Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

go back to main search page
Accession:CHEBI:145330 term browser browse the term
Definition:An imidazobenzodiazepine that is midazolam in which one of the hydrogens of the methyl group is substituted by a hydroxy group. It is the major metabolite of the anesthetic, midazolam.
Synonyms:exact_synonym: [8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-1-yl]methanol
 related_synonym: 1-OH-MDZ;   1-hydroxymethylmidazolam;   8-chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5-a][1,4]benzodiazepine;   8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol;   Formula=C18H13ClFN3O;   InChI=1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2;   InChIKey=QHSMEGADRFZVNE-UHFFFAOYSA-N;   Ro 21-6347;   SMILES=C1(=NCC=2N(C=3C1=CC(=CC3)Cl)C(=NC2)CO)C=4C=CC=CC4F;   alpha-hydroxymidazolam
 xref: CAS:59468-90-5;   HMDB:HMDB0061089
 xref_mesh: MESH:C040081
 xref: PMID:15914101;   PMID:17452028;   PMID:20850770;   PMID:21204116;   PMID:21531182;   PMID:21993197;   PMID:23674377;   PMID:28615640;   PMID:28978489;   PMID:31469454;   PMID:6691561;   PMID:7199324;   PMID:7603229;   PMID:8924728;   PMID:9187388;   PMID:9725490

show annotations for term's descendants           Sort by:
1-hydroxymidazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases chemical synthesis ISO CYP3A5 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam CTD PMID:18191104 PMID:26958860 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Tspo translocator protein affects binding EXP 1-hydroxymethylmidazolam binds to TSPO protein; 1-hydroxymethylmidazolam metabolite binds to TSPO protein CTD PMID:7603229 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      biological role 19732
        biochemical role 19333
          apoptosis inducer 13097
            midazolam 27
              1-hydroxymidazolam 2
                1-hydroxymidazolam beta-D-glucuronide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic molecule 19519
                              organic cyclic compound 19349
                                carbocyclic compound 18304
                                  benzenoid aromatic compound 17416
                                    benzenes 17188
                                      fluorobenzenes 1772
                                        monofluorobenzenes 1432
                                          midazolam 27
                                            1-hydroxymidazolam 2
                                              1-hydroxymidazolam beta-D-glucuronide 0
paths to the root