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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitrosothio compound
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Accession:CHEBI:145545 term browser browse the term
Definition:Any nitroso compound in which a carbon atom of an organyl group is attached to the sulfur atom of a nitrosothio group: R-S-N=O.
Synonyms:related_synonym: Formula=NOSR;   S-nitrosothiol compound;   S-nitrosothiols;   SMILES=*SN=O;   SNO compound;   nitrosothio compounds



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S-nitroso-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 multiple interactions ISO S-nitrosocysteine inhibits the reaction [Isoproterenol affects the localization of ARRB2 protein] CTD PMID:17482545 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Casp3 caspase 3 multiple interactions ISO S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] CTD PMID:24451382 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 increases nitrosation ISO S-nitrosocysteine results in increased nitrosation of GRK2 protein CTD PMID:17482545 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP [S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein] CTD PMID:16386761 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein]; S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] CTD PMID:24451382 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein] CTD PMID:24451382 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
S-nitroso-N-acetyl-D-penicillamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO AIFM1 protein inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Glutathione]; AIFM1 protein promotes the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Adenine Nucleotides] CTD PMID:15316071 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]; wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]] CTD PMID:21138475 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of AQP3 mRNA CTD PMID:12102619 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation
multiple interactions
ISO S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein]
CTD PMID:21138475 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein]
CTD PMID:21138475 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein]
S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 mRNA; S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein
CTD PMID:17135264 PMID:21138475 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases secretion
EXP Carbon Dioxide inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased secretion of CALCA protein] CTD PMID:18052948 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased activity of and results in increased cleavage of CASP1 protein CTD PMID:10903723 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
increases activity
ISO
EXP
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of CASP3 protein]
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein]
S-Nitroso-N-Acetylpenicillamine results in decreased activity of CASP3 protein
CTD PMID:10811113 PMID:12006578 PMID:12220328 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO S-Nitroso-N-Acetylpenicillamine inhibits the reaction [3,5-dimethoxy-4'-hydroxystilbene results in decreased phosphorylation of CREB1 protein]; S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Quercetin results in decreased phosphorylation of CREB1 protein] CTD PMID:17135264 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of CSRP3 mRNA CTD PMID:12102619 NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653
JBrowse link
G Drgx dorsal root ganglia homeobox decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of DRGX mRNA CTD PMID:12102619 NCBI chr16:7,854,849...7,884,404
Ensembl chr16:7,854,849...7,900,600
JBrowse link
G Edn1 endothelin 1 increases secretion EXP S-Nitroso-N-Acetylpenicillamine results in increased secretion of EDN1 protein CTD PMID:15640287 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Eln elastin decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of ELN mRNA CTD PMID:12102619 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Exoc6 exocyst complex component 6 decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of SEC15 mRNA CTD PMID:12102619 NCBI chr 1:235,314,612...235,457,824
Ensembl chr 1:235,300,369...235,457,015
JBrowse link
G Faslg Fas ligand multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter] CTD PMID:10811113 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fcgr2a Fc gamma receptor 2A decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of FCGR3 mRNA CTD PMID:12102619 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
JBrowse link
G Fcgr2b Fc gamma receptor 2B decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of FCGR2B mRNA CTD PMID:12102619 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO S-Nitroso-N-Acetylpenicillamine promotes the reaction [FGF2 protein results in increased expression of TP53 protein] CTD PMID:16351512 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Ghrh growth hormone releasing hormone decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of GHRH mRNA CTD PMID:12102619 NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889
JBrowse link
G Gnai2 G protein subunit alpha i2 multiple interactions
decreases expression
EXP 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein] CTD PMID:16962941 PMID:19252090 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions
decreases expression
EXP 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein] CTD PMID:16962941 PMID:19252090 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of GOT1 mRNA CTD PMID:12102619 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; GPX1 protein affects the susceptibility to [Diquat co-treated with S-Nitroso-N-Acetylpenicillamine]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased expression of GPX1 protein] CTD PMID:11672444 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions EXP [S-Nitroso-N-Acetylpenicillamine co-treated with 2-tert-butylhydroquinone] results in increased expression of GSTA2 CTD PMID:15357004 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of HCK mRNA CTD PMID:12102619 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP S-Nitroso-N-Acetylpenicillamine results in increased expression of HMOX1 protein CTD PMID:16439612 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma multiple interactions ISO S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Streptozocin results in increased expression of IFNG protein] CTD PMID:15892581 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Itpka inositol-trisphosphate 3-kinase A decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of ITPKA mRNA CTD PMID:12102619 NCBI chr 3:106,726,036...106,734,601
Ensembl chr 3:106,726,036...106,734,600
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression
decreases phosphorylation
increases phosphorylation
multiple interactions
EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of MAPK1 protein
S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK1 protein
S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK1 protein]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK1 protein]
CTD PMID:15640287 PMID:19252090 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression
multiple interactions
increases phosphorylation
decreases phosphorylation
EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK3 protein]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK3 protein]
CTD PMID:15640287 PMID:19252090 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mme membrane metallo-endopeptidase decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of MME mRNA CTD PMID:12102619 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 affects localization ISO S-Nitroso-N-Acetylpenicillamine affects the localization of MTF1 protein CTD PMID:16423564 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of NFKB1 mRNA CTD PMID:12102619 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 decreases activity
decreases expression
ISO
EXP
S-Nitroso-N-Acetylpenicillamine results in decreased activity of NOS2 protein
S-Nitroso-N-Acetylpenicillamine results in decreased expression of NOS2 promoter
CTD PMID:11076874 PMID:15565661 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11799084 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Npr3 natriuretic peptide receptor 3 multiple interactions
decreases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of NPR3 protein] CTD PMID:16962941 PMID:19252090 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCA protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RAF1 protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RGS17 protein] CTD PMID:18652891 PMID:21235400 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of PAM mRNA CTD PMID:12102619 NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]] CTD PMID:10811113 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCA protein] CTD PMID:18652891 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein] CTD PMID:18652891 PMID:21235400 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions
increases activity
EXP [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
S-Nitroso-N-Acetylpenicillamine results in increased activity of PRKG1 protein
CTD PMID:11799084 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases activity EXP SNAP increases activity of Ptpn1 protein in aortic smooth muscle cells RGD PMID:10484424 RGD:401965470 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Rack1 receptor for activated C kinase 1 decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of RACK1 mRNA CTD PMID:12102619 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RAF1 protein] CTD PMID:21235400 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rgs17 regulator of G-protein signaling 17 multiple interactions ISO S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr 1:42,222,248...42,324,625
Ensembl chr 1:42,227,070...42,324,609
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of RPLP0 mRNA CTD PMID:12102619 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632
JBrowse link
G Sftpa1 surfactant protein A1 decreases expression
multiple interactions
EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA
bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA]
CTD PMID:15640287 NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
JBrowse link
G Sftpb surfactant protein B multiple interactions
decreases expression
EXP bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA] CTD PMID:15640287 NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
JBrowse link
G Sftpc surfactant protein C multiple interactions
decreases expression
EXP bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA] CTD PMID:15640287 NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
affects response to substance
ISO GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]
SOD1 protein affects the susceptibility to S-Nitroso-N-Acetylpenicillamine
CTD PMID:10698074 PMID:11672444 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO
EXP
GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA
CTD PMID:11672444 PMID:14996425 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of TRP53 mRNA
S-Nitroso-N-Acetylpenicillamine promotes the reaction [FGF2 protein results in increased expression of TP53 protein]
CTD PMID:7673702 PMID:16351512 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions EXP S-Nitroso-N-Acetylpenicillamine inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein] CTD PMID:20177073 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation EXP S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of VASP protein CTD PMID:11799084 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
increases secretion
EXP S-Nitroso-N-Acetylpenicillamine results in increased expression of VEGFA mRNA
S-Nitroso-N-Acetylpenicillamine results in increased secretion of VEGFA protein
CTD PMID:10613739 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
S-nitrosoglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 affects the transport of S-Nitrosoglutathione CTD PMID:20683964 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases reduction
multiple interactions
ISO ADH5 protein results in increased reduction of S-Nitrosoglutathione
decanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; dodecanedioic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; Glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; lauric acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; octanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; pelargonic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; S-methyl glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Ethanol]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Formaldehyde]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Octanols]; sebacic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; undecanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]
[SPL-334 results in decreased activity of ADH5 protein] which results in decreased metabolism of S-Nitrosoglutathione
CTD PMID:19038239 PMID:19428350 PMID:26209236 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
JBrowse link
G Atm ATM serine/threonine kinase increases response to substance ISO ATM results in increased susceptibility to S-Nitrosoglutathione CTD PMID:8958160 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of BAX protein CTD PMID:10828028 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased expression of BCL2 protein CTD PMID:10828028 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO S-Nitrosoglutathione results in decreased expression of BNIP3 mRNA CTD PMID:11592958 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein; [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]
Cyclosporine inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]
CTD PMID:10205001 PMID:10828028 PMID:20153346 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO S-Nitrosoglutathione results in increased activity of CASP8 protein CTD PMID:20153346 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions
increases reduction
ISO [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 1,4-naphthoquinone]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 2,3-hexanedione]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 4-benzoylpyridine]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Vitamin K 3]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 1,2-naphthoquinone]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin]; Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]]; S-Nitrosoglutathione binds to and results in decreased activity of CBR1 protein; S-Nitrosoglutathione binds to and results in increased activity of CBR1 protein; S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione] CTD PMID:21256830 PMID:23295225 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases secretion ISO S-Nitrosoglutathione results in decreased secretion of CCL5 protein CTD PMID:13678430 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 multiple interactions ISO CCT7 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased abundance of Cyclic GMP] CTD PMID:24213632 NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580
JBrowse link
G Cd86 CD86 molecule decreases expression ISO S-Nitrosoglutathione results in decreased expression of CD86 protein CTD PMID:13678430 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases expression
decreases expression
decreases activity
ISO acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA]; DDT inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein
S-Nitrosoglutathione results in decreased expression of CFTR mRNA
S-Nitrosoglutathione results in decreased activity of CFTR protein
CTD PMID:14766015 PMID:15657297 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO S-Nitrosoglutathione results in decreased secretion of CXCL10 protein CTD PMID:13678430 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Faslg Fas ligand multiple interactions ISO [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter] CTD PMID:10811113 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO GUCY1A1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased abundance of Cyclic GMP] CTD PMID:24213632 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO S-Nitrosoglutathione results in increased expression of HIF1A mRNA CTD PMID:11514583 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [linsidomine co-treated with S-Nitrosoglutathione] results in increased expression of HMOX1 mRNA; Nitroprusside promotes the reaction [S-Nitrosoglutathione results in increased expression of HMOX1 mRNA]; S-Nitrosoglutathione promotes the reaction [Nitroprusside results in increased expression of HMOX1 mRNA] CTD PMID:8764571 PMID:10423162 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions
affects localization
ISO [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] CTD PMID:20153346 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
JBrowse link
G Ifng interferon gamma increases secretion ISO S-Nitrosoglutathione results in increased secretion of IFNG protein CTD PMID:13678430 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 decreases secretion ISO S-Nitrosoglutathione results in decreased secretion of IL10 protein CTD PMID:13678430 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B decreases expression ISO S-Nitrosoglutathione results in decreased expression of IL12B protein CTD PMID:13678430 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il5 interleukin 5 decreases secretion ISO S-Nitrosoglutathione results in decreased secretion of IL5 protein CTD PMID:13678430 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 affects metabolic processing
multiple interactions
EXP S-Nitrosoglutathione affects the metabolism of MGST1 protein
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]
CTD PMID:16386761 PMID:16899233 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [NOS2 protein results in increased chemical synthesis of S-Nitrosoglutathione] which results in decreased susceptibility to Carmustine CTD PMID:15110396 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases nitrosation EXP S-Nitrosoglutathione results in increased nitrosation of P4HB protein CTD PMID:28823167 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein binds to TP53 promoter]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione inhibits the reaction [PRKN protein binds to TP53 promoter]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione results in increased nitrosation of and affects the localization of PRKN protein CTD PMID:23985028 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Rasd1 ras related dexamethasone induced 1 multiple interactions EXP S-Nitrosoglutathione results in increased nitrosation of and results in increased activity of RASD1 protein CTD PMID:16908409 NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO S-Nitrosoglutathione promotes the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein] CTD PMID:21464294 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sp1 Sp1 transcription factor increases activity ISO S-Nitrosoglutathione results in increased activity of SP1 protein CTD PMID:14766015 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sp3 Sp3 transcription factor decreases activity
increases activity
ISO S-Nitrosoglutathione results in decreased activity of SP3 protein
S-Nitrosoglutathione results in increased activity of SP3 protein
CTD PMID:14766015 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO S-Nitrosoglutathione results in increased secretion of TNF protein CTD PMID:13678430 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP
ISO
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein
[S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein binds to TP53 promoter]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione inhibits the reaction [PRKN protein binds to TP53 promoter]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]
CTD PMID:8982730 PMID:23985028 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19860
    chemical entity 19858
      group 19816
        nitrogen group 12305
          nitroso group 5068
            nitroso compound 5068
              nitrosothio compound 85
                S-nitroso-L-cysteine + 6
                S-nitroso-L-cysteinylglycine 0
                S-nitroso-N-acetyl-D-penicillamine 57
                S-nitroso-coenzyme A 0
                S-nitrosoglutathione 33
                S-nitrosomycothiol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      carbon group element atom 19745
                        carbon atom 19741
                          organic molecular entity 19741
                            heteroorganic entity 19494
                              organochalcogen compound 19257
                                organosulfur compound 17455
                                  nitrosothio compound 85
                                    S-nitroso-L-cysteine + 6
                                    S-nitroso-L-cysteinylglycine 0
                                    S-nitroso-N-acetyl-D-penicillamine 57
                                    S-nitroso-coenzyme A 0
                                    S-nitrosoglutathione 33
                                    S-nitrosomycothiol 0
paths to the root