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Accession:CHEBI:145330 term browser browse the term
Definition:An imidazobenzodiazepine that is midazolam in which one of the hydrogens of the methyl group is substituted by a hydroxy group. It is the major metabolite of the anesthetic, midazolam.
Synonyms:exact_synonym: [8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-1-yl]methanol
 related_synonym: 1-OH-MDZ;   1-hydroxymethylmidazolam;   8-chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5-a][1,4]benzodiazepine;   8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol;   Formula=C18H13ClFN3O;   InChI=1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2;   InChIKey=QHSMEGADRFZVNE-UHFFFAOYSA-N;   Ro 21-6347;   SMILES=C1(=NCC=2N(C=3C1=CC(=CC3)Cl)C(=NC2)CO)C=4C=CC=CC4F;   alpha-hydroxymidazolam
 xref: CAS:59468-90-5;   HMDB:HMDB0061089
 xref_mesh: MESH:C040081
 xref: PMID:15914101;   PMID:17452028;   PMID:20850770;   PMID:21204116;   PMID:21531182;   PMID:21993197;   PMID:23674377;   PMID:28615640;   PMID:28978489;   PMID:31469454;   PMID:6691561;   PMID:7199324;   PMID:7603229;   PMID:8924728;   PMID:9187388;   PMID:9725490

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1-hydroxymidazolam term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Tspo translocator protein JBrowse link 7 124,460,358 124,470,610 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      biological role 19726
        biochemical role 19220
          apoptosis inducer 10889
            midazolam 28
              1-hydroxymidazolam 3
                1-hydroxymidazolam beta-D-glucuronide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    p-block element atom 19664
                      carbon group element atom 19559
                        carbon atom 19548
                          organic molecular entity 19548
                            organic molecule 19472
                              organic cyclic compound 19236
                                carbocyclic compound 17626
                                  benzenoid aromatic compound 17169
                                    benzenes 16913
                                      fluorobenzenes 1645
                                        monofluorobenzenes 1310
                                          midazolam 28
                                            1-hydroxymidazolam 3
                                              1-hydroxymidazolam beta-D-glucuronide 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.