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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tideglusib
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Accession:CHEBI:147398 term browser browse the term
Definition:A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy.
Synonyms:exact_synonym: 4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
 related_synonym: Formula=C19H14N2O2S;   InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2;   InChIKey=PMJIHLSCWIDGMD-UHFFFAOYSA-N;   NP-031112;   NP-12;   NP031112;   Nypta;   SMILES=O=C1N(C=2C3=C(C=CC=C3)C=CC2)SC(=O)N1CC4=CC=CC=C4;   Zentylor;   tideglusibum
 xref: CAS:865854-05-3;   DrugBank:DB12129
 xref_mesh: MESH:C520571
 xref: PMID:17522320;   PMID:22936007;   PMID:24488721;   PMID:24532007;   PMID:25537011;   PMID:26289787;   PMID:26398371;   PMID:27378458;   PMID:27490211;   PMID:28982059;   PMID:29388174;   PMID:29431064;   PMID:29603837;   PMID:30574063;   PMID:30666199;   PMID:30965670;   PMID:31156177;   PMID:32195836;   Wikipedia:Tideglusib



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tideglusib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3b glycogen synthase kinase 3 beta increases expression
decreases activity
ISO tideglusib results in increased expression of GSK3B protein modified form
tideglusib results in decreased activity of GSK3B protein
CTD PMID:30965670 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 mRNA]]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 mRNA]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA] CTD PMID:30965670 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 mRNA]]; NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]]; NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 mRNA]; tideglusib promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 mRNA] CTD PMID:30965670 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]]; NFE2L2 protein promotes the reaction [tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]; tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NQO1 mRNA] CTD PMID:30965670 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO tideglusib inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of PPARG protein] CTD PMID:30965670 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link

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  CHEBI ontology 20089
    role 20042
      application 19781
        anti-inflammatory agent 16481
          tideglusib 5
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  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                carbocyclic compound 18542
                                  carbopolycyclic compound 17152
                                    carbobicyclic compound 5866
                                      naphthalenes 3817
                                        tideglusib 5
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