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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:triacsin C
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Accession:CHEBI:144441 term browser browse the term
Definition:A nitroso compound that is N-undecylnitrous hydrazide carrying double bonds at positions 1,2,4, and 7. It is a long-chain fatty acyl CoA synthetase inhibitor and interferes with lipid metabolism by inhibiting the de novo synthesis of glycerolipids and cholesterol esters.
Synonyms:exact_synonym: N-[(1E,2E,4E,7E)-undeca-2,4,7-trien-1-ylidene]nitrous hydrazide
 related_synonym: (2E,4E,7E)-2,4,7-undecatrienal nitrosohydrazone;   2,4,7-undecatrienal nitrosohydrazone;   FR 900190;   Formula=C11H17N3O;   InChI=1S/C11H17N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h4-5,7-11H,2-3,6H2,1H3,(H,13,15)/b5-4+,8-7+,10-9+,12-11+;   InChIKey=NKTGCVUIESDXPU-YLEPRARLSA-N;   SMILES=C(/C=C/C=C/C/C=C/CCC)=N\\NN=O;   WS 1228A;   nitrosohydrazone-2E,4E,7E-undecatrienal
 xref: CAS:76896-80-5;   LINCS:LSM-43284
 xref_mesh: MESH:C034613
 xref: MetaCyc:CPD-14770;   PMID:15249192;   PMID:17446697;   PMID:18653998;   PMID:1999415;   PMID:23565210;   PMID:26719343;   PMID:28918598;   PMID:3117118;   PMID:6804425;   PMID:6804426;   PMID:9182714;   Wikipedia:Triacsin_C


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triacsin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO triacsin C inhibits the reaction [Fatty Acids results in increased degradation of ABCA1 protein]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]; triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein] CTD PMID:16118212 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473 		JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 decreases expression ISO triacsin C results in decreased expression of ABCD3 mRNA CTD PMID:16704987 NCBI chr 2:212,536,791...212,590,379
Ensembl chr 2:212,536,791...212,590,504 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of ACACA protein] CTD PMID:18390901 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases activity EXP triacsin C results in decreased activity of ACSL1 protein CTD PMID:11319222 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases activity EXP triacsin C results in decreased activity of ACSL4 protein CTD PMID:11319222 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:110,739,648...110,803,261 		JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 decreases expression ISO triacsin C results in decreased expression of ADARB1 mRNA CTD PMID:16704987 NCBI chr20:11,222,171...11,350,416
Ensembl chr20:11,222,164...11,350,415 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) decreases expression ISO triacsin C results in decreased expression of AQP3 mRNA CTD PMID:16704987 NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:61,035,166...61,040,685 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO triacsin C results in increased expression of ARHGDIA mRNA CTD PMID:16704987 NCBI chr10:106,352,858...106,356,347
Ensembl chr10:106,353,491...106,356,347 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO triacsin C results in increased expression of ATF3 mRNA CTD PMID:16704987 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression ISO triacsin C results in decreased expression of BDNF mRNA CTD PMID:16704987 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Casp3 caspase 3 increases activity ISO triacsin C results in increased activity of CASP3 protein CTD PMID:16704987 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression ISO triacsin C results in decreased expression of COL18A1 mRNA CTD PMID:16704987 NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,473,645...11,582,112 		JBrowse link
G Ctdspl CTD small phosphatase like decreases expression ISO triacsin C results in decreased expression of CTDSPL mRNA CTD PMID:16704987 NCBI chr 8:127,520,478...127,644,999
Ensembl chr 8:127,520,499...127,644,999 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO triacsin C results in increased expression of DDIT4 mRNA CTD PMID:16704987 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037 		JBrowse link
G Ddx24 DEAD-box helicase 24 decreases expression ISO triacsin C results in decreased expression of DDX24 mRNA CTD PMID:16704987 NCBI chr 6:128,329,554...128,346,818
Ensembl chr 6:128,329,554...128,349,625 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO triacsin C results in decreased expression of DHCR7 mRNA CTD PMID:16704987 NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase decreases expression ISO triacsin C results in decreased expression of EBP mRNA CTD PMID:16704987 NCBI chr  X:16,971,372...16,977,782
Ensembl chr  X:16,971,405...16,977,781 		JBrowse link
G Egr1 early growth response 1 increases expression ISO triacsin C results in increased expression of EGR1 mRNA CTD PMID:16704987 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Erg28 ergosterol biosynthesis 28 homolog decreases expression ISO triacsin C results in decreased expression of ERG28 mRNA CTD PMID:16704987 NCBI chr 6:111,205,102...111,214,068
Ensembl chr 6:111,205,103...111,214,068 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases expression ISO triacsin C results in decreased expression of FGFR3 mRNA CTD PMID:16704987 NCBI chr14:81,211,800...81,227,215
Ensembl chr14:81,211,800...81,227,209 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO triacsin C results in increased expression of FOS mRNA CTD PMID:16704987 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO triacsin C results in increased expression of FOSL1 mRNA CTD PMID:16704987 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO triacsin C results in increased expression of GCLC mRNA CTD PMID:16704987 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO triacsin C results in increased expression of GCLM mRNA CTD PMID:16704987 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gnpda1 glucosamine-6-phosphate deaminase 1 decreases expression ISO triacsin C results in decreased expression of GNPDA1 mRNA CTD PMID:16704987 NCBI chr18:30,416,599...30,428,630
Ensembl chr18:30,416,607...30,428,630 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO triacsin C results in decreased expression of HMGCR mRNA CTD PMID:16704987 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO triacsin C results in increased expression of HMOX1 mRNA CTD PMID:16704987 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 decreases expression ISO triacsin C results in decreased expression of HS2ST1 mRNA CTD PMID:16704987 NCBI chr 2:236,168,391...236,302,186
Ensembl chr 2:236,168,392...236,302,133 		JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO triacsin C results in decreased expression of ID3 mRNA CTD PMID:16704987 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO triacsin C results in decreased expression of IDI1 mRNA CTD PMID:16704987 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524 		JBrowse link
G Ift25 intraflagellar transport 25 decreases expression ISO triacsin C results in decreased expression of IFT25 mRNA CTD PMID:16704987 NCBI chr 5:127,264,450...127,291,225
Ensembl chr 5:127,264,498...127,291,225 		JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 decreases expression ISO triacsin C results in decreased expression of IGFBP7 mRNA CTD PMID:16704987 NCBI chr14:31,091,681...31,151,623
Ensembl chr14:31,091,347...31,151,620 		JBrowse link
G Ilvbl ilvB acetolactate synthase like decreases expression ISO triacsin C results in decreased expression of HACL2 mRNA CTD PMID:16704987 NCBI chr 7:11,690,445...11,700,498
Ensembl chr 7:11,690,445...11,700,498 		JBrowse link
G Isl1 ISL LIM homeobox 1 decreases expression ISO triacsin C results in decreased expression of ISL1 mRNA CTD PMID:16704987 NCBI chr 2:49,813,618...49,823,442
Ensembl chr 2:49,813,618...49,823,442 		JBrowse link
G Itga6 integrin subunit alpha 6 increases expression ISO triacsin C results in increased expression of ITGA6 mRNA CTD PMID:16704987 NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression 		ISO triacsin C results in increased expression of and results in increased phosphorylation of JUN protein
triacsin C results in increased expression of JUN mRNA 		CTD PMID:16704987 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Klf5 KLF transcription factor 5 increases expression ISO triacsin C results in increased expression of KLF5 mRNA CTD PMID:16704987 NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262 		JBrowse link
G Lss lanosterol synthase decreases expression ISO triacsin C results in decreased expression of LSS mRNA CTD PMID:16704987 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Luc7l3 LUC7 pre-mRNA splicing factor like 3 decreases expression ISO triacsin C results in decreased expression of LUC7L3 mRNA CTD PMID:16704987 NCBI chr10:79,737,457...79,773,478
Ensembl chr10:79,736,853...79,773,429 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO triacsin C results in increased expression of MAFF mRNA CTD PMID:16704987 NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147 		JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 decreases expression ISO triacsin C results in decreased expression of NR2F1 mRNA CTD PMID:16704987 NCBI chr 2:9,776,179...9,785,924
Ensembl chr 2:9,776,179...9,785,924 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO triacsin C results in decreased expression of NR4A2 mRNA CTD PMID:16704987 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769 		JBrowse link
G Nrtn neurturin decreases expression ISO triacsin C results in decreased expression of NRTN mRNA CTD PMID:16704987 NCBI chr 9:1,669,099...1,674,957
Ensembl chr 9:1,641,618...1,675,133 		JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein decreases expression ISO triacsin C results in decreased expression of PDE4DIP mRNA CTD PMID:16704987 NCBI chr 2:187,982,002...188,178,937
Ensembl chr 2:187,981,878...188,178,869 		JBrowse link
G Pdss2 decaprenyl diphosphate synthase subunit 2 decreases expression ISO triacsin C results in decreased expression of PDSS2 mRNA CTD PMID:16704987 NCBI chr20:48,291,788...48,520,846
Ensembl chr20:48,291,797...48,535,689 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression ISO triacsin C results in increased expression of PHLDA1 mRNA CTD PMID:16704987 NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO triacsin C results in increased expression of PMAIP1 mRNA CTD PMID:16704987 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein] CTD PMID:18390901 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Prpf4 pre-mRNA splicing tri-snRNP complex factor PRPF4 decreases expression ISO triacsin C results in decreased expression of PRPF4 mRNA CTD PMID:16704987 NCBI chr 5:80,875,511...80,889,501
Ensembl chr 5:80,875,498...80,889,497 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO triacsin C results in increased expression of PSAT1 mRNA CTD PMID:16704987 NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693 		JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression ISO triacsin C results in increased expression of PTP4A1 mRNA CTD PMID:16704987 NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:40,710,250...40,718,176 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 increases expression ISO triacsin C results in increased expression of RAPGEF2 mRNA CTD PMID:16704987 NCBI chr 2:166,505,868...166,728,139
Ensembl chr 2:166,505,868...166,726,698 		JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO triacsin C results in decreased expression of SKP2 mRNA CTD PMID:16704987 NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO triacsin C results in increased expression of SLC7A11 mRNA CTD PMID:16704987 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO triacsin C results in increased expression of SNAI2 mRNA CTD PMID:16704987 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349 		JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO triacsin C results in decreased expression of SOX9 mRNA CTD PMID:16704987 NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250 		JBrowse link
G Sparc secreted protein acidic and cysteine rich decreases expression ISO triacsin C results in decreased expression of SPARC mRNA CTD PMID:16704987 NCBI chr10:40,017,065...40,038,816
Ensembl chr10:40,017,075...40,039,268 		JBrowse link
G Spast spastin decreases expression ISO triacsin C results in decreased expression of SPAST mRNA CTD PMID:16704987 NCBI chr 6:26,807,220...26,858,456
Ensembl chr 6:26,807,220...26,858,446 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO triacsin C results in increased expression of SQSTM1 mRNA CTD PMID:16704987 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 decreases expression ISO triacsin C results in decreased expression of SRGAP2 mRNA CTD PMID:16704987 NCBI chr13:45,298,192...45,519,330
Ensembl chr13:45,298,192...45,519,330 		JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO triacsin C results in increased expression of STC2 mRNA CTD PMID:16704987 NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447 		JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression ISO triacsin C results in increased expression of TNFRSF12A mRNA CTD PMID:16704987 NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704 		JBrowse link
G Tns3 tensin 3 decreases expression ISO triacsin C results in decreased expression of TNS3 mRNA CTD PMID:16704987 NCBI chr14:87,387,441...87,619,457
Ensembl chr14:87,387,441...87,619,712 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression ISO triacsin C results in decreased expression of TOP2A mRNA CTD PMID:16704987 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Ucp3 uncoupling protein 3 increases expression ISO triacsin C results in increased expression of UCP3 mRNA CTD PMID:11056218 NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:164,227,882...164,241,210 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta increases expression ISO triacsin C results in increased expression of YWHAZ mRNA CTD PMID:16704987 NCBI chr 7:69,826,404...69,848,702
Ensembl chr 7:69,826,404...69,849,007 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        inhibitor 19476
          apoptosis inhibitor 9861
            triacsin C 66
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon group molecular entity 20715
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organonitrogen compound 19403
                                hydrazone 595
                                  triacsin C 66
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