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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acetone
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Accession:CHEBI:15347 term browser browse the term
Definition:A methyl ketone that consists of propane bearing an oxo group at C2.
Synonyms:exact_synonym: propan-2-one
 related_synonym: 2-Propanone;   Aceton;   Azeton;   Dimethyl ketone;   Dimethylketon;   Formula=C3H6O;   InChI=1S/C3H6O/c1-3(2)4/h1-2H3;   InChIKey=CSCPPACGZOOCGX-UHFFFAOYSA-N;   Propanon;   Pyroacetic ether;   SMILES=CC(C)=O;   beta-Ketopropane;   dimethylcetone;   dimethylketone;   methyl ketone;   propanone
 alt_id: CHEBI:13708;   CHEBI:22182;   CHEBI:2398;   CHEBI:40571
 xref: Beilstein:635680;   CAS:67-64-1;   Gmelin:1466;   HMDB:HMDB0001659;   KEGG:C00207;   KEGG:D02311;   LIPID_MAPS_instance:LMFA12000057
 xref_mesh: MESH:D000096
 xref: MetaCyc:ACETONE;   PDBeChem:ACN;   PMID:17190852;   PMID:17347819;   Reaxys:635680;   UM-BBD_compID:c0556;   Wikipedia:Acetone



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acetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide multiple interactions ISO [ADH1 protein results in increased oxidation of allyl alcohol] which results in increased abundance of Acetone CTD PMID:11981770 NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746
JBrowse link
G CAT catalase decreases activity EXP
ISO
Acetone results in decreased activity of CAT protein CTD PMID:16169704 PMID:20127315 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCND1 cyclin D1 increases expression EXP Acetone results in increased expression of CCND1 mRNA CTD PMID:12720008 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO Acetone promotes the reaction [Toluene results in increased expression of CYP1A1 protein] CTD PMID:8996725 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions
increases expression
ISO Acetone promotes the reaction [Toluene results in increased expression of CYP1A2 protein]
acetone increased expression of Cyp1a2 protein in thoracic aorta of rats
CTD
RGD
PMID:8996725 PMID:12688525 RGD:401900656 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions EXP Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide] CTD PMID:10611138 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
increases expression
increases activity
increases metabolic processing
ISO
EXP
[Acetone results in increased activity of CYP2E1 protein] which results in increased oxidation of Benzene; [Acetone results in increased expression of CYP2E1 protein] which results in increased susceptibility to allyl cyanide; Acetone results in increased expression of and results in increased activity of CYP2E1 protein
Acetone results in increased expression of CYP2E1 mRNA; Acetone results in increased expression of CYP2E1 protein
CYP2E1 protein results in increased metabolism of Acetone
1,2-dichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]; [Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Acetone promotes the reaction [2-xylene results in increased expression of CYP2E1 protein]; Acetone promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; Acetone promotes the reaction [Toluene results in increased expression of CYP2E1 protein]; Trichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]
CTD PMID:1968335 PMID:2241968 PMID:3416296 PMID:3782137 PMID:7587954 More... NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 increases expression EXP Acetone results in increased expression of FGFR2 mRNA CTD PMID:12720008 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458
JBrowse link
G FN1 fibronectin 1 increases expression EXP Acetone results in increased expression of FN1 mRNA CTD PMID:33064461 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G IL13 interleukin 13 multiple interactions EXP [Acetone co-treated with Olive Oil] results in increased expression of IL13 mRNA CTD PMID:21252390 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G IL4 interleukin 4 multiple interactions EXP [Acetone co-treated with Olive Oil] results in increased expression of IL4 mRNA CTD PMID:21252390 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL5 interleukin 5 multiple interactions EXP [Acetone co-treated with Olive Oil] results in increased expression of IL5 mRNA CTD PMID:21252390 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G ITGA5 integrin subunit alpha 5 increases expression EXP Acetone results in increased expression of ITGA5 mRNA CTD PMID:12720008 NCBI chr12:54,395,261...54,419,266
Ensembl chr12:54,395,261...54,419,266
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Acetone results in increased expression of NQO1 mRNA CTD PMID:9496914 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [Acetone co-treated with Olive Oil] results in increased expression of TNF mRNA CTD PMID:21252390 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRPM8 transient receptor potential cation channel subfamily M member 8 increases response to substance ISO TRPM8 protein results in increased susceptibility to Acetone CTD PMID:17481392 NCBI chr 2:233,917,373...234,019,522
Ensembl chr 2:233,917,373...234,019,522
JBrowse link
aminoacetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions ISO CAT protein results in decreased susceptibility to [aminoacetone co-treated with Copper] CTD PMID:18729331 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO [aminoacetone co-treated with Copper] results in increased expression of GSR mRNA CTD PMID:18729331 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO [aminoacetone co-treated with Copper] results in increased expression of SOD1 mRNA CTD PMID:18729331 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO [aminoacetone co-treated with Copper] results in increased expression of SOD2 mRNA CTD PMID:18729331 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      application 25180
        solvent 18735
          polar solvent 17003
            polar aprotic solvent 632
              acetone 19
                1-hydroxy-3-methoxyacetone 0
                2-oxopropylidene group 0
                2-oxopropylidyne group 0
                acetonyl group 0
                aminoacetone 4
                bromoacetone 0
                chloroacetone 0
                hydroxyacetone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic group 23608
                              organic divalent group 23569
                                organodiyl group 23569
                                  carbonyl group 23563
                                    carbonyl compound 23563
                                      carboxylic acid 22717
                                        monocarboxylic acid 21715
                                          fatty acid 18995
                                            fatty acid derivative 9193
                                              ketone body 24
                                                acetone 19
                                                  1-hydroxy-3-methoxyacetone 0
                                                  2-oxopropylidene group 0
                                                  2-oxopropylidyne group 0
                                                  acetonyl group 0
                                                  aminoacetone 4
                                                  bromoacetone 0
                                                  chloroacetone 0
                                                  hydroxyacetone + 0
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