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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 3.1.1.64 (retinoid isomerohydrolase) inhibitor
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Accession:CHEBI:144455 term browser browse the term
Definition:An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of retinoid isomerohydrolase (EC 3.1.1.64).
Synonyms:related_synonym: EC 3.1.1.64 (retinoid isomerohydrolase) inhibitors;   EC 3.1.1.64 inhibitor;   EC 3.1.1.64 inhibitors;   RPE65 inhibitor;   RPE65 inhibitors;   all-trans-retinol isomerase:hydrolase inhibitor;   all-trans-retinol isomerase:hydrolase inhibitors;   all-trans-retinyl-palmitate hydrolase inhibitor;   all-trans-retinyl-palmitate hydrolase inhibitors;   all-trans-retinylester 11-cis isomerohydrolase inhibitor;   all-trans-retinylester 11-cis isomerohydrolase inhibitors;   retinoid isomerohydrolase inhibitor;   retinoid isomerohydrolase inhibitors;   retinol isomerase inhibitor;   retinol isomerase inhibitors
 xref: Wikipedia:RPE65


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triacsin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO triacsin C inhibits the reaction [Fatty Acids results in increased degradation of ABCA1 protein]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]; triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein] CTD PMID:16118212 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473 		JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 decreases expression ISO triacsin C results in decreased expression of ABCD3 mRNA CTD PMID:16704987 NCBI chr 2:212,536,791...212,590,379
Ensembl chr 2:212,536,791...212,590,504 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of ACACA protein] CTD PMID:18390901 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases activity EXP triacsin C results in decreased activity of ACSL1 protein CTD PMID:11319222 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases activity EXP triacsin C results in decreased activity of ACSL4 protein CTD PMID:11319222 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:110,739,648...110,803,261 		JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 decreases expression ISO triacsin C results in decreased expression of ADARB1 mRNA CTD PMID:16704987 NCBI chr20:11,222,171...11,350,416
Ensembl chr20:11,222,164...11,350,415 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) decreases expression ISO triacsin C results in decreased expression of AQP3 mRNA CTD PMID:16704987 NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:61,035,166...61,040,685 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO triacsin C results in increased expression of ARHGDIA mRNA CTD PMID:16704987 NCBI chr10:106,352,858...106,356,347
Ensembl chr10:106,353,491...106,356,347 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO triacsin C results in increased expression of ATF3 mRNA CTD PMID:16704987 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression ISO triacsin C results in decreased expression of BDNF mRNA CTD PMID:16704987 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Casp3 caspase 3 increases activity ISO triacsin C results in increased activity of CASP3 protein CTD PMID:16704987 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression ISO triacsin C results in decreased expression of COL18A1 mRNA CTD PMID:16704987 NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,473,645...11,582,112 		JBrowse link
G Ctdspl CTD small phosphatase like decreases expression ISO triacsin C results in decreased expression of CTDSPL mRNA CTD PMID:16704987 NCBI chr 8:127,520,478...127,644,999
Ensembl chr 8:127,520,499...127,644,999 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO triacsin C results in increased expression of DDIT4 mRNA CTD PMID:16704987 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037 		JBrowse link
G Ddx24 DEAD-box helicase 24 decreases expression ISO triacsin C results in decreased expression of DDX24 mRNA CTD PMID:16704987 NCBI chr 6:128,329,554...128,346,818
Ensembl chr 6:128,329,554...128,349,625 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO triacsin C results in decreased expression of DHCR7 mRNA CTD PMID:16704987 NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase decreases expression ISO triacsin C results in decreased expression of EBP mRNA CTD PMID:16704987 NCBI chr  X:16,971,372...16,977,782
Ensembl chr  X:16,971,405...16,977,781 		JBrowse link
G Egr1 early growth response 1 increases expression ISO triacsin C results in increased expression of EGR1 mRNA CTD PMID:16704987 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Erg28 ergosterol biosynthesis 28 homolog decreases expression ISO triacsin C results in decreased expression of ERG28 mRNA CTD PMID:16704987 NCBI chr 6:111,205,102...111,214,068
Ensembl chr 6:111,205,103...111,214,068 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases expression ISO triacsin C results in decreased expression of FGFR3 mRNA CTD PMID:16704987 NCBI chr14:81,211,800...81,227,215
Ensembl chr14:81,211,800...81,227,209 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO triacsin C results in increased expression of FOS mRNA CTD PMID:16704987 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO triacsin C results in increased expression of FOSL1 mRNA CTD PMID:16704987 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO triacsin C results in increased expression of GCLC mRNA CTD PMID:16704987 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO triacsin C results in increased expression of GCLM mRNA CTD PMID:16704987 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gnpda1 glucosamine-6-phosphate deaminase 1 decreases expression ISO triacsin C results in decreased expression of GNPDA1 mRNA CTD PMID:16704987 NCBI chr18:30,416,599...30,428,630
Ensembl chr18:30,416,607...30,428,630 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO triacsin C results in decreased expression of HMGCR mRNA CTD PMID:16704987 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO triacsin C results in increased expression of HMOX1 mRNA CTD PMID:16704987 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 decreases expression ISO triacsin C results in decreased expression of HS2ST1 mRNA CTD PMID:16704987 NCBI chr 2:236,168,391...236,302,186
Ensembl chr 2:236,168,392...236,302,133 		JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO triacsin C results in decreased expression of ID3 mRNA CTD PMID:16704987 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO triacsin C results in decreased expression of IDI1 mRNA CTD PMID:16704987 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524 		JBrowse link
G Ift25 intraflagellar transport 25 decreases expression ISO triacsin C results in decreased expression of IFT25 mRNA CTD PMID:16704987 NCBI chr 5:127,264,450...127,291,225
Ensembl chr 5:127,264,498...127,291,225 		JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 decreases expression ISO triacsin C results in decreased expression of IGFBP7 mRNA CTD PMID:16704987 NCBI chr14:31,091,681...31,151,623
Ensembl chr14:31,091,347...31,151,620 		JBrowse link
G Ilvbl ilvB acetolactate synthase like decreases expression ISO triacsin C results in decreased expression of HACL2 mRNA CTD PMID:16704987 NCBI chr 7:11,690,445...11,700,498
Ensembl chr 7:11,690,445...11,700,498 		JBrowse link
G Isl1 ISL LIM homeobox 1 decreases expression ISO triacsin C results in decreased expression of ISL1 mRNA CTD PMID:16704987 NCBI chr 2:49,813,618...49,823,442
Ensembl chr 2:49,813,618...49,823,442 		JBrowse link
G Itga6 integrin subunit alpha 6 increases expression ISO triacsin C results in increased expression of ITGA6 mRNA CTD PMID:16704987 NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression 		ISO triacsin C results in increased expression of and results in increased phosphorylation of JUN protein
triacsin C results in increased expression of JUN mRNA 		CTD PMID:16704987 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Klf5 KLF transcription factor 5 increases expression ISO triacsin C results in increased expression of KLF5 mRNA CTD PMID:16704987 NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262 		JBrowse link
G Lss lanosterol synthase decreases expression ISO triacsin C results in decreased expression of LSS mRNA CTD PMID:16704987 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Luc7l3 LUC7 pre-mRNA splicing factor like 3 decreases expression ISO triacsin C results in decreased expression of LUC7L3 mRNA CTD PMID:16704987 NCBI chr10:79,737,457...79,773,478
Ensembl chr10:79,736,853...79,773,429 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO triacsin C results in increased expression of MAFF mRNA CTD PMID:16704987 NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147 		JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 decreases expression ISO triacsin C results in decreased expression of NR2F1 mRNA CTD PMID:16704987 NCBI chr 2:9,776,179...9,785,924
Ensembl chr 2:9,776,179...9,785,924 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO triacsin C results in decreased expression of NR4A2 mRNA CTD PMID:16704987 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769 		JBrowse link
G Nrtn neurturin decreases expression ISO triacsin C results in decreased expression of NRTN mRNA CTD PMID:16704987 NCBI chr 9:1,669,099...1,674,957
Ensembl chr 9:1,641,618...1,675,133 		JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein decreases expression ISO triacsin C results in decreased expression of PDE4DIP mRNA CTD PMID:16704987 NCBI chr 2:187,982,002...188,178,937
Ensembl chr 2:187,981,878...188,178,869 		JBrowse link
G Pdss2 decaprenyl diphosphate synthase subunit 2 decreases expression ISO triacsin C results in decreased expression of PDSS2 mRNA CTD PMID:16704987 NCBI chr20:48,291,788...48,520,846
Ensembl chr20:48,291,797...48,535,689 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression ISO triacsin C results in increased expression of PHLDA1 mRNA CTD PMID:16704987 NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO triacsin C results in increased expression of PMAIP1 mRNA CTD PMID:16704987 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein] CTD PMID:18390901 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Prpf4 pre-mRNA splicing tri-snRNP complex factor PRPF4 decreases expression ISO triacsin C results in decreased expression of PRPF4 mRNA CTD PMID:16704987 NCBI chr 5:80,875,511...80,889,501
Ensembl chr 5:80,875,498...80,889,497 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO triacsin C results in increased expression of PSAT1 mRNA CTD PMID:16704987 NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693 		JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression ISO triacsin C results in increased expression of PTP4A1 mRNA CTD PMID:16704987 NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:40,710,250...40,718,176 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 increases expression ISO triacsin C results in increased expression of RAPGEF2 mRNA CTD PMID:16704987 NCBI chr 2:166,505,868...166,728,139
Ensembl chr 2:166,505,868...166,726,698 		JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO triacsin C results in decreased expression of SKP2 mRNA CTD PMID:16704987 NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO triacsin C results in increased expression of SLC7A11 mRNA CTD PMID:16704987 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO triacsin C results in increased expression of SNAI2 mRNA CTD PMID:16704987 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349 		JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO triacsin C results in decreased expression of SOX9 mRNA CTD PMID:16704987 NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250 		JBrowse link
G Sparc secreted protein acidic and cysteine rich decreases expression ISO triacsin C results in decreased expression of SPARC mRNA CTD PMID:16704987 NCBI chr10:40,017,065...40,038,816
Ensembl chr10:40,017,075...40,039,268 		JBrowse link
G Spast spastin decreases expression ISO triacsin C results in decreased expression of SPAST mRNA CTD PMID:16704987 NCBI chr 6:26,807,220...26,858,456
Ensembl chr 6:26,807,220...26,858,446 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO triacsin C results in increased expression of SQSTM1 mRNA CTD PMID:16704987 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 decreases expression ISO triacsin C results in decreased expression of SRGAP2 mRNA CTD PMID:16704987 NCBI chr13:45,298,192...45,519,330
Ensembl chr13:45,298,192...45,519,330 		JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO triacsin C results in increased expression of STC2 mRNA CTD PMID:16704987 NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447 		JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression ISO triacsin C results in increased expression of TNFRSF12A mRNA CTD PMID:16704987 NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704 		JBrowse link
G Tns3 tensin 3 decreases expression ISO triacsin C results in decreased expression of TNS3 mRNA CTD PMID:16704987 NCBI chr14:87,387,441...87,619,457
Ensembl chr14:87,387,441...87,619,712 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression ISO triacsin C results in decreased expression of TOP2A mRNA CTD PMID:16704987 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Ucp3 uncoupling protein 3 increases expression ISO triacsin C results in increased expression of UCP3 mRNA CTD PMID:11056218 NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:164,227,882...164,241,210 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta increases expression ISO triacsin C results in increased expression of YWHAZ mRNA CTD PMID:16704987 NCBI chr 7:69,826,404...69,848,702
Ensembl chr 7:69,826,404...69,849,007 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          enzyme inhibitor 19247
            EC 3.* (hydrolase) inhibitor 18773
              EC 3.1.* (ester hydrolase) inhibitor 15494
                EC 3.1.1.* (carboxylic ester hydrolase) inhibitor 12440
                  EC 3.1.1.64 (retinoid isomerohydrolase) inhibitor 66
                    triacsin C 66
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