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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dinophysistoxin 2
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Accession:CHEBI:145981 term browser browse the term
Definition:A ketal that is a rare marine toxin structurally related to okadaic acid. Found yearly along with okadaic acid in Portuguese shellfish, its presence has been correlated with the occurrence of Dinophysis acta.
Synonyms:exact_synonym: (2R)-3-[(2S,5R,6R,8S)-8-{(2R,3E)-4-[(2R,4'aR,5R,6'S,8'R,8'aS)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,6R,11R)-11-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl}-7'-methylidenehexahydro-3'H-spiro[oxolane-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl}-5-hydroxy-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-hydroxy-2-methylpropanoic acid
 related_synonym: (2R)-2-hydroxy-3-[(2S,5R,6R,8S)-5-hydroxy-8-{(2R,3E)-4-[(2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,6R,11R)-11-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl}-7'-methyleneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl}-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-methylpropanoic acid;   DTX-2;   DTX2;   Formula=C44H68O13;   InChI=1S/C44H68O13/c1-25-21-35(56-44(23-25)36(46)14-13-31(54-44)24-41(6,50)40(48)49)26(2)11-12-30-15-18-42(53-30)19-16-34-39(57-42)37(47)29(5)38(52-34)32(45)22-27(3)33-10-7-17-43(55-33)28(4)9-8-20-51-43/h11-12,23,26-28,30-39,45-47,50H,5,7-10,13-22,24H2,1-4,6H3,(H,48,49)/b12-11+/t26-,27+,28-,30+,31+,32+,33+,34-,35+,36-,37-,38+,39-,41-,42-,43-,44-/m1/s1;   InChIKey=BRFKTXCAUCYQBT-KIXJXINUSA-N;   SMILES=[C@@]12(O[C@]3([C@H](O)C(=C)[C@@H]([C@@H](O)C[C@@H]([C@]4(O[C@]5(OCCC[C@H]5C)CCC4)[H])C)O[C@@H]3CC1)[H])O[C@H](CC2)\\C=C\\[C@H]([C@]6(O[C@]7(O[C@H](C[C@](C(=O)O)(O)C)CC[C@H]7O)C=C(C)C6)[H])C
 xref: CAS:139933-46-3
 xref_mesh: MESH:C076221
 xref: PMID:10400295;   PMID:10775759;   PMID:15141105;   PMID:17092529;   PMID:17286044;   PMID:18226903;   PMID:18342356;   PMID:19481560;   PMID:19916524;   PMID:22285596;   PMID:23406170;   PMID:25238672;   PMID:28089692;   PMID:28223118;   PMID:30176657

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dinophysistoxin 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccna1 cyclin A1 affects expression ISO dinophysistoxin 2 affects the expression of CCNA1 mRNA CTD PMID:21512803 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccnb2 cyclin B2 affects expression ISO dinophysistoxin 2 affects the expression of CCNB2 mRNA CTD PMID:21512803 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO dinophysistoxin 2 results in decreased expression of CDK2 mRNA CTD PMID:21512803 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Tp53 tumor protein p53 affects localization ISO dinophysistoxin 2 affects the localization of TP53 protein CTD PMID:21512803 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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  CHEBI ontology 20072
    role 20026
      biological role 20025
        poison 18589
          toxin 15927
            dinophysistoxin 2 4
Path 2
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  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19974
                    p-block element atom 19974
                      carbon group element atom 19903
                        carbon atom 19896
                          organic molecular entity 19896
                            heteroorganic entity 19607
                              organochalcogen compound 19373
                                organooxygen compound 19276
                                  ether 17016
                                    cyclic ether 10511
                                      polycyclic ether 1422
                                        okadaic acid 462
                                          dinophysistoxin 2 4
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