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G |
Abcb11 |
ATP-binding cassette, sub-family B (MDR/TAP), member 11 |
decreases activity |
ISO |
estradiol-3-glucuronide results in decreased activity of ABCB11 protein |
CTD |
PMID:10869290 |
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NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
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G |
Kl |
klotho |
multiple interactions increases hydrolysis |
EXP |
estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] KL protein results in increased hydrolysis of estradiol-3-glucuronide |
CTD |
PMID:14701853 |
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NCBI chr 5:150,952,607...150,993,817
Ensembl chr 5:150,952,607...150,993,817
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G |
Ugt1a1 |
UDP glucuronosyltransferase 1 family, polypeptide A1 |
multiple interactions |
ISO |
[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 |
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NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
multiple interactions |
ISO |
[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 |
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NCBI chr 1:88,200,611...88,220,002
Ensembl chr 1:88,200,601...88,218,997
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G |
Ugt1a6b |
UDP glucuronosyltransferase 1 family, polypeptide A6B |
multiple interactions |
ISO |
[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 |
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NCBI chr 1:88,103,257...88,218,998
Ensembl chr 1:88,103,252...88,219,003
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G |
Ugt1a9 |
UDP glucuronosyltransferase 1 family, polypeptide A9 |
multiple interactions |
ISO |
[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 |
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NCBI chr 1:88,070,779...88,220,002
Ensembl chr 1:88,070,800...88,218,997
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G |
Ugt2b34 |
UDP glucuronosyltransferase 2 family, polypeptide B34 |
multiple interactions |
ISO |
[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 |
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NCBI chr 5:86,889,770...86,906,937
Ensembl chr 5:86,889,767...86,906,937
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G |
Abcc4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
multiple interactions |
ISO |
4-nitrophenylglucuronide inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate] |
CTD |
PMID:11856762 |
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NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
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G |
Abcc3 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
increases activity affects export multiple interactions |
ISO EXP |
acetaminophen glucuronide results in increased activity of ABCC3 protein ABCC3 protein affects the export of acetaminophen glucuronide Ethinyl Estradiol promotes the reaction [ABCC3 protein results in increased secretion of acetaminophen glucuronide] |
CTD |
PMID:16250050 PMID:16554369 PMID:17569508 |
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NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
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G |
Ins2 |
insulin II |
increases abundance |
ISO |
INS protein results in increased abundance of acetaminophen glucuronide |
CTD |
PMID:26739624 |
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NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
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G |
Ogt |
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) |
multiple interactions |
EXP |
OGT gene mutant form inhibits the reaction [Acetaminophen results in increased abundance of acetaminophen glucuronide] |
CTD |
PMID:29325178 |
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NCBI chr X:101,640,011...101,684,351
Ensembl chr X:101,640,060...101,684,351
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G |
Kl |
klotho |
multiple interactions |
EXP |
androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] |
CTD |
PMID:14701853 |
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NCBI chr 5:150,952,607...150,993,817
Ensembl chr 5:150,952,607...150,993,817
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G |
Abcb1a |
ATP-binding cassette, sub-family B (MDR/TAP), member 1A |
multiple interactions |
ISO |
estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide] |
CTD |
PMID:9794924 |
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NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
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G |
Kl |
klotho |
increases hydrolysis multiple interactions |
EXP |
KL protein results in increased hydrolysis of estrone-3-glucuronide estrone-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] |
CTD |
PMID:14701853 |
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NCBI chr 5:150,952,607...150,993,817
Ensembl chr 5:150,952,607...150,993,817
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G |
Acadm |
acyl-Coenzyme A dehydrogenase, medium chain |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of ACADM mRNA] |
CTD |
PMID:26190035 |
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NCBI chr 3:153,922,353...153,944,643
Ensembl chr 3:153,922,357...153,944,632
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G |
Adrb2 |
adrenergic receptor, beta 2 |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine binds to ADRB2 protein] |
CTD |
PMID:24929186 |
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NCBI chr18:62,177,713...62,179,981
Ensembl chr18:62,177,816...62,179,959
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G |
Agt |
angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
multiple interactions |
ISO |
quercetin 3-O-glucuronide analog inhibits the reaction [AGT protein results in increased phosphorylation of JUN protein] |
CTD |
PMID:12054679 |
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NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4] |
CTD |
PMID:18096136 |
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NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
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G |
App |
amyloid beta (A4) precursor protein |
multiple interactions decreases expression |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [APP protein binds to APP protein modified form] quercetin 3-O-glucuronide results in decreased expression of APP protein |
CTD |
PMID:23097297 |
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NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
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G |
Cat |
catalase |
multiple interactions |
ISO |
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT protein |
CTD |
PMID:25716194 |
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NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
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G |
Cav1 |
caveolin 1, caveolae protein |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA] |
CTD |
PMID:27257344 |
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NCBI chr 6:17,306,335...17,341,328
Ensembl chr 6:17,306,335...17,341,452
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G |
Cd36 |
CD36 molecule |
decreases expression |
EXP |
quercetin 3-O-glucuronide results in decreased expression of CD36 mRNA |
CTD |
PMID:18199750 |
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NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
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G |
Cpt1a |
carnitine palmitoyltransferase 1a, liver |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of CPT1A mRNA] |
CTD |
PMID:26190035 |
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NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
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G |
Fas |
Fas (TNF receptor superfamily member 6) |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FAS mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA] |
CTD |
PMID:26190035 |
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NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein |
CTD |
PMID:25716194 |
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NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of HMOX1 mRNA] [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein |
CTD |
PMID:24929186 PMID:25716194 |
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NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA] |
CTD |
PMID:27257344 |
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NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
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G |
Ikbkb |
inhibitor of kappaB kinase beta |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:23504962 |
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NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein] |
CTD |
PMID:26190035 |
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NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased secretion of IL6 protein] |
CTD |
PMID:23504962 |
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NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
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G |
Ins2 |
insulin II |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] |
CTD |
PMID:23504962 |
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NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] |
CTD |
PMID:23504962 |
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NCBI chr 1:82,233,105...82,291,439
Ensembl chr 1:82,233,112...82,235,933 Ensembl chr 1:82,233,112...82,235,933
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G |
Jun |
jun proto-oncogene |
multiple interactions |
ISO |
quercetin 3-O-glucuronide analog inhibits the reaction [AGT protein results in increased phosphorylation of JUN protein] |
CTD |
PMID:12054679 |
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NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA] |
CTD |
PMID:24929186 |
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NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA] |
CTD |
PMID:24929186 |
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NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
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G |
Msr1 |
macrophage scavenger receptor 1 |
decreases expression |
EXP |
quercetin 3-O-glucuronide results in decreased expression of MSR1 mRNA |
CTD |
PMID:18199750 |
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NCBI chr 8:39,543,232...39,642,750
Ensembl chr 8:39,581,685...39,642,673
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G |
Nos2 |
nitric oxide synthase 2, inducible |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] |
CTD |
PMID:27257013 |
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NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
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G |
Nos3 |
nitric oxide synthase 3, endothelial cell |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] |
CTD |
PMID:23504962 |
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NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA]; quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA protein]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein] |
CTD |
PMID:26190035 |
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NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
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G |
Pparg |
peroxisome proliferator activated receptor gamma |
increases expression |
ISO |
quercetin 3-O-glucuronide results in increased expression of PPARG mRNA |
CTD |
PMID:25765892 |
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NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] |
CTD |
PMID:27257013 |
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NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
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G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of RELA protein] |
CTD |
PMID:23504962 |
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NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
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G |
Slc22a8 |
solute carrier family 22 (organic anion transporter), member 8 |
multiple interactions increases uptake |
ISO |
quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein] SLC22A8 protein results in increased uptake of quercetin 3-O-glucuronide analog |
CTD |
PMID:21244849 |
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NCBI chr19:8,591,254...8,611,835
Ensembl chr19:8,591,254...8,611,835
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] |
CTD |
PMID:26190035 |
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NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with TNF protein] results in increased expression of VCAM1 protein]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased secretion of TNF protein] quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of TNF protein] |
CTD |
PMID:17880982 PMID:23504962 PMID:26190035 |
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NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
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G |
Tnfsf11 |
tumor necrosis factor (ligand) superfamily, member 11 |
decreases activity |
EXP |
quercetin 3-O-glucuronide results in decreased activity of TNFSF11 protein |
CTD |
PMID:19495926 |
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NCBI chr14:78,277,446...78,308,043
Ensembl chr14:78,277,445...78,308,043
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with TNF protein] results in increased expression of VCAM1 protein] |
CTD |
PMID:17880982 |
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NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
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G |
Kl |
klotho |
multiple interactions |
EXP |
testosterone glucuronate inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] |
CTD |
PMID:14701853 |
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NCBI chr 5:150,952,607...150,993,817
Ensembl chr 5:150,952,607...150,993,817
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