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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trilobatin
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Accession:CHEBI:145829 term browser browse the term
Definition:An aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 4' via a glycosidic linkage. It is isolated from the leaves of the Chinese sweet tea Lithocarpus polystachyus and exhibits significant anti-hyperglycemic, anti-oxidative and anti-inflammatory properties.
Synonyms:exact_synonym: 3,5-dihydroxy-4-[3-(4-hydroxyphenyl)propanoyl]phenyl beta-D-glucopyranoside
 related_synonym: 1-(4-(beta-D-glucopyranosyloxy)-2,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1-propanone;   Formula=C21H24O10;   InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-12-7-14(25)17(15(26)8-12)13(24)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-23,25-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1;   InChIKey=GSTCPEBQYSOEHV-QNDFHXLGSA-N;   SMILES=O1[C@@H]([C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC2=CC(O)=C(C(O)=C2)C(=O)CCC3=CC=C(O)C=C3)CO;   p-phloridzin;   p-phlorizin;   phloretin-4'-beta-D-glucopyranoside;   phloretin-4'-beta-D-glucoside
 xref: AGR:IND601124268;   AGR:IND605946551;   AGR:IND606090210;   CAS:4192-90-9;   FooDB:FDB016580;   HMDB:HMDB0037505;   KNApSAcK:C00007991;   LIPID_MAPS_instance:LMPK12120518
 xref_mesh: MESH:C000598619
 xref: PMID:22792798;   PMID:23562371;   PMID:25053100;   PMID:26363372;   PMID:27893760;   PMID:28450013;   PMID:29757201;   PMID:29802645;   PMID:29865928;   PMID:31540429


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trilobatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide affects the localization of BAX protein] CTD PMID:30104959 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:30104959 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cat catalase multiple interactions ISO NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein] CTD PMID:32663520 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ESRRA protein] CTD PMID:30104959 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of FOXO3 protein] CTD PMID:30104959 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 protein] CTD PMID:30104959 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP
trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 protein]
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]
CTD PMID:30104959, PMID:32663520 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased activity of IDH2 protein]; trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDH2 protein] CTD PMID:30104959 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:25053100 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:25053100 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:30104959 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP6 mRNA] CTD PMID:30104959 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX1 mRNA] CTD PMID:30104959 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CYTB mRNA] CTD PMID:30104959 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND2 mRNA] CTD PMID:30104959 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND5 mRNA] CTD PMID:30104959 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP
ISO
trilobatin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]
NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; trilobatin promotes the reaction [Isoflurane results in increased expression of NFE2L2 protein]
CTD PMID:30104959, PMID:32663520 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:25053100 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP
ISO
trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]
trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 protein]
CTD PMID:30104959, PMID:32663520 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPARGC1A protein] CTD PMID:30104959 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:25053100 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt3 sirtuin 3 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]; trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 protein] CTD PMID:30104959 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein]; trilobatin inhibits the reaction [Hydrogen Peroxide results in increased acetylation of SOD2 protein] CTD PMID:30104959 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; trilobatin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:25053100 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP trilobatin inhibits the reaction [Hydrogen Peroxide results in increased expression of UCP2 protein] CTD PMID:30104959 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      chemical role 19250
        antioxidant 14211
          trilobatin 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            heteroorganic entity 19148
                              organochalcogen compound 18856
                                organooxygen compound 18778
                                  carbohydrates and carbohydrate derivatives 12180
                                    carbohydrate 12180
                                      monosaccharide 4023
                                        aldose 2537
                                          aldohexose 2184
                                            glucose 2146
                                              D-glucose 2146
                                                D-glucopyranose 1712
                                                  beta-D-glucose 1603
                                                    beta-D-glucoside 1411
                                                      aryl beta-D-glucoside 248
                                                        trilobatin 25
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.