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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-iodo-2'-deoxyuridine
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Accession:CHEBI:147675 term browser browse the term
Definition:A pyrimidine 2'-deoxyribonucleoside compound having 5-iodouracil as the nucleobase; used as an antiviral agent.
Synonyms:related_synonym: 1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil;   1-beta-D-2'-Deoxyribofuranosyl-5-iodouracil;   1beta-D-2'-Deoxyribofuranosyl-5-iodouracil;   2'-Deoxy-5-iodouridine;   5-Iododeoxyuridine;   5-Iodouracil deoxyriboside;   Formula=C9H11IN2O5;   IdU;   Idoxuridin;   Idoxuridinum;   InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1;   InChIKey=XQFRJNBWHJMXHO-RRKCRQDMSA-N;   Iododeoxyridine;   Iodoxuridine;   Joddeoxiuridin;   SMILES=OC[C@H]1O[C@H](C[C@@H]1O)n1cc(I)c(=O)[nH]c1=O;   idoxuridina;   idoxuridine
 alt_id: CHEBI:43233;   CHEBI:5863
 xref: CAS:54-42-2;   DrugBank:DB03778;   Drug_Central:1417;   LINCS:LSM-5836
 xref_mesh: MESH:D007065
 xref: PMID:17341060;   PMID:17438061;   PMID:18555978;   PMID:3950402;   Reaxys:30397


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5-iodo-2'-deoxyuridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase affects response to substance ISO MBD4 protein affects the susceptibility to Idoxuridine CTD PMID:16885370 NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Idoxuridine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions EXP Idoxuridine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine] CTD PMID:8713072 NCBI chr 1:135,079,375...135,122,791
Ensembl chr 1:135,081,385...135,122,464
JBrowse link
G Tyms thymidylate synthetase affects uptake ISO TYMS protein affects the uptake of Idoxuridine CTD PMID:15001691 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          antiviral agent 10293
            antiviral drug 1862
              5-iodo-2'-deoxyuridine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            heteroorganic entity 19294
                              organochalcogen compound 19064
                                organooxygen compound 19014
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11947
                                        glycosyl compound 10977
                                          N-glycosyl compound 5514
                                            nucleoside 5375
                                              deoxyribonucleoside 2736
                                                2'-deoxyribonucleoside 2218
                                                  pyrimidine 2'-deoxyribonucleoside 340
                                                    5-iodo-2'-deoxyuridine 4
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