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ONTOLOGY REPORT - ANNOTATIONS


Term:SKF-96365 hydrochloride
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Accession:CHEBI:145121 term browser browse the term
Definition:The hydrochloride salt of SKF-96365. It is a TRP channel blocker.
Synonyms:exact_synonym: 1-{2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl}-1H-imidazole hydrochloride
 related_synonym: 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole hydrochloride;   Formula=C22H26N2O3.ClH;   InChI=1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H;   InChIKey=FWLPKVQUECFKSW-UHFFFAOYSA-N;   SK&F 96365;   SKF-96365 HCl;   SKF-963656;   SKF963656;   SMILES=C=1(C=CC(=CC1)OC)C(CN2C=NC=C2)OCCCC3=CC=C(C=C3)OC.[H]Cl
 xref: CAS:130495-35-1 "ChemIDplus"
 xref_mesh: MESH:C063159
 xref: PMID:20590636 "Europe PMC";   PMID:21767581 "Europe PMC";   PMID:22212354 "Europe PMC";   PMID:22369768 "Europe PMC";   PMID:2306207 "Europe PMC";   PMID:24641279 "Europe PMC";   PMID:25218985 "Europe PMC";   PMID:27616575 "Europe PMC";   Reaxys:7402134 "Reaxys"


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SKF-96365 hydrochloride term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6480464
G Casr calcium-sensing receptor JBrowse link 11 67,188,204 67,262,261 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Grm1 glutamate metabotropic receptor 1 JBrowse link 1 4,753,141 5,165,859 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Myl9 myosin light chain 9 JBrowse link 3 152,857,573 152,863,961 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 JBrowse link 2 123,329,954 123,467,574 RGD:6480464
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 JBrowse link 8 6,811,543 6,917,534 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      biological role 19710
        biochemical role 19210
          apoptosis inducer 10883
            SKF-96365 hydrochloride 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    p-block element atom 19646
                      halogen 17904
                        chlorine atom 17665
                          chlorine molecular entity 17665
                            elemental chlorine 8378
                              monoatomic chlorine 8359
                                chloride 8359
                                  chloride salt 8359
                                    organic chloride salt 654
                                      hydrochloride 427
                                        SKF-96365 hydrochloride 14
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.