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ONTOLOGY REPORT - ANNOTATIONS


Term:GS-441524
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Accession:CHEBI:147281 term browser browse the term
Definition:A C-nucleoside analog that is (2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile substituted by a 4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl group at position 2. It is the active metabolite of remdesivir and exhibits a broad range of inhibitory activity against various RNA viruses including HCV, parainfluenza and SARS-CoV.
Synonyms:exact_synonym: (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
 related_synonym: EVO-984;   EVO984;   Formula=C12H13N5O4;   GS441524;   InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1;   InChIKey=BRDWIEOJOWJCLU-LTGWCKQJSA-N;   SMILES=[C@]1(O[C@@H]([C@H]([C@H]1O)O)CO)(C#N)C=2N3N=CN=C(C3=CC2)N
 xref: CAS:1191237-69-0;   PMID:22446091;   PMID:28124907;   PMID:29778200;   PMID:30755068


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remdesivir term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:30309211
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:30309211
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:30309211
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:30309211
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:30309211

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      biological role 19726
        antimicrobial agent 17315
          antiviral agent 10235
            GS-441524 5
              GS-441524 monophosphate 0
              GS-443902 0
              remdesivir 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    p-block element atom 19664
                      carbon group element atom 19559
                        carbon atom 19548
                          organic molecular entity 19548
                            heteroorganic entity 19145
                              organochalcogen compound 18846
                                organooxygen compound 18764
                                  carbohydrates and carbohydrate derivatives 12165
                                    carbohydrate 12165
                                      carbohydrate derivative 11790
                                        glycosyl compound 10827
                                          C-glycosyl compound 232
                                            C-nucleoside 5
                                              GS-441524 5
                                                GS-441524 monophosphate 0
                                                GS-443902 0
                                                remdesivir 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.