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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:steviol
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Accession:CHEBI:145024 term browser browse the term
Definition:An ent-kaurane diterpenoid that is 5beta,8alpha,9beta,10alpha-kaur-16-en-18-oic acid in which the hydrogen at position 13 has been replaced by a hydroxy group.
Synonyms:exact_synonym: 13alpha-hydroxy-5beta,8alpha,9beta,10alpha-kaur-16-en-18-oic acid
 related_synonym: (14-alpha)-13-hydroxykaur-16-en-18-oic acid;   Formula=C20H30O3;   InChI=1S/C20H30O3/c1-13-11-19-9-5-14-17(2,7-4-8-18(14,3)16(21)22)15(19)6-10-20(13,23)12-19/h14-15,23H,1,4-12H2,2-3H3,(H,21,22)/t14-,15-,17+,18+,19+,20-/m0/s1;   InChIKey=QFVOYBUQQBFCRH-VQSWZGCSSA-N;   SMILES=O=C([C@]1([C@@]2([C@]([C@]3([C@]4(C[C@@](CC3)(C(C4)=C)O)CC2)[H])(CCC1)C)[H])C)O;   hydroxydehydrostevic acid
 xref: AGR:IND605891739;   CAS:471-80-7;   FooDB:FDB015642;   HMDB:HMDB0036706;   KEGG:C20212;   KNApSAcK:C00034695
 xref_mesh: MESH:C012042
 xref: MetaCyc:CPD-14501;   PMID:15610349;   PMID:28903608;   PMID:29064007;   PMID:29892740;   PMID:29899860;   PMID:31182573;   PMID:31324778;   Wikipedia:Steviol
 cyclic_relationship: is_conjugate_acid_of CHEBI:145011


show annotations for term's descendants           Sort by:
steviol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACACA mRNA] CTD PMID:25554529 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Ace angiotensin I converting enzyme decreases expression ISO steviol results in decreased expression of ACE mRNA CTD PMID:31655124 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] CTD PMID:25554529 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression ISO steviol results in increased expression of AGTR1 mRNA CTD PMID:31655124 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO steviol binds to and results in increased activity of AHR protein CTD PMID:28887089 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO steviol results in increased expression of ALOX5 mRNA CTD PMID:31655124 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO steviol results in decreased expression of BAX mRNA CTD PMID:31655124 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression ISO steviol results in increased expression of CALCA mRNA CTD PMID:31655124 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Cat catalase multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA] CTD PMID:25554529 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO steviol results in decreased expression of CCL2 mRNA CTD PMID:31655124 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO steviol results in decreased expression of CFLAR mRNA CTD PMID:31655124 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA] CTD PMID:25554529 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO steviol results in increased expression of CYP1A1 mRNA; steviol results in increased expression of CYP1A1 protein CTD PMID:28887089 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO steviol results in increased expression of CYP1A2 mRNA; steviol results in increased expression of CYP1A2 protein CTD PMID:28887089 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO steviol results in increased expression of CYP1B1 mRNA CTD PMID:28887089 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO steviol results in increased expression of CYP2B6 mRNA CTD PMID:28887089 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions ISO steviol binds to and results in decreased activity of CYP2C9 protein CTD PMID:28887089 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO steviol results in increased expression of CYP3A4 mRNA; steviol results in increased expression of CYP3A4 protein
steviol binds to and results in decreased activity of CYP3A4 protein		 CTD PMID:28887089 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA] CTD PMID:25554529 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Edn1 endothelin 1 decreases expression ISO steviol results in decreased expression of EDN1 mRNA CTD PMID:31655124 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A increases expression ISO steviol results in increased expression of EDNRA mRNA CTD PMID:31655124 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO steviol results in decreased expression of F2R mRNA CTD PMID:31655124 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G Faslg Fas ligand increases expression ISO steviol results in increased expression of FASLG mRNA CTD PMID:31655124 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FASN mRNA] CTD PMID:25554529 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO steviol results in increased expression of FGF1 mRNA CTD PMID:31655124 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression ISO steviol results in decreased expression of FLT1 mRNA CTD PMID:31655124 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA] CTD PMID:25554529 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA] CTD PMID:25554529 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of GPAM mRNA] CTD PMID:25554529 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Insr insulin receptor multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA] CTD PMID:25554529 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA] CTD PMID:25554529 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Itgav integrin subunit alpha V decreases expression ISO steviol results in decreased expression of ITGAV mRNA CTD PMID:31655124 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO steviol results in decreased expression of KIT mRNA CTD PMID:31655124 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACACA mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FASN mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of GPAM mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PRKAA1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lep leptin multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACACA mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FASN mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of GPAM mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PRKAA1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA] CTD PMID:25554529 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO steviol results in increased expression of MMP9 mRNA CTD PMID:31655124 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA] CTD PMID:25554529 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA] CTD PMID:25554529 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA] CTD PMID:25554529 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO steviol binds to and results in increased activity of NR1I2 protein CTD PMID:28887089 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA] CTD PMID:25554529 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pf4 platelet factor 4 increases expression ISO steviol results in increased expression of PF4 mRNA CTD PMID:31655124 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Plin2 perilipin 2 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA] CTD PMID:25554529 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA] CTD PMID:25554529 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA] CTD PMID:25554529 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA] CTD PMID:25554529 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA] CTD PMID:25554529 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PRKAA1 mRNA] CTD PMID:25554529 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO steviol results in decreased expression of PTGS2 mRNA CTD PMID:31655124 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA] CTD PMID:25554529 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sele selectin E decreases expression ISO steviol results in decreased expression of SELE mRNA CTD PMID:31655124 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA] CTD PMID:25554529 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA] CTD PMID:25554529 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression ISO steviol results in decreased expression of TNFSF10 mRNA CTD PMID:31655124 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
rebaudioside A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases expression ISO rebaudioside A results in decreased expression of ACE mRNA CTD PMID:31655124 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] CTD PMID:25554529 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] CTD PMID:30883860 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression ISO rebaudioside A results in increased expression of AGTR1 mRNA CTD PMID:31655124 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO rebaudioside A results in increased expression of ALOX5 mRNA CTD PMID:31655124 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO rebaudioside A results in decreased expression of BAX mRNA CTD PMID:31655124 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression ISO rebaudioside A results in increased expression of CALCA mRNA CTD PMID:31655124 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Cat catalase multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA] CTD PMID:25554529 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav1 caveolin 1 decreases expression ISO rebaudioside A results in decreased expression of CAV1 mRNA CTD PMID:31655124 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO rebaudioside A results in decreased expression of CCL2 mRNA CTD PMID:31655124 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO rebaudioside A results in decreased expression of CFLAR mRNA CTD PMID:31655124 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA] CTD PMID:25554529 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA] CTD PMID:25554529 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Edn1 endothelin 1 decreases expression ISO rebaudioside A results in decreased expression of EDN1 mRNA CTD PMID:31655124 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A increases expression ISO rebaudioside A results in increased expression of EDNRA mRNA CTD PMID:31655124 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO rebaudioside A results in decreased expression of F2R mRNA CTD PMID:31655124 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G Faslg Fas ligand increases expression ISO rebaudioside A results in increased expression of FASLG mRNA CTD PMID:31655124 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO rebaudioside A results in increased expression of FGF1 mRNA CTD PMID:31655124 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression ISO rebaudioside A results in decreased expression of FLT1 mRNA CTD PMID:31655124 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA] CTD PMID:25554529 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA] CTD PMID:25554529 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of IL10 protein] CTD PMID:30883860 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] CTD PMID:30883860 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Insr insulin receptor multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA] CTD PMID:25554529 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA] CTD PMID:25554529 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Itgav integrin subunit alpha V decreases expression ISO rebaudioside A results in decreased expression of ITGAV mRNA CTD PMID:31655124 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO rebaudioside A results in decreased expression of KIT mRNA CTD PMID:31655124 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lep leptin multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA] CTD PMID:25554529 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of MMP13 protein] CTD PMID:30883860 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP rebaudioside A inhibits the reaction [Thioacetamide results in increased activity of MMP2 protein] CTD PMID:30883860 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions		 ISO
EXP		 rebaudioside A results in increased expression of MMP9 mRNA
rebaudioside A inhibits the reaction [Thioacetamide results in increased activity of MMP9 protein]		 CTD PMID:30883860 PMID:31655124 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA] CTD PMID:25554529 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP rebaudioside A inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein] CTD PMID:30883860 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA] CTD PMID:25554529 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA] CTD PMID:25554529 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA] CTD PMID:25554529 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pf4 platelet factor 4 increases expression ISO rebaudioside A results in increased expression of PF4 mRNA CTD PMID:31655124 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA] CTD PMID:25554529 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA] CTD PMID:25554529 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA] CTD PMID:25554529 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA] CTD PMID:25554529 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO rebaudioside A results in decreased expression of PTGS2 mRNA CTD PMID:31655124 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of RELA protein] CTD PMID:30883860 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA] CTD PMID:25554529 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sele selectin E decreases expression ISO rebaudioside A results in decreased expression of SELE mRNA CTD PMID:31655124 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA] CTD PMID:25554529 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA] CTD PMID:25554529 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Smad7 SMAD family member 7 multiple interactions EXP rebaudioside A inhibits the reaction [Thioacetamide results in decreased expression of SMAD7 protein] CTD PMID:30883860 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein] CTD PMID:30883860 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP rebaudioside A inhibits the reaction [Thioacetamide results in increased expression of TNF protein] CTD PMID:30883860 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression ISO rebaudioside A results in decreased expression of TNFSF10 mRNA CTD PMID:31655124 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
stevioside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases expression ISO stevioside results in decreased expression of ACE mRNA CTD PMID:31655124 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP stevioside inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:20871768 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] CTD PMID:25554529 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant decreases secretion EXP stevioside results in decreased secretion of ACP5 protein CTD PMID:21089163 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression ISO stevioside results in increased expression of AGTR1 mRNA CTD PMID:31655124 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO stevioside results in increased expression of ALOX5 mRNA CTD PMID:31655124 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO stevioside results in decreased expression of BAX mRNA CTD PMID:31655124 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression ISO stevioside results in increased expression of CALCA mRNA CTD PMID:31655124 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Cat catalase multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA] CTD PMID:25554529 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO stevioside results in decreased expression of CCL2 mRNA CTD PMID:31655124 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO stevioside results in decreased expression of CFLAR mRNA CTD PMID:31655124 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA] CTD PMID:25554529 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO stevioside results in increased expression of CYP1A1 mRNA CTD PMID:28887089 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO stevioside results in increased expression of CYP1A2 mRNA; stevioside results in increased expression of CYP1A2 protein CTD PMID:28887089 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO stevioside results in increased expression of CYP1B1 mRNA CTD PMID:28887089 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression ISO stevioside results in decreased expression of CYP2C9 mRNA CTD PMID:28887089 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO stevioside binds to and results in decreased activity of CYP3A4 protein
stevioside results in increased expression of CYP3A4 mRNA; stevioside results in increased expression of CYP3A4 protein		 CTD PMID:28887089 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA] CTD PMID:25554529 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Edn1 endothelin 1 decreases expression ISO stevioside results in decreased expression of EDN1 mRNA CTD PMID:31655124 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A increases expression ISO stevioside results in increased expression of EDNRA mRNA CTD PMID:31655124 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO stevioside results in decreased expression of F2R mRNA CTD PMID:31655124 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G Faslg Fas ligand increases expression ISO stevioside results in increased expression of FASLG mRNA CTD PMID:31655124 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO stevioside results in increased expression of FGF1 mRNA CTD PMID:31655124 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression ISO stevioside results in decreased expression of FLT1 mRNA CTD PMID:31655124 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA] CTD PMID:25554529 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA] CTD PMID:25554529 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Insr insulin receptor multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA] CTD PMID:25554529 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] CTD PMID:25554529 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA] CTD PMID:25554529 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Itgav integrin subunit alpha V decreases expression ISO stevioside results in decreased expression of ITGAV mRNA CTD PMID:31655124 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO stevioside results in decreased expression of KIT mRNA CTD PMID:31655124 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lep leptin multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA]; stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA] CTD PMID:25554529 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO stevioside results in increased expression of MMP9 mRNA CTD PMID:31655124 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA] CTD PMID:25554529 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA] CTD PMID:25554529 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA] CTD PMID:25554529 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA] CTD PMID:25554529 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pf4 platelet factor 4 increases expression ISO stevioside results in increased expression of PF4 mRNA CTD PMID:31655124 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Plin2 perilipin 2 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA] CTD PMID:25554529 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA] CTD PMID:25554529 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA] CTD PMID:25554529 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA] CTD PMID:25554529 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA] CTD PMID:25554529 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO stevioside results in decreased expression of PTGS2 mRNA CTD PMID:31655124 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA] CTD PMID:25554529 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sele selectin E decreases expression ISO stevioside results in decreased expression of SELE mRNA CTD PMID:31655124 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] CTD PMID:25554529 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA] CTD PMID:25554529 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA] CTD PMID:25554529 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA] CTD PMID:25554529 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression ISO stevioside results in decreased expression of TNFSF10 mRNA CTD PMID:31655124 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19908
    role 19883
      application 19717
        pharmaceutical 19544
          drug 19544
            antineoplastic agent 17697
              steviol 71
                rebaudioside + 56
                rubusoside + 64
                steviol glycoside + 64
                steviolmonoside + 0
                stevioside + 53
Path 2
Term Annotations click to browse term
  CHEBI ontology 19908
    subatomic particle 19906
      composite particle 19906
        hadron 19906
          baryon 19906
            nucleon 19906
              atomic nucleus 19906
                atom 19906
                  main group element atom 19853
                    p-block element atom 19853
                      carbon group element atom 19799
                        carbon atom 19794
                          organic molecular entity 19794
                            organic group 18960
                              organic divalent group 18941
                                organodiyl group 18941
                                  carbonyl group 18893
                                    carbonyl compound 18893
                                      carboxylic acid 18614
                                        monocarboxylic acid 17936
                                          steviol 71
                                            rebaudioside + 56
                                            rubusoside + 64
                                            steviol glycoside + 64
                                            steviolmonoside + 0
                                            stevioside + 53
paths to the root