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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:C-X-C chemokine receptor type 4 antagonist
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Accession:CHEBI:145438 term browser browse the term
Definition:An antogonist that blocks C-X-C chemokine receptor type 4 (CXCR-4).
Synonyms:related_synonym: C-X-C chemokine receptor type 4 antagonists;   C-X-C motif chemokine receptor 4 antagonist;   C-X-C motif chemokine receptor 4 antagonists;   CD184 antagonist;   CD184 antagonists;   CXCR-4 antagonist;   CXCR-4 antagonists;   CXCR4 antagonist;   CXCR4 antagonists;   fusin antagonist;   fusin antagonists
 xref: Wikipedia:CXCR4


show annotations for term's descendants           Sort by:
plerixafor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO		 plerixafor inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]
plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]		 CTD PMID:18660423 PMID:29510123 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression		 ISO plerixafor inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]
plerixafor increases expression of CDH1 protein in lymph node and prostate epithelium		 CTD
RGD		 PMID:28844962 PMID:30537000 RGD:152025215 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO plerixafor decreases expression of CDH2 protein in lymph node and prostate epithelium RGD PMID:30537000 RGD:152025215 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
decreases expression		 ISO plerixafor inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]; plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]
plerixafor results in decreased expression of CXCL12 mRNA		 CTD PMID:12220670 PMID:18660423 PMID:24157575 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases activity
decreases expression
multiple interactions
decreases expression
decreases phosphorylation		 ISO
EXP		 plerixafor results in decreased activity of CXCR4 protein
plerixafor results in decreased expression of CXCR4 protein
plerixafor binds to and results in decreased activity of CXCR4 protein; plerixafor inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]
Plerixafor decreases expression of CXCR4 protein in liver
plerixafor decreases expression of CXCR4 mRNA and protein in lymph node and prostate epithelium
plerixafor decreases phosphorylation of CXCR4 protein in lymph node and prostate epithelium		 CTD
RGD		 PMID:12220670 PMID:17121897 PMID:28844962 PMID:24912495 PMID:30537000 More... RGD:151893463, RGD:152025215, RGD:152025215 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein] CTD PMID:18660423 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO plerixafor inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]; plerixafor inhibits the reaction [Triclosan results in increased expression of SNAI2 protein] CTD PMID:28844962 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Particulate Matter results in decreased susceptibility to [VEGFA protein modified form co-treated with plerixafor]
plerixafor inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]		 CTD PMID:22418586 PMID:25815440 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin decreases expression ISO plerixafor decreases expression on VIM protein in lymph node and prostate epithelium RGD PMID:30537000 RGD:152025215 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        pharmacological role 19072
          antagonist 17233
            C-X-C chemokine receptor type 4 antagonist 9
              motixafortide + 0
              motixafortide acetate 0
              plerixafor 9
paths to the root