Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

go back to main search page
Accession:CHEBI:145371 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib.
Synonyms:exact_synonym: 5-(4-bromo-2-fluoroanilino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
 related_synonym: 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide;   5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;   ARRY 162;   ARRY-438162;   Formula=C17H15BrF2N4O3;   InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26);   InChIKey=ACWZRVQXLIRSDF-UHFFFAOYSA-N;   MEK-162;   MEK162;   Mektovi;   N-(2-hydroxyethoxy)-4-fluoro-5-(2-fluoro-4-bromophenylamino)-1-methyl-1H-benzoimidazole-6-carboxamide;   NVP-MEK162;   SMILES=BrC=1C=C(F)C(NC=2C(F)=C3N=CN(C3=CC2C(=O)NOCCO)C)=CC1;   binimetinibum
 xref: CAS:606143-89-9;   DrugBank:DB11967;   KEGG:D10604;   LINCS:LSM-45640
 xref_mesh: MESH:C581313
 xref: PMCID:PMC6012544;   PMID:23414587;   PMID:27071922;   PMID:28152546;   PMID:28412197;   PMID:28587477;   PMID:28851243;   PMID:29785570;   PMID:29946554;   PMID:30117021;   PMID:30635233;   PMID:30648436;   PMID:30652516;   PMID:30956763;   PMID:31050693;   PMID:31129802;   PMID:31213500;   PMID:31312030;   PMID:31395751;   PMID:31436845;   PMID:31437754;   PMID:31631932;   Wikipedia:Binimetinib

show annotations for term's descendants           Sort by:
binimetinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [NADP co-treated with binimetinib] results in decreased activity of CYP1A2 protein CTD PMID:33728909 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      biological role 19782
        biochemical role 19495
          apoptosis inducer 13497
            binimetinib 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic group 18902
                              organic divalent group 18884
                                organodiyl group 18884
                                  carbonyl group 18850
                                    carbonyl compound 18850
                                      carboxylic acid 18564
                                        carboacyl group 17681
                                          univalent carboacyl group 17681
                                            carbamoyl group 17527
                                              carboxamide 17527
                                                hydroxamic acid 6327
                                                  hydroxamic acid ester 153
                                                    binimetinib 1
paths to the root