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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor
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Accession:CHEBI:145410 term browser browse the term
Definition:An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of any isocitrate dehydrogenase (EC 1.1.1.42).
Synonyms:related_synonym: EC 1.1.1.42 inhibitor;   EC 1.1.1.42 inhibitors;   IDH inhibitor;   IDH inhibitors;   IDP inhibitor;   IDP inhibitors;   IDP1 inhibitor;   IDP1 inhibitors;   IDP2 inhibitor;   IDP2 inhibitors;   IDP3 inhibitor;   IDP3 inhibitors;   NADP isocitric dehydrogenase inhibitor;   NADP isocitric dehydrogenase inhibitors;   NADP(+)-ICDH inhibitor;   NADP(+)-ICDH inhibitors;   NADP(+)-IDH inhibitor;   NADP(+)-IDH inhibitors;   NADP-dependent isocitrate dehydrogenase inhibitor;   NADP-dependent isocitrate dehydrogenase inhibitors;   NADP-dependent isocitric dehydrogenase inhibitor;   NADP-dependent isocitric dehydrogenase inhibitors;   NADP-linked isocitrate dehydrogenase inhibitor;   NADP-linked isocitrate dehydrogenase inhibitors;   NADP-specific isocitrate dehydrogenase inhibitor;   NADP-specific isocitrate dehydrogenase inhibitors;   dual-cofactor-specific isocitrate dehydrogenase inhibitor;   dual-cofactor-specific isocitrate dehydrogenase inhibitors;   isocitrate (NADP) dehydrogenase inhibitor;   isocitrate (NADP) dehydrogenase inhibitors;   isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase inhibitor;   isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase inhibitors;   isocitrate dehydrogenase inhibitor;   isocitrate dehydrogenase inhibitors;   oxalosuccinate decarboxylase inhibitor;   oxalosuccinate decarboxylase inhibitors;   oxalsuccinic decarboxylase inhibitor;   oxalsuccinic decarboxylase inhibitors;   triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase inhibitor;   triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase inhibitors
 xref: Wikipedia:Isocitrate_dehydrogenase



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enasidenib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [enasidenib inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]] which results in increased susceptibility to Daunorubicin; enasidenib inhibits the reaction [ABCB1 protein results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin] CTD PMID:35972551 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [enasidenib inhibits the reaction [ABCC1 protein results in increased export of Daunorubicin]] which results in increased susceptibility to Daunorubicin; enasidenib inhibits the reaction [ABCC1 protein results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [ABCC1 protein results in increased export of Daunorubicin] CTD PMID:35972551 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO [enasidenib inhibits the reaction [ABCG2 protein results in increased export of Daunorubicin]] which results in increased susceptibility to Daunorubicin; enasidenib inhibits the reaction [ABCG2 protein results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [ABCG2 protein results in increased export of Daunorubicin] CTD PMID:35972551 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
decreases activity
ISO enasidenib inhibits the reaction [[AKR1C3 protein results in increased reduction of Daunorubicin] which results in increased abundance of daunorubicinol]; enasidenib inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [AKR1C3 protein results in increased reduction of Daunorubicin]
enasidenib results in decreased activity of AKR1C3 protein
CTD PMID:35972551 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19911
    role 19887
      biological role 19885
        biochemical role 19581
          enzyme inhibitor 18765
            EC 1.* (oxidoreductase) inhibitor 17554
              EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor 7235
                EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor 5780
                  EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor 4
                    SYC-435 0
                    enasidenib 4
                    ivosidenib 0
paths to the root