uncoupling protein inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	uncoupling protein inhibitor	go back to main search page
Accession:	CHEBI:145437	browse the term
Definition:	Any inhibitor that acts on uncoupling protein.
Synonyms:	related_synonym:	UCP inhibitor; UCP inhibitors; mitochondrial uncoupling protein inhibitor; mitochondrial uncoupling protein inhibitors; uncoupling protein inhibitors
	xref:	PMID:22420157; PMID:23008094; PMID:23609063; PMID:24904988; PMID:28089824; PMID:29858912; Patent:US2009258064; Patent:US7510710

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Genes (138)

7-methyl-GTP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

eukaryotic translation initiation factor 4E

multiple interactions

7-methylguanosine triphosphate inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]; 7-methylguanosine triphosphate inhibits the reaction [RNA Caps binds to EIF4E protein]

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
affects binding

1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [EIF4EBP1 protein binds to 7-methylguanosine triphosphate]; Sirolimus promotes the reaction [EIF4EBP1 protein binds to 7-methylguanosine triphosphate]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 4 gamma 1

multiple interactions
affects binding

1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to 7-methylguanosine triphosphate]; Sirolimus inhibits the reaction [EIF4G1 protein binds to 7-methylguanosine triphosphate]

NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941

GDP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

fucosyltransferase 8

multiple interactions
decreases activity

Guanosine Diphosphate inhibits the reaction [Mersalyl results in decreased activity of FUT8 protein]; Guanosine Diphosphate inhibits the reaction [p-Chloromercuribenzoic Acid results in decreased activity of FUT8 protein]; Guanosine Diphosphate inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein]
Guanosine Diphosphate results in decreased activity of FUT8 protein

NCBI chr 6:95,949,246...96,176,677
Ensembl chr 6:95,949,991...96,176,677

G

GDP-mannose 4, 6-dehydratase

affects binding

Guanosine Diphosphate binds to GMDS protein

NCBI chr17:32,095,315...32,621,975
Ensembl chr17:32,095,386...32,621,961

G

H2A.X variant histone

multiple interactions

Guanosine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

HRas proto-oncogene, GTPase

multiple interactions

[Enzyme Inhibitors binds to and results in decreased activity of SOS1 protein] promotes the reaction [HRAS protein binds to Guanosine Diphosphate]; Enzyme Inhibitors inhibits the reaction [SOS1 protein binds to [HRAS protein binds to Guanosine Diphosphate]]

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

5-hydroxytryptamine receptor 1A

multiple interactions

Guanosine Diphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

KRAS proto-oncogene, GTPase

multiple interactions
affects binding

KRAS protein mutant form inhibits the reaction [SOS1 protein inhibits the reaction [Guanosine Diphosphate binds to KRAS protein]]; SOS1 protein inhibits the reaction [Guanosine Diphosphate binds to KRAS protein]
Guanosine Diphosphate binds to KRAS protein; Guanosine Diphosphate binds to KRAS protein mutant form

NCBI chr 4:178,185,418...178,218,484

G

phosphoglycolate phosphatase

decreases phosphorylation

PGP protein results in decreased phosphorylation of Guanosine Diphosphate

NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858

G

RAB3A, member RAS oncogene family

affects binding
multiple interactions

Guanosine Diphosphate binds to RAB3A protein
[alpha-latrotoxin promotes the reaction [RAB3A protein results in increased cleavage of Guanosine Triphosphate]] promotes the reaction [Guanosine Diphosphate binds to RAB3A protein]; [black widow spider venom promotes the reaction [RAB3A protein results in increased cleavage of Guanosine Triphosphate]] promotes the reaction [Guanosine Diphosphate binds to RAB3A protein]

NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336

G

SOS Ras/Rac guanine nucleotide exchange factor 1

multiple interactions

[Enzyme Inhibitors binds to and results in decreased activity of SOS1 protein] promotes the reaction [HRAS protein binds to Guanosine Diphosphate]; Enzyme Inhibitors inhibits the reaction [SOS1 protein binds to [HRAS protein binds to Guanosine Diphosphate]]; KRAS protein mutant form inhibits the reaction [SOS1 protein inhibits the reaction [Guanosine Diphosphate binds to KRAS protein]]; SOS1 protein inhibits the reaction [Guanosine Diphosphate binds to KRAS protein]

PMID:25825487 PMID:28154176

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

tumor protein p53 binding protein 1

multiple interactions

Guanosine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]

NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822

GDP-alpha-D-glucose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions
increases abundance

Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of guanosine diphosphate glucose]

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

GDP-beta-S

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA acetyltransferase 1

multiple interactions

guanosine 5'-O-(2-thiodiphosphate) inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]

NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855

G

transient receptor potential cation channel, subfamily C, member 6

decreases activity

guanosine 5'-O-(2-thiodiphosphate) results in decreased activity of TRPC6 protein

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

Genipin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

genipin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

angiopoietin-like 4

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of ANGPTL4 mRNA]

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

BCL2 associated X, apoptosis regulator

increases expression

genipin results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCAS2, pre-mRNA processing factor

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of BCAS2 mRNA]

NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389

G

BCL2, apoptosis regulator

decreases expression

genipin results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

baculoviral IAP repeat-containing 3

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of BIRC3 mRNA]

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

bone marrow stromal cell antigen 2

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of BST2 mRNA]

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

calcium homeostasis modulator family member 6

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CALHM6 mRNA]

NCBI chr20:26,095,591...26,097,336
Ensembl chr20:26,095,592...26,097,278

G

carbonic anhydrase 9

multiple interactions

genipin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

G

caspase 3

increases activity

genipin results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

C-C motif chemokine receptor 7

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CCR7 mRNA]

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

C-C motif chemokine receptor like 2

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CCRL2 mRNA]

NCBI chr 8:111,034,279...111,036,914
Ensembl chr 8:111,034,279...111,036,664

G

CD14 molecule

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 mRNA]

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD40 molecule

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CCAAT/enhancer binding protein delta

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CEBPD mRNA]

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

colony stimulating factor 3

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 mRNA]

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

C-X-C motif chemokine ligand 10

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 6

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL5 mRNA]

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

C-X-C motif chemokine ligand 9

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 mRNA]

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

dynamin 1-like

multiple interactions

genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of DNM1L protein]

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

guanylate binding protein 7

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of GBP7 mRNA]

NCBI chr 2:231,275,521...231,297,289
Ensembl chr 2:231,275,640...231,297,278

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

genipin affects the reaction [[Oxygen deficiency co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the expression of HIF1A protein]; genipin affects the reaction [[Oxygen deficiency co-treated with Cycloheximide] affects the expression of HIF1A protein]; genipin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

increases expression

genipin results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interferon-induced protein 35

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of IFI35 mRNA]

NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952

G

interferon-induced protein 44

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of IFI44 mRNA]

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interferon induced with helicase C domain 1

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of IFIH1 mRNA]

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456

G

interferon-induced protein with tetratricopeptide repeats 3

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of IFIT3 mRNA]

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interleukin 1 beta

multiple interactions

genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL1B protein]; genipin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

PMID:22687549 PMID:28477916

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 6

multiple interactions

genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

ISG15 ubiquitin-like modifier

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of ISG15 mRNA]

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

KLF transcription factor 2

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of KLF2 mRNA]

NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944

G

lysosomal protein transmembrane 5

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in decreased expression of LAPTM5 mRNA]

NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807

G

mitogen-activated protein kinase kinase kinase 8

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

genipin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]
genipin results in decreased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions

genipin results in decreased phosphorylation of MAPK3 protein
genipin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

multiple EGF-like-domains 11

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of MEGF11 mRNA]

NCBI chr 8:64,892,312...65,218,984
Ensembl chr 8:64,892,387...65,216,061

G

mitofusin 2

multiple interactions

genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of MFN2 protein]

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

matrix metallopeptidase 13

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP13 mRNA]

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

multiple interactions

genipin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

genipin inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MX dynamin like GTPase 1

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of MX1 mRNA]

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

MYD88, innate immune signal transduction adaptor

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NFE2 like bZIP transcription factor 2

multiple interactions

[Lipopolysaccharides co-treated with genipin] results in increased activity of NFE2L2 protein

PMID:30114225 PMID:30203046

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

increases expression

genipin results in increased expression of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

Notch-regulated ankyrin repeat protein

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in decreased expression of NRARP mRNA]

NCBI chr 3:7,992,582...7,995,136
Ensembl chr 3:7,992,552...7,995,133

G

nuclear respiratory factor 1

multiple interactions

genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of NRF1 protein]

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

2'-5' oligoadenylate synthetase 2

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of OAS2 mRNA]

NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371

G

2'-5'-oligoadenylate synthetase-like

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of OASL mRNA]

NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641

G

oncostatin M receptor

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of OSMR mRNA]

NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262

G

phosphodiesterase 4B

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

PHD finger protein 11

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of PHF11D mRNA]

NCBI chr15:33,390,290...33,414,647
Ensembl chr15:33,390,292...33,413,009

G

PTEN induced kinase 1

multiple interactions

genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of PINK1 protein]

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

plasminogen activator, urokinase

multiple interactions

genipin inhibits the reaction [Oxygen deficiency results in increased expression of PLAU protein]

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

PPARG coactivator 1 alpha

multiple interactions

genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]; sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PRKN protein]; sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PRKN protein]]

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

proteasome 20S subunit beta 8

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of PSMB8 mRNA]

NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283

G

ribonuclease A family member 3

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of EAR1 mRNA]

NCBI chr15:24,511,894...24,512,764
Ensembl chr15:24,511,891...24,512,790

G

radical S-adenosyl methionine domain containing 2

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of RSAD2 mRNA]

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of SAMHD1 mRNA]

NCBI chr 3:145,761,549...145,794,420
Ensembl chr 3:145,761,558...145,794,386

G

SH3 domain binding kinase 1

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in decreased expression of SBK1 mRNA]

NCBI chr 1:180,807,092...180,851,910
Ensembl chr 1:180,807,099...180,851,885

G

sirtuin 1

multiple interactions

genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]; sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 10 member 6

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of SLC10A6 mRNA]

NCBI chr14:6,080,716...6,102,902
Ensembl chr14:6,080,717...6,103,037

G

solute carrier family 16, member 11

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of SLC16A11 mRNA]

NCBI chr10:54,929,129...54,933,021
Ensembl chr10:54,927,725...54,942,915

G

solute carrier family 2 member 1

multiple interactions

genipin inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA]

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

schlafen family member 2

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of SLFN2 mRNA]

NCBI chr10:67,953,322...67,959,659
Ensembl chr10:67,953,171...67,959,458

G

SNF related kinase

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in decreased expression of SNRK mRNA]

NCBI chr 8:121,779,704...121,833,949
Ensembl chr 8:121,793,302...121,832,323

G

sequestosome 1

multiple interactions

genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

decreases expression

Genipin decreases expression of Srebf1 mRNA and protein in liver

RGD

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

transporter 2, ATP binding cassette subfamily B member

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of TAP2 mRNA]

NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407

G

TEK receptor tyrosine kinase

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in decreased expression of TEK mRNA]

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

G

transcription factor A, mitochondrial

multiple interactions

genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of TFAM protein]

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

tumor necrosis factor

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

torsin family 3, member A

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of TOR3A mRNA]

NCBI chr13:68,769,893...68,798,738
Ensembl chr13:68,769,605...68,798,475

G

three prime repair exonuclease 1

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of TREX1 mRNA]

NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796

G

ubiquitin D

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of UBD mRNA]

NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639

G

ubiquitin specific peptidase 18

multiple interactions

genipin inhibits the reaction [Lipopolysaccharides results in increased expression of USP18 mRNA]

NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144

G

vascular endothelial growth factor A

multiple interactions
decreases expression

genipin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; genipin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]
genipin results in decreased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

GTP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases hydrolysis

ABCB1 protein results in increased hydrolysis of Guanosine Triphosphate

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

aryl hydrocarbon receptor

multiple interactions

Guanosine Triphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

amyloid beta precursor protein

increases secretion

Guanosine Triphosphate results in increased secretion of APP protein modified form

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

cell division cycle 42

multiple interactions

Resveratrol promotes the reaction [CDC42 protein binds to Guanosine Triphosphate]; Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]; Zoledronic Acid results in increased expression of [CDC42 protein binds to Guanosine Triphosphate]
Ethanol results in decreased expression of [CDC42 protein binds to Guanosine Triphosphate]
Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]; Zoledronic Acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]

PMID:15217905 PMID:16734383 PMID:20829428 PMID:28871336

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

corticotropin releasing hormone

decreases activity

Guanosine Triphosphate results in decreased activity of CRH protein

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

colony stimulating factor 1

multiple interactions

CSF1 protein results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]; Risedronic Acid promotes the reaction [CSF1 protein results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]]

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

fucosyltransferase 8

decreases activity

Guanosine Triphosphate results in decreased activity of FUT8 protein

NCBI chr 6:95,949,246...96,176,677
Ensembl chr 6:95,949,991...96,176,677

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

[dicyanocobinamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]] which results in increased metabolism of Guanosine Triphosphate

NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

[dicyanocobinamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]] which results in increased metabolism of Guanosine Triphosphate

NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916

G

glycophorin A

increases expression

Guanosine Triphosphate results in increased expression of GYPA protein

NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822

G

H2A.X variant histone

multiple interactions

Guanosine Triphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

HRas proto-oncogene, GTPase

multiple interactions

[Enzyme Inhibitors binds to and results in decreased activity of SOS1 protein] inhibits the reaction [HRAS protein binds to Guanosine Triphosphate]

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

histamine receptor H 1

multiple interactions

Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]]

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

histamine receptor H3

multiple interactions
affects binding

6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]

NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642

G

5-hydroxytryptamine receptor 1A

multiple interactions

Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]; Guanosine Triphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]]

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

KRAS proto-oncogene, GTPase

affects binding
multiple interactions
increases hydrolysis

Guanosine Triphosphate binds to KRAS protein; Guanosine Triphosphate binds to KRAS protein mutant form
KRAS protein mutant form inhibits the reaction [RASA1 protein promotes the reaction [KRAS protein results in increased hydrolysis of Guanosine Triphosphate]]; RASA1 protein promotes the reaction [KRAS protein results in increased hydrolysis of Guanosine Triphosphate]
KRAS protein mutant form results in increased hydrolysis of Guanosine Triphosphate; KRAS protein results in increased hydrolysis of Guanosine Triphosphate

NCBI chr 4:178,185,418...178,218,484

G

leucine-rich repeat kinase 2

affects binding
multiple interactions

LRRK2 protein binds to Guanosine Triphosphate
sodium arsenite inhibits the reaction [LRRK2 protein binds to Guanosine Triphosphate]

NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703

G

melatonin receptor 1B

multiple interactions

Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]; Guanosine Triphosphate inhibits the reaction [Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]]

NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737

G

opioid receptor, mu 1

affects binding
multiple interactions

Guanosine Triphosphate binds to OPRM1 protein
Dronabinol promotes the reaction [Guanosine Triphosphate binds to OPRM1 protein]

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

purinergic receptor P2X 5

affects transport

GTP affects transport ion flux of P2rx5 receptor

RGD

NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423

G

pyrimidinergic receptor P2Y4

multiple interactions

Guanosine Triphosphate binds to and results in increased activity of P2RY4 protein

NCBI chr X:65,681,680...65,717,404
Ensembl chr X:65,683,232...65,721,748

G

Pannexin 1

decreases activity

Guanosine Triphosphate results in decreased activity of PANX1 protein

NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774

G

phosphoglycolate phosphatase

decreases phosphorylation

PGP protein results in decreased phosphorylation of Guanosine Triphosphate

NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858

G

proopiomelanocortin

multiple interactions

[Guanosine Triphosphate co-treated with Lithium] results in decreased activity of POMC protein modified form; [Guanosine Triphosphate co-treated with Potassium] results in decreased activity of POMC protein modified form; [Guanosine Triphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

RAB3A, member RAS oncogene family

affects binding
increases cleavage
multiple interactions

[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein; Guanosine Triphosphate binds to RAB3A protein; RAB3A protein binds to Guanosine Triphosphate; SNCA protein binds to [RAB3A protein binds to Guanosine Triphosphate]
RAB3A protein results in increased cleavage of Guanosine Triphosphate
[alpha-latrotoxin promotes the reaction [RAB3A protein results in increased cleavage of Guanosine Triphosphate]] promotes the reaction [Guanosine Diphosphate binds to RAB3A protein]; [black widow spider venom promotes the reaction [RAB3A protein results in increased cleavage of Guanosine Triphosphate]] promotes the reaction [Guanosine Diphosphate binds to RAB3A protein]; manganese chloride inhibits the reaction [[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein]; manganese chloride promotes the reaction [SNCA protein binds to [RAB3A protein binds to Guanosine Triphosphate]]; manganese chloride results in increased expression of [RAB3A protein binds to Guanosine Triphosphate]; SNCA protein promotes the reaction [manganese chloride inhibits the reaction [[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein]]

PMID:7929154 PMID:29289693

NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336

G

RAB GTPase activating protein 1

multiple interactions
affects binding

manganese chloride inhibits the reaction [[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein]; SNCA protein promotes the reaction [manganese chloride inhibits the reaction [[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein]]

NCBI chr 3:21,208,012...21,326,013
Ensembl chr 3:21,208,055...21,326,013

G

Rac family small GTPase 1

multiple interactions

Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]; Zoledronic Acid results in increased expression of [RAC1 protein binds to Guanosine Triphosphate]
Ethanol results in decreased expression of [RAC1 protein binds to Guanosine Triphosphate]
CSF1 protein results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]; GGTI 298 results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]; mevastatin results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]; Risedronic Acid promotes the reaction [CSF1 protein results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]]; Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]; Zoledronic Acid results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]

PMID:16734383 PMID:20829428 PMID:28871336

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

RAP1B, member of RAS oncogene family

multiple interactions

[Pentoxifylline results in increased abundance of Cyclic AMP] results in increased abundance of [RAP1B protein binds to Guanosine Triphosphate]

NCBI chr 7:53,423,039...53,456,349
Ensembl chr 7:53,423,130...53,456,370

G

RAS p21 protein activator 1

multiple interactions

KRAS protein mutant form inhibits the reaction [RASA1 protein promotes the reaction [KRAS protein results in increased hydrolysis of Guanosine Triphosphate]]; RASA1 protein promotes the reaction [KRAS protein results in increased hydrolysis of Guanosine Triphosphate]

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

ras homolog family member A

multiple interactions
affects binding

Dronabinol inhibits the reaction [Guanosine Triphosphate binds to and results in increased activity of RHOA protein]; Guanosine Triphosphate binds to and results in increased activity of RHOA protein; Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]; Zoledronic Acid results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]
Asbestos, Crocidolite inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]; Cadmium Chloride promotes the reaction [RHOA protein binds to Guanosine Triphosphate]; Dronabinol inhibits the reaction [Guanosine Triphosphate binds to and results in increased activity of RHOA protein]; Guanosine Triphosphate binds to and results in increased activity of RHOA protein; Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]; tempol inhibits the reaction [Asbestos, Crocidolite inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]; tempol inhibits the reaction [Vitamin K 3 inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]; Vitamin K 3 inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]; Zoledronic Acid results in increased expression of [RHOA protein binds to Guanosine Triphosphate]

PMID:16734383 PMID:21257924 PMID:26220685 PMID:28871336 PMID:29307655

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

synuclein alpha

multiple interactions
affects binding

manganese chloride promotes the reaction [SNCA protein binds to [RAB3A protein binds to Guanosine Triphosphate]]; SNCA protein promotes the reaction [manganese chloride inhibits the reaction [[RAB3A protein binds to Guanosine Triphosphate] which binds to RABGAP1 protein]]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

SOS Ras/Rac guanine nucleotide exchange factor 1

multiple interactions

[Enzyme Inhibitors binds to and results in decreased activity of SOS1 protein] inhibits the reaction [HRAS protein binds to Guanosine Triphosphate]

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

transglutaminase 2

affects binding

Guanosine Triphosphate binds to TGM2 protein

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

tumor protein p53 binding protein 1

multiple interactions

Guanosine Triphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]

NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822

guanosine 5'-[gamma-thio]triphosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine A2a receptor

multiple interactions

ADORA2A protein affects the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] which results in increased activity of Guanosine 5'-O-(3-Thiotriphosphate)]

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

cannabinoid receptor 1

multiple interactions
affects binding

(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone metabolite promotes the reaction [CNR1 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)]; (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone promotes the reaction [CNR1 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)]; 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester promotes the reaction [CNR1 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)]; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol promotes the reaction [CNR1 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)]; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR1 protein]; 5F-CUMYL-PICA promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR1 protein]; AM 6527 promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR1 protein]; delta(9)-tetrahydrocannabinolic acid promotes the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR1 protein]]; delta(9)-tetrahydrocannabinolic acid promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR1 protein]; Dronabinol promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR1 protein]; methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR1 protein]; methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR1 protein]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR1 protein]; XLR-11 metabolite promotes the reaction [CNR1 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)]; XLR-11 promotes the reaction [CNR1 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)]

PMID:28087785 PMID:29549157 PMID:32510591

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

cannabinoid receptor 2

multiple interactions
affects binding

(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone metabolite promotes the reaction [CNR2 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)]; (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone promotes the reaction [CNR2 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)]; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol promotes the reaction [CNR2 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)]; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; 4-hydroxy-N-desmethyltamoxifen inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; 5F-CUMYL-PICA promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; afimoxifene inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; AM 281 inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; AM 6527 promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; cannabinoid CB2 receptor agonist ABK5 promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; Dronabinol promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; iodopravadoline inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; ridaifen-B inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; Tamoxifen inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]; XLR-11 metabolite promotes the reaction [CNR2 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)]; XLR-11 promotes the reaction [CNR2 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)]

PMID:27936172 PMID:28087785 PMID:29549157 PMID:29906493 PMID:30951717 More...

NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548

G

G protein subunit alpha 13

affects binding
multiple interactions

Guanosine 5'-O-(3-Thiotriphosphate) binds to GNA13 protein
[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of GPR55 protein] affects the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to GNA13 protein]

NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774

G

G protein subunit alpha i1

affects binding

GNAI1 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)

NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417

G

G protein subunit alpha i3

affects binding

GNAI3 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)

NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742

G

G protein subunit alpha o1

affects binding

GNAO1 protein binds to Guanosine 5'-O-(3-Thiotriphosphate)

NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493

G

GNAS complex locus

affects binding

GNAS protein binds to Guanosine 5'-O-(3-Thiotriphosphate)

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein subunit alpha z

affects binding

GNAZ protein binds to Guanosine 5'-O-(3-Thiotriphosphate)

NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907

G

G protein-coupled receptor 55

multiple interactions

[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of GPR55 protein] affects the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to GNA13 protein]

NCBI chr 9:86,584,906...86,640,601
Ensembl chr 9:86,590,885...86,640,613

G

histamine receptor H4

affects binding
multiple interactions

Guanosine 5'-O-(3-Thiotriphosphate) binds to HRH4 protein
Histamine promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to HRH4 protein]

NCBI chr18:4,166,270...4,182,426
Ensembl chr18:4,166,270...4,246,345

G

myosin light chain 9

multiple interactions

[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein; Glycodeoxycholic Acid inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein]; Y 27632 inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased phosphorylation of MYL9 protein]

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

opioid receptor, mu 1

multiple interactions

[7-benzylidenenaltrexone binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate); [chlornaltrexamine binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate); [clocinnamox binds to and results in decreased activity of OPRM1 protein] which affects the localization of Guanosine 5'-O-(3-Thiotriphosphate)
[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] which results in increased activity of Guanosine 5'-O-(3-Thiotriphosphate); ADORA2A protein affects the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] which results in increased activity of Guanosine 5'-O-(3-Thiotriphosphate)]

PMID:11413242 PMID:14756803

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

phospholipase C beta 1

multiple interactions
increases activity

[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein; Caffeine inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]; Theophylline inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Theophylline inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]

NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869

G

phospholipase C, gamma 2

multiple interactions

[[RAC2 protein co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCG2 protein] which results in increased chemical synthesis of Inositol Phosphates; [Guanosine 5'-O-(3-Thiotriphosphate) co-treated with RAC2 protein] promotes the reaction [PLCG2 protein mutant form results in increased chemical synthesis of Inositol Phosphates]; [Guanosine 5'-O-(3-Thiotriphosphate) co-treated with RAC2 protein] promotes the reaction [PLCG2 protein results in increased chemical synthesis of Inositol Phosphates]; [RAC2 protein co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCG2 protein; PLCG2 protein mutant form results in decreased susceptibility to [RAC2 protein co-treated with Guanosine 5'-O-(3-Thiotriphosphate)]

PMID:25903139 PMID:27542411

NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930

G

pleckstrin

increases phosphorylation
multiple interactions

Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein
dioleoylphosphatidic acid analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein]; Oleic Acid promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein]; phosphatidylethanol analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein]

NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131

G

protein phosphatase 1, regulatory subunit 12A

multiple interactions
increases phosphorylation

Guanosine 5'-O-(3-Thiotriphosphate) inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased phosphorylation of PPP1R12A protein]
Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PPP1R12A protein

NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425

G

prostaglandin D2 receptor

multiple interactions

Guanosine 5'-O-(3-Thiotriphosphate) inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]

NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679

G

Rac family small GTPase 1

multiple interactions

Methohexital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]; Pentobarbital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]; Secobarbital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]; Thiamylal inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein]

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

Rac family small GTPase 2

multiple interactions

[[RAC2 protein co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCG2 protein] which results in increased chemical synthesis of Inositol Phosphates; [Guanosine 5'-O-(3-Thiotriphosphate) co-treated with RAC2 protein] promotes the reaction [PLCG2 protein mutant form results in increased chemical synthesis of Inositol Phosphates]; [Guanosine 5'-O-(3-Thiotriphosphate) co-treated with RAC2 protein] promotes the reaction [PLCG2 protein results in increased chemical synthesis of Inositol Phosphates]; [RAC2 protein co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCG2 protein; PLCG2 protein mutant form results in decreased susceptibility to [RAC2 protein co-treated with Guanosine 5'-O-(3-Thiotriphosphate)]

PMID:25903139 PMID:27542411

NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720

G

ras homolog family member A

affects localization
multiple interactions

Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of RHOA protein
[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased localization of RHOA protein; Glycodeoxycholic Acid inhibits the reaction [[Escin affects the susceptibility to Guanosine 5'-O-(3-Thiotriphosphate)] which results in increased localization of RHOA protein]; Sevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of RHOA protein]

PMID:12960549 PMID:29660437

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

Rho-associated coiled-coil containing protein kinase 2

affects localization
multiple interactions

Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of ROCK2 protein
sevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of ROCK2 protein]

NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031

G

transient receptor potential cation channel, subfamily C, member 6

increases activity

Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of TRPC6 protein

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19853
role	19825
biological role	19823
inhibitor	18902
uncoupling protein inhibitor	138
GDP +	13
GTP +	57
Genipin	78

paths to the root