affects the abundance of Calcium]; Ryanodine inhibits the reaction [FKBP1B gene mutant form inhibits the reaction [Acetylcholine affects the localization of and affects the abundance of Calcium]] CTD PMID:17261647 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451 		JBrowse link
G Gch1 GTP cyclohydrolase 1 multiple interactions
decreases response to substance		 EXP
ISO		 [2,4-diaminohypoxanthine results in decreased activity of GCH1 protein] which affects the susceptibility to Acetylcholine
GCH1 gene mutant form results in decreased susceptibility to Acetylcholine
EPO protein inhibits the reaction [GCH1 gene mutant form results in decreased susceptibility to Acetylcholine]		 CTD PMID:12855421, PMID:25490417 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases response to substance ISO GCLC promoter SNP results in decreased susceptibility to Acetylcholine CTD PMID:12598062 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit affects response to substance ISO GCLM gene SNP affects the susceptibility to Acetylcholine CTD PMID:12975258 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases response to substance ISO GPX1 gene mutant form results in decreased susceptibility to Acetylcholine CTD PMID:24296279 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Hmox1 heme oxygenase 1 affects response to substance
multiple interactions		 EXP HMOX1 protein affects the susceptibility to Acetylcholine
[chromium mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Desoxycorticosterone Acetate results in decreased susceptibility to Acetylcholine]		 CTD PMID:14693679, PMID:16309587 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion		 ISO [IL1B protein co-treated with APP protein] results in increased secretion of Acetylcholine; IL1B protein inhibits the reaction [APP protein results in decreased secretion of Acetylcholine]
IL1B protein results in increased secretion of Acetylcholine		 CTD PMID:16122837 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1rn interleukin 1 receptor antagonist affects response to substance ISO IL1RN protein affects the susceptibility to Acetylcholine CTD PMID:10487780 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614 		JBrowse link
G Il5 interleukin 5 increases response to substance ISO IL5 protein results in increased susceptibility to Acetylcholine CTD PMID:11897983 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Il5ra interleukin 5 receptor subunit alpha increases response to substance
affects response to substance		 ISO IL5RA protein results in increased susceptibility to Acetylcholine
IL5RA protein affects the susceptibility to Acetylcholine		 CTD PMID:10487780, PMID:10848907, PMID:11897983 NCBI chr 4:138,796,165...138,834,164
Ensembl chr 4:138,795,327...138,830,117 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 affects response to substance ISO KCNJ5 protein affects the susceptibility to Acetylcholine CTD PMID:26831068 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 multiple interactions EXP ABCC8 protein inhibits the reaction [Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium]]; Acetylcholine promotes the reaction [KCNJ8 protein results in increased transport of Potassium] CTD PMID:15894309 NCBI chr 4:176,783,287...176,789,143
Ensembl chr 4:176,782,498...176,789,304 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 affects response to substance EXP KCNMA1 protein affects the susceptibility to Acetylcholine CTD PMID:22226998 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956 		JBrowse link
G Lepr leptin receptor multiple interactions
decreases response to substance		 ISO acetovanillone inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; resveratrol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; tempol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; TNF gene mutant form affects the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine] CTD PMID:19478208 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Lpl lipoprotein lipase affects response to substance ISO LPL protein affects the susceptibility to Acetylcholine CTD PMID:11786490 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496 		JBrowse link
G Lynx1 Ly6/neurotoxin 1 multiple interactions EXP LYNX1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]] CTD PMID:19619141 NCBI chr 7:115,982,877...115,988,121
Ensembl chr 7:115,982,876...115,988,090 		JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 multiple interactions EXP LYPD1 protein promotes the reaction [Acetylcholine results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]] CTD PMID:19619141 NCBI chr13:42,219,884...42,263,024
Ensembl chr13:42,219,887...42,263,024 		JBrowse link
G Mmp9 matrix metallopeptidase 9 affects response to substance ISO MMP9 protein affects the susceptibility to Acetylcholine CTD PMID:16979597 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO NCF1 gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine] CTD PMID:18522491 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine] CTD PMID:11498454 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 affects response to substance
increases phosphorylation
multiple interactions
increases response to substance		 ISO
EXP		 NOS3 protein affects the susceptibility to Acetylcholine
Acetylcholine results in increased phosphorylation of NOS3 protein
AICA ribonucleotide inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; Metformin inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; NOS3 protein results in increased susceptibility to [Acetylcholine co-treated with Phenylephrine]; Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]; resveratrol inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]; Salicylic Acid inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]
NOS3 protein results in increased susceptibility to Acetylcholine		 CTD PMID:10954898, PMID:15381055, PMID:17403420, PMID:25108154 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting affects response to substance ISO PKD1 protein affects the susceptibility to Acetylcholine CTD PMID:18679710 NCBI chr10:13,914,057...13,962,008
Ensembl chr10:13,915,214...13,962,008 		JBrowse link
G Pomc proopiomelanocortin increases expression
multiple interactions		 EXP Acetylcholine results in increased expression of POMC mRNA; Acetylcholine results in increased expression of POMC protein
Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein]; Pentobarbital inhibits the reaction [Acetylcholine results in increased expression of POMC protein]		 CTD PMID:7588217 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A increases phosphorylation
multiple interactions		 EXP Acetylcholine results in increased phosphorylation of PPP1R14A protein
Beclomethasone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein]; Prednisolone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein]		 CTD PMID:18577381 NCBI chr 1:87,224,683...87,232,842
Ensembl chr 1:87,224,677...87,232,848 		JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine; Beclomethasone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]; Prednisolone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine] CTD PMID:18391481 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167 		JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions EXP [1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4-dihydro-5-methoxy-2(1H)-quinolinone binds to and results in increased activity of SIGMAR1 protein] which results in increased secretion of Acetylcholine; [N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride binds to and results in decreased activity of SIGMAR1 protein] inhibits the reaction [1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4-dihydro-5-methoxy-2(1H)-quinolinone results in increased secretion of Acetylcholine] CTD PMID:11907181 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681 		JBrowse link
G Sirt1 sirtuin 1 affects response to substance EXP SIRT1 protein affects the susceptibility to Acetylcholine CTD PMID:23422569 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 affects secretion ISO SLC17A8 protein affects the secretion of Acetylcholine CTD PMID:18278042 NCBI chr 7:30,215,231...30,274,993
Ensembl chr 7:30,216,104...30,274,984 		JBrowse link
G Slurp1 secreted Ly6/Plaur domain containing 1 multiple interactions
increases abundance		 ISO methyllycaconitine inhibits the reaction [SLURP1 protein results in increased abundance of Acetylcholine] CTD PMID:24365495 NCBI chr 7:115,961,655...115,963,071
Ensembl chr 7:115,961,731...115,963,046 		JBrowse link
G Sod1 superoxide dismutase 1 affects activity EXP Acetylcholine affects the activity of SOD1 protein CTD PMID:9024144 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 affects response to substance
multiple interactions		 ISO SOD2 protein affects the susceptibility to Acetylcholine
catalase-polyethylene glycol affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]; Indomethacin affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]; tempol affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]; valerylsalicylate affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]		 CTD PMID:20304815 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
affects abundance		 EXP Urethane affects the reaction [TAC1 protein affects the abundance of Acetylcholine] CTD PMID:11020227 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression		 EXP conotoxin AuIB inhibits the reaction [Acetylcholine results in increased expression of TH mRNA]; conotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]]; imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Acetylcholine results in increased expression of TH mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]] CTD PMID:29246838 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Thrb thyroid hormone receptor beta affects response to substance ISO THRB protein affects the susceptibility to Acetylcholine CTD PMID:17461985 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF gene mutant form affects the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine] CTD PMID:19478208 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions EXP 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; 1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; 2-aminoethyl diphenylborinate inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]; Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Manganese] CTD PMID:11535132 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535 		JBrowse link
G Vim vimentin multiple interactions ISO VIM protein affects the susceptibility to [Acetylcholine co-treated with Cyclic GMP co-treated with Indomethacin]; VIM protein affects the susceptibility to [Acetylcholine co-treated with Indomethacin] CTD PMID:11588525 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        molecular messenger 18275
          hormone 18027
            acetylcholine 78
              acetylcholine bromide 0
              acetylcholine chloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        monocarboxylic acid 17475
                                          acetic acid 10809
                                            acetate ester 3794
                                              acetylcholine 78
                                                acetylcholine bromide 0
                                                acetylcholine chloride 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.