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Accession:CHEBI:144676 term browser browse the term
Definition:A piperidinylimidazole that is 1H-imidazole carrying a piperidin-4-yl group, 4-fluorophenyl group and a 2-([biphenyl]-4-yloxy)pyrimidin-4-yl group at positions 1, 4 and 5 respectively. It is a potent inhibitor of p38alpha mitogen-activated protein kinase.
Synonyms:exact_synonym: 2-([biphenyl]-4-yloxy)-4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidine
 related_synonym: 2-(4-biphenylyloxy)-4-[1-(piperidine-4-yl)-4-(4-fluorophenyl)-5-imidazolyl]pyrimidine;   2-[([1,1'-biphenyl]-4-yl)oxy]-4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidine;   Formula=C30H26FN5O;   InChI=1S/C30H26FN5O/c31-24-10-6-23(7-11-24)28-29(36(20-34-28)25-14-17-32-18-15-25)27-16-19-33-30(35-27)37-26-12-8-22(9-13-26)21-4-2-1-3-5-21/h1-13,16,19-20,25,32H,14-15,17-18H2;   InChIKey=WHARNYOKNQYQGR-UHFFFAOYSA-N;   SMILES=C1(=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCNCC4)=N1)OC=5C=CC(=CC5)C=6C=CC=CC6
 xref: PMID:11354358 "Europe PMC"

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  CHEBI ontology 19654
    chemical entity 19652
      molecular entity 19649
        polyatomic entity 19567
          molecule 19363
            cyclic compound 19116
              ring assembly 6137
                biphenyls 4787
                  SB-245391 0
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  CHEBI ontology 19654
    subatomic particle 19650
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                  main group element atom 19531
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                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic molecule 19327
                              organic cyclic compound 19076
                                organic heterocyclic compound 18151
                                  heteroarene 15151
                                    monocyclic heteroarene 11614
                                      azole 10473
                                        diazole 8041
                                          imidazoles 7591
                                            piperidinylimidazole 0
                                              SB-245391 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.