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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acetoacetic acid
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Accession:CHEBI:15344 term browser browse the term
Definition:A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.
Synonyms:related_synonym: 3-Ketobutyric acid;   3-Oxobutanoic acid;   3-Oxobutyric acid;   3-ketobutanoic acid;   Formula=C4H6O3;   InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7);   InChIKey=WDJHALXBUFZDSR-UHFFFAOYSA-N;   SMILES=CC(=O)CC(O)=O;   beta-Ketobutyric acid
 alt_id: CHEBI:22172;   CHEBI:2391;   CHEBI:40507
 xref: Beilstein:1747690;   CAS:541-50-4;   DrugBank:DB01762;   HMDB:HMDB0000060;   KEGG:C00164;   KNApSAcK:C00007458;   LIPID_MAPS_instance:LMFA01060003
 xref_mesh: MESH:C016635
 xref: MetaCyc:3-KETOBUTYRATE;   PMID:17190852;   PMID:20444635;   PMID:21806064;   PMID:22382897;   PMID:3884391;   Reaxys:1747690;   UM-BBD_compID:c0069;   Wikipedia:Acetoacetic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:13705;   is_tautomer_of CHEBI:131367


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acetoacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO acetoacetic acid results in increased secretion of CCL2 protein CTD PMID:17665966 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Il6 interleukin 6 increases secretion ISO acetoacetic acid results in increased secretion of IL6 protein CTD PMID:17665966 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Slc13a5 solute carrier family 13 member 5 decreases abundance ISO SLC13A5 protein results in decreased abundance of acetoacetic acid CTD PMID:32634519 NCBI chr10:58,806,581...58,835,549
Ensembl chr10:58,810,058...58,834,538
JBrowse link
acetoacetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects binding ISO acetoacetyl CoA binds to HSD17B2 protein CTD PMID:25526675 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            acetoacetic acid 4
              (R)-acetoacetylcarnitine 0
              2-methylacetoacetic acid + 0
              acetoacetamide 0
              acetoacetyl group + 0
              acetoacetyl-CoA 1
              geranyl acetoacetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          fatty acid 15844
                                            short-chain fatty acid 15498
                                              fatty acid 4:0 7010
                                                butyric acid 5292
                                                  acetoacetic acid 4
                                                    (R)-acetoacetylcarnitine 0
                                                    2-methylacetoacetic acid + 0
                                                    acetoacetamide 0
                                                    acetoacetyl group + 0
                                                    acetoacetyl-CoA 1
                                                    geranyl acetoacetate 0
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