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ONTOLOGY REPORT - ANNOTATIONS


Term:prednisolone phosphate
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Accession:CHEBI:145705 term browser browse the term
Definition:A synthetic glucocorticoid resulting from the formal condensation of the 21-hydroxy group of prednisolone with one of the hydroxy groups of phosphoric acid. It is a prodrug for prednisolone that is activated in vivo by phosphatases.
Synonyms:exact_synonym: 11beta,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate
 related_synonym: Formula=C21H29O8P;   InChI=1S/C21H29O8P/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19/h5,7,9,14-16,18,23,25H,3-4,6,8,10-11H2,1-2H3,(H2,26,27,28)/t14-,15-,16-,18+,19-,20-,21-/m0/s1;   InChIKey=JDOZJEUDSLGTLU-VWUMJDOOSA-N;   SMILES=C[C@@]12C[C@@H]([C@]3([C@]([C@]2([H])CC[C@@]1(C(COP(=O)(O)O)=O)O)(CCC=4[C@]3(C)C=CC(C4)=O)[H])[H])O;   prednisolone 21-(dihydrogen phosphate);   prednisolone 21-monophosphate;   prednisolone 21-phosphate
 xref: CAS:302-25-0;   DrugBank:DB14631;   Drug_Central:4451;   PMID:13783671;   PMID:15802017;   PMID:18283332;   PMID:21896328;   PMID:25791805;   PMID:26319748;   PMID:30547315;   PMID:31578578;   PMID:5090826
 cyclic_relationship: is_conjugate_acid_of CHEBI:145706


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  CHEBI ontology 19758
    role 19705
      application 19359
        anti-inflammatory agent 14958
          prednisolone phosphate 0
Path 2
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  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    p-block element atom 19641
                      carbon group element atom 19532
                        carbon atom 19521
                          organic molecular entity 19521
                            organic group 18428
                              organic divalent group 18419
                                organodiyl group 18419
                                  carbonyl group 18309
                                    carbonyl compound 18309
                                      ketone 15948
                                        oxo steroid 9289
                                          3-oxo steroid 8814
                                            3-oxo-Delta(4) steroid 7942
                                              progesterone 2713
                                                Delta(1)-progesterone 235
                                                  prednisolone 230
                                                    prednisolone phosphate 0
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