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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1-hydroxymidazolam beta-D-glucuronide
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Accession:CHEBI:145334 term browser browse the term
Definition:A beta-D-glucosiduronic acid that is beta-D-glucuronic acid in which the anomeric hydroxyl hydrogen has been replaced by a 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-yl group. It is the glucuronidated conjugate of the midazolam metabolite, 1-hydroxymidazolam.
Synonyms:exact_synonym: [8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-1-yl]methyl beta-D-glucopyranosiduronic acid
 related_synonym: 1'-OH MDZ glucuronide;   1-hydroxymethylmidazolam glucuronide;   1-hydroxymidazolam glucuronide;   Formula=C24H21ClFN3O7;   InChI=1S/C24H21ClFN3O7/c25-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)26)28-9-12-8-27-17(29(12)16)10-35-24-21(32)19(30)20(31)22(36-24)23(33)34/h1-8,19-22,24,30-32H,9-10H2,(H,33,34)/t19-,20-,21+,22-,24+/m0/s1;   InChIKey=ICIUMXQTLQXWGL-QMDPOKHVSA-N;   MDZ-glucuronide;   SMILES=C1(=NCC=2N(C=3C1=CC(=CC3)Cl)C(=NC2)CO[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(O)=O)O)O)O)C=5C=CC=CC5F
 xref: CAS:81256-81-7
 xref_mesh: MESH:C061795
 xref: PMCID:PMC2934138;   PMID:10519446;   PMID:14513773;   PMID:1767626;   PMID:17998299;   PMID:18256203;   PMID:18537963;   PMID:20713656;   PMID:22660604;   PMID:2582710;   PMID:6691561



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1-hydroxymidazolam beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide CTD PMID:27485346 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        biochemical role 19361
          apoptosis inducer 13311
            midazolam 27
              1-hydroxymidazolam 3
                1-hydroxymidazolam beta-D-glucuronide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            heteroorganic entity 19273
                              organochalcogen compound 19047
                                organooxygen compound 18993
                                  carbohydrates and carbohydrate derivatives 12344
                                    carbohydrate 12344
                                      carbohydrate derivative 11948
                                        glycosyl compound 10985
                                          glycoside 9267
                                            glycosiduronic acid 156
                                              glucosiduronic acid 156
                                                beta-D-glucosiduronic acid 48
                                                  1-hydroxymidazolam beta-D-glucuronide 1
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