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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:steviol glycoside
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Accession:CHEBI:145027 term browser browse the term
Definition:A diterpene glycoside derived from steviol by formal esterification of the carboxy group with glucose (or a glucose derivative) and glycosylation of the tertiary hydroxy group with combinations of glucose and rhamnose to give the corresponding glycosides.
Synonyms:related_synonym: steviol glycosides
 xref: PMID:29537255;   PMID:29863335;   PMID:30466787;   PMID:30506508;   PMID:30897351;   PMID:31063378;   PMID:31195254;   PMID:31295559;   PMID:31438580;   PMID:31491712;   Wikipedia:Steviol_glycoside


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rebaudioside A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme decreases expression EXP rebaudioside A results in decreased expression of ACE mRNA CTD PMID:31655124 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] CTD PMID:25554529 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] CTD PMID:30883860 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G AGTR1 angiotensin II receptor type 1 increases expression EXP rebaudioside A results in increased expression of AGTR1 mRNA CTD PMID:31655124 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase increases expression EXP rebaudioside A results in increased expression of ALOX5 mRNA CTD PMID:31655124 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression EXP rebaudioside A results in decreased expression of BAX mRNA CTD PMID:31655124 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G CALCA calcitonin related polypeptide alpha increases expression EXP rebaudioside A results in increased expression of CALCA mRNA CTD PMID:31655124 NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354 		JBrowse link
G CAT catalase multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA] CTD PMID:25554529 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CAV1 caveolin 1 decreases expression EXP rebaudioside A results in decreased expression of CAV1 mRNA CTD PMID:31655124 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases expression EXP rebaudioside A results in decreased expression of CCL2 mRNA CTD PMID:31655124 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator decreases expression EXP rebaudioside A results in decreased expression of CFLAR mRNA CTD PMID:31655124 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA] CTD PMID:25554529 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA] CTD PMID:25554529 NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535 		JBrowse link
G EDN1 endothelin 1 decreases expression EXP rebaudioside A results in decreased expression of EDN1 mRNA CTD PMID:31655124 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EDNRA endothelin receptor type A increases expression EXP rebaudioside A results in increased expression of EDNRA mRNA CTD PMID:31655124 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954 		JBrowse link
G F2R coagulation factor II thrombin receptor decreases expression EXP rebaudioside A results in decreased expression of F2R mRNA CTD PMID:31655124 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770 		JBrowse link
G FASLG Fas ligand increases expression EXP rebaudioside A results in increased expression of FASLG mRNA CTD PMID:31655124 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FGF1 fibroblast growth factor 1 increases expression EXP rebaudioside A results in increased expression of FGF1 mRNA CTD PMID:31655124 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 decreases expression EXP rebaudioside A results in decreased expression of FLT1 mRNA CTD PMID:31655124 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145 		JBrowse link
G FOXO1 forkhead box O1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA] CTD PMID:25554529 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA] CTD PMID:25554529 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of IL10 protein] CTD PMID:30883860 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] CTD PMID:30883860 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INSR insulin receptor multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA] CTD PMID:25554529 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414 		JBrowse link
G IRS1 insulin receptor substrate 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820 		JBrowse link
G IRS2 insulin receptor substrate 2 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA] CTD PMID:25554529 NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583 		JBrowse link
G ITGAV integrin subunit alpha V decreases expression EXP rebaudioside A results in decreased expression of ITGAV mRNA CTD PMID:31655124 NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,010...186,680,901 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase decreases expression EXP rebaudioside A results in decreased expression of KIT mRNA CTD PMID:31655124 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783 		JBrowse link
G LDLR low density lipoprotein receptor multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820 		JBrowse link
G LEP leptin multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LIPC lipase C, hepatic type multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA] CTD PMID:25554529 NCBI chr15:58,431,991...58,569,844
Ensembl chr15:58,410,569...58,569,844 		JBrowse link
G MMP13 matrix metallopeptidase 13 multiple interactions ISO rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of MMP13 protein] CTD PMID:30883860 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions ISO rebaudioside A inhibits the reaction [Thioacetamide results in increased activity of MMP2 protein] CTD PMID:30883860 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression
multiple interactions		 EXP
ISO		 rebaudioside A results in increased expression of MMP9 mRNA
rebaudioside A inhibits the reaction [Thioacetamide results in increased activity of MMP9 protein]		 CTD PMID:30883860 PMID:31655124 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA] CTD PMID:25554529 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO rebaudioside A inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein] CTD PMID:30883860 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA] CTD PMID:25554529 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA] CTD PMID:25554529 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA] CTD PMID:25554529 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121 		JBrowse link
G PF4 platelet factor 4 increases expression EXP rebaudioside A results in increased expression of PF4 mRNA CTD PMID:31655124 NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA] CTD PMID:25554529 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA] CTD PMID:25554529 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA] CTD PMID:25554529 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA] CTD PMID:25554529 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP rebaudioside A results in decreased expression of PTGS2 mRNA CTD PMID:31655124 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of RELA protein] CTD PMID:30883860 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SELE selectin E decreases expression EXP rebaudioside A results in decreased expression of SELE mRNA CTD PMID:31655124 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC27A1 solute carrier family 27 member 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA] CTD PMID:25554529 NCBI chr19:17,468,767...17,506,168
Ensembl chr19:17,468,769...17,506,168 		JBrowse link
G SLC2A2 solute carrier family 2 member 2 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA] CTD PMID:25554529 NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743 		JBrowse link
G SMAD7 SMAD family member 7 multiple interactions ISO rebaudioside A inhibits the reaction [Thioacetamide results in decreased expression of SMAD7 protein] CTD PMID:30883860 NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein] CTD PMID:30883860 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of TNF protein] CTD PMID:30883860 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFSF10 TNF superfamily member 10 decreases expression EXP rebaudioside A results in decreased expression of TNFSF10 mRNA CTD PMID:31655124 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
stevioside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme decreases expression EXP stevioside results in decreased expression of ACE mRNA CTD PMID:31655124 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ACHE acetylcholinesterase (Yt blood group) multiple interactions ISO stevioside inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:20871768 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] CTD PMID:25554529 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177 		JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant decreases secretion ISO stevioside results in decreased secretion of ACP5 protein CTD PMID:21089163 NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993 		JBrowse link
G AGTR1 angiotensin II receptor type 1 increases expression EXP stevioside results in increased expression of AGTR1 mRNA CTD PMID:31655124 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase increases expression EXP stevioside results in increased expression of ALOX5 mRNA CTD PMID:31655124 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression EXP stevioside results in decreased expression of BAX mRNA CTD PMID:31655124 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G CALCA calcitonin related polypeptide alpha increases expression EXP stevioside results in increased expression of CALCA mRNA CTD PMID:31655124 NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354 		JBrowse link
G CAT catalase multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA] CTD PMID:25554529 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases expression EXP stevioside results in decreased expression of CCL2 mRNA CTD PMID:31655124 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator decreases expression EXP stevioside results in decreased expression of CFLAR mRNA CTD PMID:31655124 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA] CTD PMID:25554529 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP stevioside results in increased expression of CYP1A1 mRNA CTD PMID:28887089 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression EXP stevioside results in increased expression of CYP1A2 mRNA; stevioside results in increased expression of CYP1A2 protein CTD PMID:28887089 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases expression EXP stevioside results in increased expression of CYP1B1 mRNA CTD PMID:28887089 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases expression EXP stevioside results in decreased expression of CYP2C9 mRNA CTD PMID:28887089 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases expression		 EXP stevioside binds to and results in decreased activity of CYP3A4 protein
stevioside results in increased expression of CYP3A4 mRNA; stevioside results in increased expression of CYP3A4 protein		 CTD PMID:28887089 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA] CTD PMID:25554529 NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535 		JBrowse link
G EDN1 endothelin 1 decreases expression EXP stevioside results in decreased expression of EDN1 mRNA CTD PMID:31655124 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EDNRA endothelin receptor type A increases expression EXP stevioside results in increased expression of EDNRA mRNA CTD PMID:31655124 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954 		JBrowse link
G F2R coagulation factor II thrombin receptor decreases expression EXP stevioside results in decreased expression of F2R mRNA CTD PMID:31655124 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770 		JBrowse link
G FASLG Fas ligand increases expression EXP stevioside results in increased expression of FASLG mRNA CTD PMID:31655124 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FGF1 fibroblast growth factor 1 increases expression EXP stevioside results in increased expression of FGF1 mRNA CTD PMID:31655124 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 decreases expression EXP stevioside results in decreased expression of FLT1 mRNA CTD PMID:31655124 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145 		JBrowse link
G FOXO1 forkhead box O1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA] CTD PMID:25554529 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA] CTD PMID:25554529 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438 		JBrowse link
G INSR insulin receptor multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA] CTD PMID:25554529 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414 		JBrowse link
G IRS1 insulin receptor substrate 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820 		JBrowse link
G IRS2 insulin receptor substrate 2 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA] CTD PMID:25554529 NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583 		JBrowse link
G ITGAV integrin subunit alpha V decreases expression EXP stevioside results in decreased expression of ITGAV mRNA CTD PMID:31655124 NCBI chr 2:186,590,056...186,680,901
Ensembl chr 2:186,590,010...186,680,901 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase decreases expression EXP stevioside results in decreased expression of KIT mRNA CTD PMID:31655124 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783 		JBrowse link
G LDLR low density lipoprotein receptor multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820 		JBrowse link
G LEP leptin multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LIPC lipase C, hepatic type multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA] CTD PMID:25554529 NCBI chr15:58,431,991...58,569,844
Ensembl chr15:58,410,569...58,569,844 		JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression EXP stevioside results in increased expression of MMP9 mRNA CTD PMID:31655124 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA] CTD PMID:25554529 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA] CTD PMID:25554529 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA] CTD PMID:25554529 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA] CTD PMID:25554529 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121 		JBrowse link
G PF4 platelet factor 4 increases expression EXP stevioside results in increased expression of PF4 mRNA CTD PMID:31655124 NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027 		JBrowse link
G PLIN2 perilipin 2 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA] CTD PMID:25554529 NCBI chr 9:19,108,388...19,127,492
Ensembl chr 9:19,108,375...19,149,290 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA] CTD PMID:25554529 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA] CTD PMID:25554529 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA] CTD PMID:25554529 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA] CTD PMID:25554529 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP stevioside results in decreased expression of PTGS2 mRNA CTD PMID:31655124 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G SELE selectin E decreases expression EXP stevioside results in decreased expression of SELE mRNA CTD PMID:31655124 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC27A1 solute carrier family 27 member 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA] CTD PMID:25554529 NCBI chr19:17,468,767...17,506,168
Ensembl chr19:17,468,769...17,506,168 		JBrowse link
G SLC2A2 solute carrier family 2 member 2 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA] CTD PMID:25554529 NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G TNFSF10 TNF superfamily member 10 decreases expression EXP stevioside results in decreased expression of TNFSF10 mRNA CTD PMID:31655124 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      application 25179
        food additive 18340
          flavouring agent 4786
            sweetening agent 2422
              steviol glycoside 63
                rebaudioside + 55
                rubusoside + 63
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            heteroorganic entity 24773
                              organochalcogen compound 24384
                                organooxygen compound 24061
                                  carbohydrates and carbohydrate derivatives 16791
                                    carbohydrate 16791
                                      carbohydrate derivative 15665
                                        glycosyl compound 13730
                                          glycoside 12289
                                            terpene glycoside 479
                                              diterpene glycoside 67
                                                steviol glycoside 63
                                                  rebaudioside + 55
                                                  rubusoside + 63
paths to the root