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ONTOLOGY REPORT - ANNOTATIONS


Term:palytoxin
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Accession:CHEBI:146207 term browser browse the term
Definition:A polyol marine coelenterate toxin composed of substituted N-3-hydroxypropyl-trans-3-amidoacrylamides and produced by species of Palythoa and Zoanthus soft corals (collectively called zoantharians), either as a defence mechanism or to assist them in capturing prey. An ionophore that forms cation channels through Na+/K+-ATPase, it is a potent vasoconstrictor useful in evaluation of anti-angina agents. It is considered to be one of the most poisonous non-protein substances known, second only to maitotoxin in terms of toxicity in mice.
Synonyms:exact_synonym: (2S,3R,5R,6E,8R,9S)-10-[(2R,3R,4R,5S,6R)-6-{(1S,2R,3S,4S,5R,11S)-12-[(1R,3S,5S,7R)-5-{(8S)-9-[(2R,3R,4R,5R,6S)-6-{(2S,3S,4E,6S,9R,10R)-10-[(2S,4R,5S,6R)-6-{(2R,3R)-4-[(2R,3S,4R,5R,6S)-6-{(2S,3Z,5E,8R,9S,10R,12Z,17S,18R,19R,20R)-21-[(2R,3R,4R,5S,6R)-6-{(1Z,3R,4R)-5-[(1S,3R,5R,7R)-7-{2-[(2R,3R,5S)-5-(aminomethyl)-3-hydroxytetrahydrofuran-2-yl]ethyl}-2,6-dioxabicyclo[3.2.1]octan-3-yl]-3,4-dihydroxypent-1-en-1-yl}-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]-2,8,9,10,17,18,19-heptahydroxy-20-methyl-14-methylenehenicosa-3,5,12-trien-1-yl}-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]-2,3-dihydroxybutyl}-4,5-dihydroxytetrahydro-2H-pyran-2-yl]-2,6,9,10-tetrahydroxy-3-methyldec-4-en-1-yl}-3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-yl]-8-hydroxynonyl}-1,3-dimethyl-6,8-dioxabicyclo[3.2.1]octan-7-yl]-1,2,3,4,5-pentahydroxy-11-methyldodecyl}-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]-2,5,8,9-tetrahydroxy-N-{(1E)-3-[(3-hydroxypropyl)amino]-3-oxoprop-1-en-1-yl}-3,7-dimethyldec-6-enamide
 related_synonym: (2S,3R,5R,6E,8R,9S)-10-[(2R,3R,4R,5S,6R)-6-[(1S,2R,3S,4S,5R,11S)-11-{[(1R,3S,5S,7R)-5-[(8S)-9-[(2R,3R,4R,5R,6S)-6-[(2S,3S,4E,6S,9R,10R)-10-[(2S,4R,5S,6R)-6-[(2R,3R)-4-[(2R,3S,4R,5R,6S)-6-[(2S,3Z,5E,8R,9S,10R,12Z,17S,18R,19R,20R)-20-{[(2R,3R,4R,5S,6R)-6-[(1Z,3R,4R)-5-[(1S,3R,5R,7R)-7-{2-[(2R,3R,5S)-5-(aminomethyl)-3-hydroxyoxolan-2-yl]ethyl}-2,6-dioxabicyclo[3.2.1]octan-3-yl]-3,4-dihydroxypent-1-en-1-yl]-3,4,5-trihydroxyoxan-2-yl]methyl}-2,8,9,10,17,18,19-heptahydroxy-14-methylidenehenicosa-3,5,12-trien-1-yl]-3,4,5-trihydroxyoxan-2-yl]-2,3-dihydroxybutyl]-4,5-dihydroxyoxan-2-yl]-2,6,9,10-tetrahydroxy-3-methyldec-4-en-1-yl]-3,4,5,6-tetrahydroxyoxan-2-yl]-8-hydroxynonyl]-1,3-dimethyl-6,8-dioxabicyclo[3.2.1]octan-7-yl]methyl}-1,2,3,4,5-pentahydroxydodecyl]-3,4,5-trihydroxyoxan-2-yl]-2,5,8,9-tetrahydroxy-N-[(1E)-2-[(3-hydroxypropyl)-C-hydroxycarbonimidoyl]eth-1-en-1-yl]-3,7-dimethyldec-6-enimidic acid;   Formula=C129H223N3O54;   InChI=1S/C129H223N3O54/c1-62(29-33-81(143)108(158)103(153)68(7)47-93-111(161)117(167)110(160)91(180-93)36-35-76(138)82(144)51-73-50-74-53-92(178-73)90(177-74)38-37-89-85(147)52-75(61-130)179-89)23-20-28-78(140)105(155)77(139)26-18-13-16-25-70(135)48-94-112(162)118(168)113(163)97(181-94)55-84(146)83(145)54-95-107(157)87(149)57-96(182-95)106(156)80(142)34-32-69(134)31-30-65(4)88(150)60-129(176)125(174)123(173)115(165)99(184-129)49-71(136)24-15-10-9-11-19-40-128-59-64(3)58-127(8,186-128)100(185-128)44-63(2)22-14-12-17-27-79(141)109(159)116(166)120(170)122(172)124-121(171)119(169)114(164)98(183-124)56-86(148)102(152)66(5)45-72(137)46-67(6)104(154)126(175)132-42-39-101(151)131-41-21-43-133/h13,16,18,20,23,25,30-31,35-36,39,42,45,63-65,67-100,102-125,133-150,152-174,176H,1,9-12,14-15,17,19,21-22,24,26-29,32-34,37-38,40-41,43-44,46-61,130H2,2-8H3,(H,131,151)(H,132,175)/b18-13+,23-20-,25-16-,31-30+,36-35-,42-39+,66-45+/t63-,64-,65-,67+,68+,69+,70+,71-,72-,73-,74+,75-,76+,77+,78+,79+,80+,81-,82+,83+,84+,85+,86-,87+,88-,89+,90+,91+,92-,93+,94-,95+,96-,97+,98+,99+,100+,102+,103+,104-,105-,106+,107-,108+,109-,110+,111-,112-,113+,114-,115-,116-,117-,118+,119+,120+,121-,122-,123+,124-,125+,127+,128-,129-/m0/s1;   InChIKey=CWODDUGJZSCNGB-HQNRRURTSA-N;   PLTX;   PTX;   SMILES=[C@H]1([C@@H](C[C@H](O1)CN)O)CC[C@@H]2[C@H]3O[C@@H](C[C@@H](O2)C3)C[C@H]([C@H](O)/C=C\\[C@H]4O[C@@H]([C@@H]([C@H]([C@@H]4O)O)O)C[C@H]([C@@H](O)[C@H](O)[C@H](CCC(/C=C\\C[C@H]([C@@H](O)[C@@H](C/C=C/C=C\\[C@@H](O)C[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)C[C@H]([C@@H](C[C@@H]6[C@H]([C@@H](C[C@](O6)([C@@H]([C@H](O)CC[C@@H](\\C=C\\[C@@H]([C@H](C[C@@]7(O)[C@@H]([C@@H]([C@H]([C@@H](C[C@H](CCCCCCC[C@]89C[C@H](C[C@]([C@H](O8)C[C@H](CCCCC[C@@H](O)[C@@H]([C@@H]([C@H]([C@@H]([C@@]%10([C@H]([C@@H]([C@H]([C@H](O%10)C[C@@H]([C@@H](\\C(=C\\[C@@H](C[C@H]([C@@H](C(N\\C=C\\C(NCCCO)=O)=O)O)C)O)\\C)O)O)O)O)O)[H])O)O)O)O)C)(O9)C)C)O)O7)O)O)O)O)C)O)O)[H])O)O)O)O)O)O)O)O)O)=C)O)C)O
 xref: CAS:11077-03-5;   CAS:77734-91-9
 xref_mesh: MESH:C010272
 xref: PMID:1354900;   PMID:23442788;   PMID:26489638;   PMID:26587298;   PMID:26861356;   PMID:27129894;   PMID:27343702;   PMID:27793603;   PMID:27816587;   PMID:27843763;   PMID:28648045;   PMID:28843098;   PMID:29110038;   PMID:29611245;   PMID:29657808;   PMID:29902540;   PMID:30090423;   PMID:30110919;   PMID:30475097;   PMID:30528507;   PMID:30558165;   PMID:30956217;   PMID:31664144;   PMID:32056831


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palytoxin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abi1 abl-interactor 1 JBrowse link 17 89,951,662 90,033,334 RGD:6480464
G Angpt2 angiopoietin 2 JBrowse link 16 75,966,480 76,016,147 RGD:6480464
G Ca13 carbonic anhydrase 13 JBrowse link 2 88,282,961 88,314,254 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6480464
G Cybb cytochrome b-245 beta chain JBrowse link X 14,578,330 14,610,049 RGD:6480464
G Egr2 early growth response 2 JBrowse link 20 22,452,170 22,461,018 RGD:6480464
G Fam78b family with sequence similarity 78, member B JBrowse link 13 85,110,536 85,233,243 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Fosl1 FOS like 1, AP-1 transcription factor subunit JBrowse link 1 220,826,560 220,835,066 RGD:6480464
G Gpr12 G protein-coupled receptor 12 JBrowse link 12 10,253,710 10,257,135 RGD:6480464
G Hells helicase, lymphoid specific JBrowse link 1 257,901,856 257,953,889 RGD:6480464
G Il1rl1 interleukin 1 receptor-like 1 JBrowse link 9 47,133,483 47,184,316 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Lgi1 leucine-rich, glioma inactivated 1 JBrowse link 1 256,955,944 256,996,835 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:6480464
G Mcm3 minichromosome maintenance complex component 3 JBrowse link 9 26,914,057 26,932,201 RGD:6480464
G Megf10 multiple EGF-like domains 10 JBrowse link 18 52,215,652 52,366,212 RGD:6480464
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Nup54 nucleoporin 54 JBrowse link 14 17,123,434 17,141,832 RGD:6480464
G Orm1 orosomucoid 1 JBrowse link 5 79,179,668 79,182,820 RGD:6480464
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6480464
G Prkg2 protein kinase cGMP-dependent 2 JBrowse link 14 12,217,121 12,313,616 RGD:6480464
G Rad51ap1 RAD51 associated protein 1 JBrowse link 4 159,469,803 159,482,869 RGD:6480464
G Rif1 replication timing regulatory factor 1 JBrowse link 3 37,599,540 37,648,818 RGD:6480464
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6480464
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      biological role 19716
        poison 17974
          toxin 13894
            palytoxin 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      chalcogen 19356
                        oxygen atom 19319
                          oxygen molecular entity 19319
                            hydroxides 19063
                              organic hydroxy compound 18626
                                polyol 7782
                                  palytoxin 32
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.