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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acetone
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Accession:CHEBI:15347 term browser browse the term
Definition:A methyl ketone that consists of propane bearing an oxo group at C2.
Synonyms:exact_synonym: propan-2-one
 related_synonym: 2-Propanone;   Aceton;   Azeton;   Dimethyl ketone;   Dimethylketon;   Formula=C3H6O;   InChI=1S/C3H6O/c1-3(2)4/h1-2H3;   InChIKey=CSCPPACGZOOCGX-UHFFFAOYSA-N;   Propanon;   Pyroacetic ether;   SMILES=CC(C)=O;   beta-Ketopropane;   dimethylcetone;   dimethylketone;   methyl ketone;   propanone
 alt_id: CHEBI:13708;   CHEBI:22182;   CHEBI:2398;   CHEBI:40571
 xref: Beilstein:635680;   CAS:67-64-1;   Gmelin:1466;   HMDB:HMDB0001659;   KEGG:C00207;   KEGG:D02311;   LIPID_MAPS_instance:LMFA12000057
 xref_mesh: MESH:D000096
 xref: MetaCyc:ACETONE;   PDBeChem:ACN;   PMID:17190852;   PMID:17347819;   Reaxys:635680;   UM-BBD_compID:c0556;   Wikipedia:Acetone


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acetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) multiple interactions ISO [ADH1 protein results in increased oxidation of allyl alcohol] which results in increased abundance of Acetone CTD PMID:11981770 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Cat catalase decreases activity ISO
EXP
Acetone results in decreased activity of CAT protein CTD PMID:16169704, PMID:20127315 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Acetone results in increased expression of CCND1 mRNA CTD PMID:12720008 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Acetone promotes the reaction [Toluene results in increased expression of CYP1A1 protein] CTD PMID:8996725 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Acetone promotes the reaction [Toluene results in increased expression of CYP1A2 protein] CTD PMID:8996725 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression EXP Acetone results in decreased expression of CYP2B1 protein CTD PMID:8267643 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
increases activity
increases metabolic processing
ISO
EXP
[Acetone results in increased activity of CYP2E1 protein] which results in increased oxidation of Benzene; [Acetone results in increased expression of CYP2E1 protein] which results in increased susceptibility to allyl cyanide; Acetone results in increased expression of and results in increased activity of CYP2E1 protein
Acetone results in increased expression of CYP2E1 mRNA; Acetone results in increased expression of CYP2E1 protein
1,2-dichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]; [Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Acetone promotes the reaction [2-xylene results in increased expression of CYP2E1 protein]; Acetone promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; Acetone promotes the reaction [Toluene results in increased expression of CYP2E1 protein]; Trichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]
CYP2E1 protein results in increased metabolism of Acetone
CTD PMID:1968335, PMID:2241968, PMID:3416296, PMID:3782137, PMID:7587954, PMID:8013281, PMID:8117100, PMID:8267643, PMID:8560479, PMID:8734847, PMID:8996725, PMID:9851676, PMID:11939710, PMID:12919724, PMID:15576447, PMID:15763544, PMID:18990727, PMID:20127315, PMID:22499231 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO Acetone results in increased expression of FGFR2 mRNA CTD PMID:12720008 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of IL13 mRNA CTD PMID:21252390 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of IL4 mRNA CTD PMID:21252390 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of IL5 mRNA CTD PMID:21252390 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Itga5 integrin subunit alpha 5 increases expression ISO Acetone results in increased expression of ITGA5 mRNA CTD PMID:12720008 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Acetone results in increased expression of NQO1 mRNA CTD PMID:9496914 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of TNF mRNA CTD PMID:21252390 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 increases response to substance ISO TRPM8 protein results in increased susceptibility to Acetone CTD PMID:17481392 NCBI chr 9:95,393,370...95,484,528
Ensembl chr 9:95,398,237...95,482,890
JBrowse link
aminoacetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP CAT protein results in decreased susceptibility to [aminoacetone co-treated with Copper] CTD PMID:18729331 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP [aminoacetone co-treated with Copper] results in increased expression of GSR mRNA CTD PMID:18729331 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [aminoacetone co-treated with Copper] results in increased expression of SOD1 mRNA CTD PMID:18729331 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [aminoacetone co-treated with Copper] results in increased expression of SOD2 mRNA CTD PMID:18729331 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        solvent 16489
          polar solvent 15280
            polar aprotic solvent 571
              acetone 18
                1-hydroxy-3-methoxyacetone 0
                2-oxopropylidene group 0
                2-oxopropylidyne group 0
                acetonyl group 0
                aminoacetone 4
                bromoacetone 0
                chloroacetone 0
                hydroxyacetone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        monocarboxylic acid 17476
                                          fatty acid 15990
                                            fatty acid derivative 1021
                                              ketone body 22
                                                acetone 18
                                                  1-hydroxy-3-methoxyacetone 0
                                                  2-oxopropylidene group 0
                                                  2-oxopropylidyne group 0
                                                  acetonyl group 0
                                                  aminoacetone 4
                                                  bromoacetone 0
                                                  chloroacetone 0
                                                  hydroxyacetone + 0
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