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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-hydroxymidazolam
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Accession:CHEBI:145331 term browser browse the term
Definition:An imidazobenzodiazepine that is midazolam which is substituted by a hydroxy group at position 4. It is the minor hydroxylated metabolite of the anesthetic, midazolam.
Synonyms:exact_synonym: 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol
 related_synonym: 4-OH midazolam;   4-OH-MDZ;   Formula=C18H13ClFN3O;   InChI=1S/C18H13ClFN3O/c1-10-21-9-16-18(24)22-17(12-4-2-3-5-14(12)20)13-8-11(19)6-7-15(13)23(10)16/h2-9,18,24H,1H3;   InChIKey=ZYISITHKPKHPKG-UHFFFAOYSA-N;   Ro 21-5975;   SMILES=C1(=NC(C=2N(C=3C1=CC(=CC3)Cl)C(=NC2)C)O)C=4C=CC=CC4F
 xref: CAS:59468-85-8;   HMDB:HMDB0061090
 xref_mesh: MESH:C042940
 xref: PMID:15018796;   PMID:20434409;   PMID:20713656;   PMID:21204116;   PMID:21992114;   PMID:22841553;   PMID:23870610;   PMID:28978489;   PMID:31474719;   PMID:9187388


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4-hydroxymidazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 multiple interactions
increases chemical synthesis		 ISO diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Luteolin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        biochemical role 21431
          apoptosis inducer 13763
            midazolam 31
              4-hydroxymidazolam 1
                4-hydroxymidazolam beta-D-glucuronide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                carbocyclic compound 19682
                                  benzenoid aromatic compound 18819
                                    benzenes 18620
                                      fluorobenzenes 6676
                                        monofluorobenzenes 5306
                                          midazolam 31
                                            4-hydroxymidazolam 1
                                              4-hydroxymidazolam beta-D-glucuronide 0
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