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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acetoacetic acid
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Accession:CHEBI:15344 term browser browse the term
Definition:A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.
Synonyms:related_synonym: 3-Ketobutyric acid;   3-Oxobutanoic acid;   3-Oxobutyric acid;   3-ketobutanoic acid;   Formula=C4H6O3;   InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7);   InChIKey=WDJHALXBUFZDSR-UHFFFAOYSA-N;   SMILES=CC(=O)CC(O)=O;   beta-Ketobutyric acid
 alt_id: CHEBI:22172;   CHEBI:2391;   CHEBI:40507
 xref: Beilstein:1747690;   CAS:541-50-4;   DrugBank:DB01762;   HMDB:HMDB0000060;   KEGG:C00164;   KNApSAcK:C00007458;   LIPID_MAPS_instance:LMFA01060003
 xref_mesh: MESH:C016635
 xref: MetaCyc:3-KETOBUTYRATE;   PMID:17190852;   PMID:20444635;   PMID:21806064;   PMID:22382897;   PMID:3884391;   Reaxys:1747690;   UM-BBD_compID:c0069;   Wikipedia:Acetoacetic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:13705;   is_tautomer_of CHEBI:131367



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acetoacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO acetoacetic acid results in increased secretion of CCL2 protein CTD PMID:17665966 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Il6 interleukin 6 increases secretion ISO acetoacetic acid results in increased secretion of IL6 protein CTD PMID:17665966 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Slc13a5 solute carrier family 13 member 5 decreases abundance ISO SLC13A5 protein results in decreased abundance of acetoacetic acid CTD PMID:32634519 NCBI chr10:56,866,249...56,891,189
Ensembl chr10:56,866,249...56,890,945
JBrowse link
acetoacetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects binding ISO acetoacetyl CoA binds to HSD17B2 protein CTD PMID:25526675 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          metabolite 19574
            acetoacetic acid 4
              (R)-acetoacetylcarnitine 0
              2-methylacetoacetic acid + 0
              acetoacetamide 0
              acetoacetyl group + 0
              acetoacetyl-CoA 1
              ethyl acetoacetate 0
              geranyl acetoacetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        monocarboxylic acid 17984
                                          fatty acid 16709
                                            short-chain fatty acid 15941
                                              fatty acid 4:0 8227
                                                butyric acid 6721
                                                  acetoacetic acid 4
                                                    (R)-acetoacetylcarnitine 0
                                                    2-methylacetoacetic acid + 0
                                                    acetoacetamide 0
                                                    acetoacetyl group + 0
                                                    acetoacetyl-CoA 1
                                                    ethyl acetoacetate 0
                                                    geranyl acetoacetate 0
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