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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:epoxy steroid
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Accession:CHEBI:145217 term browser browse the term
Definition:Any steroid whose structure includes an epoxy group.
Synonyms:related_synonym: epoxy-steroids


show annotations for term's descendants           Sort by:
 
5,6alpha-epoxy-5alpha-cholestan-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor increases phosphorylation ISO cholesterol alpha-oxide results in increased phosphorylation of EGFR protein CTD PMID:20466046 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G EPHX1 epoxide hydrolase 1 increases metabolic processing
multiple interactions		 ISO EPHX1 protein results in increased metabolism of cholesterol alpha-oxide
disparlure promotes the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]; Lanosterol analog inhibits the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]		 CTD PMID:2043152 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563 		JBrowse link
G EPHX2 epoxide hydrolase 2 multiple interactions ISO cholesterol alpha-oxide inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] CTD PMID:2043152 NCBI chr 8:27,491,143...27,545,564
Ensembl chr 8:27,490,781...27,545,564 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK1 protein] CTD PMID:20466046 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein]		 CTD PMID:20466046 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MMP2 matrix metallopeptidase 2 increases expression ISO cholesterol alpha-oxide results in increased expression of MMP2 mRNA CTD PMID:20466046 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression ISO cholesterol alpha-oxide results in increased expression of MMP9 mRNA CTD PMID:20466046 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MTOR mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions		 ISO cholesterol alpha-oxide results in increased phosphorylation of MTOR protein
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MTOR protein]		 CTD PMID:20466046 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
bufogenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases metabolic processing
increases expression
increases activity		 EXP bufogenin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin]
bufogenin results in increased expression of CYP3A4 mRNA
bufogenin results in increased activity of CYP3A4 protein		 CTD PMID:22178124 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions EXP eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] CTD PMID:17596522 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G AGT angiotensinogen multiple interactions ISO eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]; eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:20175999 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G CAT catalase increases expression ISO eplerenone results in increased expression of CAT protein CTD PMID:17324946 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CD80 CD80 molecule multiple interactions ISO Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of CD80 mRNA] CTD PMID:27773435 NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614 		JBrowse link
G CDH1 cadherin 1 multiple interactions EXP eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein] CTD PMID:17596522 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA] CTD PMID:27773435 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL3A1 collagen type III alpha 1 chain multiple interactions ISO Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL3A1 mRNA] CTD PMID:27773435 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746 		JBrowse link
G COL4A1 collagen type IV alpha 1 chain multiple interactions
decreases expression		 ISO [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]
eplerenone results in decreased expression of COL4A1 mRNA; eplerenone results in decreased expression of COL4A1 protein		 CTD PMID:18682491 NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,157 		JBrowse link
G CYBA cytochrome b-245 alpha chain decreases expression
multiple interactions		 ISO eplerenone results in decreased expression of CYBA mRNA
[trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA		 CTD PMID:17324946 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases abundance
increases metabolic processing		 EXP CYP3A4 protein results in increased abundance of Eplerenone metabolite
CYP3A4 protein results in increased metabolism of Eplerenone		 CTD PMID:31408697 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 increases abundance
increases metabolic processing		 EXP CYP3A5 protein results in increased abundance of Eplerenone metabolite
CYP3A5 protein results in increased metabolism of Eplerenone		 CTD PMID:31408697 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998 		JBrowse link
G FN1 fibronectin 1 multiple interactions ISO [trandolapril co-treated with eplerenone] results in decreased expression of FN1 protein CTD PMID:17324946 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G IL18 interleukin 18 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:17596522 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:17596522 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 decreases expression
multiple interactions		 ISO eplerenone results in decreased expression of NCF1 mRNA; eplerenone results in decreased expression of NCF1 protein
[trandolapril co-treated with eplerenone] results in decreased expression of NCF1 mRNA; [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 protein		 CTD PMID:17324946 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases activity
increases expression
decreases expression		 ISO [Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA
eplerenone results in increased activity of NOS3 protein
eplerenone results in increased expression of NOS3 mRNA
eplerenone results in decreased expression of NOS3 mRNA; eplerenone results in decreased expression of NOS3 protein		 CTD PMID:15974890 PMID:20571278 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 multiple interactions ISO eplerenone binds to and results in decreased activity of NR3C2 protein CTD PMID:15974890 NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698 		JBrowse link
G OSR1 odd-skipped related transcription factor 1 multiple interactions ISO eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein] CTD PMID:20175999 NCBI chr 2:19,344,874...19,358,623
Ensembl chr 2:19,351,485...19,358,623 		JBrowse link
G OXSR1 oxidative stress responsive kinase 1 multiple interactions ISO [eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of OXSR1 protein CTD PMID:22949526 NCBI chr 3:38,164,063...38,255,484
Ensembl chr 3:38,165,089...38,255,484 		JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions
decreases expression		 ISO [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
eplerenone results in decreased expression of SERPINE1 mRNA; eplerenone results in decreased expression of SERPINE1 protein		 CTD PMID:18682491 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SLC12A3 solute carrier family 12 member 3 multiple interactions ISO [eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of SLC12A3 protein; eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:20175999 PMID:22949526 NCBI chr16:56,865,207...56,915,850
Ensembl chr16:56,865,207...56,915,850 		JBrowse link
G SLC9A1 solute carrier family 9 member A1 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased expression of SLC9A1 mRNA] CTD PMID:16373419 NCBI chr 1:27,098,809...27,155,125
Ensembl chr 1:27,098,809...27,166,981 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 multiple interactions EXP eplerenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA] CTD PMID:17596522 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886 		JBrowse link
G SOD1 superoxide dismutase 1 increases expression ISO eplerenone results in increased expression of SOD1 protein CTD PMID:17324946 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression ISO eplerenone results in increased expression of SOD2 protein CTD PMID:17324946 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G STK39 serine/threonine kinase 39 multiple interactions ISO [eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of STK39 protein CTD PMID:22949526 NCBI chr 2:167,954,022...168,247,595
Ensembl chr 2:167,954,020...168,247,595 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
decreases expression		 ISO [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]
eplerenone results in decreased expression of TGFB1 mRNA; eplerenone results in decreased expression of TGFB1 protein		 CTD PMID:18682491 PMID:27773435 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFBI transforming growth factor beta induced decreases secretion
multiple interactions		 ISO eplerenone results in decreased secretion of TGFBI protein
[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein		 CTD PMID:18682491 NCBI chr 5:136,028,988...136,063,818
Ensembl chr 5:136,028,988...136,063,818 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNF mRNA] CTD PMID:27773435 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
marinobufagenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL1A1 collagen type I alpha 1 chain increases expression ISO marinobufagenin results in increased expression of COL1A1 mRNA CTD PMID:26702050 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G MIR101-1 microRNA 101-1 decreases expression ISO marinobufagenin results in decreased expression of MIR101A mRNA CTD PMID:26702050 NCBI chr 1:65,058,434...65,058,508
Ensembl chr 1:65,058,434...65,058,508 		JBrowse link
G MIR106B microRNA 106b decreases expression ISO marinobufagenin results in decreased expression of MIR106B mRNA CTD PMID:26702050 NCBI chr 7:100,093,993...100,094,074
Ensembl chr 7:100,093,993...100,094,074 		JBrowse link
G MIR122 microRNA 122 increases expression ISO marinobufagenin results in increased expression of MIR122 mRNA CTD PMID:26702050 NCBI chr18:58,451,074...58,451,158
Ensembl chr18:58,451,074...58,451,158 		JBrowse link
G MIR130A microRNA 130a decreases expression ISO marinobufagenin results in decreased expression of MIR130A mRNA CTD PMID:26702050 NCBI chr11:57,641,198...57,641,286
Ensembl chr11:57,641,198...57,641,286 		JBrowse link
G MIR140 microRNA 140 decreases expression ISO marinobufagenin results in decreased expression of MIR140 mRNA CTD PMID:26702050 NCBI chr16:69,933,081...69,933,180
Ensembl chr16:69,933,081...69,933,180 		JBrowse link
G MIR141 microRNA 141 decreases expression ISO marinobufagenin results in decreased expression of MIR141 mRNA CTD PMID:26702050 NCBI chr12:6,964,097...6,964,191
Ensembl chr12:6,964,097...6,964,191 		JBrowse link
G MIR142 microRNA 142 decreases expression ISO marinobufagenin results in decreased expression of MIR142 mRNA CTD PMID:26702050 NCBI chr17:58,331,232...58,331,318
Ensembl chr17:58,331,232...58,331,318 		JBrowse link
G MIR144 microRNA 144 decreases expression ISO marinobufagenin results in decreased expression of MIR144 mRNA CTD PMID:26702050 NCBI chr17:28,861,533...28,861,618
Ensembl chr17:28,861,533...28,861,618 		JBrowse link
G MIR185 microRNA 185 decreases expression ISO marinobufagenin results in decreased expression of MIR185 mRNA CTD PMID:26702050 NCBI chr22:20,033,139...20,033,220
Ensembl chr22:20,033,139...20,033,220 		JBrowse link
G MIR18A microRNA 18a decreases expression ISO marinobufagenin results in decreased expression of MIR18A mRNA CTD PMID:26702050 NCBI chr13:91,350,751...91,350,821
Ensembl chr13:91,350,751...91,350,821 		JBrowse link
G MIR196A2 microRNA 196a-2 decreases expression ISO marinobufagenin results in decreased expression of MIR196A mRNA CTD PMID:26702050 NCBI chr12:53,991,738...53,991,847
Ensembl chr12:53,991,738...53,991,847 		JBrowse link
G MIR196B microRNA 196b decreases expression ISO marinobufagenin results in decreased expression of MIR196B mRNA CTD PMID:26702050 NCBI chr 7:27,169,480...27,169,563
Ensembl chr 7:27,169,480...27,169,563 		JBrowse link
G MIR210 microRNA 210 decreases expression ISO marinobufagenin results in decreased expression of MIR210 mRNA CTD PMID:26702050 NCBI chr11:568,089...568,198
Ensembl chr11:568,089...568,198 		JBrowse link
G MIR222 microRNA 222 decreases expression ISO marinobufagenin results in decreased expression of MIR222 mRNA CTD PMID:26702050 NCBI chr  X:45,747,015...45,747,124
Ensembl chr  X:45,747,015...45,747,124 		JBrowse link
G MIR23A microRNA 23a increases expression ISO marinobufagenin results in increased expression of MIR23A mRNA CTD PMID:26702050 NCBI chr19:13,836,587...13,836,659
Ensembl chr19:13,836,587...13,836,659 		JBrowse link
G MIR29B1 microRNA 29b-1 decreases expression ISO marinobufagenin results in decreased expression of MIR29B1 mRNA CTD PMID:26702050 NCBI chr 7:130,877,459...130,877,539
Ensembl chr 7:130,877,459...130,877,539 		JBrowse link
G MIR32 microRNA 32 decreases expression ISO marinobufagenin results in decreased expression of MIR32 mRNA CTD PMID:26702050 NCBI chr 9:109,046,229...109,046,298
Ensembl chr 9:109,046,229...109,046,298 		JBrowse link
G MIR320A microRNA 320a decreases expression ISO marinobufagenin results in decreased expression of MIR320A mRNA CTD PMID:26702050 NCBI chr 8:22,244,966...22,245,037
Ensembl chr 8:22,244,962...22,245,043 		JBrowse link
G MIR324 microRNA 324 decreases expression ISO marinobufagenin results in decreased expression of MIR324 mRNA CTD PMID:26702050 NCBI chr17:7,223,297...7,223,379
Ensembl chr17:7,223,297...7,223,379 		JBrowse link
G MIR375 microRNA 375 decreases expression ISO marinobufagenin results in decreased expression of MIR375 mRNA CTD PMID:26702050 NCBI chr 2:219,001,645...219,001,708
Ensembl chr 2:219,001,645...219,001,708 		JBrowse link
G MIR423 microRNA 423 decreases expression ISO marinobufagenin results in decreased expression of MIR423 mRNA CTD PMID:26702050 NCBI chr17:30,117,079...30,117,172
Ensembl chr17:30,117,079...30,117,172 		JBrowse link
G MIR424 microRNA 424 increases expression ISO marinobufagenin results in increased expression of MIR322 mRNA CTD PMID:26702050 NCBI chr  X:134,546,614...134,546,711
Ensembl chr  X:134,546,614...134,546,711 		JBrowse link
G MIR93 microRNA 93 decreases expression ISO marinobufagenin results in decreased expression of MIR93 mRNA CTD PMID:26702050 NCBI chr 7:100,093,768...100,093,847
Ensembl chr 7:100,093,768...100,093,847 		JBrowse link
G MIR96 microRNA 96 decreases expression ISO marinobufagenin results in decreased expression of MIR96 mRNA CTD PMID:26702050 NCBI chr 7:129,774,692...129,774,769
Ensembl chr 7:129,774,692...129,774,769 		JBrowse link
trilostane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein multiple interactions ISO trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]] CTD PMID:25461682 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]] CTD PMID:25461682 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G ESR2 estrogen receptor 2 increases expression ISO trilostane results in increased expression of ESR2 mRNA CTD PMID:20981412 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FGF9 fibroblast growth factor 9 multiple interactions EXP FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr13:21,671,073...21,704,498
Ensembl chr13:21,671,073...21,704,498 		JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP [FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone; FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP [FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone; FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G POMC proopiomelanocortin decreases expression ISO trilostane results in decreased expression of POMC protein CTD PMID:19117688 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G PSEN1 presenilin 1 multiple interactions ISO trilostane inhibits the reaction [Trenbolone Acetate analog inhibits the reaction [Dihydrotestosterone results in increased expression of PSEN1 protein]] CTD PMID:25461682 NCBI chr14:73,136,417...73,223,691
Ensembl chr14:73,136,418...73,223,691 		JBrowse link
withaferin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] CTD PMID:20438634 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ACACA acetyl-CoA carboxylase alpha multiple interactions ISO withaferin A promotes the reaction [Ethanol results in decreased expression of ACACA mRNA] CTD PMID:34995708 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 multiple interactions EXP withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732 		JBrowse link
G ATF4 activating transcription factor 4 multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein] CTD PMID:21266191 NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683 		JBrowse link
G BAD BCL2 associated agonist of cell death multiple interactions EXP withaferin A results in decreased expression of and results in decreased phosphorylation of BAD protein CTD PMID:20438634 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP withaferin A results in decreased expression of BCL2 protein CTD PMID:20438634 PMID:21256832 PMID:21964475 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2A1 BCL2 related protein A1 multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196 		JBrowse link
G BCL2L11 BCL2 like 11 decreases expression EXP withaferin A results in decreased expression of BCL2L11 protein CTD PMID:20438634 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] CTD PMID:20438634 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCND1 cyclin D1 multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] CTD PMID:20438634 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
affects binding
increases expression		 EXP withaferin A results in increased expression of and affects the localization of CDKN1A protein
withaferin A binds to CDKN1A protein
withaferin A results in increased expression of CDKN1A mRNA		 CTD PMID:22973447 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CDKN2AIP CDKN2A interacting protein decreases expression EXP withaferin A results in decreased expression of CDKN2AIP protein CTD PMID:22973447 NCBI chr 4:183,444,636...183,449,064
Ensembl chr 4:183,444,635...183,449,064 		JBrowse link
G CLDN1 claudin 1 decreases response to substance
decreases expression		 EXP CLDN1 protein results in decreased susceptibility to withaferin A
withaferin A results in decreased expression of CLDN1 mRNA; withaferin A results in decreased expression of CLDN1 protein		 CTD PMID:33665778 NCBI chr 3:190,305,707...190,322,446
Ensembl chr 3:190,305,707...190,322,446 		JBrowse link
G CPT1C carnitine palmitoyltransferase 1C multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in decreased expression of CPT1C mRNA] CTD PMID:34995708 NCBI chr19:49,690,662...49,713,731
Ensembl chr19:49,690,898...49,713,731 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA] CTD PMID:20438634 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 affects response to substance
increases expression
multiple interactions		 EXP DDIT3 mRNA affects the susceptibility to withaferin A
withaferin A results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]		 CTD PMID:21266191 NCBI chr12:57,516,588...57,521,698
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DDIT4 DNA damage inducible transcript 4 multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein] CTD PMID:21266191 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036 		JBrowse link
G DNMT1 DNA methyltransferase 1 decreases expression EXP withaferin A results in decreased expression of DNMT1 mRNA; withaferin A results in decreased expression of DNMT1 protein CTD PMID:23593078 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha decreases expression EXP withaferin A results in decreased expression of DNMT3A mRNA CTD PMID:23593078 NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta decreases expression EXP withaferin A results in decreased expression of DNMT3B mRNA CTD PMID:23593078 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359 		JBrowse link
G EDIL3 EGF like repeats and discoidin domains 3 decreases expression EXP withaferin A results in decreased expression of EDIL3 mRNA CTD PMID:33665778 NCBI chr 5:83,940,554...84,384,880
Ensembl chr 5:83,940,554...84,384,880 		JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions ISO withaferin A promotes the reaction [Ethanol results in decreased expression of EHHADH mRNA] CTD PMID:34995708 NCBI chr 3:185,190,624...185,254,049
Ensembl chr 3:185,190,624...185,281,990 		JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation EXP withaferin A results in increased phosphorylation of EIF2A protein CTD PMID:21266191 NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016 		JBrowse link
G EZR ezrin multiple interactions EXP [withanone co-treated with withaferin A] results in decreased expression of EZR protein CTD PMID:25236891 NCBI chr 6:158,765,748...158,819,368
Ensembl chr 6:158,765,741...158,819,368 		JBrowse link
G FASN fatty acid synthase multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of FASN mRNA] CTD PMID:34995708 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit increases expression EXP withaferin A results in increased expression of FOSL1 mRNA CTD PMID:33665778 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of GCLC mRNA] CTD PMID:34995708 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of GPT protein] CTD PMID:34995708 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G HDAC1 histone deacetylase 1 decreases expression EXP withaferin A results in decreased expression of HDAC1 protein CTD PMID:23593078 NCBI chr 1:32,292,083...32,333,626
Ensembl chr 1:32,292,083...32,333,635 		JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K multiple interactions EXP [withanone co-treated with withaferin A] results in decreased expression of HNRNPK protein; withaferin A binds to and results in decreased activity of HNRNPK protein CTD PMID:25236891 NCBI chr 9:83,968,083...83,980,615
Ensembl chr 9:83,968,083...83,980,616 		JBrowse link
G HSF1 heat shock transcription factor 1 increases activity EXP withaferin A results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720 		JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 affects binding
multiple interactions		 EXP withaferin A binds to HSPA9 protein
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; [withanone co-treated with withaferin A] results in decreased expression of HSPA9 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]		 CTD PMID:22973447 PMID:25236891 NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,675 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein] CTD PMID:20438634 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KRT13 keratin 13 decreases expression EXP withaferin A results in decreased expression of KRT13 mRNA CTD PMID:33665778 NCBI chr17:41,500,981...41,505,612
Ensembl chr17:41,500,981...41,505,705 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK1 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:24019090 PMID:24632454 PMID:25236891 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK3 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:24019090 PMID:24632454 PMID:25236891 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP withaferin A results in increased phosphorylation of MAPK8 protein CTD PMID:21964475 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases expression		 EXP MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]
withaferin A results in increased expression of MCL1 protein		 CTD PMID:24019090 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738 		JBrowse link
G MECP2 methyl-CpG binding protein 2 decreases expression EXP withaferin A results in decreased expression of MECP2 protein CTD PMID:23593078 NCBI chr  X:154,021,573...154,097,717
Ensembl chr  X:154,021,573...154,137,103 		JBrowse link
G METTL7A methyltransferase like 7A decreases expression EXP withaferin A results in decreased expression of METTL7A mRNA CTD PMID:33665778 NCBI chr12:50,925,015...50,932,508
Ensembl chr12:50,923,472...50,932,510 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP [withanone co-treated with withaferin A] results in decreased expression of MMP2 protein CTD PMID:25236891 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 affects binding EXP withaferin A binds to NFE2L2 protein CTD PMID:22973447 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] CTD PMID:20438634 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of NQO1 mRNA] CTD PMID:34995708 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NT5E 5'-nucleotidase ecto increases expression EXP withaferin A results in increased expression of NT5E mRNA CTD PMID:33665778 NCBI chr 6:85,450,083...85,495,784
Ensembl chr 6:85,449,584...85,495,791 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 EXP Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein] CTD PMID:20438634 PMID:24019090 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PROCR protein C receptor multiple interactions EXP withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr20:35,171,096...35,216,259
Ensembl chr20:35,172,072...35,216,240 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21396905 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] CTD PMID:20438634 NCBI chr11:65,653,601...65,662,916
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SLCO4A1 solute carrier organic anion transporter family member 4A1 increases expression EXP withaferin A results in increased expression of SLCO4A1 mRNA CTD PMID:33665778 NCBI chr20:62,642,503...62,690,740
Ensembl chr20:62,642,503...62,685,785 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein] CTD PMID:24019090 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] CTD PMID:34995708 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF2 mRNA] CTD PMID:34995708 NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,079...41,907,307 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions ISO withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein] CTD PMID:21396905 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein] CTD PMID:21396905 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,540 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases activity		 EXP
ISO		 withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]
withaferin A results in decreased activity of TNF protein		 CTD PMID:20438634 PMID:24632454 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 multiple interactions EXP withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314 		JBrowse link
G TP53 tumor protein p53 increases expression
affects binding
multiple interactions		 EXP withaferin A results in increased expression of TP53 mRNA
withaferin A binds to TP53 protein
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]		 CTD PMID:22973447 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TUBA1A tubulin alpha 1a decreases expression EXP withaferin A results in decreased expression of TUBA1A mRNA CTD PMID:24297176 NCBI chr12:49,184,795...49,189,080
Ensembl chr12:49,184,686...49,189,080 		JBrowse link
G TUBB tubulin beta class I decreases expression EXP withaferin A results in decreased expression of TUBB mRNA CTD PMID:24297176 NCBI chr 6:30,720,352...30,725,422
Ensembl chr 6:30,717,435...30,725,538 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
decreases expression		 EXP [withanone co-treated with withaferin A] results in decreased secretion of VEGFA protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]
withaferin A results in decreased expression of VEGFA protein		 CTD PMID:20438634 PMID:25236891 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G XBP1 X-box binding protein 1 increases expression
increases splicing		 EXP withaferin A results in increased expression of XBP1 protein
withaferin A results in increased splicing of XBP1 mRNA		 CTD PMID:21266191 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 25538
    chemical entity 25513
      molecular entity 25491
        main group molecular entity 25358
          gas molecular entity 19911
            oxirane 10023
              epoxide 10022
                epoxy steroid 126
                  (22E,24R)-ergosta-5alpha,6alpha-epoxide-8,22-diene-3beta,7alpha-diol 0
                  (24S,25)-epoxy-7alpha-hydroxycholesterol 0
                  (3beta,24R,24'R)-fucosterol epoxide 0
                  17alpha-hydroxywithanolide D 0
                  2,3-dihydro-3beta-O-sulfate withaferin A 0
                  2,3-dihydro-3beta-methoxy withaferin A 0
                  2,3-dihydrowithaferin A 0
                  20-hydroxytubocapsanolide A 0
                  23-hydroxytubocapsanolide A 0
                  24(S),25-epoxycholesterol 0
                  3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + 0
                  3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside 0
                  5,6alpha-epoxy-5alpha-cholestan-3beta-ol 8
                  5,6alpha-epoxy-5alpha-cholestane 0
                  5,6beta-epoxy-5alpha-cholestan-3beta-ol 0
                  7-deacetyl-7-benzoylepoxyazadiradione 0
                  9,11alpha-epoxypregn-4-ene-3,20-dione 0
                  bufogenin 1
                  cholestanol 7alpha,8alpha-epoxide 0
                  cholesterol beta-epoxide 0
                  deacetyltanghinin 0
                  eplerenone 30
                  marinobufagenin 25
                  physalin F 0
                  resibufagenin 0
                  sitoindoside IX 0
                  tanghinigenin + 0
                  trilostane 8
                  tubocapsanolide A + 0
                  tubocapsanolide F 0
                  viscosalactone B 0
                  withaferin A + 63
                  withalongolide A 0
                  withalongolide B 0
                  withalongolide C 0
                  withalongolide D 0
                  withalongolide E 0
                  withalongolide G 0
                  withalongolide H 0
                  withanolide D + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 25538
    subatomic particle 25509
      composite particle 25509
        hadron 25509
          baryon 25509
            nucleon 25509
              atomic nucleus 25509
                atom 25509
                  main group element atom 25358
                    p-block element atom 25358
                      carbon group element atom 24926
                        carbon atom 24902
                          organic molecular entity 24902
                            organic molecule 24758
                              organic cyclic compound 24105
                                organic heterocyclic compound 22138
                                  organic heteromonocyclic compound 18829
                                    saturated organic heteromonocyclic parent 10051
                                      oxirane 10023
                                        epoxide 10022
                                          epoxy steroid 126
                                            (22E,24R)-ergosta-5alpha,6alpha-epoxide-8,22-diene-3beta,7alpha-diol 0
                                            (24S,25)-epoxy-7alpha-hydroxycholesterol 0
                                            (3beta,24R,24'R)-fucosterol epoxide 0
                                            17alpha-hydroxywithanolide D 0
                                            2,3-dihydro-3beta-O-sulfate withaferin A 0
                                            2,3-dihydro-3beta-methoxy withaferin A 0
                                            2,3-dihydrowithaferin A 0
                                            20-hydroxytubocapsanolide A 0
                                            23-hydroxytubocapsanolide A 0
                                            24(S),25-epoxycholesterol 0
                                            3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + 0
                                            3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside 0
                                            5,6alpha-epoxy-5alpha-cholestan-3beta-ol 8
                                            5,6alpha-epoxy-5alpha-cholestane 0
                                            5,6beta-epoxy-5alpha-cholestan-3beta-ol 0
                                            7-deacetyl-7-benzoylepoxyazadiradione 0
                                            9,11alpha-epoxypregn-4-ene-3,20-dione 0
                                            bufogenin 1
                                            cholestanol 7alpha,8alpha-epoxide 0
                                            cholesterol beta-epoxide 0
                                            deacetyltanghinin 0
                                            eplerenone 30
                                            marinobufagenin 25
                                            physalin F 0
                                            resibufagenin 0
                                            sitoindoside IX 0
                                            tanghinigenin + 0
                                            trilostane 8
                                            tubocapsanolide A + 0
                                            tubocapsanolide F 0
                                            viscosalactone B 0
                                            withaferin A + 63
                                            withalongolide A 0
                                            withalongolide B 0
                                            withalongolide C 0
                                            withalongolide D 0
                                            withalongolide E 0
                                            withalongolide G 0
                                            withalongolide H 0
                                            withanolide D + 0
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