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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:HU-308
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Accession:CHEBI:146244 term browser browse the term
Definition:A carbobicyclic compound that is bicyclo[3.1.1]hept-2-ene which is substituted by a hydroxymethyl group at position 2, a 2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl group at position 4, and two methyl groups at position 6 (the 1S,4S,5S stereoisomer). A highly selective and effective cannabinoid type-2 agonist and the enantiomer of HU-433.
Synonyms:related_synonym: (+)-{(1S,4S,5S)-4-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl}methanol;   Formula=C27H42O3;   HU308;   InChI=1S/C27H42O3/c1-8-9-10-11-12-26(2,3)19-14-23(29-6)25(24(15-19)30-7)20-13-18(17-28)21-16-22(20)27(21,4)5/h13-15,20-22,28H,8-12,16-17H2,1-7H3/t20-,21+,22-/m0/s1;   InChIKey=CFMRIVODIXTERW-BDTNDASRSA-N;   SMILES=[C@@H]1(C=C([C@@H]2C([C@H]1C2)(C)C)CO)C=3C(=CC(=CC3OC)C(CCCCCC)(C)C)OC
 xref_mesh: MESH:C402416
 xref: PMID:10588688;   PMID:17652447;   PMID:21542549;   PMID:26124120;   PMID:26846967;   PMID:29450258;   PMID:30372893;   Wikipedia:HU-308


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HU-308 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 multiple interactions EXP HU 308 promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of ARG1 mRNA] CTD PMID:29560022 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO ATG5 protein affects the reaction [HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]]; ATG5 protein affects the reaction [HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]] CTD PMID:27611972 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Becn1 beclin 1 multiple interactions ISO [HU 308 co-treated with Dextran Sulfate] affects the expression of BECN1 protein; HU 308 inhibits the reaction [Glucose results in decreased expression of BECN1 protein]; HU 308 inhibits the reaction [Streptozocin results in decreased expression of BECN1 protein]; HU 308 promotes the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased expression of BECN1 protein] CTD PMID:27611972 PMID:30459625 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp1 caspase 1 multiple interactions ISO 3-methyladenine affects the reaction [[HU 308 co-treated with Dextran Sulfate] affects the cleavage of CASP1 protein]; [HU 308 co-treated with Dextran Sulfate] affects the cleavage of CASP1 protein; ATG5 protein affects the reaction [HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]]; dorsomorphin inhibits the reaction [HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]]; HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein] CTD PMID:27611972 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of CD68 protein] CTD PMID:29560022 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Chi3l3 chitinase 3-like 3 multiple interactions EXP HU 308 promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of CHI3L3 mRNA] CTD PMID:29560022 NCBI chr 2:208,899,871...208,936,858
Ensembl chr 2:208,900,103...208,936,860
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions EXP
ISO
HU 308 promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of CNR2 mRNA]; HU 308 promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of CNR2 protein]
[HU 308 co-treated with lipopolysaccharide, E. coli O26-B6] results in increased expression of CNR2 mRNA; HU 308 binds to and results in increased activity of CNR2 protein
CTD PMID:27194477 PMID:29560022 PMID:30232034 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
HU 308 promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL10 protein]
HU 308 promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL10 mRNA]
CTD PMID:29560022 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B mRNA]
3-methyladenine affects the reaction [[HU 308 co-treated with Dextran Sulfate] affects the expression of IL1B protein]; [HU 308 co-treated with Dextran Sulfate] affects the expression of IL1B protein; ATG5 protein affects the reaction [HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]]; dorsomorphin inhibits the reaction [HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]]; HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein]; HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL1B protein]; HU 308 inhibits the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]
CTD PMID:27611972 PMID:29560022 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL6 mRNA]
HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL6 protein]
CTD PMID:29560022 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions EXP HU 308 promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of MRC1 protein] CTD PMID:29560022 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP
ISO
HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased phosphorylation of MTOR protein]
HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased phosphorylation of MTOR protein]; HU 308 inhibits the reaction [Glucose results in increased phosphorylation of MTOR protein]
CTD PMID:29560022 PMID:30459625 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO
HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased phosphorylation of NFKBIA protein] CTD PMID:29560022 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO [HU 308 co-treated with Dextran Sulfate] affects the expression of NLRP3 protein CTD PMID:27611972 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of NOS2 protein] CTD PMID:29560022 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP HU 308 promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased phosphorylation of PIK3R1 protein] CTD PMID:29560022 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO HU 308 inhibits the reaction [Glucose results in increased phosphorylation of RPS6KB1 protein] CTD PMID:30459625 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [HU 308 co-treated with Dextran Sulfate] affects the expression of SQSTM1 protein; HU 308 inhibits the reaction [Glucose results in increased expression of SQSTM1 protein]; HU 308 inhibits the reaction [Streptozocin results in increased expression of SQSTM1 protein]; HU 308 promotes the reaction [[Dextran Sulfate co-treated with Lipopolysaccharides] results in decreased expression of SQSTM1 protein] CTD PMID:27611972 PMID:30459625 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
HU 308 promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of TGFB1 mRNA]
HU 308 promotes the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of TGFB1 protein]
CTD PMID:29560022 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of TNF mRNA]
HU 308 inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of TNF protein]
CTD PMID:29560022 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

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  CHEBI ontology 19770
    role 19720
      application 19411
        anti-inflammatory agent 15758
          HU-308 20
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  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      chalcogen 19391
                        oxygen atom 19354
                          oxygen molecular entity 19354
                            hydroxides 19077
                              organic hydroxy compound 18656
                                alcohol 15010
                                  allylic alcohol 954
                                    primary allylic alcohol 666
                                      HU-308 20
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