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G |
Ache |
acetylcholinesterase |
decreases activity affects binding multiple interactions affects activity |
ISO EXP |
Donepezil results in decreased activity of ACHE protein Donepezil binds to ACHE protein Donepezil inhibits the reaction [Celecoxib results in increased activity of ACHE protein]; Donepezil inhibits the reaction [Streptozocin results in increased activity of ACHE protein] ALB protein affects the reaction [Donepezil results in decreased activity of ACHE protein]; Donepezil binds to and results in decreased activity of ACHE protein; Donepezil inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Donepezil inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Donepezil promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]] Donepezil affects the activity of ACHE protein AFDX 384 affects the reaction [Donepezil affects the activity of ACHE protein]; Donepezil inhibits the reaction [Streptozocin results in increased activity of ACHE protein] |
CTD |
PMID:9228650 PMID:12111444 PMID:12589378 PMID:14535624 PMID:15135892 PMID:18061284 PMID:18208924 PMID:18343489 PMID:18571635 PMID:19345205 PMID:19705549 PMID:23060470 PMID:25522658 PMID:26902639 PMID:27238725 PMID:30481507 PMID:31176713 |
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NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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G |
Alb |
albumin |
multiple interactions |
ISO |
ALB protein affects the reaction [Donepezil results in decreased activity of ACHE protein] |
CTD |
PMID:26902639 |
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NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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G |
App |
amyloid beta precursor protein |
increases abundance decreases response to substance multiple interactions |
ISO EXP |
Donepezil results in increased abundance of APP protein Donepezil results in decreased susceptibility to APP protein Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein alternative form]; Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of TNF protein] Donepezil inhibits the reaction [APP protein modified form affects the localization of RELA protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of NOS2 protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of PTGS2 protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of TNF protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of APP protein] |
CTD |
PMID:18061284 PMID:18571635 PMID:24189446 PMID:28734741 PMID:30481507 |
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NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G |
Arg1 |
arginase 1 |
multiple interactions |
ISO |
Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 protein]] |
CTD |
PMID:26114860 |
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NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
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G |
Bace1 |
beta-secretase 1 |
multiple interactions |
ISO |
Donepezil inhibits the reaction [Streptozocin results in increased expression of BACE1 protein] |
CTD |
PMID:30481507 |
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NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
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G |
Bche |
butyrylcholinesterase |
decreases activity |
ISO EXP |
Donepezil results in decreased activity of BCHE protein |
CTD |
PMID:16036213 PMID:18656440 PMID:19345205 |
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NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] |
CTD |
PMID:19345205 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO EXP |
Donepezil results in increased activity of CASP3 protein Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased expression of CASP3 protein] |
CTD |
PMID:19345205 PMID:20522977 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
Donepezil results in increased activity of CASP8 protein |
CTD |
PMID:20522977 |
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NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Casp9 |
caspase 9 |
increases activity |
ISO |
Donepezil results in increased activity of CASP9 protein |
CTD |
PMID:20522977 |
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NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Cat |
catalase |
multiple interactions |
ISO |
Donepezil inhibits the reaction [Streptozocin results in decreased activity of CAT protein] |
CTD |
PMID:30481507 |
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NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Egr1 |
early growth response 1 |
multiple interactions affects expression |
ISO |
Donepezil inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein] EGR1 protein affects the reaction [Donepezil affects the expression of ICAM1 protein] Donepezil affects the expression of EGR1 mRNA; Donepezil affects the expression of EGR1 protein |
CTD |
PMID:29133030 PMID:32174113 |
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NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
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G |
F3 |
coagulation factor III, tissue factor |
affects expression |
ISO |
Donepezil affects the expression of F3 mRNA; Donepezil affects the expression of F3 protein |
CTD |
PMID:32174113 |
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NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
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G |
Fiz1 |
FLT3-interacting zinc finger 1 |
multiple interactions |
ISO |
Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 protein]] |
CTD |
PMID:26114860 |
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NCBI chr 1:72,379,705...72,387,301
Ensembl chr 1:72,380,711...72,387,301
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Donepezil inhibits the reaction [Scopolamine results in decreased expression of FOS protein] |
CTD |
PMID:29133030 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions affects expression |
ISO |
EGR1 protein affects the reaction [Donepezil affects the expression of ICAM1 protein] Donepezil affects the expression of ICAM1 mRNA; Donepezil affects the expression of ICAM1 protein |
CTD |
PMID:32174113 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL10]] |
CTD |
PMID:26114860 |
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NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL13]] |
CTD |
PMID:26114860 |
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NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B mRNA]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of IL1B protein] |
CTD |
PMID:26114860 PMID:30481507 PMID:31369746 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 protein]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of CHIL3 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of CHIL3 protein]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 protein]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL10]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL13]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of TGFB2]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]] |
CTD |
PMID:26114860 |
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NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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G |
Il6 |
interleukin 6 |
multiple interactions affects expression affects secretion |
ISO |
Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 mRNA]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of IL6 protein] Donepezil affects the expression of IL6 mRNA Donepezil affects the secretion of IL6 protein |
CTD |
PMID:26114860 PMID:30481507 PMID:31369746 PMID:32174113 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Donepezil inhibits the reaction [Scopolamine results in decreased expression of JUN protein] |
CTD |
PMID:29133030 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
Donepezil inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein] |
CTD |
PMID:23562514 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
Donepezil inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK3 protein] |
CTD |
PMID:23562514 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of MAPK8 protein] |
CTD |
PMID:19345205 |
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NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
EXP |
Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of MAPK9 protein] |
CTD |
PMID:19345205 |
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NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression multiple interactions |
ISO |
Donepezil results in decreased expression of MMP9 protein Donepezil results in decreased expression of and results in decreased activity of MMP9 protein |
CTD |
PMID:21750701 |
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NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
Donepezil inhibits the reaction [Streptozocin results in increased activity of MPO protein] |
CTD |
PMID:23060470 |
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NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Donepezil inhibits the reaction [APP protein modified form results in increased expression of NOS2 protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein] |
CTD |
PMID:24189446 PMID:31369746 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nppb |
natriuretic peptide B |
decreases expression |
ISO |
Donepezil results in decreased expression of NPPB protein |
CTD |
PMID:19879468 |
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NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
affects expression |
ISO |
Donepezil affects the expression of OLR1 mRNA; Donepezil affects the expression of OLR1 protein |
CTD |
PMID:32174113 |
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NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
decreases expression multiple interactions affects expression |
ISO |
Donepezil results in decreased expression of PTGS1 mRNA [Rivastigmine co-treated with Donepezil] results in decreased expression of PTGS1 mRNA; [Rivastigmine co-treated with Donepezil] results in decreased expression of PTGS1 protein; [Sodium Fluoride co-treated with Donepezil] results in increased expression of PTGS1 mRNA; [Sodium Fluoride co-treated with Donepezil] results in increased expression of PTGS1 protein; [Sodium Fluoride co-treated with Rivastigmine co-treated with Donepezil] results in increased expression of PTGS1 mRNA; [Sodium Fluoride co-treated with Rivastigmine co-treated with Donepezil] results in increased expression of PTGS1 protein Donepezil affects the expression of PTGS1 protein |
CTD |
PMID:29777723 |
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NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions decreases expression |
ISO |
[Donepezil co-treated with Rivastigmine] results in decreased expression of PTGS2 protein; [Rivastigmine co-treated with Donepezil] results in decreased expression of PTGS2 mRNA Donepezil inhibits the reaction [APP protein modified form results in increased expression of PTGS2 protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of PTGS2 protein] Donepezil results in decreased expression of PTGS2 mRNA; Donepezil results in decreased expression of PTGS2 protein |
CTD |
PMID:24189446 PMID:29777723 PMID:31369746 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Donepezil inhibits the reaction [APP protein modified form affects the localization of RELA protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of RELA protein] |
CTD |
PMID:24189446 PMID:31369746 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Donepezil inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD1 mRNA] |
CTD |
PMID:28734741 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sod3 |
superoxide dismutase 3 |
multiple interactions |
EXP |
Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA] |
CTD |
PMID:28734741 |
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NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
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G |
Stat6 |
signal transducer and activator of transcription 6 |
multiple interactions |
ISO |
Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]] |
CTD |
PMID:26114860 |
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NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
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G |
Tgfb2 |
transforming growth factor, beta 2 |
multiple interactions |
ISO |
Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of TGFB2]] |
CTD |
PMID:26114860 |
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NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
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G |
Tnf |
tumor necrosis factor |
multiple interactions affects expression affects secretion |
ISO EXP |
Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF mRNA]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of TNF protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of TNF protein] Donepezil affects the expression of TNF mRNA Donepezil affects the secretion of TNF protein |
CTD |
PMID:24189446 PMID:26114860 PMID:30481507 PMID:31369746 PMID:32174113 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
Donepezil inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein] |
CTD |
PMID:19345205 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions |
EXP |
Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased expression of XIAP protein] |
CTD |
PMID:19345205 |
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NCBI chr X:128,409,425...128,455,786
Ensembl chr X:128,409,472...128,453,000
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