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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-acetyldeoxynivalenol
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Accession:CHEBI:146195 term browser browse the term
Definition:A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-3. A skin and eye irritant, along with its 15-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.
Synonyms:exact_synonym: 7alpha,15-dihydroxy-8-oxo-12,13-epoxytrichothec-9-en-3alpha-yl acetate
 related_synonym: (3alpha,7alpha)-3-(acetyloxy)-12,13-epoxy-7,15-dihydroxytrichothec-9-en-8-one;   15-ADON;   3-(acetyloxy)-12,13-epoxy-7alpha,15alpha-dihydroxytrichothec-9-en-8-one;   3-acetyl-DON;   3-acetyl-deoxynivalenol;   Formula=C17H22O7;   InChI=1S/C17H22O7/c1-8-4-11-16(6-18,13(21)12(8)20)15(3)5-10(23-9(2)19)14(24-11)17(15)7-22-17/h4,10-11,13-14,18,21H,5-7H2,1-3H3/t10-,11-,13-,14-,15-,16-,17-/m1/s1;   InChIKey=ADFIQZBYNGPCGY-HTJQZXIKSA-N;   SMILES=[H][C@@]12O[C@]3([H])C=C(C)C(=O)[C@@H](O)[C@]3(CO)[C@@](C)(C[C@H]1OC(C)=O)[C@]21CO1
 xref: AGR:IND45257683;   CAS:50722-38-8;   FooDB:FDB014986;   HMDB:HMDB0036137
 xref_mesh: MESH:C043247
 xref: MetaCyc:CPD-18419;   PMID:11510664;   PMID:14620907;   PMID:16521158;   PMID:21204935;   PMID:22016651;   PMID:22367943;   PMID:22465835;   PMID:22997060;   PMID:23025486;   PMID:23470877;   PMID:23605932;   PMID:23792671;   PMID:24385417;   PMID:25772259;   PMID:26274975;   PMID:26343882;   PMID:27131905;   PMID:27483321;   PMID:29914486;   PMID:30806951;   PMID:31442898;   PMID:32454357


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3-acetyldeoxynivalenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases activity
multiple interactions
ISO 3-acetyldeoxynivalenol results in decreased activity of AR protein
[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of AR protein; [15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol] results in decreased activity of AR protein
CTD PMID:27481073 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO 3-acetyldeoxynivalenol results in increased expression of ATF6 mRNA CTD PMID:20682335 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Cck cholecystokinin increases expression ISO 3-acetyldeoxynivalenol results in increased expression of CCK protein CTD PMID:24385417 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 3-acetyldeoxynivalenol results in increased expression of CCL2 mRNA CTD PMID:24793808 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO 3-acetyldeoxynivalenol results in increased expression of CCL7 mRNA CTD PMID:24793808 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO 3-acetyldeoxynivalenol results in increased expression of CXCL2 mRNA CTD PMID:24793808 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO 3-acetyldeoxynivalenol results in increased phosphorylation of EIF2A protein CTD PMID:20682335 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO 3-acetyldeoxynivalenol results in increased expression of ERN1 mRNA CTD PMID:20682335 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO 3-acetyldeoxynivalenol results in decreased expression of HSPA5 mRNA CTD PMID:20682335 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il1b interleukin 1 beta increases expression ISO 3-acetyldeoxynivalenol results in increased expression of IL1B mRNA CTD PMID:24793808 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 affects secretion
increases expression
ISO 3-acetyldeoxynivalenol affects the secretion of IL2 protein
3-acetyldeoxynivalenol results in increased expression of IL2 mRNA
CTD PMID:8560498 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 affects secretion ISO 3-acetyldeoxynivalenol affects the secretion of IL4 protein CTD PMID:8560498 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 affects secretion ISO 3-acetyldeoxynivalenol affects the secretion of IL5 protein CTD PMID:8560498 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 increases expression ISO 3-acetyldeoxynivalenol results in increased expression of IL6 mRNA CTD PMID:24793808 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases activity ISO 3-acetyldeoxynivalenol results in decreased activity of PPARG protein CTD PMID:27481073 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 3-acetyldeoxynivalenol results in increased expression of PTGS2 mRNA CTD PMID:14514436 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Thrb thyroid hormone receptor beta decreases activity
multiple interactions
ISO 3-acetyldeoxynivalenol results in decreased activity of THRB protein
[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of THRB protein
CTD PMID:27481073 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tnf tumor necrosis factor increases expression ISO 3-acetyldeoxynivalenol results in increased expression of TNF mRNA CTD PMID:24793808 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        epitope 6980
          3-acetyldeoxynivalenol 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        oxyketone 8659
                                          alpha-oxyketone 8659
                                            alpha-hydroxy ketone 8659
                                              secondary alpha-hydroxy ketone 892
                                                deoxynivalenol 756
                                                  3-acetyldeoxynivalenol 18
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