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G |
Arrb2 |
arrestin, beta 2 |
multiple interactions |
ISO |
S-nitrosocysteine inhibits the reaction [Isoproterenol affects the localization of ARRB2 protein] |
CTD |
PMID:17482545 |
|
NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] |
CTD |
PMID:24451382 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Grk2 |
G protein-coupled receptor kinase 2 |
increases nitrosation |
ISO |
S-nitrosocysteine results in increased nitrosation of GRK2 protein |
CTD |
PMID:17482545 |
|
NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
multiple interactions |
EXP |
[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein] |
CTD |
PMID:16386761 |
|
NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
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G |
Sirt1 |
sirtuin 1 |
multiple interactions |
ISO |
S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein]; S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] |
CTD |
PMID:24451382 |
|
NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein] |
CTD |
PMID:24451382 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
AIFM1 protein inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Glutathione]; AIFM1 protein promotes the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Adenine Nucleotides] |
CTD |
PMID:15316071 |
|
NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]; wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]] |
CTD |
PMID:21138475 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Aqp3 |
aquaporin 3 (Gill blood group) |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of AQP3 mRNA |
CTD |
PMID:12102619 |
|
NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
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G |
Bad |
BCL2-associated agonist of cell death |
decreases phosphorylation multiple interactions |
ISO |
S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein] |
CTD |
PMID:21138475 |
|
NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein] |
CTD |
PMID:21138475 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein] S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 mRNA; S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein |
CTD |
PMID:17135264 PMID:21138475 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions increases secretion |
EXP |
Carbon Dioxide inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased secretion of CALCA protein] |
CTD |
PMID:18052948 |
|
NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
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|
G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased activity of and results in increased cleavage of CASP1 protein |
CTD |
PMID:10903723 |
|
NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity decreases activity |
ISO EXP |
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of CASP3 protein] S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein S-Nitroso-N-Acetylpenicillamine results in decreased activity of CASP3 protein Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein] |
CTD |
PMID:10811113 PMID:12006578 PMID:12220328 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
S-Nitroso-N-Acetylpenicillamine inhibits the reaction [3,5-dimethoxy-4'-hydroxystilbene results in decreased phosphorylation of CREB1 protein]; S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Quercetin results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:17135264 |
|
NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
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G |
Csrp3 |
cysteine and glycine rich protein 3 |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of CSRP3 mRNA |
CTD |
PMID:12102619 |
|
NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367
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G |
Drgx |
dorsal root ganglia homeobox |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of PRRXL1 mRNA |
CTD |
PMID:12102619 |
|
NCBI chr16:8,823,872...8,853,430
Ensembl chr16:8,823,872...8,853,430
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G |
Edn1 |
endothelin 1 |
increases secretion |
EXP |
S-Nitroso-N-Acetylpenicillamine results in increased secretion of EDN1 protein |
CTD |
PMID:15640287 |
|
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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G |
Eln |
elastin |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of ELN mRNA |
CTD |
PMID:12102619 |
|
NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
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G |
Exoc6 |
exocyst complex component 6 |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of SEC15 mRNA |
CTD |
PMID:12102619 |
|
NCBI chr 1:256,211,879...256,369,318
Ensembl chr 1:256,226,179...256,368,813
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G |
Faslg |
Fas ligand |
multiple interactions |
ISO |
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter] |
CTD |
PMID:10811113 |
|
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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G |
Fcgr2a |
Fc fragment of IgG receptor IIa |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of FCGR3 mRNA |
CTD |
PMID:12102619 |
|
NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036 Ensembl chr13:91,168,973...91,198,036
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G |
Fcgr2b |
Fc fragment of IgG receptor IIb |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of FCGR2B mRNA |
CTD |
PMID:12102619 |
|
NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
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G |
Fgf2 |
fibroblast growth factor 2 |
multiple interactions |
ISO |
S-Nitroso-N-Acetylpenicillamine promotes the reaction [FGF2 protein results in increased expression of TP53 protein] |
CTD |
PMID:16351512 |
|
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
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G |
Ghrh |
growth hormone releasing hormone |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of GHRH mRNA |
CTD |
PMID:12102619 |
|
NCBI chr 3:153,449,124...153,468,794
Ensembl chr 3:153,449,125...153,468,794
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G |
Gnai2 |
G protein subunit alpha i2 |
multiple interactions decreases expression |
EXP |
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein] |
CTD |
PMID:16962941 PMID:19252090 |
|
NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
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G |
Gnai3 |
G protein subunit alpha i3 |
multiple interactions decreases expression |
EXP |
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein] |
CTD |
PMID:16962941 PMID:19252090 |
|
NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of GOT1 mRNA |
CTD |
PMID:12102619 |
|
NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; GPX1 protein affects the susceptibility to [Diquat co-treated with S-Nitroso-N-Acetylpenicillamine]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased expression of GPX1 protein] |
CTD |
PMID:11672444 |
|
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
multiple interactions |
EXP |
[S-Nitroso-N-Acetylpenicillamine co-treated with 2-tert-butylhydroquinone] results in increased expression of GSTA2 |
CTD |
PMID:15357004 |
|
NCBI chr 8:85,640,081...85,645,621
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G |
Hck |
HCK proto-oncogene, Src family tyrosine kinase |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of HCK mRNA |
CTD |
PMID:12102619 |
|
NCBI chr 3:148,579,917...148,623,026
Ensembl chr 3:148,579,920...148,623,033
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in increased expression of HMOX1 protein |
CTD |
PMID:16439612 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Streptozocin results in increased expression of IFNG protein] |
CTD |
PMID:15892581 |
|
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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G |
Itpka |
inositol-trisphosphate 3-kinase A |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of ITPKA mRNA |
CTD |
PMID:12102619 |
|
NCBI chr 3:111,545,007...111,553,605
Ensembl chr 3:111,545,007...111,553,604
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases expression multiple interactions increases phosphorylation decreases phosphorylation |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of MAPK1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK1 protein]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK1 protein] |
CTD |
PMID:15640287 PMID:19252090 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases expression decreases phosphorylation increases phosphorylation multiple interactions |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of MAPK3 protein S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK3 protein S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK3 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK3 protein]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK3 protein] |
CTD |
PMID:15640287 PMID:19252090 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mme |
membrane metallo-endopeptidase |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of MME mRNA |
CTD |
PMID:12102619 |
|
NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
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G |
Mtf1 |
metal-regulatory transcription factor 1 |
affects localization |
ISO |
S-Nitroso-N-Acetylpenicillamine affects the localization of MTF1 protein |
CTD |
PMID:16423564 |
|
NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of NFKB1 mRNA |
CTD |
PMID:12102619 |
|
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Nos2 |
nitric oxide synthase 2 |
decreases activity decreases expression |
ISO EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased activity of NOS2 protein S-Nitroso-N-Acetylpenicillamine results in decreased expression of NOS2 promoter |
CTD |
PMID:11076874 PMID:15565661 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nppa |
natriuretic peptide A |
multiple interactions |
EXP |
[S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] |
CTD |
PMID:11799084 |
|
NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
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G |
Npr3 |
natriuretic peptide receptor 3 |
multiple interactions decreases expression |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of NPR3 protein] |
CTD |
PMID:16962941 PMID:19252090 |
|
NCBI chr 2:61,883,946...61,950,291
Ensembl chr 2:61,888,950...61,949,926
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G |
Oprm1 |
opioid receptor, mu 1 |
multiple interactions |
ISO |
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCA protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RAF1 protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RGS17 protein] |
CTD |
PMID:18652891 PMID:21235400 |
|
NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
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G |
Pam |
peptidylglycine alpha-amidating monooxygenase |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of PAM mRNA |
CTD |
PMID:12102619 |
|
NCBI chr 9:111,028,543...111,177,588
Ensembl chr 9:111,028,575...111,177,602
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]] |
CTD |
PMID:10811113 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Prkca |
protein kinase C, alpha |
multiple interactions |
ISO |
S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCA protein] |
CTD |
PMID:18652891 |
|
NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
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G |
Prkcg |
protein kinase C, gamma |
multiple interactions |
ISO |
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein] |
CTD |
PMID:18652891 PMID:21235400 |
|
NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
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G |
Prkg1 |
protein kinase cGMP-dependent 1 |
multiple interactions increases activity |
EXP |
[S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] S-Nitroso-N-Acetylpenicillamine results in increased activity of PRKG1 protein |
CTD |
PMID:11799084 |
|
NCBI chr 1:248,982,039...250,300,952
|
|
G |
Rack1 |
receptor for activated C kinase 1 |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of RACK1 mRNA |
CTD |
PMID:12102619 |
|
NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198 Ensembl chr12:34,149,717...34,155,198
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
multiple interactions |
ISO |
S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RAF1 protein] |
CTD |
PMID:21235400 |
|
NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
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G |
Rgs17 |
regulator of G-protein signaling 17 |
multiple interactions |
ISO |
S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RGS17 protein] |
CTD |
PMID:18652891 |
|
NCBI chr 1:42,491,566...42,587,735
Ensembl chr 1:42,492,761...42,587,721
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G |
Rplp0 |
ribosomal protein lateral stalk subunit P0 |
decreases expression |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of RPLP0 mRNA |
CTD |
PMID:12102619 |
|
NCBI chr12:46,791,528...46,794,797
Ensembl chr12:46,791,528...46,794,797
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G |
Sftpa1 |
surfactant protein A1 |
decreases expression multiple interactions |
EXP |
S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA] |
CTD |
PMID:15640287 |
|
NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403
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G |
Sftpb |
surfactant protein B |
multiple interactions decreases expression |
EXP |
bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA] |
CTD |
PMID:15640287 |
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NCBI chr 4:100,166,855...100,175,941
Ensembl chr 4:100,166,863...100,175,938
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G |
Sftpc |
surfactant protein C |
multiple interactions decreases expression |
EXP |
bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA] |
CTD |
PMID:15640287 |
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NCBI chr15:52,211,538...52,214,480
Ensembl chr15:52,211,544...52,214,616
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions affects response to substance |
ISO |
GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein] SOD1 protein affects the susceptibility to S-Nitroso-N-Acetylpenicillamine |
CTD |
PMID:10698074 PMID:11672444 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO EXP |
GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein] [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA |
CTD |
PMID:11672444 PMID:14996425 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of TRP53 mRNA S-Nitroso-N-Acetylpenicillamine promotes the reaction [FGF2 protein results in increased expression of TP53 protein] |
CTD |
PMID:7673702 PMID:16351512 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Trpc6 |
transient receptor potential cation channel, subfamily C, member 6 |
multiple interactions |
EXP |
S-Nitroso-N-Acetylpenicillamine inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein] |
CTD |
PMID:20177073 |
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NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
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G |
Vasp |
vasodilator-stimulated phosphoprotein |
increases phosphorylation |
EXP |
S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of VASP protein |
CTD |
PMID:11799084 |
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NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression increases secretion |
EXP |
S-Nitroso-N-Acetylpenicillamine results in increased expression of VEGFA mRNA S-Nitroso-N-Acetylpenicillamine results in increased secretion of VEGFA protein |
CTD |
PMID:10613739 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects transport |
EXP |
ABCC2 affects the transport of S-Nitrosoglutathione |
CTD |
PMID:20683964 |
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NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
multiple interactions increases reduction |
ISO |
[SPL-334 results in decreased activity of ADH5 protein] which results in decreased metabolism of S-Nitrosoglutathione decanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; dodecanedioic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; Glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; lauric acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; octanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; pelargonic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; S-methyl glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Ethanol]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Formaldehyde]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Octanols]; sebacic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; undecanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] |
CTD |
PMID:19038239 PMID:19428350 PMID:26209236 |
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NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
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G |
Atm |
ATM serine/threonine kinase |
increases response to substance |
ISO |
ATM results in increased susceptibility to S-Nitrosoglutathione |
CTD |
PMID:8958160 |
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NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of BAX protein |
CTD |
PMID:10828028 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased expression of BCL2 protein |
CTD |
PMID:10828028 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bnip3 |
BCL2 interacting protein 3 |
decreases expression |
ISO |
S-Nitrosoglutathione results in decreased expression of BNIP3 mRNA |
CTD |
PMID:11592958 |
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NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein; [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein] Cyclosporine inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein] |
CTD |
PMID:10205001 PMID:10828028 PMID:20153346 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
S-Nitrosoglutathione results in increased activity of CASP8 protein |
CTD |
PMID:20153346 |
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NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Cbr1 |
carbonyl reductase 1 |
multiple interactions increases reduction |
ISO |
[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 1,4-naphthoquinone]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 2,3-hexanedione]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 4-benzoylpyridine]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Vitamin K 3]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 1,2-naphthoquinone]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin]; Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]]; S-Nitrosoglutathione binds to and results in decreased activity of CBR1 protein; S-Nitrosoglutathione binds to and results in increased activity of CBR1 protein; S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione] |
CTD |
PMID:21256830 PMID:23295225 |
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NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
decreases secretion |
ISO |
S-Nitrosoglutathione results in decreased secretion of CCL5 protein |
CTD |
PMID:13678430 |
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NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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G |
Cct7 |
chaperonin containing TCP1 subunit 7 |
multiple interactions |
ISO |
CCT7 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased abundance of Cyclic GMP] |
CTD |
PMID:24213632 |
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NCBI chr 4:117,235,023...117,252,265
Ensembl chr 4:117,235,023...117,252,265
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G |
Cd86 |
CD86 molecule |
decreases expression |
ISO |
S-Nitrosoglutathione results in decreased expression of CD86 protein |
CTD |
PMID:13678430 |
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NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions increases expression decreases expression decreases activity |
ISO |
acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA]; DDT inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein S-Nitrosoglutathione results in decreased expression of CFTR mRNA S-Nitrosoglutathione results in decreased activity of CFTR protein |
CTD |
PMID:14766015 PMID:15657297 |
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NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
decreases secretion |
ISO |
S-Nitrosoglutathione results in decreased secretion of CXCL10 protein |
CTD |
PMID:13678430 |
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NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
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G |
Faslg |
Fas ligand |
multiple interactions |
ISO |
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter] |
CTD |
PMID:10811113 |
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NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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G |
Gucy1a1 |
guanylate cyclase 1 soluble subunit alpha 1 |
multiple interactions |
ISO |
GUCY1A1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased abundance of Cyclic GMP] |
CTD |
PMID:24213632 |
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NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression |
ISO |
S-Nitrosoglutathione results in increased expression of HIF1A mRNA |
CTD |
PMID:11514583 |
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NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO |
[linsidomine co-treated with S-Nitrosoglutathione] results in increased expression of HMOX1 mRNA; Nitroprusside promotes the reaction [S-Nitrosoglutathione results in increased expression of HMOX1 mRNA]; S-Nitrosoglutathione promotes the reaction [Nitroprusside results in increased expression of HMOX1 mRNA] |
CTD |
PMID:8764571 PMID:10423162 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Htra2 |
HtrA serine peptidase 2 |
multiple interactions affects localization |
ISO |
[tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] |
CTD |
PMID:20153346 |
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NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
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G |
Ifng |
interferon gamma |
increases secretion |
ISO |
S-Nitrosoglutathione results in increased secretion of IFNG protein |
CTD |
PMID:13678430 |
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NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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G |
Il10 |
interleukin 10 |
decreases secretion |
ISO |
S-Nitrosoglutathione results in decreased secretion of IL10 protein |
CTD |
PMID:13678430 |
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NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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G |
Il12b |
interleukin 12B |
decreases expression |
ISO |
S-Nitrosoglutathione results in decreased expression of IL12B protein |
CTD |
PMID:13678430 |
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NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
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G |
Il5 |
interleukin 5 |
decreases secretion |
ISO |
S-Nitrosoglutathione results in decreased secretion of IL5 protein |
CTD |
PMID:13678430 |
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NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
affects metabolic processing multiple interactions |
EXP |
S-Nitrosoglutathione affects the metabolism of MGST1 protein [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein] |
CTD |
PMID:16386761 PMID:16899233 |
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NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
[NOS2 protein results in increased chemical synthesis of S-Nitrosoglutathione] which results in decreased susceptibility to Carmustine |
CTD |
PMID:15110396 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
P4hb |
prolyl 4-hydroxylase subunit beta |
increases nitrosation |
EXP |
S-Nitrosoglutathione results in increased nitrosation of P4HB protein |
CTD |
PMID:28823167 |
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NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
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G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions |
ISO |
[S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein binds to TP53 promoter]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione inhibits the reaction [PRKN protein binds to TP53 promoter]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione results in increased nitrosation of and affects the localization of PRKN protein |
CTD |
PMID:23985028 |
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NCBI chr 1:48,880,015...50,069,998
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G |
Rasd1 |
ras related dexamethasone induced 1 |
multiple interactions |
EXP |
S-Nitrosoglutathione results in increased nitrosation of and results in increased activity of RASD1 protein |
CTD |
PMID:16908409 |
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NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
S-Nitrosoglutathione promotes the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein] |
CTD |
PMID:21464294 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Sp1 |
Sp1 transcription factor |
increases activity |
ISO |
S-Nitrosoglutathione results in increased activity of SP1 protein |
CTD |
PMID:14766015 |
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NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
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G |
Sp3 |
Sp3 transcription factor |
decreases activity increases activity |
ISO |
S-Nitrosoglutathione results in decreased activity of SP3 protein S-Nitrosoglutathione results in increased activity of SP3 protein |
CTD |
PMID:14766015 |
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NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
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G |
Tnf |
tumor necrosis factor |
increases secretion |
ISO |
S-Nitrosoglutathione results in increased secretion of TNF protein |
CTD |
PMID:13678430 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP ISO |
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein binds to TP53 promoter]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione inhibits the reaction [PRKN protein binds to TP53 promoter]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 protein] |
CTD |
PMID:8982730 PMID:23985028 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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