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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:149696 term browser browse the term
Definition:A member of the class of thiazolidinones that is 2-sulfanylidene-1,3-thiazolidin-4-one which is substituted at position 5 by a (4-ethylphenyl)methylidene group. It is a cell permeable inhibitor of c-Myc-Max dimerization and exhibits antitumour effects in vivo. It downregulates c-Myc expression and upregulates CDK inhibitors, p21 and p27 resulting in the inhibition of proliferation, induction of apoptosis and cell cycle arrest in G0/G1 phase.
Synonyms:exact_synonym: 5-(4-ethylbenzylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
 related_synonym: 10058F4;   5-(4-ethylbenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one;   5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one;   5-[(4-ethylphenyl)methylene]-2-thioxo-4-thiazolidinone;   Formula=C12H11NOS2;   InChI=1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15);   InChIKey=SVXDHPADAXBMFB-UHFFFAOYSA-N;   SMILES=C=1C=C(C=CC1C(=C2SC(NC2=O)=S)[H])CC
 xref: CAS:403811-55-2;   PMID:17046567;   PMID:17159602;   PMID:18509642;   PMID:25120723;   PMID:26211592;   PMID:29790697;   PMID:30639430;   PMID:30957273;   PMID:31770526;   PMID:32160736

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  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          apoptosis inducer 10979
            10058-F4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteromonocyclic compound 16469
                                    thiazolidines 3251
                                      thiazolidinone 2746
                                        10058-F4 0
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