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ONTOLOGY REPORT - ANNOTATIONS
Term:remdesivir
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Accession:CHEBI:145994 term browser browse the term
Definition:A carboxylic ester resulting from the formal condensation of the carboxy group of N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alanine with the hydroxy group of 2-ethylbutan-1-ol. A broad-spectrum antiviral prodrug with potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. It is currently in Phase III clinical trials for the treatment of Covid-19 in adults.
Synonyms:exact_synonym: 2-ethylbutyl N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate
 related_synonym: (2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester;   2-ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate;   Formula=C27H35N6O8P;   GS-5734;   GS5734;   InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1;   InChIKey=RWWYLEGWBNMMLJ-YSOARWBDSA-N;   SMILES=[C@]1(O[C@@H]([C@H]([C@H]1O)O)CO[P@@](N[C@H](C(OCC(CC)CC)=O)C)(OC=2C=CC=CC2)=O)(C#N)C=3N4N=CN=C(C4=CC3)N;   remdesivirum
 xref: CAS:1809249-37-3;   DrugBank:DB14761;   KEGG:D11472;   PMCID:PMC5630887;   PMID:26934220;   PMID:28124907;   PMID:28262699;   PMID:28659436;   PMID:29511076;   PMID:30275474;   PMID:30987343;   PMID:31142680;   PMID:31233808;   PMID:31924756;   PMID:32020029;   PMID:32054787;   PMID:32094225;   PMID:32145386;   PMID:32147516;   PMID:32152082;   Wikipedia:Remdesivir

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remdesivir term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:30309211
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:30309211
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:30309211
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:30309211
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:30309211
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      application 19373
        pro-agent 8838
          prodrug 8627
            remdesivir 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    p-block element atom 19664
                      carbon group element atom 19559
                        carbon atom 19548
                          organic molecular entity 19548
                            heteroorganic entity 19145
                              organochalcogen compound 18846
                                organooxygen compound 18764
                                  carbohydrates and carbohydrate derivatives 12165
                                    carbohydrate 12165
                                      carbohydrate derivative 11790
                                        glycosyl compound 10827
                                          C-glycosyl compound 232
                                            C-nucleoside 5
                                              GS-441524 5
                                                remdesivir 5
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