|
G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
multiple interactions |
EXP |
[CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide |
CTD |
PMID:27485346 |
|
NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
|
|
|
G |
ABCB11 |
ATP binding cassette subfamily B member 11 |
decreases activity |
ISO |
estradiol-3-glucuronide results in decreased activity of ABCB11 protein |
CTD |
PMID:10869290 |
|
NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
|
|
G |
KL |
klotho |
multiple interactions increases hydrolysis |
ISO |
estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] KL protein results in increased hydrolysis of estradiol-3-glucuronide |
CTD |
PMID:14701853 |
|
NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143
|
|
|
G |
UGT1A1 |
UDP glucuronosyltransferase family 1 member A1 |
multiple interactions |
EXP |
[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
|
|
G |
UGT1A10 |
UDP glucuronosyltransferase family 1 member A10 |
multiple interactions |
EXP |
[UGT1A10 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide |
CTD |
PMID:33290829 |
|
NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300
|
|
G |
UGT1A3 |
UDP glucuronosyltransferase family 1 member A3 |
multiple interactions |
EXP |
[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300
|
|
G |
UGT1A6 |
UDP glucuronosyltransferase family 1 member A6 |
multiple interactions |
EXP |
[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300
|
|
G |
UGT1A7 |
UDP glucuronosyltransferase family 1 member A7 |
multiple interactions |
EXP |
[UGT1A7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:33290829 |
|
NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300
|
|
G |
UGT1A8 |
UDP glucuronosyltransferase family 1 member A8 |
multiple interactions |
EXP |
[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Phenylbutazone inhibits the reaction [[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300
|
|
G |
UGT1A9 |
UDP glucuronosyltransferase family 1 member A9 |
multiple interactions |
EXP |
[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
|
|
G |
UGT2B15 |
UDP glucuronosyltransferase family 2 member B15 |
multiple interactions |
EXP |
[UGT2B15 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B15 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B15 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT2B15 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652
|
|
G |
UGT2B17 |
UDP glucuronosyltransferase family 2 member B17 |
multiple interactions |
EXP |
[UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide |
CTD |
PMID:33290829 |
|
NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413
|
|
G |
UGT2B4 |
UDP glucuronosyltransferase family 2 member B4 |
multiple interactions |
EXP |
[UGT2B4 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B4 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT2B4 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT2B4 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr 4:69,480,165...69,526,014
Ensembl chr 4:69,480,165...69,526,014
|
|
G |
UGT2B7 |
UDP glucuronosyltransferase family 2 member B7 |
multiple interactions |
EXP |
[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] |
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987
|
|
|
G |
ABCC4 |
ATP binding cassette subfamily C member 4 (PEL blood group) |
multiple interactions |
EXP |
4-nitrophenylglucuronide inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate] |
CTD |
PMID:11856762 |
|
NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
|
|
|
G |
UGT2B15 |
UDP glucuronosyltransferase family 2 member B15 |
increases abundance |
EXP |
UGT2B15 protein results in increased abundance of 7-hydroxycoumarin glucuronide |
CTD |
PMID:7835232 |
|
NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652
|
|
|
G |
ABCC3 |
ATP binding cassette subfamily C member 3 |
increases activity affects export multiple interactions |
EXP ISO |
acetaminophen glucuronide results in increased activity of ABCC3 protein ABCC3 protein affects the export of acetaminophen glucuronide Ethinyl Estradiol promotes the reaction [ABCC3 protein results in increased secretion of acetaminophen glucuronide] |
CTD |
PMID:16250050 PMID:16554369 PMID:17569508 |
|
NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
|
|
G |
INS |
insulin |
increases abundance |
EXP |
INS protein results in increased abundance of acetaminophen glucuronide |
CTD |
PMID:26739624 |
|
NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
|
|
G |
OGT |
O-linked N-acetylglucosamine (GlcNAc) transferase |
multiple interactions |
ISO |
OGT gene mutant form inhibits the reaction [Acetaminophen results in increased abundance of acetaminophen glucuronide] |
CTD |
PMID:29325178 |
|
NCBI chr X:71,533,104...71,575,892
Ensembl chr X:71,533,087...71,575,892
|
|
|
G |
KL |
klotho |
multiple interactions |
ISO |
androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] |
CTD |
PMID:14701853 |
|
NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143
|
|
|
G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
multiple interactions |
ISO |
estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide] |
CTD |
PMID:9794924 |
|
NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
|
|
|
G |
KL |
klotho |
increases hydrolysis multiple interactions |
ISO |
KL protein results in increased hydrolysis of estrone-3-glucuronide estrone-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] |
CTD |
PMID:14701853 |
|
NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143
|
|
|
G |
ACADM |
acyl-CoA dehydrogenase medium chain |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of ACADM mRNA] |
CTD |
PMID:26190035 |
|
NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,431...75,787,575
|
|
G |
ADRB2 |
adrenoceptor beta 2 |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine binds to ADRB2 protein] |
CTD |
PMID:24929186 |
|
NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623
|
|
G |
AGT |
angiotensinogen |
multiple interactions |
EXP |
quercetin 3-O-glucuronide analog inhibits the reaction [AGT protein results in increased phosphorylation of JUN protein] |
CTD |
PMID:12054679 |
|
NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
|
|
G |
ALOX5 |
arachidonate 5-lipoxygenase |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4] |
CTD |
PMID:18096136 |
|
NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
|
|
G |
APP |
amyloid beta precursor protein |
multiple interactions decreases expression |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [APP protein binds to APP protein modified form] quercetin 3-O-glucuronide results in decreased expression of APP protein |
CTD |
PMID:23097297 |
|
NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
|
|
G |
CAT |
catalase |
multiple interactions |
ISO |
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT protein |
CTD |
PMID:25716194 |
|
NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
|
|
G |
CAV1 |
caveolin 1 |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA] |
CTD |
PMID:27257344 |
|
NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179
|
|
G |
CD36 |
CD36 molecule (CD36 blood group) |
decreases expression |
ISO |
quercetin 3-O-glucuronide results in decreased expression of CD36 mRNA |
CTD |
PMID:18199750 |
|
NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277
|
|
G |
CPT1A |
carnitine palmitoyltransferase 1A |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of CPT1A mRNA] |
CTD |
PMID:26190035 |
|
NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
|
|
G |
FAS |
Fas cell surface death receptor |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FAS mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA] |
CTD |
PMID:26190035 |
|
NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
|
|
G |
GCLC |
glutamate-cysteine ligase catalytic subunit |
multiple interactions |
ISO |
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein |
CTD |
PMID:25716194 |
|
NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
|
|
G |
HMOX1 |
heme oxygenase 1 |
multiple interactions |
EXP ISO |
quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of HMOX1 mRNA] [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein |
CTD |
PMID:24929186 PMID:25716194 |
|
NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
|
|
G |
ICAM1 |
intercellular adhesion molecule 1 |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA] |
CTD |
PMID:27257344 |
|
NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
|
|
G |
IKBKB |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:23504962 |
|
NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460
|
|
G |
IL1B |
interleukin 1 beta |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein] |
CTD |
PMID:26190035 |
|
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
|
|
G |
IL6 |
interleukin 6 |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased secretion of IL6 protein] |
CTD |
PMID:23504962 |
|
NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
|
|
G |
INS |
insulin |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] |
CTD |
PMID:23504962 |
|
NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
|
|
G |
IRS1 |
insulin receptor substrate 1 |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein] |
CTD |
PMID:23504962 |
|
NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820
|
|
G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
quercetin 3-O-glucuronide analog inhibits the reaction [AGT protein results in increased phosphorylation of JUN protein] |
CTD |
PMID:12054679 |
|
NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
|
|
G |
MMP2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA] |
CTD |
PMID:24929186 |
|
NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
|
|
G |
MMP9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA] |
CTD |
PMID:24929186 |
|
NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
|
|
G |
MSR1 |
macrophage scavenger receptor 1 |
decreases expression |
ISO |
quercetin 3-O-glucuronide results in decreased expression of MSR1 mRNA |
CTD |
PMID:18199750 |
|
NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490
|
|
G |
NOS2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] |
CTD |
PMID:27257013 |
|
NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
|
|
G |
NOS3 |
nitric oxide synthase 3 |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] |
CTD |
PMID:23504962 |
|
NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
|
|
G |
PPARA |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA]; quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA protein]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein] |
CTD |
PMID:26190035 |
|
NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
|
|
G |
PPARG |
peroxisome proliferator activated receptor gamma |
increases expression |
EXP |
quercetin 3-O-glucuronide results in increased expression of PPARG mRNA |
CTD |
PMID:25765892 |
|
NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
|
|
G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] |
CTD |
PMID:27257013 |
|
NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
|
|
G |
RELA |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of RELA protein] |
CTD |
PMID:23504962 |
|
NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
|
|
G |
SLC22A8 |
solute carrier family 22 member 8 |
multiple interactions increases uptake |
EXP |
quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein] SLC22A8 protein results in increased uptake of quercetin 3-O-glucuronide analog |
CTD |
PMID:21244849 |
|
NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
|
|
G |
SREBF1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] |
CTD |
PMID:26190035 |
|
NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
|
|
G |
TNF |
tumor necrosis factor |
multiple interactions |
EXP ISO |
quercetin 3-O-glucuronide inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with TNF protein] results in increased expression of VCAM1 protein]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased secretion of TNF protein] quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of TNF protein] |
CTD |
PMID:17880982 PMID:23504962 PMID:26190035 |
|
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
|
|
G |
TNFSF11 |
TNF superfamily member 11 |
decreases activity |
ISO |
quercetin 3-O-glucuronide results in decreased activity of TNFSF11 protein |
CTD |
PMID:19495926 |
|
NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013
|
|
G |
VCAM1 |
vascular cell adhesion molecule 1 |
multiple interactions |
EXP |
quercetin 3-O-glucuronide inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with TNF protein] results in increased expression of VCAM1 protein] |
CTD |
PMID:17880982 |
|
NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
|
|
|
G |
KL |
klotho |
multiple interactions |
ISO |
testosterone glucuronate inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] |
CTD |
PMID:14701853 |
|
NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143
|
|
G |
UGT2B15 |
UDP glucuronosyltransferase family 2 member B15 |
increases abundance |
EXP |
UGT2B15 protein results in increased abundance of testosterone glucuronate |
CTD |
PMID:7835232 |
|
NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652
|
|