Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:dinophysistoxin 1
go back to main search page
Accession:CHEBI:144400 term browser browse the term
Definition:A ketal that is a marine toxin structurally related to okadaic acid. Produced by dinoflagellates it is known to accumulate in shellfish and cause diarrhoeic shellfish poisoning. It is an inhibitor of serine/threonine protein phosphatases 1 (PP1) and PP2A and has been shown to promote cancer cell growth in tumour cell lines and animal models.
Synonyms:exact_synonym: (2R)-3-[(2S,5R,6R,8S)-8-{(2R,3E)-4-[(2R,4'aR,5R,6'S,8'R,8'aS)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,6R,11R)-11-methyl-1,8-dioxaspiro[5.5]undecan-2-yl]butyl}-7'-methylidenehexahydro-3'H-spiro[oxolane-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl}-5-hydroxy-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-hydroxy-2-methylpropanoic acid
 related_synonym: (2R)-2-hydroxy-3-[(2S,5R,6R,8S)-5-hydroxy-8-{(2R,3E)-4-[(2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,6R,11R)-11-methyl-1,8-dioxaspiro[5.5]undecan-2-yl]butyl}-7'-methyleneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl}-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-methylpropanoic acid;   35-Methylokadaic acid;   DTX 1;   DTX1;   Formula=C44H68O13;   InChI=1S/C44H68O13/c1-25-20-35(56-44(22-25)36(46)12-11-31(54-44)23-41(6,50)40(48)49)26(2)9-10-30-13-17-43(53-30)18-14-34-39(57-43)37(47)29(5)38(52-34)32(45)21-27(3)33-8-7-16-42(55-33)24-51-19-15-28(42)4/h9-10,22,26-28,30-39,45-47,50H,5,7-8,11-21,23-24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27+,28-,30+,31+,32+,33+,34-,35+,36-,37-,38+,39-,41-,42+,43-,44-/m1/s1;   InChIKey=CFXGUVKORZKACE-ZLEMCYMFSA-N;   SMILES=[C@@]12(O[C@]3([C@H](O)C(=C)[C@@H]([C@@H](O)C[C@@H]([C@]4(O[C@@]5([C@@H](CCOC5)C)CCC4)[H])C)O[C@@H]3CC1)[H])O[C@H](CC2)\\C=C\\[C@H]([C@]6(O[C@]7(O[C@H](C[C@](C(=O)O)(O)C)CC[C@H]7O)C=C(C)C6)[H])C
 xref: CAS:81720-10-7;   KEGG:C16870
 xref_mesh: MESH:C051904
 xref: PMID:10398517;   PMID:17455957;   PMID:1905699;   PMID:19481560;   PMID:23127709;   PMID:24394641;   PMID:25238672;   PMID:25826053;   PMID:26426049;   PMID:27956244;   PMID:28366404;   PMID:29491228;   PMID:30176657


show annotations for term's descendants       view all columns           Sort by:
 
dinophysistoxin 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abtb2 ankyrin repeat and BTB domain containing 2 JBrowse link 3 93,494,706 93,648,750 RGD:6480464
G Aldoc aldolase, fructose-bisphosphate C JBrowse link 10 65,586,504 65,590,093 RGD:6480464
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:6480464
G Atxn3 ataxin 3 JBrowse link 6 125,817,420 125,853,461 RGD:6480464
G Bace1 beta-secretase 1 JBrowse link 8 50,140,092 50,162,388 RGD:6480464
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:6480464
G Bfsp1 beaded filament structural protein 1 JBrowse link 3 137,935,345 137,992,652 RGD:6480464
G Bik BCL2-interacting killer JBrowse link 7 124,390,924 124,410,449 RGD:6480464
G Bpgm bisphosphoglycerate mutase JBrowse link 4 61,912,210 61,940,697 RGD:6480464
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:6480464
G Canx calnexin JBrowse link 10 35,800,942 35,833,939 RGD:6480464
G Cck cholecystokinin JBrowse link 8 130,120,525 130,127,515 RGD:6480464
G Cct4 chaperonin containing TCP1 subunit 4 JBrowse link 14 107,767,392 107,780,270 RGD:6480464
G Cct7 chaperonin containing TCP1 subunit 7 JBrowse link 4 117,235,023 117,252,265 RGD:6480464
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:6480464
G Cdkn1c cyclin-dependent kinase inhibitor 1C JBrowse link 1 216,661,067 216,663,791 RGD:6480464
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:6480464
G Chst9 carbohydrate sulfotransferase 9 JBrowse link 18 6,833,408 7,115,815 RGD:6480464
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6480464
G Creg2 cellular repressor of E1A-stimulated genes 2 JBrowse link 9 46,328,088 46,402,237 RGD:6480464
G Cryl1 crystallin, lambda 1 JBrowse link 15 37,543,727 37,663,586 RGD:6480464
G Cul2 cullin 2 JBrowse link 17 56,952,480 56,992,716 RGD:6480464
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link 13 45,314,952 45,318,856 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:6480464
G Depp1 DEPP1, autophagy regulator JBrowse link 4 148,780,330 148,784,566 RGD:6480464
G Dhcr24 24-dehydrocholesterol reductase JBrowse link 5 126,164,708 126,188,926 RGD:6480464
G Dhtkd1 dehydrogenase E1 and transketolase domain containing 1 JBrowse link 17 76,306,585 76,358,058 RGD:6480464
G Dlat dihydrolipoamide S-acetyltransferase JBrowse link 8 55,062,549 55,087,832 RGD:6480464
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:6480464
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link 9 82,436,453 82,444,669 RGD:6480464
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 JBrowse link 6 64,165,913 64,170,122 RGD:6480464
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 JBrowse link 3 67,538,289 67,578,308 RGD:6480464
G Dnajc4 DnaJ heat shock protein family (Hsp40) member C4 JBrowse link 1 222,242,889 222,247,115 RGD:6480464
G Dusp4 dual specificity phosphatase 4 JBrowse link 16 61,080,767 61,090,973 RGD:6480464
G Dusp5 dual specificity phosphatase 5 JBrowse link 1 274,245,184 274,258,595 RGD:6480464
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:6480464
G Egln2 egl-9 family hypoxia-inducible factor 2 JBrowse link 1 83,969,456 83,977,665 RGD:6480464
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 6 75,050,329 75,075,795 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Elob elongin B JBrowse link 10 13,163,032 13,168,217 RGD:6480464
G Eloc elongin C JBrowse link 5 2,042,991 2,059,357 RGD:6480464
G Emp1 epithelial membrane protein 1 JBrowse link 4 169,161,076 169,181,967 RGD:6480464
G Eno2 enolase 2 JBrowse link 4 157,285,192 157,294,090 RGD:6480464
G Eno3 enolase 3 JBrowse link 10 57,278,271 57,283,661 RGD:6480464
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6480464
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:6480464
G Ephx2 epoxide hydrolase 2 JBrowse link 15 42,757,241 42,794,211 RGD:6480464
G Epsti1 epithelial stromal interaction 1 JBrowse link 15 60,084,966 60,190,360 RGD:6480464
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:6480464
G Ero1b endoplasmic reticulum oxidoreductase 1 beta JBrowse link 17 90,709,394 90,783,110 RGD:6480464
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:6480464
G FAM120C family with sequence similarity 120C JBrowse link X 20,481,800 21,016,980 RGD:6480464
G Fdft1 farnesyl diphosphate farnesyl transferase 1 JBrowse link 15 46,339,248 46,367,302 RGD:6480464
G Fdps farnesyl diphosphate synthase JBrowse link 2 188,403,595 188,413,219 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gpc5 glypican 5 JBrowse link 15 100,283,131 101,776,838 RGD:6480464
G Gpi glucose-6-phosphate isomerase JBrowse link 1 90,063,411 90,091,287 RGD:6480464
G Gsta1 glutathione S-transferase alpha 1 JBrowse link 9 27,366,404 27,381,004 RGD:6480464
G Gsta4 glutathione S-transferase alpha 4 JBrowse link 8 85,497,557 85,514,732 RGD:6480464
G Gstk1 glutathione S-transferase kappa 1 JBrowse link 4 71,621,777 71,626,096 RGD:6480464
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:6480464
G Gstm3 glutathione S-transferase mu 3 JBrowse link 2 210,685,204 210,688,273 RGD:6480464
G Gstm5 glutathione S-transferase, mu 5 JBrowse link 2 210,685,338 210,688,133 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Gstz1 glutathione S-transferase zeta 1 JBrowse link 6 111,176,798 111,187,246 RGD:6480464
G H1f4 H1.4 linker histone, cluster member JBrowse link 17 43,734,461 43,735,120 RGD:6480464
G Hebp1 heme binding protein 1 JBrowse link 4 168,903,586 168,933,102 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor JBrowse link 1 264,309,214 264,319,269 RGD:6480464
G Hif3a hypoxia inducible factor 3 subunit alpha JBrowse link 1 78,976,318 78,997,869 RGD:6480464
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:6480464
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6480464
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase JBrowse link 5 154,294,841 154,308,582 RGD:6480464
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:6480464
G Hspa2 heat shock protein family A (Hsp70) member 2 JBrowse link 6 99,433,575 99,436,288 RGD:6480464
G Htra2 HtrA serine peptidase 2 JBrowse link 4 113,883,671 113,886,833 RGD:6480464
G Ier3 immediate early response 3 JBrowse link 20 3,438,798 3,440,002 RGD:6480464
G Iqcd IQ motif containing D JBrowse link 12 41,490,451 41,507,416 RGD:6480464
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 JBrowse link 10 99,330,894 99,391,551 RGD:6480464
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:6480464
G Lama1 laminin subunit alpha 1 JBrowse link 9 115,916,907 116,042,123 RGD:6480464
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:6480464
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase JBrowse link 12 16,117,767 16,126,211 RGD:6480464
G Lgsn lengsin, lens protein with glutamine synthetase domain JBrowse link 9 37,458,603 37,490,117 RGD:6480464
G LOC103690190 histone H2A type 1-E JBrowse link 17 44,747,686 44,748,229 RGD:6480464
G Lyrm9 LYR motif containing 9 JBrowse link 10 66,099,478 66,113,559 RGD:6480464
G Mab21l4 mab-21 like 4 JBrowse link 9 100,296,780 100,307,415 RGD:6480464
G Mafb MAF bZIP transcription factor B JBrowse link 3 156,338,993 156,340,913 RGD:6480464
G Manf mesencephalic astrocyte-derived neurotrophic factor JBrowse link 8 115,623,175 115,626,408 RGD:6480464
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mdh1 malate dehydrogenase 1 JBrowse link 14 106,378,349 106,393,642 RGD:6480464
G Mdh2 malate dehydrogenase 2 JBrowse link 12 23,941,451 23,954,406 RGD:6480464
G Mgst1 microsomal glutathione S-transferase 1 JBrowse link 4 172,119,382 172,134,609 RGD:6480464
G Mgst3 microsomal glutathione S-transferase 3 JBrowse link 13 85,601,499 85,622,392 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Mvd mevalonate diphosphate decarboxylase JBrowse link 19 55,258,910 55,268,933 RGD:6480464
G Myo5c myosin VC JBrowse link 8 82,171,296 82,248,109 RGD:6480464
G Neurl1b neuralized E3 ubiquitin protein ligase 1B JBrowse link 10 17,048,251 17,075,139 RGD:6480464
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 JBrowse link 8 106,317,038 106,429,535 RGD:6480464
G Nppb natriuretic peptide B JBrowse link 5 164,796,176 164,797,538 RGD:6480464
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 JBrowse link 1 131,447,671 131,465,749 RGD:6480464
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 JBrowse link 7 142,899,358 142,920,216 RGD:6480464
G Nrip3 nuclear receptor interacting protein 3 JBrowse link 1 174,385,424 174,411,141 RGD:6480464
G Ntn4 netrin 4 JBrowse link 7 34,533,543 34,649,330 RGD:6480464
G Ogdhl oxoglutarate dehydrogenase L JBrowse link 16 8,497,495 8,523,552 RGD:6480464
G Osr2 odd-skipped related transciption factor 2 JBrowse link 7 74,047,820 74,055,096 RGD:6480464
G Palm3 paralemmin 3 JBrowse link 19 25,143,464 25,152,275 RGD:6480464
G Pdgfrl platelet-derived growth factor receptor-like JBrowse link 16 54,386,269 54,450,426 RGD:6480464
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 JBrowse link X 37,329,779 37,343,410 RGD:6480464
G Pdzk1 PDZ domain containing 1 JBrowse link 2 198,965,685 198,999,323 RGD:6480464
G Pfdn2 prefoldin subunit 2 JBrowse link 13 89,725,113 89,743,849 RGD:6480464
G Pfkm phosphofructokinase, muscle JBrowse link 7 139,702,066 139,722,132 RGD:6480464
G Pgm1 phosphoglucomutase 1 JBrowse link 5 118,743,632 118,803,055 RGD:6480464
G Phlda2 pleckstrin homology-like domain, family A, member 2 JBrowse link 1 216,701,345 216,704,479 RGD:6480464
G Pigz phosphatidylinositol glycan anchor biosynthesis, class Z JBrowse link 11 72,930,040 72,936,002 RGD:6480464
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:6480464
G Plaur plasminogen activator, urokinase receptor JBrowse link 1 81,328,171 81,344,954 RGD:6480464
G Plk2 polo-like kinase 2 JBrowse link 2 41,911,143 41,916,901 RGD:6480464
G Plk3 polo-like kinase 3 JBrowse link 5 135,997,725 136,002,900 RGD:6480464
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:6480464
G Rasd1 ras related dexamethasone induced 1 JBrowse link 10 46,330,361 46,339,326 RGD:6480464
G Rbks ribokinase JBrowse link 6 26,051,568 26,128,762 RGD:6480464
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:6480464
G Reep1 receptor accessory protein 1 JBrowse link 4 99,618,622 99,735,329 RGD:6480464
G RGD1564664 similar to LOC387763 protein JBrowse link 3 82,854,779 82,856,171 RGD:6480464
G Rgs16 regulator of G-protein signaling 16 JBrowse link 13 71,163,411 71,185,147 RGD:6480464
G Rhoc ras homolog family member C JBrowse link 2 207,271,692 207,278,010 RGD:6480464
G Rnf128 ring finger protein 128 JBrowse link X 110,789,061 110,877,964 RGD:6480464
G Rps27a ribosomal protein S27a JBrowse link 14 113,966,163 113,968,440 RGD:6480464
G Sc5d sterol-C5-desaturase JBrowse link 8 46,525,406 46,537,014 RGD:6480464
G Serpinb8 serpin family B member 8 JBrowse link 13 27,876,662 27,914,038 RGD:6480464
G Serpine2 serpin family E member 2 JBrowse link 9 85,560,852 85,629,410 RGD:6480464
G Sil1 SIL1 nucleotide exchange factor JBrowse link 18 28,067,476 28,302,008 RGD:6480464
G Slc16a3 solute carrier family 16 member 3 JBrowse link 10 110,138,519 110,148,360 RGD:6480464
G Slc1a1 solute carrier family 1 member 1 JBrowse link 1 246,955,017 247,035,159 RGD:6480464
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6480464
G Smim14 small integral membrane protein 14 JBrowse link 14 44,413,636 44,460,044 RGD:6480464
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:6480464
G Sox8 SRY-box transcription factor 8 JBrowse link 10 14,932,348 14,937,336 RGD:6480464
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:6480464
G Stard4 StAR-related lipid transfer domain containing 4 JBrowse link 18 25,982,210 25,997,555 RGD:6480464
G Tbc1d8b TBC1 domain family member 8B JBrowse link X 110,894,831 110,983,269 RGD:6480464
G Tcp1 t-complex 1 JBrowse link 1 48,025,664 48,033,343 RGD:6480464
G Tmem54 transmembrane protein 54 JBrowse link 5 147,288,700 147,295,191 RGD:6480464
G Tor1a torsin family 1, member A JBrowse link 3 9,800,322 9,807,318 RGD:6480464
G Tpi1 triosephosphate isomerase 1 JBrowse link 4 157,328,375 157,331,905 RGD:6480464
G Tubb3 tubulin, beta 3 class III JBrowse link 19 56,220,759 56,229,813 RGD:6480464
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 JBrowse link 16 20,668,925 20,671,127 RGD:6480464
G Ubb ubiquitin B JBrowse link 10 48,880,231 48,881,896 RGD:6480464
G Ubc ubiquitin C JBrowse link 12 36,638,457 36,642,734 RGD:6480464
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 JBrowse link 20 18,547,370 18,580,291 RGD:6480464
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 JBrowse link 18 28,561,957 28,603,335 RGD:6480464
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 JBrowse link 2 240,626,198 240,655,874 RGD:6480464
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 JBrowse link 9 42,692,156 42,805,680 RGD:6480464
G Vasn vasorin JBrowse link 10 11,121,041 11,131,548 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Wnt6 Wnt family member 6 JBrowse link 9 82,033,543 82,047,172 RGD:6480464
G Zc3h6 zinc finger CCCH type containing 6 JBrowse link 3 121,497,709 121,554,131 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      biological role 19716
        poison 17974
          toxin 13894
            dinophysistoxin 1 164
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            heteroorganic entity 19129
                              organochalcogen compound 18828
                                organooxygen compound 18747
                                  ether 15857
                                    cyclic ether 6655
                                      polycyclic ether 1307
                                        okadaic acid 447
                                          dinophysistoxin 1 164
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.