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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.1.1.64 (retinoid isomerohydrolase) inhibitor
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Accession:CHEBI:144455 term browser browse the term
Definition:An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of retinoid isomerohydrolase (EC 3.1.1.64).
Synonyms:related_synonym: EC 3.1.1.64 (retinoid isomerohydrolase) inhibitors;   EC 3.1.1.64 inhibitor;   EC 3.1.1.64 inhibitors;   RPE65 inhibitor;   RPE65 inhibitors;   all-trans-retinol isomerase:hydrolase inhibitor;   all-trans-retinol isomerase:hydrolase inhibitors;   all-trans-retinyl-palmitate hydrolase inhibitor;   all-trans-retinyl-palmitate hydrolase inhibitors;   all-trans-retinylester 11-cis isomerohydrolase inhibitor;   all-trans-retinylester 11-cis isomerohydrolase inhibitors;   retinoid isomerohydrolase inhibitor;   retinoid isomerohydrolase inhibitors;   retinol isomerase inhibitor;   retinol isomerase inhibitors
 xref: Wikipedia:RPE65



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triacsin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 multiple interactions ISO triacsin C inhibits the reaction [Fatty Acids results in increased degradation of ABCA1 protein]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]; triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein] CTD PMID:16118212 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcd3 ATP-binding cassette, sub-family D (ALD), member 3 decreases expression ISO triacsin C results in decreased expression of ABCD3 mRNA CTD PMID:16704987 NCBI chr 3:121,758,904...121,815,302
Ensembl chr 3:121,758,774...121,815,302
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions EXP triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of ACACA protein] CTD PMID:18390901 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 decreases expression ISO triacsin C results in decreased expression of ADARB1 mRNA CTD PMID:16704987 NCBI chr10:77,290,727...77,418,292
Ensembl chr10:77,290,726...77,418,270
JBrowse link
G Aqp3 aquaporin 3 decreases expression ISO triacsin C results in decreased expression of AQP3 mRNA CTD PMID:16704987 NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor (GDI) alpha increases expression ISO triacsin C results in increased expression of ARHGDIA mRNA CTD PMID:16704987 NCBI chr11:120,578,099...120,581,624
Ensembl chr11:120,578,104...120,581,624
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO triacsin C results in increased expression of ATF3 mRNA CTD PMID:16704987 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Bdnf brain derived neurotrophic factor decreases expression ISO triacsin C results in decreased expression of BDNF mRNA CTD PMID:16704987 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Casp3 caspase 3 increases activity ISO triacsin C results in increased activity of CASP3 protein CTD PMID:16704987 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Col18a1 collagen, type XVIII, alpha 1 decreases expression ISO triacsin C results in decreased expression of COL18A1 mRNA CTD PMID:16704987 NCBI chr10:77,052,178...77,166,530
Ensembl chr10:77,052,178...77,166,548
JBrowse link
G Ctdspl CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like decreases expression ISO triacsin C results in decreased expression of CTDSPL mRNA CTD PMID:16704987 NCBI chr 9:118,926,536...119,044,119
Ensembl chr 9:118,926,453...119,043,998
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO triacsin C results in increased expression of DDIT4 mRNA CTD PMID:16704987 NCBI chr10:59,949,675...59,951,770
Ensembl chr10:59,949,669...59,951,834
JBrowse link
G Ddx24 DEAD box helicase 24 decreases expression ISO triacsin C results in decreased expression of DDX24 mRNA CTD PMID:16704987 NCBI chr12:103,407,976...103,425,847
Ensembl chr12:103,407,982...103,425,830
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO triacsin C results in decreased expression of DHCR7 mRNA CTD PMID:16704987 NCBI chr 7:143,823,167...143,848,410
Ensembl chr 7:143,823,145...143,848,410
JBrowse link
G Ebp phenylalkylamine Ca2+ antagonist (emopamil) binding protein decreases expression ISO triacsin C results in decreased expression of EBP mRNA CTD PMID:16704987 NCBI chr  X:8,185,329...8,193,512
Ensembl chr  X:8,185,329...8,193,512
JBrowse link
G Egr1 early growth response 1 increases expression ISO triacsin C results in increased expression of EGR1 mRNA CTD PMID:16704987 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Erg28 ergosterol biosynthesis 28 decreases expression ISO triacsin C results in decreased expression of ERG28 mRNA CTD PMID:16704987 NCBI chr12:85,815,447...85,824,893
Ensembl chr12:85,815,448...85,824,550
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases expression ISO triacsin C results in decreased expression of FGFR3 mRNA CTD PMID:16704987 NCBI chr 5:33,721,724...33,737,068
Ensembl chr 5:33,721,674...33,737,068
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO triacsin C results in increased expression of FOS mRNA CTD PMID:16704987 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fosl1 fos-like antigen 1 increases expression ISO triacsin C results in increased expression of FOSL1 mRNA CTD PMID:16704987 NCBI chr19:5,447,698...5,455,938
Ensembl chr19:5,447,547...5,455,946
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO triacsin C results in increased expression of GCLC mRNA CTD PMID:16704987 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO triacsin C results in increased expression of GCLM mRNA CTD PMID:16704987 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gnpda1 glucosamine-6-phosphate deaminase 1 decreases expression ISO triacsin C results in decreased expression of GNPDA1 mRNA CTD PMID:16704987 NCBI chr18:38,327,537...38,338,993
Ensembl chr18:38,327,535...38,339,003
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase decreases expression ISO triacsin C results in decreased expression of HMGCR mRNA CTD PMID:16704987 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO triacsin C results in increased expression of HMOX1 mRNA CTD PMID:16704987 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 decreases expression ISO triacsin C results in decreased expression of HS2ST1 mRNA CTD PMID:16704987 NCBI chr 3:144,429,701...144,570,216
Ensembl chr 3:144,429,706...144,570,181
JBrowse link
G Hspb11 heat shock protein family B (small), member 11 decreases expression ISO triacsin C results in decreased expression of HSPB11 mRNA CTD PMID:16704987 NCBI chr 4:107,253,593...107,284,497
Ensembl chr 4:107,253,593...107,279,938
JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO triacsin C results in decreased expression of ID3 mRNA CTD PMID:16704987 NCBI chr 4:136,143,822...136,145,392
Ensembl chr 4:136,143,497...136,145,755
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase decreases expression ISO triacsin C results in decreased expression of IDI1 mRNA CTD PMID:16704987 NCBI chr13:8,885,606...8,892,396
Ensembl chr13:8,885,501...8,892,451
JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 decreases expression ISO triacsin C results in decreased expression of IGFBP7 mRNA CTD PMID:16704987 NCBI chr 5:77,349,240...77,408,045
Ensembl chr 5:77,349,240...77,408,041
JBrowse link
G Ilvbl ilvB (bacterial acetolactate synthase)-like decreases expression ISO triacsin C results in decreased expression of ILVBL mRNA CTD PMID:16704987 NCBI chr10:78,574,344...78,584,502
Ensembl chr10:78,574,346...78,584,502
JBrowse link
G Isl1 ISL1 transcription factor, LIM/homeodomain decreases expression ISO triacsin C results in decreased expression of ISL1 mRNA CTD PMID:16704987 NCBI chr13:116,298,270...116,309,688
Ensembl chr13:116,298,281...116,309,689
JBrowse link
G Itga6 integrin alpha 6 increases expression ISO triacsin C results in increased expression of ITGA6 mRNA CTD PMID:16704987 NCBI chr 2:71,786,886...71,858,427
Ensembl chr 2:71,745,616...71,858,416
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
ISO triacsin C results in increased expression of and results in increased phosphorylation of JUN protein
triacsin C results in increased expression of JUN mRNA
CTD PMID:16704987 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Klf5 Kruppel-like factor 5 increases expression ISO triacsin C results in increased expression of KLF5 mRNA CTD PMID:16704987 NCBI chr14:99,298,691...99,313,412
Ensembl chr14:99,298,691...99,315,036
JBrowse link
G Lss lanosterol synthase decreases expression ISO triacsin C results in decreased expression of LSS mRNA CTD PMID:16704987 NCBI chr10:76,531,565...76,557,139
Ensembl chr10:76,531,588...76,557,138
JBrowse link
G Luc7l3 LUC7-like 3 (S. cerevisiae) decreases expression ISO triacsin C results in decreased expression of LUC7L3 mRNA CTD PMID:16704987 NCBI chr11:94,291,073...94,322,329
Ensembl chr11:94,287,890...94,321,988
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO triacsin C results in increased expression of MAFF mRNA CTD PMID:16704987 NCBI chr15:79,346,621...79,359,078
Ensembl chr15:79,346,621...79,359,076
JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 decreases expression ISO triacsin C results in decreased expression of NR2F1 mRNA CTD PMID:16704987 NCBI chr13:78,188,971...78,198,873
Ensembl chr13:78,188,973...78,199,757
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO triacsin C results in decreased expression of NR4A2 mRNA CTD PMID:16704987 NCBI chr 2:57,106,830...57,124,003
Ensembl chr 2:57,106,830...57,124,003
JBrowse link
G Nrtn neurturin decreases expression ISO triacsin C results in decreased expression of NRTN mRNA CTD PMID:16704987 NCBI chr17:56,751,323...56,757,548
Ensembl chr17:56,751,325...56,757,530
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein (myomegalin) decreases expression ISO triacsin C results in decreased expression of PDE4DIP mRNA CTD PMID:16704987 NCBI chr 3:97,689,828...97,888,707
Ensembl chr 3:97,689,824...97,888,707
JBrowse link
G Pdss2 prenyl (solanesyl) diphosphate synthase, subunit 2 decreases expression ISO triacsin C results in decreased expression of PDSS2 mRNA CTD PMID:16704987 NCBI chr10:43,218,248...43,464,882
Ensembl chr10:43,221,486...43,464,882
JBrowse link
G Phlda1 pleckstrin homology like domain, family A, member 1 increases expression ISO triacsin C results in increased expression of PHLDA1 mRNA CTD PMID:16704987 NCBI chr10:111,506,286...111,508,649
Ensembl chr10:111,506,286...111,508,645
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO triacsin C results in increased expression of PMAIP1 mRNA CTD PMID:16704987 NCBI chr18:66,458,604...66,465,558
Ensembl chr18:66,458,533...66,465,565
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit multiple interactions EXP triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein] CTD PMID:18390901 NCBI chr15:5,143,861...5,181,899
Ensembl chr15:5,143,861...5,181,899
JBrowse link
G Prpf4 pre-mRNA processing factor 4 decreases expression ISO triacsin C results in decreased expression of PRPF4 mRNA CTD PMID:16704987 NCBI chr 4:62,408,762...62,426,990
Ensembl chr 4:62,408,797...62,426,990
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO triacsin C results in increased expression of PSAT1 mRNA CTD PMID:16704987 NCBI chr19:15,905,123...15,925,059
Ensembl chr19:15,904,678...15,947,337
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4a1 increases expression ISO triacsin C results in increased expression of PTP4A1 mRNA CTD PMID:16704987 NCBI chr 1:30,940,303...30,949,877
Ensembl chr 1:30,940,302...30,949,309
Ensembl chr 1:30,940,302...30,949,309
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor (GEF) 2 increases expression ISO triacsin C results in increased expression of RAPGEF2 mRNA CTD PMID:16704987 NCBI chr 3:79,062,511...79,286,545
Ensembl chr 3:79,062,516...79,286,517
JBrowse link
G Skp2 S-phase kinase-associated protein 2 decreases expression ISO triacsin C results in decreased expression of SKP2 mRNA CTD PMID:16704987 NCBI chr15:9,111,982...9,155,425
Ensembl chr15:9,111,985...9,155,425
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression ISO triacsin C results in increased expression of SLC7A11 mRNA CTD PMID:16704987 NCBI chr 3:50,364,936...50,499,087
Ensembl chr 3:49,892,526...50,443,614
JBrowse link
G Snai2 snail family zinc finger 2 increases expression ISO triacsin C results in increased expression of SNAI2 mRNA CTD PMID:16704987 NCBI chr16:14,705,852...14,709,395
Ensembl chr16:14,705,852...14,709,385
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 decreases expression ISO triacsin C results in decreased expression of SOX9 mRNA CTD PMID:16704987 NCBI chr11:112,782,210...112,787,757
Ensembl chr11:112,782,224...112,787,760
JBrowse link
G Sparc secreted acidic cysteine rich glycoprotein decreases expression ISO triacsin C results in decreased expression of SPARC mRNA CTD PMID:16704987 NCBI chr11:55,394,159...55,420,080
Ensembl chr11:55,394,500...55,423,183
JBrowse link
G Spast spastin decreases expression ISO triacsin C results in decreased expression of SPAST mRNA CTD PMID:16704987 NCBI chr17:74,337,923...74,391,115
Ensembl chr17:74,338,987...74,391,115
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO triacsin C results in increased expression of SQSTM1 mRNA CTD PMID:16704987 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 decreases expression ISO triacsin C results in decreased expression of SRGAP2 mRNA CTD PMID:16704987 NCBI chr 1:131,285,251...131,527,531
Ensembl chr 1:131,285,251...131,527,352
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO triacsin C results in increased expression of STC2 mRNA CTD PMID:16704987 NCBI chr11:31,359,441...31,370,061
Ensembl chr11:31,357,307...31,370,074
JBrowse link
G Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a increases expression ISO triacsin C results in increased expression of TNFRSF12A mRNA CTD PMID:16704987 NCBI chr17:23,675,445...23,677,449
Ensembl chr17:23,675,445...23,677,468
JBrowse link
G Tns3 tensin 3 decreases expression ISO triacsin C results in decreased expression of TNS3 mRNA CTD PMID:16704987 NCBI chr11:8,431,652...8,664,758
Ensembl chr11:8,431,652...8,664,681
JBrowse link
G Top2a topoisomerase (DNA) II alpha decreases expression ISO triacsin C results in decreased expression of TOP2A mRNA CTD PMID:16704987 NCBI chr11:98,992,947...99,024,199
Ensembl chr11:98,992,943...99,024,189
JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) increases expression EXP triacsin C results in increased expression of UCP3 mRNA CTD PMID:11056218 NCBI chr 7:100,472,991...100,486,432
Ensembl chr 7:100,472,990...100,486,432
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide increases expression ISO triacsin C results in increased expression of YWHAZ mRNA CTD PMID:16704987 NCBI chr15:36,770,261...36,802,984
Ensembl chr15:36,770,770...36,796,929
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 21797
    role 21776
      biological role 21774
        biochemical role 21012
          enzyme inhibitor 19348
            EC 3.* (hydrolase) inhibitor 18861
              EC 3.1.* (ester hydrolase) inhibitor 13592
                EC 3.1.1.* (carboxylic ester hydrolase) inhibitor 9660
                  EC 3.1.1.64 (retinoid isomerohydrolase) inhibitor 64
                    triacsin C 64
paths to the root