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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:binimetinib
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Accession:CHEBI:145371 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib.
Synonyms:exact_synonym: 5-(4-bromo-2-fluoroanilino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
 related_synonym: 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide;   5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;   ARRY 162;   ARRY-438162;   Formula=C17H15BrF2N4O3;   InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26);   InChIKey=ACWZRVQXLIRSDF-UHFFFAOYSA-N;   MEK-162;   MEK162;   Mektovi;   N-(2-hydroxyethoxy)-4-fluoro-5-(2-fluoro-4-bromophenylamino)-1-methyl-1H-benzoimidazole-6-carboxamide;   NVP-MEK162;   SMILES=BrC=1C=C(F)C(NC=2C(F)=C3N=CN(C3=CC2C(=O)NOCCO)C)=CC1;   binimetinibum
 xref: CAS:606143-89-9;   DrugBank:DB11967;   KEGG:D10604;   LINCS:LSM-45640
 xref_mesh: MESH:C581313
 xref: PMCID:PMC6012544;   PMID:23414587;   PMID:27071922;   PMID:28152546;   PMID:28412197;   PMID:28587477;   PMID:28851243;   PMID:29785570;   PMID:29946554;   PMID:30117021;   PMID:30635233;   PMID:30648436;   PMID:30652516;   PMID:30956763;   PMID:31050693;   PMID:31129802;   PMID:31213500;   PMID:31312030;   PMID:31395751;   PMID:31436845;   PMID:31437754;   PMID:31631932;   Wikipedia:Binimetinib


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binimetinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [NADP co-treated with binimetinib] results in decreased activity of CYP1A2 protein CTD PMID:33728909 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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  CHEBI ontology 19773
    role 19719
      biological role 19719
        biochemical role 19312
          apoptosis inducer 11029
            binimetinib 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic group 18613
                              organic divalent group 18604
                                organodiyl group 18604
                                  carbonyl group 18521
                                    carbonyl compound 18521
                                      carboxylic acid 18196
                                        carboacyl group 17418
                                          univalent carboacyl group 17418
                                            carbamoyl group 17218
                                              carboxamide 17218
                                                hydroxamic acid 6282
                                                  hydroxamic acid ester 145
                                                    binimetinib 1
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