CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: triacsin C
Accession: CHEBI:144441
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Definition: A nitroso compound that is N-undecylnitrous hydrazide carrying double bonds at positions 1,2,4, and 7. It is a long-chain fatty acyl CoA synthetase inhibitor and interferes with lipid metabolism by inhibiting the de novo synthesis of glycerolipids and cholesterol esters.
Synonyms: exact_synonym: N-[(1E,2E,4E,7E)-undeca-2,4,7-trien-1-ylidene]nitrous hydrazide
related_synonym: (2E,4E,7E)-2,4,7-undecatrienal nitrosohydrazone; 2,4,7-undecatrienal nitrosohydrazone; FR 900190; Formula=C11H17N3O; InChI=1S/C11H17N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h4-5,7-11H,2-3,6H2,1H3,(H,13,15)/b5-4+,8-7+,10-9+,12-11+; InChIKey=NKTGCVUIESDXPU-YLEPRARLSA-N; SMILES=C(/C=C/C=C/C/C=C/CCC)=N\\NN=O; WS 1228A; nitrosohydrazone-2E,4E,7E-undecatrienal
xref: CAS:76896-80-5; LINCS:LSM-43284
xref_mesh: MESH:C034613
xref: MetaCyc:CPD-14770; PMID:15249192; PMID:17446697; PMID:18653998; PMID:1999415; PMID:23565210; PMID:26719343; PMID:28918598; PMID:3117118; PMID:6804425; PMID:6804426; PMID:9182714; Wikipedia:Triacsin_C
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Abca1
ATP binding cassette subfamily A member 1
multiple interactions
ISO
triacsin C inhibits the reaction [Fatty Acids results in increased degradation of ABCA1 protein]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]; triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein]
CTD
PMID:16118212
NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473
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Abcd3
ATP binding cassette subfamily D member 3
decreases expression
ISO
triacsin C results in decreased expression of ABCD3 mRNA
CTD
PMID:16704987
NCBI chr 2:212,536,791...212,590,379
Ensembl chr 2:212,536,791...212,590,504
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Acaca
acetyl-CoA carboxylase alpha
multiple interactions
ISO
triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of ACACA protein]
CTD
PMID:18390901
NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
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Acsl1
acyl-CoA synthetase long-chain family member 1
decreases activity
EXP
triacsin C results in decreased activity of ACSL1 protein
CTD
PMID:11319222
NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023
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Acsl4
acyl-CoA synthetase long-chain family member 4
decreases activity
EXP
triacsin C results in decreased activity of ACSL4 protein
CTD
PMID:11319222
NCBI chr X:110,739,633...110,803,416
Ensembl chr X:110,739,648...110,803,261
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Adarb1
adenosine deaminase, RNA-specific, B1
decreases expression
ISO
triacsin C results in decreased expression of ADARB1 mRNA
CTD
PMID:16704987
NCBI chr20:11,222,171...11,350,416
Ensembl chr20:11,222,164...11,350,415
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Aqp3
aquaporin 3 (Gill blood group)
decreases expression
ISO
triacsin C results in decreased expression of AQP3 mRNA
CTD
PMID:16704987
NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:61,035,166...61,040,685
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Arhgdia
Rho GDP dissociation inhibitor alpha
increases expression
ISO
triacsin C results in increased expression of ARHGDIA mRNA
CTD
PMID:16704987
NCBI chr10:106,352,858...106,356,347
Ensembl chr10:106,353,491...106,356,347
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Atf3
activating transcription factor 3
increases expression
ISO
triacsin C results in increased expression of ATF3 mRNA
CTD
PMID:16704987
NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750
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Bdnf
brain-derived neurotrophic factor
decreases expression
ISO
triacsin C results in decreased expression of BDNF mRNA
CTD
PMID:16704987
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
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Casp3
caspase 3
increases activity
ISO
triacsin C results in increased activity of CASP3 protein
CTD
PMID:16704987
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Col18a1
collagen type XVIII alpha 1 chain
decreases expression
ISO
triacsin C results in decreased expression of COL18A1 mRNA
CTD
PMID:16704987
NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,473,645...11,582,112
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Ctdspl
CTD small phosphatase like
decreases expression
ISO
triacsin C results in decreased expression of CTDSPL mRNA
CTD
PMID:16704987
NCBI chr 8:127,520,478...127,644,999
Ensembl chr 8:127,520,499...127,644,999
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Ddit4
DNA-damage-inducible transcript 4
increases expression
ISO
triacsin C results in increased expression of DDIT4 mRNA
CTD
PMID:16704987
NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037
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Ddx24
DEAD-box helicase 24
decreases expression
ISO
triacsin C results in decreased expression of DDX24 mRNA
CTD
PMID:16704987
NCBI chr 6:128,329,554...128,346,818
Ensembl chr 6:128,329,554...128,349,625
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Dhcr7
7-dehydrocholesterol reductase
decreases expression
ISO
triacsin C results in decreased expression of DHCR7 mRNA
CTD
PMID:16704987
NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382
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Ebp
EBP, cholestenol delta-isomerase
decreases expression
ISO
triacsin C results in decreased expression of EBP mRNA
CTD
PMID:16704987
NCBI chr X:16,971,372...16,977,782
Ensembl chr X:16,971,405...16,977,781
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Egr1
early growth response 1
increases expression
ISO
triacsin C results in increased expression of EGR1 mRNA
CTD
PMID:16704987
NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843
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Erg28
ergosterol biosynthesis 28 homolog
decreases expression
ISO
triacsin C results in decreased expression of ERG28 mRNA
CTD
PMID:16704987
NCBI chr 6:111,205,102...111,214,068
Ensembl chr 6:111,205,103...111,214,068
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Fgfr3
fibroblast growth factor receptor 3
decreases expression
ISO
triacsin C results in decreased expression of FGFR3 mRNA
CTD
PMID:16704987
NCBI chr14:81,211,800...81,227,215
Ensembl chr14:81,211,800...81,227,209
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
triacsin C results in increased expression of FOS mRNA
CTD
PMID:16704987
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
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Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
ISO
triacsin C results in increased expression of FOSL1 mRNA
CTD
PMID:16704987
NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
triacsin C results in increased expression of GCLC mRNA
CTD
PMID:16704987
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
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Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
triacsin C results in increased expression of GCLM mRNA
CTD
PMID:16704987
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
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Gnpda1
glucosamine-6-phosphate deaminase 1
decreases expression
ISO
triacsin C results in decreased expression of GNPDA1 mRNA
CTD
PMID:16704987
NCBI chr18:30,416,599...30,428,630
Ensembl chr18:30,416,607...30,428,630
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
decreases expression
ISO
triacsin C results in decreased expression of HMGCR mRNA
CTD
PMID:16704987
NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533
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Hmox1
heme oxygenase 1
increases expression
ISO
triacsin C results in increased expression of HMOX1 mRNA
CTD
PMID:16704987
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
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Hs2st1
heparan sulfate 2-O-sulfotransferase 1
decreases expression
ISO
triacsin C results in decreased expression of HS2ST1 mRNA
CTD
PMID:16704987
NCBI chr 2:236,168,391...236,302,186
Ensembl chr 2:236,168,392...236,302,133
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Id3
inhibitor of DNA binding 3
decreases expression
ISO
triacsin C results in decreased expression of ID3 mRNA
CTD
PMID:16704987
NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856
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Idi1
isopentenyl-diphosphate delta isomerase 1
decreases expression
ISO
triacsin C results in decreased expression of IDI1 mRNA
CTD
PMID:16704987
NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524
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Ift25
intraflagellar transport 25
decreases expression
ISO
triacsin C results in decreased expression of IFT25 mRNA
CTD
PMID:16704987
NCBI chr 5:127,264,450...127,291,225
Ensembl chr 5:127,264,498...127,291,225
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Igfbp7
insulin-like growth factor binding protein 7
decreases expression
ISO
triacsin C results in decreased expression of IGFBP7 mRNA
CTD
PMID:16704987
NCBI chr14:31,091,681...31,151,623
Ensembl chr14:31,091,347...31,151,620
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Ilvbl
ilvB acetolactate synthase like
decreases expression
ISO
triacsin C results in decreased expression of HACL2 mRNA
CTD
PMID:16704987
NCBI chr 7:11,690,445...11,700,498
Ensembl chr 7:11,690,445...11,700,498
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Isl1
ISL LIM homeobox 1
decreases expression
ISO
triacsin C results in decreased expression of ISL1 mRNA
CTD
PMID:16704987
NCBI chr 2:49,813,618...49,823,442
Ensembl chr 2:49,813,618...49,823,442
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Itga6
integrin subunit alpha 6
increases expression
ISO
triacsin C results in increased expression of ITGA6 mRNA
CTD
PMID:16704987
NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression
ISO
triacsin C results in increased expression of and results in increased phosphorylation of JUN protein triacsin C results in increased expression of JUN mRNA
CTD
PMID:16704987
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
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Klf5
KLF transcription factor 5
increases expression
ISO
triacsin C results in increased expression of KLF5 mRNA
CTD
PMID:16704987
NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262
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Lss
lanosterol synthase
decreases expression
ISO
triacsin C results in decreased expression of LSS mRNA
CTD
PMID:16704987
NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253
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Luc7l3
LUC7 pre-mRNA splicing factor like 3
decreases expression
ISO
triacsin C results in decreased expression of LUC7L3 mRNA
CTD
PMID:16704987
NCBI chr10:79,737,457...79,773,478
Ensembl chr10:79,736,853...79,773,429
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Maff
MAF bZIP transcription factor F
increases expression
ISO
triacsin C results in increased expression of MAFF mRNA
CTD
PMID:16704987
NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147
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Nr2f1
nuclear receptor subfamily 2, group F, member 1
decreases expression
ISO
triacsin C results in decreased expression of NR2F1 mRNA
CTD
PMID:16704987
NCBI chr 2:9,776,179...9,785,924
Ensembl chr 2:9,776,179...9,785,924
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Nr4a2
nuclear receptor subfamily 4, group A, member 2
decreases expression
ISO
triacsin C results in decreased expression of NR4A2 mRNA
CTD
PMID:16704987
NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769
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Nrtn
neurturin
decreases expression
ISO
triacsin C results in decreased expression of NRTN mRNA
CTD
PMID:16704987
NCBI chr 9:1,669,099...1,674,957
Ensembl chr 9:1,641,618...1,675,133
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Pde4dip
phosphodiesterase 4D interacting protein
decreases expression
ISO
triacsin C results in decreased expression of PDE4DIP mRNA
CTD
PMID:16704987
NCBI chr 2:187,982,002...188,178,937
Ensembl chr 2:187,981,878...188,178,869
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Pdss2
decaprenyl diphosphate synthase subunit 2
decreases expression
ISO
triacsin C results in decreased expression of PDSS2 mRNA
CTD
PMID:16704987
NCBI chr20:48,291,788...48,520,846
Ensembl chr20:48,291,797...48,535,689
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Phlda1
pleckstrin homology-like domain, family A, member 1
increases expression
ISO
triacsin C results in increased expression of PHLDA1 mRNA
CTD
PMID:16704987
NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
ISO
triacsin C results in increased expression of PMAIP1 mRNA
CTD
PMID:16704987
NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
multiple interactions
ISO
triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]
CTD
PMID:18390901
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
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Prpf4
pre-mRNA splicing tri-snRNP complex factor PRPF4
decreases expression
ISO
triacsin C results in decreased expression of PRPF4 mRNA
CTD
PMID:16704987
NCBI chr 5:80,875,511...80,889,501
Ensembl chr 5:80,875,498...80,889,497
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Psat1
phosphoserine aminotransferase 1
increases expression
ISO
triacsin C results in increased expression of PSAT1 mRNA
CTD
PMID:16704987
NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693
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Ptp4a1
protein tyrosine phosphatase 4A1
increases expression
ISO
triacsin C results in increased expression of PTP4A1 mRNA
CTD
PMID:16704987
NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:40,710,250...40,718,176
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Rapgef2
Rap guanine nucleotide exchange factor 2
increases expression
ISO
triacsin C results in increased expression of RAPGEF2 mRNA
CTD
PMID:16704987
NCBI chr 2:166,505,868...166,728,139
Ensembl chr 2:166,505,868...166,726,698
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Skp2
S-phase kinase associated protein 2
decreases expression
ISO
triacsin C results in decreased expression of SKP2 mRNA
CTD
PMID:16704987
NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438
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Slc7a11
solute carrier family 7 member 11
increases expression
ISO
triacsin C results in increased expression of SLC7A11 mRNA
CTD
PMID:16704987
NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
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Snai2
snail family transcriptional repressor 2
increases expression
ISO
triacsin C results in increased expression of SNAI2 mRNA
CTD
PMID:16704987
NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349
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Sox9
SRY-box transcription factor 9
decreases expression
ISO
triacsin C results in decreased expression of SOX9 mRNA
CTD
PMID:16704987
NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250
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Sparc
secreted protein acidic and cysteine rich
decreases expression
ISO
triacsin C results in decreased expression of SPARC mRNA
CTD
PMID:16704987
NCBI chr10:40,017,065...40,038,816
Ensembl chr10:40,017,075...40,039,268
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Spast
spastin
decreases expression
ISO
triacsin C results in decreased expression of SPAST mRNA
CTD
PMID:16704987
NCBI chr 6:26,807,220...26,858,456
Ensembl chr 6:26,807,220...26,858,446
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Sqstm1
sequestosome 1
increases expression
ISO
triacsin C results in increased expression of SQSTM1 mRNA
CTD
PMID:16704987
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
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Srgap2
SLIT-ROBO Rho GTPase activating protein 2
decreases expression
ISO
triacsin C results in decreased expression of SRGAP2 mRNA
CTD
PMID:16704987
NCBI chr13:45,298,192...45,519,330
Ensembl chr13:45,298,192...45,519,330
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Stc2
stanniocalcin 2
increases expression
ISO
triacsin C results in increased expression of STC2 mRNA
CTD
PMID:16704987
NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447
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Tnfrsf12a
TNF receptor superfamily member 12A
increases expression
ISO
triacsin C results in increased expression of TNFRSF12A mRNA
CTD
PMID:16704987
NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704
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Tns3
tensin 3
decreases expression
ISO
triacsin C results in decreased expression of TNS3 mRNA
CTD
PMID:16704987
NCBI chr14:87,387,441...87,619,457
Ensembl chr14:87,387,441...87,619,712
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Top2a
DNA topoisomerase II alpha
decreases expression
ISO
triacsin C results in decreased expression of TOP2A mRNA
CTD
PMID:16704987
NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366
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Ucp3
uncoupling protein 3
increases expression
ISO
triacsin C results in increased expression of UCP3 mRNA
CTD
PMID:11056218
NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:164,227,882...164,241,210
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Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
increases expression
ISO
triacsin C results in increased expression of YWHAZ mRNA
CTD
PMID:16704987
NCBI chr 7:69,826,404...69,848,702
Ensembl chr 7:69,826,404...69,849,007
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