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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dinophysistoxin 2
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Accession:CHEBI:145981 term browser browse the term
Definition:A ketal that is a rare marine toxin structurally related to okadaic acid. Found yearly along with okadaic acid in Portuguese shellfish, its presence has been correlated with the occurrence of Dinophysis acta.
Synonyms:exact_synonym: (2R)-3-[(2S,5R,6R,8S)-8-{(2R,3E)-4-[(2R,4'aR,5R,6'S,8'R,8'aS)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,6R,11R)-11-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl}-7'-methylidenehexahydro-3'H-spiro[oxolane-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl}-5-hydroxy-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-hydroxy-2-methylpropanoic acid
 related_synonym: (2R)-2-hydroxy-3-[(2S,5R,6R,8S)-5-hydroxy-8-{(2R,3E)-4-[(2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,6R,11R)-11-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl}-7'-methyleneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl}-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-methylpropanoic acid;   DTX-2;   DTX2;   Formula=C44H68O13;   InChI=1S/C44H68O13/c1-25-21-35(56-44(23-25)36(46)14-13-31(54-44)24-41(6,50)40(48)49)26(2)11-12-30-15-18-42(53-30)19-16-34-39(57-42)37(47)29(5)38(52-34)32(45)22-27(3)33-10-7-17-43(55-33)28(4)9-8-20-51-43/h11-12,23,26-28,30-39,45-47,50H,5,7-10,13-22,24H2,1-4,6H3,(H,48,49)/b12-11+/t26-,27+,28-,30+,31+,32+,33+,34-,35+,36-,37-,38+,39-,41-,42-,43-,44-/m1/s1;   InChIKey=BRFKTXCAUCYQBT-KIXJXINUSA-N;   SMILES=[C@@]12(O[C@]3([C@H](O)C(=C)[C@@H]([C@@H](O)C[C@@H]([C@]4(O[C@]5(OCCC[C@H]5C)CCC4)[H])C)O[C@@H]3CC1)[H])O[C@H](CC2)\\C=C\\[C@H]([C@]6(O[C@]7(O[C@H](C[C@](C(=O)O)(O)C)CC[C@H]7O)C=C(C)C6)[H])C
 xref: CAS:139933-46-3
 xref_mesh: MESH:C076221
 xref: PMID:10400295;   PMID:10775759;   PMID:15141105;   PMID:17092529;   PMID:17286044;   PMID:18226903;   PMID:18342356;   PMID:19481560;   PMID:19916524;   PMID:22285596;   PMID:23406170;   PMID:25238672;   PMID:28089692;   PMID:28223118;   PMID:30176657



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dinophysistoxin 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccna1 cyclin A1 affects expression ISO dinophysistoxin 2 affects the expression of CCNA1 mRNA CTD PMID:21512803 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccnb2 cyclin B2 affects expression ISO dinophysistoxin 2 affects the expression of CCNB2 mRNA CTD PMID:21512803 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO dinophysistoxin 2 results in decreased expression of CDK2 mRNA CTD PMID:21512803 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Tp53 tumor protein p53 affects localization ISO dinophysistoxin 2 affects the localization of TP53 protein CTD PMID:21512803 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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  CHEBI ontology 20059
    role 20009
      biological role 20008
        poison 18479
          toxin 15299
            dinophysistoxin 2 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            heteroorganic entity 19555
                              organochalcogen compound 19293
                                organooxygen compound 19239
                                  ether 16975
                                    cyclic ether 10445
                                      polycyclic ether 1418
                                        okadaic acid 460
                                          dinophysistoxin 2 4
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