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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:anticoronaviral agent
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Accession:CHEBI:149553 term browser browse the term
Definition:Any antiviral agent which inhibits the activity of coronaviruses.
Synonyms:related_synonym: anti-coronaviral agent;   anti-coronaviral agents;   anti-coronavirus agent;   anti-coronavirus agents;   anticoronaviral agents;   anticoronaviral drug;   anticoronaviral drugs;   anticoronavirus agent;   anticoronavirus agents;   anticoronviral agent;   anticoronviral agents
 xref: Wikipedia:Coronavirus


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chloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPD1 protein] CTD PMID:17727805 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,526 		JBrowse link
G IFIT3 interferon induced protein with tetratricopeptide repeats 3 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFIT1 mRNA] CTD PMID:27079946 NCBI chr14:101,237,403...101,249,486
Ensembl chr14:101,237,571...101,249,498 		JBrowse link
G IFNB1 interferon beta 1 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNB1 mRNA] CTD PMID:27079946 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495 		JBrowse link
G IFNG interferon gamma multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNG mRNA] CTD PMID:27079946 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL12B interleukin 12B multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL12B mRNA] CTD PMID:27079946 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,143,268...64,158,929 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL6 mRNA] CTD PMID:27079946 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G IRF7 interferon regulatory factor 7 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IRF7 mRNA] CTD PMID:27079946 NCBI chr 2:372,235...375,572
Ensembl chr 2:372,238...375,378 		JBrowse link
G ISG15 ISG15 ubiquitin like modifier multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of ISG15 mRNA] CTD PMID:27079946 NCBI chr 6:63,363,201...63,364,211
Ensembl chr 6:63,363,173...63,364,208 		JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL1B mRNA] CTD PMID:27079946
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein] CTD PMID:30287338 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of RELA protein] CTD PMID:27079946 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469 		JBrowse link
G SQSTM1 sequestosome 1 increases expression
multiple interactions		 EXP Chloroquine results in increased expression of SQSTM1 protein
Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein]		 CTD PMID:30287338 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938 		JBrowse link
G TLR7 toll like receptor 7 multiple interactions EXP Chloroquine affects the localization of and results in decreased activity of TLR7 protein CTD PMID:27079946 NCBI chr  X:9,573,178...9,576,987 JBrowse link
chlorpromazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAO D-amino acid oxidase decreases activity EXP Chlorpromazine results in decreased activity of DAO protein CTD PMID:18615285 NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633 		JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases oxidation EXP FMO1 protein results in increased oxidation of Chlorpromazine CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076 		JBrowse link
cycloheximide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 multiple interactions EXP Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of ATF4 protein]; Cycloheximide inhibits the reaction [Cadmium results in increased expression of ATF4 protein] CTD PMID:16759985 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G CLIC5 chloride intracellular channel 5 multiple interactions
decreases expression		 EXP Cycloheximide promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]
Cycloheximide results in decreased expression of CLIC5 protein		 CTD PMID:20576581 NCBI chr 7:40,683,044...40,808,017
Ensembl chr 7:40,682,907...40,863,886 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; Cycloheximide inhibits the reaction [Cadmium results in increased expression of HSPA5 protein] CTD PMID:16759985 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G LRP2 LDL receptor related protein 2 multiple interactions
decreases expression		 EXP Cycloheximide promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]
Cycloheximide results in decreased expression of LRP2 protein		 CTD PMID:20576581 NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,303...75,716,694 		JBrowse link
cyclosporin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions
affects localization		 EXP Vitamin E inhibits the reaction [Cyclosporine affects the localization of BAX protein] CTD PMID:19523970 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G CASP6 caspase 6 multiple interactions
increases expression		 EXP Vitamin E inhibits the reaction [Cyclosporine results in increased expression of CASP6 mRNA] CTD PMID:19523970 NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,520,629...112,537,045 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions
affects localization		 EXP Vitamin E inhibits the reaction [Cyclosporine affects the localization of CYCS protein] CTD PMID:23347876 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G EDN1 endothelin 1 increases secretion EXP Cyclosporine results in increased secretion of EDN1 protein CTD PMID:16391421 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G FGD4 FYVE, RhoGEF and PH domain containing 4 multiple interactions
increases expression		 EXP Vitamin E inhibits the reaction [Cyclosporine results in increased expression of DNM1L protein] CTD PMID:23347876 NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028 		JBrowse link
G MFN2 mitofusin 2 multiple interactions
decreases expression		 EXP Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of MFN2 protein] CTD PMID:23347876 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438 		JBrowse link
G NOS3 nitric oxide synthase 3 decreases expression EXP Cyclosporine results in decreased expression of NOS3 protein CTD PMID:12695417 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase decreases expression
multiple interactions		 EXP Cyclosporine results in decreased expression of OPA1 protein
Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of OPA1 protein]		 CTD PMID:23347876 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083 		JBrowse link
G RAC1 Rac family small GTPase 1 affects localization EXP Cyclosporine affects the localization of RAC1 protein CTD PMID:12695417 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 decreases response to substance
multiple interactions
increases expression		 EXP SLC2A1 protein results in decreased susceptibility to Cyclosporine
Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]; Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]; Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 protein]
Cyclosporine results in increased expression of SLC2A1 mRNA; Cyclosporine results in increased expression of SLC2A1 protein		 CTD PMID:12081571 NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,535,440...168,560,867 		JBrowse link
ebselen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP4A ATPase H+/K+ transporting subunit alpha multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr 6:44,984,014...45,057,796
Ensembl chr 6:44,984,233...44,997,552 		JBrowse link
G ATP4B ATPase H+/K+ transporting subunit beta multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr11:78,780,013...78,785,143
Ensembl chr11:78,780,013...78,785,116 		JBrowse link
sirolimus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ATF6 protein] CTD PMID:37659622 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2L1 protein] CTD PMID:36754226 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G BECN1 beclin 1 multiple interactions EXP Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]] CTD PMID:34811946 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased cleavage of CASP3 protein] CTD PMID:37659622 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CLDN1 claudin 1 multiple interactions EXP Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of CLDN1 protein] CTD PMID:36754226 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657 		JBrowse link
G CLDN4 claudin 4 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in decreased expression of CLDN4 protein] CTD PMID:37659622 NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CYCS protein] CTD PMID:37659622 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G DCTN4 dynactin subunit 4 multiple interactions EXP Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA] CTD PMID:34811946 NCBI chr 2:151,681,001...151,713,923
Ensembl chr 2:151,681,003...151,783,746 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of DDIT3 protein] CTD PMID:37659622 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased phosphorylation of ERN1 protein] CTD PMID:37659622 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G FGD4 FYVE, RhoGEF and PH domain containing 4 multiple interactions EXP Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]] CTD PMID:34811946 NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028 		JBrowse link
G FIS1 fission, mitochondrial 1 multiple interactions EXP Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]] CTD PMID:34811946 NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955 		JBrowse link
G FOXO1 forkhead box O1 increases expression
affects localization		 EXP Sirolimus results in increased expression of FOXO1 mRNA; Sirolimus results in increased expression of FOXO1 protein
Sirolimus affects the localization of FOXO1 protein		 CTD PMID:20622751 NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473 		JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA] CTD PMID:34811946 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G H2AX H2A.X variant histone multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of H2AX protein] CTD PMID:37659622 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in decreased expression of HSPA5 protein] CTD PMID:37659622 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G IGF2 insulin like growth factor 2 decreases expression EXP Sirolimus results in decreased expression of IGF2 mRNA; Sirolimus results in decreased expression of IGF2 protein CTD PMID:20622751 NCBI chr 2:1,469,183...1,496,417 JBrowse link
G INS insulin multiple interactions
decreases expression		 EXP Sirolimus inhibits the reaction [Glucose results in increased secretion of INS protein]
Sirolimus results in decreased expression of INS mRNA; Sirolimus results in decreased expression of INS protein		 CTD PMID:20622751 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841 		JBrowse link
G LAMP2 lysosomal associated membrane protein 2 multiple interactions EXP Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of LAMP2 protein] CTD PMID:36754226 NCBI chr  X:98,586,718...98,623,939
Ensembl chr  X:98,556,710...98,623,940 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions EXP Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased lipidation of MAP1LC3B protein] CTD PMID:34811946 PMID:36754226 NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069 		JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased phosphorylation of MTOR protein] CTD PMID:37659622 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions EXP Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]] CTD PMID:34811946 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G NEUROD1 neuronal differentiation 1 decreases expression EXP Sirolimus results in decreased expression of NEUROD1 mRNA CTD PMID:20622751 NCBI chr15:87,175,629...87,179,953
Ensembl chr15:87,175,765...87,179,959 		JBrowse link
G OCLN occludin multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in decreased expression of OCLN protein] CTD PMID:37659622 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions EXP Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]] CTD PMID:34811946 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083 		JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 decreases expression EXP Sirolimus results in decreased expression of PDX1 mRNA CTD PMID:20622751 NCBI chr11:5,303,609...5,309,063
Ensembl chr11:5,303,609...5,309,063 		JBrowse link
G SELP selectin P multiple interactions EXP Sirolimus inhibits the reaction [Zymosan analog results in increased expression of SELP protein] CTD PMID:16797888 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,399,955 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA] CTD PMID:34811946 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G SQSTM1 sequestosome 1 multiple interactions EXP Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]] CTD PMID:34811946 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938 		JBrowse link
G TJP2 tight junction protein 2 multiple interactions EXP Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in decreased expression of TJP2 protein] CTD PMID:37659622 NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP Sirolimus inhibits the reaction [Zymosan analog results in increased expression of VCAM1 protein] CTD PMID:16797888 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222 		JBrowse link
Tanshinone I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions EXP tanshinone inhibits the reaction [AGT protein results in decreased expression of NOS3 mRNA]; tanshinone inhibits the reaction [AGT protein results in decreased expression of NOS3 protein] CTD PMID:17717927 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP tanshinone inhibits the reaction [AGT protein results in decreased expression of NOS3 mRNA]; tanshinone inhibits the reaction [AGT protein results in decreased expression of NOS3 protein] CTD PMID:17717927 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
wortmannin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] CTD PMID:16239170
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP Wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of NOS3 protein] CTD PMID:16239170 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G RPS6 ribosomal protein S6 decreases phosphorylation
multiple interactions		 EXP Wortmannin results in decreased phosphorylation of RPS6 protein
Wortmannin promotes the reaction [Ivermectin results in decreased phosphorylation of RPS6 protein]		 CTD PMID:31400776 NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Wortmannin inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 5066
    role 5030
      biological role 5030
        antimicrobial agent 257
          antiviral agent 86
            anticoronaviral agent 62
              (-)-anisomycin 0
              (1-Methylsulfonylpiperidin-4-yl) N-[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]carbamate 0
              (1R,2R,19R,22R,34S,37R,40R,52R)-2-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-(benzenesulfonamido)-5,15-dichloro-26,31,38,44,47,49,64-heptahydroxy-21,35,54,56,59-pentaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid 0
              (1R,2R,19R,22R,34S,37R,40R,52R)-2-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-[3,4-bis(butylsulfanyl)-2,5-dioxopyrrol-1-yl]-5,15-dichloro-26,31,38,44,47,49,64-heptahydroxy-21,35,54,56,59-pentaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid 0
              (1R,2R,19R,22R,34S,37R,40R,52R)-2-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-[3,4-bis(hexylsulfanyl)-2,5-dioxopyrrol-1-yl]-5,15-dichloro-26,31,38,44,47,49,64-heptahydroxy-21,35,54,56,59-pentaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid 0
              (1R,2R,19R,22R,34S,37R,40R,52R)-2-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,15-dichloro-22-(dodecylsulfonylamino)-26,31,38,44,47,49,64-heptahydroxy-21,35,54,56,59-pentaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid 0
              (1R,2R,19R,22R,34S,37R,40R,52R)-2-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,15-dichloro-22-(hexylsulfonylamino)-26,31,38,44,47,49,64-heptahydroxy-21,35,54,56,59-pentaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid 0
              (1R,2R,19R,22R,34S,37R,40R,52R)-2-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,15-dichloro-26,31,38,44,47,49,64-heptahydroxy-22-(octylsulfonylamino)-21,35,54,56,59-pentaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid 0
              (1R,2R,19R,22R,34S,37R,40R,52R)-2-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,15-dichloro-26,31,38,44,47,49,64-heptahydroxy-22-[(4-methylphenyl)sulfonylamino]-21,35,54,56,59-pentaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid 0
              (1R,2R,19R,22R,34S,37R,40R,52R)-2-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,15-dichloro-26,31,38,44,47,49,64-heptahydroxy-22-[4-[2-[2-[2-[2-[4-(octoxymethyl)triazol-1-yl]ethoxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]-21,35,54,56,59-pentaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid 0
              (1R,2R,19R,34S,37R,40R,52R)-2-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-[4-[2-[2-[2-[2-[3,4-bis(butylsulfanyl)-2,5-dioxopyrrol-1-yl]ethoxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]-5,15-dichloro-26,31,38,44,47,49,64-heptahydroxy-21,35,54,56,59-pentaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid 0
              (1R,2R,19R,34S,37R,40R,52R)-2-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-[4-[2-[2-[2-[2-[3,4-bis(hexylsulfanyl)-2,5-dioxopyrrol-1-yl]ethoxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]-5,15-dichloro-26,31,38,44,47,49,64-heptahydroxy-21,35,54,56,59-pentaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid 0
              (1R,2R,19R,34S,37R,40R,52R)-2-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-[4-[[3,4-bis(butylsulfanyl)-2,5-dioxopyrrol-1-yl]methyl]triazol-1-yl]-5,15-dichloro-26,31,38,44,47,49,64-heptahydroxy-21,35,54,56,59-pentaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid 0
              (1R,2R,19R,34S,37R,40R,52R)-2-[(2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-22-[4-[[3,4-bis(hexylsulfanyl)-2,5-dioxopyrrol-1-yl]methyl]triazol-1-yl]-5,15-dichloro-26,31,38,44,47,49,64-heptahydroxy-21,35,54,56,59-pentaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14,16,23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,62,65-henicosaene-52-carboxylic acid 0
              (1S,2R,5R,6R,7R,8R)-6-(Hydroxymethyl)-2,6,8-trimethyltricyclo[5.3.1.01,5]undecan-8-ol 0
              (2,5-Dichlorothiophen-3-yl)methyl N-(pyridin-3-ylmethyl)carbamodithioate 0
              (2E)-3-Ethyl-2-[(2Z)-2-[[3-ethyl-6-[(E)-2-phenylethenyl]-1,3-benzothiazol-3-ium-2-yl]methylidene]butylidene]-5,6-dimethyl-1,3-benzothiazole 0
              (2E)-3-Ethyl-2-[(E)-3-(3-ethyl-4,5-diphenyl-1,3-thiazol-3-ium-2-yl)prop-2-enylidene]benzo[g][1,3]benzothiazole 0
              (2E)-5-(1,3-Benzothiazol-2-yl)-2-[(E)-3-[5-(1,3-benzothiazol-2-yl)-3-ethyl-1,3-benzothiazol-3-ium-2-yl]prop-2-enylidene]-3-ethyl-1,3-benzothiazole 0
              (2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-amino-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-amino-5-oxopentanoic acid 0
              (2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-carboxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-5-amino-5-oxopentanoic acid 0
              (2Z)-3-Ethyl-2-[[(3Z)-3-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)prop-2-enylidene]-5-methylcyclohexen-1-yl]methylidene]-1,3-benzothiazole 0
              (4-Benzyl-1-methylsulfonylpiperidin-4-yl) N-[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]carbamate 0
              (4-Ethyl-2-oxochromen-7-yl) furan-2-carboxylate 0
              (4-Methoxyphenyl)-(2-methylsulfanyl-6,7-dihydro-[1,4]dioxino[2,3-f]benzimidazol-3-yl)methanone 0
              (4-Methyl-2-oxochromen-7-yl) furan-2-carboxylate 0
              (4Bs,8aS,10S)-3-methoxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenanthrene-4,10-diol 0
              (4Bs,8aS,10aR)-10a-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenanthren-3-one 0
              (5-Chloropyridin-3-yl) (3S)-2-acetyl-3,4-dihydro-1H-isoquinoline-3-carboxylate 0
              (5-Chloropyridin-3-yl) 1-(3-nitrophenyl)sulfonylindole-5-carboxylate 0
              (5-Chloropyridin-3-yl) 1-(4-methylphenyl)sulfonylindole-5-carboxylate 0
              (5-Chloropyridin-3-yl) 1-acetylindole-4-carboxylate 0
              (5-Chloropyridin-3-yl) 1-acetylindole-5-carboxylate 0
              (5-Chloropyridin-3-yl) 1H-indole-4-carboxylate 0
              (5-Chloropyridin-3-yl) 1H-indole-5-carboxylate 0
              (5-Chloropyridin-3-yl) 1H-indole-6-carboxylate 0
              (5-Chloropyridin-3-yl) 1H-indole-7-carboxylate 0
              (E)-2-[[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]benzoic acid 0
              (E)-4-Phenyl-2-(3-(thiophen-2-yl)acrylamido)thiophene-3-carboxylic acid 0
              1-(1-Benzofuran-2-ylmethyl)-5-iodoindole-2,3-dione 0
              1-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-5-ethoxy-isatin 0
              1-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-5-methoxy-isatin 0
              1-(2-Chloro-4-fluoro-benzyl)-5-iodo-1H-indole-2,3-dione 0
              1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide 0
              1-(5-Phenyl-2-pyrrolidin-1-yl-1H-pyrrol-3-yl)ethanone 0
              1-(Benzothiophen-2-ylmethyl)-5-iodo-indoline-2,3-dione 0
              1-(Chloroacetyl)-3-(1H-indol-3-yl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-4-ol 0
              1-(Chloroacetyl)-5-[4-(difluoromethoxy)-3-methoxyphenyl]-3-thien-2-yl-4,5-dihydro-1H-pyrazole 0
              1-(N-[2-(Benzotriazol-1-yl)acetyl]-4-methoxyanilino)-N-cyclopentylcyclohexane-1-carboxamide 0
              1-Benzo[b]thiophen-2-ylmethyl-5-fluoro-1H-indole-2,3-dione 0
              1-Benzo[b]thiophen-2-ylmethyl-7-bromo-1H-indole-2,3-dione 0
              1-Benzo[b]thiophen-2-ylmethyl-7-nitro-1H-indole-2,3-dione 0
              1-Benzyl-3-pyridin-3-yl-1H-pyrazole-4-carbaldehyde 0
              1-Benzyl-5-(3,5-dimethylpiperidin-1-yl)sulfonylindole-2,3-dione 0
              1-Benzyl-5-(4-methylpiperidin-1-yl)sulfonylindole-2,3-dione 0
              1-Methyl-5-(4-methylpiperidin-1-yl)sulfonylindole-2,3-dione 0
              1-Methyl-5-(4-pyridin-2-ylpiperazin-1-yl)sulfonylindole-2,3-dione 0
              1-[(3,5-Dimethyl-1,2-oxazol-4-yl)methyl]-2,3-dioxoindole-5-carbonitrile 0
              1-[2-(4-Methoxyphenyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-triazolo[4,5-c]pyridine 0
              1H-Indole-2,3-dione, 5-acetyl- 0
              2,3-Dioxoindoline-5-carboxylic acid 0
              2-(1,3-Benzodioxol-5-yl)-7-[(4-chlorophenyl)methoxy]-3,5-dihydroxychromen-4-one 0
              2-(1H-1,2,3-Benzotriazol-1-yl)-N'-(3,4,5-trimethoxybenzylidene)acetohydrazide 0
              2-(2,6-Dibromophenyl)-3-(2-thienylmethyl)thiazolidin-4-one 0
              2-(2,6-Dibromophenyl)-3-(4-methyl-6-trifluoromethylpyrimidin-2-yl)thiazolidin-4-one 0
              2-(2,6-Dichlorophenyl)-3-(2-furylmethyl)-1,3-thiazinan-4-one 0
              2-(2,6-Dichlorophenyl)-3-(2-furylmethyl)-5-methyl-thiazolidin-4-one 0
              2-(2,6-Dichlorophenyl)-3-(3-pyridylmethyl)thiazolidin-4-one 0
              2-(2,6-Dichlorophenyl)-3-(4,6-diphenylpyrimidin-2-yl)thiazolidin-4-one 0
              2-(2,6-Dichlorophenyl)-3-(4-methyl-6-phenyl-pyrimidin-2-yl)thiazolidin-4-one 0
              2-(2,6-Dichlorophenyl)-3-[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]thiazolidin-4-one 0
              2-(2,6-Dichlorophenyl)-3-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]thiazolidin-4-one 0
              2-(2,6-Dichlorophenyl)-5-methyl-3-(2-pyridyl)thiazolidin-4-one 0
              2-(2,6-Dichlorophenyl)-5-methyl-3-(3-pyridylmethyl)thiazolidin-4-one 0
              2-(2,6-Difluorophenyl)-3-(4,6-diphenylpyrimidin-2-yl)thiazolidin-4-one 0
              2-(2,6-Difluorophenyl)-3-(5-ethyl-1,3,4-thiadiazol-2-yl)thiazolidin-4-one 0
              2-(2-Chloro-6-fluoro-phenyl)-3-(2-quinolyl)thiazolidin-4-one 0
              2-(2-Chloro-6-fluoro-phenyl)-3-(4,6-diphenylpyrimidin-2-yl)thiazolidin-4-one 0
              2-(2-Chloro-6-fluoro-phenyl)-3-(4-methyl-6-phenyl-pyrimidin-2-yl)thiazolidin-4-one 0
              2-(2-Chloro-6-fluoro-phenyl)-3-[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]thiazolidin-4-one 0
              2-(3-Amino-3-oxopropyl)-3-(4-chlorobenzoyl)-2H-indazole 1-oxide 0
              2-(3-Amino-3-oxopropyl)-3-(4-methylbenzoyl)-2H-indazole 1-oxide 0
              2-(4-Dimethylaminophenyl)-3-(2-pyridyl)thiazolidin-4-one 0
              2-(4-Dimethylaminophenyl)-3-(6-methyl-2-pyridyl)thiazolidin-4-one 0
              2-(4-Fluorophenyl)-3-(2-pyridyl)thiazolidin-4-one 0
              2-(Benzenesulfonyl)-6-methoxy-3-nitropyridine 0
              2-(Benzotriazol-1-yl)-1-(4-bromophenyl)ethanone 0
              2-(Chloroacetyl)-N,2-diphenylhydrazinecarboxamide 0
              2-(N-[2-(Benzotriazol-1-yl)acetyl]-2,4,6-trimethylanilino)-N-tert-butyl-2-thiophen-3-ylacetamide 0
              2-Chloro-1-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]ethan-1-one 0
              2-Chloro-1-[3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone 0
              2-Chloro-1-[5-(3,4-dimethoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one 0
              2-Chloro-1-[5-(furan-2-yl)-3-(5-methylfuran-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one 0
              2-Methyl-5-(methylaminomethyl)-N-[(1R)-1-naphthalen-1-ylethyl]benzamide 0
              2-[(2R,3R,4R,5S,6R)-3-Acetamido-2-[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-phosphonooxypropanoic acid 0
              2-[5-[(Z)-[1-(4-Tert-butylphenyl)-5-oxo-3-phenylpyrazol-4-ylidene]methyl]furan-2-yl]-4-chlorobenzoic acid 0
              2-[5-[(Z)-[1-(4-Tert-butylphenyl)-5-oxo-3-phenylpyrazol-4-ylidene]methyl]furan-2-yl]benzoic acid 0
              2CN113 0
              2CN115 0
              3-(4-Amino-3,5-dichlorobenzoyl)-2-(3-amino-3-oxopropyl)-2H-indazole 1-oxide 0
              3-(4-Chlorophenyl)-5-(4,5-dihydro-1H-imidazol-2-ylsulfanylmethyl)-1,2,4-oxadiazole 0
              3-(6-Methylpyridin-2-yl)-2-(4-pyridin-3-ylphenyl)-1,3-thiazolidin-4-one 0
              3-Ethyl-2-[(E)-2-[(E)-(3-ethyl-5,6-dimethyl-1,3-benzothiazol-2-ylidene)methyl]but-1-enyl]benzo[g][1,3]benzothiazol-3-ium 0
              3-Pyridin-2-yl-2-(4-quinolin-4-ylphenyl)-1,3-thiazolidin-4-one 0
              3-[(4Z)-5-Oxo-3-phenyl-4-[(4-phenylphenyl)methylidene]pyrazol-1-yl]benzoic acid 0
              3-[(4Z)-5-Oxo-3-phenyl-4-[(5-phenylfuran-2-yl)methylidene]pyrazol-1-yl]benzoic acid 0
              3-[2-(3,4-Dihydroxy-phenyl)-3,5-dihydroxy-4-oxo-4H-chromen-7-yloxymethyl]-benzonitrile 0
              3-[2-[(E,3E)-3-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)-2-methoxyprop-1-enyl]-1,3-benzothiazol-3-ium-3-yl]propane-1-sulfonate 0
              3-[[2-(1,3-Benzodioxol-5-yl)-3,5-dihydroxy-4-oxochromen-7-yl]oxymethyl]benzonitrile 0
              3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-\{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl\}-L-phenylalaninamide 0
              4-(\{4-[(2,3,3-Trichloroacryloyl)oxy]phenyl\}sulfonyl)phenyl 2,3,3-trichloroacrylate 0
              4-Bromo-2-[3-(2-fluorophenyl)acryloyl]phenyl 2-furoate 0
              4-Bromo-2-[3-(2-methoxyphenyl)acryloyl]phenyl 2-furoate 0
              4-Bromoisatin 0
              4-Chloro-2-(5-methyl-1,3-dioxooctahydro-2H-isoindol-2-yl)phenyl 2-furoate 0
              4-Chloro-2-[5-[(Z)-[5-oxo-3-phenyl-1-(4-propan-2-ylphenyl)pyrazol-4-ylidene]methyl]furan-2-yl]benzoic acid 0
              4-Thiazolidinone, 2-(2,6-dichlorophenyl)-3-(2-furanylmethyl)- 0
              4-[(Z)-[1-(3-Nitrophenyl)-5-oxo-3-phenylpyrazol-4-ylidene]methyl]benzoic acid 0
              4-[(Z)-[1-(4-Cyanophenyl)-5-oxo-3-phenylpyrazol-4-ylidene]methyl]benzoic acid 0
              4-[(Z)-[1-(4-Fluorophenyl)-5-oxo-3-phenylpyrazol-4-ylidene]methyl]benzoic acid 0
              4-[4-(2,3,5,6-Tetramethylphenyl)sulfonylpiperazine-1-carbonyl]-1H-quinolin-2-one 0
              4-[4-(2,3-Dimethylphenyl)piperazine-1-carbonyl]-1H-quinolin-2-one 0
              4-[4-[3-(Trifluoromethyl)phenyl]piperazine-1-carbonyl]-1H-quinolin-2-one 0
              5-(2,4-Difluorophenyl)-N-[2-(2-fluorophenyl)-4-oxo-1,3-thiazolidin-3-yl]-2-hydroxybenzamide 0
              5-(2-Methylpiperidin-1-yl)sulfonyl-1H-indole-2,3-dione 0
              5-(3,5-Dimethylpiperidin-1-yl)sulfonyl-1-methylindole-2,3-dione 0
              5-(3,5-Dimethylpiperidin-1-yl)sulfonyl-1H-indole-2,3-dione 0
              5-(4-Chloro-benzenesulfonyl)-pyrimidine-2,4-diamine 0
              5-(4-Methylpiperazin-1-yl)sulfonyl-1H-indole-2,3-dione 0
              5-(Aminomethyl)-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide 0
              5-(Piperidin-1-ylsulfonyl)-1H-indole-2,3-dione 0
              5-Bromoisatin 0
              5-Bromopyridin-3-yl furan-2-carboxylate 0
              5-Chloro-1H-indole-2,3-dione 0
              5-Chloro-3-pyridinyl 2-furoate 0
              5-Chloropyridin-3-yl 1H-indole-2-carboxylate 0
              5-Chloropyridin-3-yl 3-methoxybenzoate 0
              5-Chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate 0
              5-Chloropyridin-3-yl benzo[b]thiophene-2-carboxylate 0
              5-Chloropyridin-3-yl benzofuran-2-carboxylate 0
              5-Chloropyridin-3-yl thiazole-4-carboxylate 0
              5-Fluoroisatin 0
              5-Iodo-1-(naphthalen-2-ylmethyl)indoline-2,3-dione 0
              5-Iodoisatin 0
              5-Methoxyisatin 0
              5-Nitroisatin 0
              7-(3-Chloro-benzyloxy)-2-(3,4-dihydroxy-phenyl)-3,5-dihydroxy-chromen-4-one 0
              7-(4-Chloro-benzyloxy)-2-(3,4-dihydroxy-phenyl)-3,5-dihydroxy-chromen-4-one 0
              8-(Trifluoromethyl)-9H-purin-6-amine 0
              8-Benzyl-4-pyridin-2-yl-1-thia-4,8-diazaspiro[4.5]decan-3-one 0
              Alisporivir 0
              Benzotriazol-1-yl 1H-indole-5-carboxylate 0
              Benzyl (2S)-2-[[[(E)-4-(5-chloro-2,4-dioxopyrimidin-1-yl)but-2-enyl]-phenoxyphosphoryl]amino]propanoate 0
              Benzyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(1S)-4-amino-1-cyano-4-oxobutyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]carbamate 0
              Benzyl N-[(2S)-1-[[(2S)-1-[[(2S)-3,4-dioxo-1-[(3S)-2-oxopyrrolidin-3-yl]-4-(propan-2-ylamino)butan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-naphthalen-1-yl-1-oxopropan-2-yl]carbamate 0
              Benzyl N-[(2S)-1-[[(2S)-3-cyclohexyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]carbamate 0
              Benzyl N-[(2S)-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-3-naphthalen-1-yl-1-oxopropan-2-yl]carbamate 0
              Benzyl N-[(2S)-1-[[6-(dimethylamino)-1-fluoro-2,6-dioxohexan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate 0
              Benzyl N-[(2S)-1-[[6-(dimethylamino)-1-fluoro-2,6-dioxohexan-3-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamate 0
              Benzyl N-[(2S)-1-[[6-(dimethylamino)-1-fluoro-2,6-dioxohexan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate 0
              Benzyl N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]-1-(1,3-thiazol-2-yl)propan-2-yl]amino]pentan-2-yl]amino]-1-oxobutan-2-yl]carbamate 0
              Betulonic acid 0
              CHEMBL1465537 0
              CHEMBL242491 0
              CHEMBL492571 0
              CID 2131972 0
              CID 3191469 0
              CID 3192987 0
              CID 3198732 0
              CID 3206295 0
              Cryptotanshinone 0
              Cyclopent[f]indole-2,3-dione, 1,5,6,7-tetrahydro- 0
              Dihydrotanshinone I 0
              Ethyl (2S,3S)-3-[[2-oxo-2-[(2-oxo-2-phenylmethoxyethyl)amino]ethyl]carbamoyl]aziridine-2-carboxylate 0
              Ethyl (E,4S)-4-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-3-phenylpropanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate 0
              Ethyl (E,4S)-4-[[(2S)-4-methyl-2-[[(2S)-3-[(2-methylpropan-2-yl)oxy]-2-(phenylmethoxycarbonylamino)butanoyl]amino]pentanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate 0
              Ethyl (E,4S)-4-[[(2S)-4-methyl-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]pentanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate 0
              Ethyl 1-[(3,4-dichlorophenyl)methyl]-7-[(4-fluorophenyl)methyl]-5-phenyl-4,6-dihydrotriazolo[4,5-c]pyridine-7-carboxylate 0
              Ethyl 2-[4-[(7-chloroquinolin-4-yl)amino]butylamino]-4-methyl-6-(2-nitrophenyl)pyrimidine-5-carboxylate 0
              Ethyl 4-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]carbamoyloxy]piperidine-1-carboxylate 0
              Ethyl 7-benzyl-1-[(4-fluorophenyl)methyl]-5-phenyl-4,6-dihydrotriazolo[4,5-c]pyridine-7-carboxylate 0
              Ethyl 7-benzyl-1-[2-(1H-indol-2-yl)ethyl]-5-phenyl-4,6-dihydrotriazolo[4,5-c]pyridine-7-carboxylate 0
              Fluphenazine hydrochloride 0
              GRL-0617 + 0
              GS-441524 + 0
              GS-441524 monophosphate 0
              GS-443902 0
              Hydron 0
              KOM70144 0
              Kaletra 0
              Methyl 2-[3-[(7-chloro-4-quinolyl)amino]propylamino]-4-methyl-6-phenyl-pyrimidine-5-carboxylate 0
              Methyl tanshinonate 0
              Mizoribine 0
              N(4)-hydroxycytidine + 0
              N-(1,3-Benzodioxol-5-Ylmethyl)-1-[(1r)-1-Naphthalen-1-Ylethyl]piperidine-4-Carboxamide 0
              N-(1,3-Benzodioxol-5-ylmethyl)-1-[(1S)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide 0
              N-(2-aminoethyl)-1-aziridine-ethanamine 0
              N-(3,5-Dichlorophenyl)-2-[4-(2-phenyl-1,3-thiazol-4-yl)pyrimidin-2-yl]sulfanylacetamide 0
              N-(3-Methyl-4-nitro-1,2-oxazol-5-yl)-5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]thiophene-2-carboxamide 0
              N-(4-Butan-2-ylphenyl)-N-[2-(cyclopentylamino)-2-oxo-1-pyridin-3-ylethyl]furan-2-carboxamide 0
              N-(4-Nitro-1,2,5-oxadiazol-3-yl)-2-pyridin-2-ylsulfanylacetamide 0
              N-(4-\{[(1H-benzotriazol-1-yl)acetyl][(thiophen-3-yl)methyl]amino\}phenyl)propanamide 0
              N-(tert-butoxycarbonyl)-L-seryl-L-valyl-N-\{(2S,3E)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl\}-L-leucinamide 0
              N-Cyclopentyl-2-(N-methyl3-chlorobenzenesulfonamido)acetamide 0
              N-[(2-Methoxypyridin-4-yl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide 0
              N-[(2S)-3-cyclohexyl-1-oxo-1-(\{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl\}amino)propan-2-yl]-1H-indole-2-carboxamide 0
              N-[(3-Acetamidophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide 0
              N-[(3-Fluorophenyl)methyl]-1-[(1r)-1-Naphthalen-1-Ylethyl]piperidine-4-Carboxamide 0
              N-[(3-Methoxyphenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide 0
              N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N-\{(2S,3E)-5-(benzyloxy)-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl\}-L-leucinamide 0
              N-[2-(2-Methoxyphenoxy)ethyl]-2-oxo-1H-quinoline-4-carboxamide 0
              N-[2-(Cyclopentylamino)-2-oxo-1-pyridin-3-ylethyl]-N-(4-propan-2-ylphenyl)furan-2-carboxamide 0
              N-[5-Bromo-1-(2-morpholin-4-ylethyl)-2-oxo-3H-indol-3-yl]acetamide 0
              N-[5-Ethyl-1-(2-morpholin-4-ylethyl)-2-oxo-3H-indol-3-yl]acetamide 0
              N-[5-Fluoro-1-(2-morpholin-4-ylethyl)-2-oxo-3H-indol-3-yl]acetamide 0
              N-\{4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl\}-2-methylpropanamide 0
              N-ethylmaleimide 0
              Nutlin-3 0
              PB28 0
              PF-00835231 + 0
              PF-07304814 0
              Paxlovid 0
              Pinusolidic acid 0
              Piperidine, 1-[(2,3-dihydro-2,3-dioxo-1H-indol-5-yl)sulfonyl]-4-methyl- 0
              Pyridin-3-yl thiophene-2-carboxylate 0
              Pyrvinium pamoate 0
              SG85 0
              Sodium 0
              Sodium 0
              Sodium 0
              Sodium 0
              Sodium 0
              Sodium 0
              Tanshinone I 2
              Tert-butyl 4-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]carbamoyloxy]piperidine-1-carboxylate 0
              Tert-butyl 4-benzyl-4-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]carbamoyloxy]piperidine-1-carboxylate 0
              Tert-butyl 4-ethyl-4-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]carbamoyloxy]piperidine-1-carboxylate 0
              Thiothixene 0
              Toremifene citrate 0
              [(2R,3R,4S,5R,6R)-3,4,5-Triacetyloxy-6-[4-(4-chlorophenyl)-3-cyano-2-oxo-6-pyridin-2-ylpyridin-1-yl]oxan-2-yl]methyl acetate 0
              [(2S,4As,10aR)-6-acetyloxy-1,1,4a-trimethyl-7-propan-2-yl-2,3,4,10a-tetrahydrophenanthren-2-yl] acetate 0
              aloxistatin 0
              amodiaquine + 0
              amodiaquine hydrochloride 0
              anacardic acid 0
              astemizole 0
              baicalein + 0
              baicalin 0
              benzatropine mesylate 0
              brequinar 0
              brequinar sodium 0
              camostat 0
              camostat mesylate 0
              chloroquine + 14
              chlorphenoxamine 0
              chlorpromazine + 2
              chlorpromazine hydrochloride 0
              cinanserin 0
              cinanserin hydrochloride 0
              clomipramine 0
              clomipramine hydrochloride 0
              cycloheximide 4
              cyclosporin A + 10
              dabrafenib + 0
              dasatinib (anhydrous) + 0
              dothiepin + 0
              ebselen 2
              emetine + 0
              emetine dihydrochloride + 0
              emetine dihydrochloride hydrate 0
              everolimus 0
              favipiravir + 0
              favipiravir-RTP 0
              fluphenazine + 0
              gemcitabine hydrochloride 0
              hydroxychloroquine 0
              hydroxyzine + 0
              imatinib methanesulfonate 0
              liquiritin 0
              loperamide 0
              loperamide hydrochloride 0
              lopinavir + 0
              lycorine 0
              mefloquine 0
              mefuparib 0
              mefuparib hydrochloride 0
              mercaptopurine + 0
              methotrimeprazine 0
              miltefosine 0
              molnupiravir 0
              mycophenolate mofetil 0
              mycophenolic acid + 0
              narlaprevir 0
              niclosamide 0
              nilotinib 0
              nirmatrelvir + 0
              omacetaxine mepesuccinate 0
              omipalisib 0
              phenazopyridine 0
              plitidepsin 0
              promethazine 0
              promethazine hydrochloride 0
              rac5c 0
              remdesivir 0
              ribavirin + 0
              saracatinib 0
              savinin 0
              selumetinib 0
              sirolimus + 31
              sorafenib + 0
              sotrastaurin 0
              tamoxifen citrate 0
              terconazole 0
              tert-butyl N-\{1-[(1S)-1-\{[(1R,2S)-1-(benzylcarbamoyl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl\}-2-cyclopropylethyl]-2-oxopyridin-3-yl\}carbamate 0
              theasinensin A 0
              thiethylperazine maleate 0
              tioguanine + 0
              trametinib + 0
              triflupromazine + 0
              triflupromazine hydrochloride 0
              triparanol 0
              wortmannin + 5
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