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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acetone
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Accession:CHEBI:15347 term browser browse the term
Definition:A methyl ketone that consists of propane bearing an oxo group at C2.
Synonyms:exact_synonym: propan-2-one
 related_synonym: 2-Propanone;   Aceton;   Azeton;   Dimethyl ketone;   Dimethylketon;   Formula=C3H6O;   InChI=1S/C3H6O/c1-3(2)4/h1-2H3;   InChIKey=CSCPPACGZOOCGX-UHFFFAOYSA-N;   Propanon;   Pyroacetic ether;   SMILES=CC(C)=O;   beta-Ketopropane;   dimethylcetone;   dimethylketone;   methyl ketone;   propanone
 alt_id: CHEBI:13708;   CHEBI:22182;   CHEBI:2398;   CHEBI:40571
 xref: Beilstein:635680;   CAS:67-64-1;   Gmelin:1466;   HMDB:HMDB0001659;   KEGG:C00207;   KEGG:D02311;   LIPID_MAPS_instance:LMFA12000057
 xref_mesh: MESH:D000096
 xref: MetaCyc:ACETONE;   PDBeChem:ACN;   PMID:17190852;   PMID:17347819;   Reaxys:635680;   UM-BBD_compID:c0556;   Wikipedia:Acetone


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acetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1C (class I), gamma polypeptide multiple interactions ISO [ADH1 protein results in increased oxidation of allyl alcohol] which results in increased abundance of Acetone CTD PMID:11981770 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Cat catalase decreases activity ISO
EXP		 Acetone results in decreased activity of CAT protein CTD PMID:16169704 PMID:20127315 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Acetone results in increased expression of CCND1 mRNA CTD PMID:12720008 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Acetone promotes the reaction [Toluene results in increased expression of CYP1A1 protein] CTD PMID:8996725 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Acetone promotes the reaction [Toluene results in increased expression of CYP1A2 protein] CTD PMID:8996725 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression EXP Acetone results in decreased expression of CYP2B1 protein CTD PMID:8267643 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions ISO Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide] CTD PMID:10611138 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
increases activity
increases metabolic processing		 ISO
EXP		 [Acetone results in increased activity of CYP2E1 protein] which results in increased oxidation of Benzene; [Acetone results in increased expression of CYP2E1 protein] which results in increased susceptibility to allyl cyanide; Acetone results in increased expression of and results in increased activity of CYP2E1 protein
Acetone results in increased expression of CYP2E1 mRNA; Acetone results in increased expression of CYP2E1 protein
1,2-dichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]; [Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Acetone promotes the reaction [2-xylene results in increased expression of CYP2E1 protein]; Acetone promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; Acetone promotes the reaction [Toluene results in increased expression of CYP2E1 protein]; Trichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]
CYP2E1 protein results in increased metabolism of Acetone		 CTD PMID:1968335 PMID:2241968 PMID:3416296 PMID:3782137 PMID:7587954 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO Acetone results in increased expression of FGFR2 mRNA CTD PMID:12720008 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Acetone results in increased expression of FN1 mRNA CTD PMID:33064461 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of IL13 mRNA CTD PMID:21252390 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of IL4 mRNA CTD PMID:21252390 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of IL5 mRNA CTD PMID:21252390 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Itga5 integrin subunit alpha 5 increases expression ISO Acetone results in increased expression of ITGA5 mRNA CTD PMID:12720008 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Acetone results in increased expression of NQO1 mRNA CTD PMID:9496914 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of TNF mRNA CTD PMID:21252390 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 increases response to substance ISO TRPM8 protein results in increased susceptibility to Acetone CTD PMID:17481392 NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552 		JBrowse link
aminoacetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP CAT protein results in decreased susceptibility to [aminoacetone co-treated with Copper] CTD PMID:18729331 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP [aminoacetone co-treated with Copper] results in increased expression of GSR mRNA CTD PMID:18729331 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [aminoacetone co-treated with Copper] results in increased expression of SOD1 mRNA CTD PMID:18729331 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [aminoacetone co-treated with Copper] results in increased expression of SOD2 mRNA CTD PMID:18729331 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        solvent 16738
          polar solvent 15485
            polar aprotic solvent 604
              acetone 20
                1-hydroxy-3-methoxyacetone 0
                2-oxopropylidene group 0
                2-oxopropylidyne group 0
                acetonyl group 0
                aminoacetone 4
                bromoacetone 0
                chloroacetone 0
                hydroxyacetone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        monocarboxylic acid 17903
                                          fatty acid 16560
                                            fatty acid derivative 8913
                                              ketone body 24
                                                acetone 20
                                                  1-hydroxy-3-methoxyacetone 0
                                                  2-oxopropylidene group 0
                                                  2-oxopropylidyne group 0
                                                  acetonyl group 0
                                                  aminoacetone 4
                                                  bromoacetone 0
                                                  chloroacetone 0
                                                  hydroxyacetone + 0
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